公开(公告)号：US20100273743A1

公开(公告)日：2010-10-28

申请号：US12429661

申请日：2009-04-24

Applicant: Philip Keith Moore ,  Choon-Hong Tan ,  Ling Li ,  Yan Yi Guan

Inventor： Philip Keith Moore ,  Choon-Hong Tan ,  Ling Li ,  Yan Yi Guan

IPC: A61K31/675 ,  A61K31/66

CPC classification number: A61K31/675 ,  A61K31/66 ,  A61K31/662 ,  Y10S514/885 ,  Y10S514/957

Abstract: The invention is directed to a method of administering hydrogen sulfide (H2S) slowly and sustainably to an individual in need thereof comprising administering an effective amount of a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明涉及向有需要的个体缓慢且可持续地施用硫化氢（H 2 S）的方法，其包括给予有效量的由下列结构式表示的化合物或其药学上可接受的盐。

公开(公告)号：US07554377B1

公开(公告)日：2009-06-30

申请号：US11856242

申请日：2007-09-17

Applicant: Charles Yong Yi Guan

Inventor： Charles Yong Yi Guan

IPC: H03K3/17

CPC classification number: H03K5/082 ,  H03F3/45094 ,  H03F2200/456 ,  H03F2203/45028 ,  H03K5/2481

Abstract: A circuit and method for limiting a signal voltage in which the minimum and maximum levels of the output signal can be controlled by selectively applying different lower and higher reference voltages from which the minimum and maximum output signal levels are derived.

Abstract translation: 用于限制信号电压的电路和方法，其中可以通过选择性地施加从其导出最小和最大输出信号电平的不同的较低和较高参考电压来控制输出信号的最小和最大电平。

公开(公告)号：US20080166439A1

公开(公告)日：2008-07-10

申请号：US12030997

申请日：2008-02-14

Applicant: Desheng TAO ,  Yongqing ZENG ,  Hui CAO ,  Yi GUAN

Inventor： Desheng TAO ,  Yongqing ZENG ,  Hui CAO ,  Yi GUAN

IPC: A61K36/00 ,  A61P31/16

CPC classification number: A61K36/11 ,  A61K36/232 ,  A61K36/282 ,  A61K36/315 ,  A61K36/355 ,  A61K36/489 ,  A61K36/78 ,  A61K36/896 ,  A61K2300/00

Abstract: A Chinese traditional medicine composition for prevention and treatment of avian influenza is provided. Its active ingredients are consisted of: herba houttuyniae 21.4 wt. %, Caulis lonicerae japonicae 17.9 wt. %, radix isatidis 14.3 wt. %, male fern rhizome 10.7 wt. %, radix et rhizoma sophorae tonkinensis 7.1 wt. %, radix angelicae dahuricae 7.1 wt. %, rhizoma paridis 7.1 wt. %, herba artemisiae annuae 7.2 wt. %, and rhizoma iridis tectoris 7.2 wt. %. This Chinese traditional medicine composition could be made into any regular medicinal types, for example, oral solutions, tablets, capsules, pellets and injection solution, etc. Modified preparation methods for this Chinese traditional medicine composition, as well as the use of the same in preparation of medicines and health foods for prevention or treatment of avian influenza were also provided in present invention. This Chinese traditional medicine composition could effectively prevent and treat avian influenza. It was a safer, more easily-obtained, and inexpensive anti-avian influenza drug.

Abstract translation: 提供了一种预防和治疗禽流感的中药组合物。 其活性成分包括：her e 21.4重量％ ％，金银花17.9重量％ ％，丹参14.3重量％ ％，雄蕨根茎10.7wt。 ％，radix et rhizoma sophorae tonkinensis 7.1 wt。 ％，当归丹参7.1重量％ ％，百草枯7.1重量％ ％，峨眉草7.2重量％ ％，和根瘤菌7.2重量％ ％。 这种中药组合物可以制成任何常规药物类型，例如口服溶液，片剂，胶囊，丸剂和注射液等。这种中药组合物的改良制剂方法以及其用途 本发明还提供了预防或治疗禽流感的药物和保健食品的制备。 这种中药组合物可以有效预防和治疗禽流感。 这是一种更安全，更容易获得和便宜的抗禽流感药物。

