发明申请
- 专利标题： Affinity Maturated T Cell Receptors And Use Thereof
- 专利标题（中）： 亲和性成熟T细胞受体及其用途
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申请号： US13958277申请日： 2013-08-02
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公开(公告)号： US20140065111A1公开(公告)日： 2014-03-06
- 发明人: Lea Eisenbach , Yosi Gozlan , Esther Tzehoval
- 申请人： Lea Eisenbach , Yosi Gozlan , Esther Tzehoval
- 主分类号： C07K14/705
- IPC分类号： C07K14/705 ; A61K35/14
摘要：
The present invention relates to methods and systems for increasing the affinity of a T cell receptor (TCR) to its ligand by subjecting the TCR gene to somatic hypermutation. The present invention further relates to use of affinity maturated TCRs to create T cells reactive against a selected antigen.
公开/授权文献
- US10081663B2 Affinity maturated T cell receptors and use thereof 公开/授权日：2018-09-25
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