公开(公告)号：US07375202B2

公开(公告)日：2008-05-20

申请号：US10808121

申请日：2004-03-24

Applicant: Joseph S. M. Peiris ,  Kwok Yung Yuen ,  Lit Man Poon ,  Yi Guan ,  Kwok Hung Chan ,  John M. Nicholls ,  Frederick C. Leung

Inventor： Joseph S. M. Peiris ,  Kwok Yung Yuen ,  Lit Man Poon ,  Yi Guan ,  Kwok Hung Chan ,  John M. Nicholls ,  Frederick C. Leung

IPC: C07H21/02 ,  C07H19/00

CPC classification number: A61K39/215 ,  A61K39/12 ,  A61K2039/6031 ,  C12N7/00 ,  C12N2770/20021 ,  C12N2770/20034 ,  C12Q1/6844 ,  C12Q1/701

Abstract: The present invention relates to an isolated novel virus causing Severe Acute Respiratory Syndrome (SARS) in humans (“hSARS virus”). The hSARS virus is identified to be morphologically and phylogenetically similar to known member of Coronaviridae. The present invention provides the complete genomic sequence of the hSARS virus. Furthermore, the invention provides the nucleic acids and peptides encoded by and/or derived from the hSARS virus and their use in diagnostic methods and therapeutic methods, including vaccines. In addition, the invention provides chimeric or recombinant viruses encoded by said nucleotide sequences and antibodies immunospecific to the polypeptides encoded by the nucleotide sequences.

Abstract translation: 本发明涉及在人类中引起严重急性呼吸综合征（SARS）的分离的新型病毒（“hSARS病毒”）。 鉴定hSARS病毒在形态和系统发育上与已知的冠状病毒科成员相似。 本发明提供了hSARS病毒的完整基因组序列。 此外，本发明提供由hSARS病毒编码和/或衍生自hSARS病毒的核酸和肽，以及它们在诊断方法和治疗方法（包括疫苗）中的用途。 此外，本发明提供由所述核苷酸序列编码的嵌合或重组病毒和对由核苷酸序列编码的多肽免疫特异性的抗体。

公开(公告)号：US20060258611A1

公开(公告)日：2006-11-16

申请号：US11452267

申请日：2006-06-14

Applicant: Hsiang-Fu Kung ,  Ming-Liang He ,  Bo-Jiang Zheng ,  Yi Guan ,  Marie Lin ,  Ying Peng

Inventor： Hsiang-Fu Kung ,  Ming-Liang He ,  Bo-Jiang Zheng ,  Yi Guan ,  Marie Lin ,  Ying Peng

IPC: A61K48/00 ,  C07H21/02 ,  C12P21/06 ,  C12N15/86 ,  C07K14/165

CPC classification number: C12N15/1131 ,  A61K39/00 ,  A61K48/005 ,  A61K2039/53 ,  C07K14/005 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2770/20022

Abstract: The present invention relates to therapeutic agents useful for the treatment of Severe Acute Respiratory Syndrome (SARS) in humans. In particular, the present invention relates to RNA interference (RNAi) molecules useful for inhibiting the infection and replication of hSARS virus. Preferably, the RNAi molecules target the replicase region of the hSARS virus, or combinations of different sites of hSARS virus genes. The present invention further encompasses methods of using the RNAi molecules for preventing and/or treating SARS. Vaccines and kits comprising therapeutically effective amounts of the RNAi molecules are also encompassed.

公开(公告)号：US20050004063A1

公开(公告)日：2005-01-06

申请号：US10848737

申请日：2004-05-19

Applicant: Hsiang-Fu Kung ,  Ming-Liang He ,  Bo-Jiang Zheng ,  Yi Guan ,  Marie Lin ,  Ying Peng

Inventor： Hsiang-Fu Kung ,  Ming-Liang He ,  Bo-Jiang Zheng ,  Yi Guan ,  Marie Lin ,  Ying Peng

IPC: A61K39/00 ,  A61K48/00 ,  C07K14/165 ,  C12N15/113 ,  C07H21/04 ,  C12Q1/70

CPC classification number: C12N15/1131 ,  A61K39/00 ,  A61K48/005 ,  A61K2039/53 ,  C07K14/005 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2770/20022

Abstract: The present invention relates to therapeutic agents useful for the treatment of Severe Acute Respiratory Syndrome (SARS) in humans. In particular, the present invention relates to RNA interference (RNAi) molecules useful for inhibiting the infection and replication of hSARS virus. Preferably, the RNAi molecules target the replicase region of the hSARS virus, or combinations of different sites of hSARS virus genes. The present invention further encompasses methods of using the RNAi molecules for preventing and/or treating SARS. Vaccines and kits comprising therapeutically effective amounts of the RNAi molecules are also encompassed.

Abstract translation: 本发明涉及可用于治疗人类中严重急性呼吸综合征（SARS）的治疗剂。 特别地，本发明涉及可用于抑制hSARS病毒的感染和复制的RNA干扰（RNAi）分子。 优选地，RNAi分子靶向hSARS病毒的复制酶区域或hSARS病毒基因的不同位点的组合。 本发明还包括使用RNAi分子来预防和/或治疗SARS的方法。 还包括包含治疗有效量的RNAi分子的疫苗和试剂盒。

公开(公告)号：US06577083B1

公开(公告)日：2003-06-10

申请号：US09973789

申请日：2001-10-09

Applicant: Charles Yong Yi Guan

Inventor： Charles Yong Yi Guan

IPC: G09G104

CPC classification number: H04N3/2335 ,  G09G1/04

Abstract: A method and apparatus for vertical S linearity correction with no external components. A periodic waveform may be cubed to produce a second waveform. This second waveform may be sampled to obtain a peak value of the periodic waveform. The peak value may be multiplied by a constant to produce an offset value. The offset value may be subtracted from the second waveform to produce a third waveform. This third waveform may be added to the periodic ramp voltage. Consequently, the periodic waveform is modified by a cubic waveform.

Abstract translation: 一种没有外部元件的垂直S线性校正的方法和装置。 周期波形可以立方以产生第二波形。 该第二波形可被采样以获得周期性波形的峰值。 峰值可以乘以常数以产生偏移值。 可以从第二波形中减去偏移值，以产生第三波形。 该第三波形可以被添加到周期性斜坡电压。 因此，周期波形被三次波形修改。

公开(公告)号：US20140023732A1

公开(公告)日：2014-01-23

申请号：US13990920

申请日：2011-12-28

Applicant: Hui Cao ,  Yi Guan ,  Yongqing Zeng ,  Desheng Tao

Inventor： Hui Cao ,  Yi Guan ,  Yongqing Zeng ,  Desheng Tao

IPC: A61K36/67 ,  A61K36/282 ,  A61K36/484 ,  A61K36/315

CPC classification number: A61K36/67 ,  A61K9/1623 ,  A61K36/11 ,  A61K36/19 ,  A61K36/232 ,  A61K36/282 ,  A61K36/315 ,  A61K36/355 ,  A61K36/484 ,  A61K36/489 ,  A61K36/78 ,  A61K36/88 ,  A61K36/896 ,  A61K2300/00

Abstract: Disclosed is a use of a pharmaceutical composition in preparation of anti-enterovirus 71 agents.

Abstract translation: 公开了药物组合物在制备抗肠道病毒71剂中的用途。

公开(公告)号：US08361708B2

公开(公告)日：2013-01-29

申请号：US12703418

申请日：2010-02-10

Applicant: Joseph S. M. Peiris ,  Kwok Yung Yuen ,  Lit Man Poon ,  Yi Guan ,  Kwok Hung Chan ,  John M. Nicholls ,  Frederick C. Leung

Inventor： Joseph S. M. Peiris ,  Kwok Yung Yuen ,  Lit Man Poon ,  Yi Guan ,  Kwok Hung Chan ,  John M. Nicholls ,  Frederick C. Leung

IPC: C12Q1/70 ,  C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C07H21/02 ,  A61K39/395 ,  A61K39/00 ,  A61K39/42

CPC classification number: A61K39/215 ,  A61K39/12 ,  A61K2039/6031 ,  C12N7/00 ,  C12N2770/20021 ,  C12N2770/20034 ,  C12Q1/6844 ,  C12Q1/701

Abstract: The present invention relates to an isolated novel virus causing Severe Acute Respiratory Syndrome (SARS) in humans (“hSARS virus”). The hSARS virus is identified to be morphologically and phylogenetically similar to known member of Coronaviridae. The present invention provides the complete genomic sequence of the hSARS virus. Furthermore, the invention provides the nucleic acids and peptides encoded by and/or derived from the hSARS virus and their use in diagnostic methods and therapeutic methods, including vaccines. In addition, the invention provides chimeric or recombinant viruses encoded by said nucleotide sequences and antibodies immunospecific to the polypeptides encoded by the nucleotide sequences.

Abstract translation: 本发明涉及一种在人类中引起严重急性呼吸综合征（SARS）的分离型新病毒（hSARS病毒）。 鉴定hSARS病毒在形态和系统发育上与已知的冠状病毒科成员相似。 本发明提供了hSARS病毒的完整基因组序列。 此外，本发明提供由hSARS病毒编码和/或衍生自hSARS病毒的核酸和肽，以及它们在诊断方法和治疗方法（包括疫苗）中的用途。 此外，本发明提供由所述核苷酸序列编码的嵌合或重组病毒和对由核苷酸序列编码的多肽免疫特异性的抗体。

公开(公告)号：US20120093951A1

公开(公告)日：2012-04-19

申请号：US13377862

申请日：2010-06-17

Applicant: Desheng Tao ,  Yongging Zeng ,  Hui Cao ,  Yi Guan

Inventor： Desheng Tao ,  Yongging Zeng ,  Hui Cao ,  Yi Guan

IPC: A61K36/78 ,  A61K36/315 ,  A61K36/489 ,  A61K36/232 ,  A61K36/19 ,  A61P31/16 ,  A61K36/282 ,  A61K36/80 ,  A61K36/534 ,  A61K36/346 ,  A61K36/484 ,  A61K36/355 ,  A61K36/906

CPC classification number: A61K36/78 ,  A61K31/12 ,  A61K36/11 ,  A61K36/185 ,  A61K36/19 ,  A61K36/232 ,  A61K36/282 ,  A61K36/288 ,  A61K36/315 ,  A61K36/34 ,  A61K36/355 ,  A61K36/484 ,  A61K36/489 ,  A61K36/534 ,  A61K36/70 ,  A61K36/88 ,  A61K36/896 ,  A61K2300/00

Abstract: The present invention relates to a traditional Chinese medicine composition for preventing and treating swine influenza, preparation method and use thereof. The said traditional Chinese medicine composition is made from Herba Houttuyniae 21.4 wt. %, Caulis Lonicerae Japonicae 17.9 wt. %, Radix Isatidis 14.3 wt. %, Rhizoma Dryopteris Crassirhizomatis 10.7%, Radix et Rhizoma Sophorae Tonkinensis 7.1 wt. %, Radix Angelicae Dahuricae 7.1 wt. %, Rhizoma Paridis 7.1 wt. %, Herba Artemisiae Annuae 7.1 wt. %, and Rhizoma Iridis Tectori 7.1 wt. %.

Abstract translation: 本发明涉及一种预防和治疗猪流感的中药组合物及其制备方法及用途。 所述中药组合物由鱼腥草21.4重量％ ％，金银花金银花17.9重量％ ％，石斛兰14.3重量％ ％，Rhizoma Dryopteris Crassirhizomatis 10.7％，Radix et Rhizoma Sophorae Tonkinensis 7.1 wt。 ％，当归甘草7.1重量％ ％，百日草7.1重量％ ％，蒿蒿7.1重量％ ％，枸杞子（Rhizoma Iridis Tectori）7.1重量％ ％。