公开(公告)号：US20060228357A1

公开(公告)日：2006-10-12

申请号：US11389358

申请日：2006-03-24

Applicant: Chien Chang ,  David Goldenberg ,  William McBride ,  Edmund Rossi

Inventor： Chien Chang ,  David Goldenberg ,  William McBride ,  Edmund Rossi

IPC: C12Q1/70 ,  G01N33/574 ,  A61K39/395 ,  C07K14/82 ,  C07K16/30 ,  C07K14/415 ,  A61K39/00 ,  C07K16/46

CPC classification number: C12N9/12 ,  B82Y5/00 ,  B82Y10/00 ,  C07K16/18 ,  C07K16/2803 ,  C07K16/2887 ,  C07K16/3007 ,  C07K16/3092 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2319/00 ,  C07K2319/70 ,  C12Y207/11011

Abstract: The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular embodiments concern homodimers comprising monomers that contain a dimerization and docking domain attached to a precursor. The precursors may be virtually any molecule or structure, such as antibodies, antibody fragments, antibody analogs or mimetics, aptamers, binding peptides, fragments of binding proteins, known ligands for proteins or other molecules, enzymes, detectable labels or tags, therapeutic agents, toxins, pharmaceuticals, cytokines, interleukins, interferons, radioisotopes, proteins, peptides, peptide mimetics, polynucleotides, RNAi, oligosaccharides, natural or synthetic polymeric substances, nanoparticles, quantum dots, organic or inorganic compounds, etc. Other embodiments concern tetramers comprising a first and second homodimer, which may be identical or different. The disclosed methods and compositions provide a facile and general way to obtain homodimers, homotetramers and heterotetramers of virtually any functionality and/or binding specificity.

公开(公告)号：US5997844A

公开(公告)日：1999-12-07

申请号：US253678

申请日：1994-06-03

Applicant: Richard T. Dean ,  Scott Buttram ,  William McBride ,  John Lister-James ,  Edgar R. Civitello

Inventor： Richard T. Dean ,  Scott Buttram ,  William McBride ,  John Lister-James ,  Edgar R. Civitello

IPC: A61K51/00 ,  A61K51/08 ,  C07K14/00 ,  A61M36/14

CPC classification number: A61K51/08 ,  A61K51/083 ,  A61K51/088 ,  A61K2121/00 ,  A61K2123/00

Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety covalently attached to a specific binding peptide via an amino acid side-chain of the peptide.

公开(公告)号：US5965107A

公开(公告)日：1999-10-12

申请号：US871282

申请日：1992-04-20

Applicant: Richard T. Dean ,  Scott Buttram ,  William McBride ,  John Lister-James ,  Edgar R. Civitello

Inventor： Richard T. Dean ,  Scott Buttram ,  William McBride ,  John Lister-James ,  Edgar R. Civitello

IPC: A61K51/00 ,  A61K51/08 ,  C07F13/00 ,  C07K1/113 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/47 ,  C07K14/745 ,  C07K14/75 ,  A61M36/14

CPC classification number: A61K51/088 ,  A61K51/08 ,  A61K51/082 ,  A61K2121/00 ,  A61K2123/00

Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety which forms a neutral complex with Tc-99m.

Abstract translation: 本发明涉及放射性标记的肽及其生产方法。 具体地说，本发明涉及用于制备这些肽的肽，方法和试剂盒，以及使用这些肽以经锝-99m（Tc-99m）标记的哺乳动物体内的位点，通过形成中性复合物的放射性标记结合部分 与Tc-99m。

公开(公告)号：US5955426A

公开(公告)日：1999-09-21

申请号：US776160

申请日：1997-06-30

Applicant: Richard T Dean ,  William McBride ,  John Lister-James

Inventor： Richard T Dean ,  William McBride ,  John Lister-James

IPC: A61K38/04 ,  A61K38/00 ,  A61K51/00 ,  A61K51/08 ,  A61P35/00 ,  C07K7/50 ,  C07K7/64 ,  C07K14/655

CPC classification number: C07K14/6555 ,  A61K51/08 ,  A61K51/083 ,  A61K38/00

Abstract: This invention relates to therapeutic reagents and peptides, including radiotherapeutic reagents and peptides, and radiodiagnostic reagents and peptides. Specifically, the invention relates to cyclic peptide derivatives and analogs of somatostatin, and embodiments of such peptides radiolabeled with a radiosiotope, as well as methods for using such peptides for radiodiagnostic and radiotherapeutic purposes.

Abstract translation: PCT No.PCT / US95 / 09276 Sec。 371日期：1997年6月30日 102（e）日期1997年6月30日PCT提交1995年7月20日PCT公布。 公开号WO96 / 04308 日期1996年2月15日本发明涉及治疗试剂和肽，包括放射治疗试剂和肽，以及放射诊断试剂和肽。 具体而言，本发明涉及生长抑素的环肽衍生物和类似物以及放射性标记的放射性物质的这些肽的实施方案，以及使用这些肽用于放射诊断和放射治疗目的的方法。

公开(公告)号：US5814297A

公开(公告)日：1998-09-29

申请号：US471741

申请日：1995-06-06

Applicant: Richard T. Dean ,  William McBride ,  Scott Buttram

Inventor： Richard T. Dean ,  William McBride ,  Scott Buttram

IPC: A61K51/00 ,  A61K38/00 ,  A61K51/08 ,  C07B59/00 ,  C07F13/00 ,  C07K5/10 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/775 ,  A61M36/14

CPC classification number: C07K7/06 ,  A61K51/08 ,  A61K51/082 ,  A61K51/088 ,  C07B59/008 ,  C07K14/775 ,  A61K2121/00 ,  A61K2123/00 ,  A61K38/00 ,  Y10S930/28

Abstract: The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention provides peptides which bind Tc-99m and which can be targeted to specific sites within a mammalian body.

Abstract translation: 本发明涉及哺乳动物体的放射性标记成像。 本发明特别提供了用于这种成像的用锝-99m标记的试剂。 本发明提供结合Tc-99m并可靶向哺乳动物体内特定位点的肽。

公开(公告)号：US5776428A

公开(公告)日：1998-07-07

申请号：US468975

申请日：1995-06-06

Applicant: Richard T. Dean ,  Scott Buttram ,  William McBride ,  John Lister-James ,  Edgar R. Civitello

Inventor： Richard T. Dean ,  Scott Buttram ,  William McBride ,  John Lister-James ,  Edgar R. Civitello

IPC: A61K51/00 ,  A61K51/08 ,  C07F13/00 ,  C07K1/113 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/47 ,  C07K14/745 ,  C07K14/75 ,  A61M36/14

CPC classification number: A61K51/088 ,  A61K51/08 ,  A61K51/082 ,  A61K2121/00 ,  A61K2123/00

Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety which forms a neutral complex with Tc-99m.

公开(公告)号：US5620675A

公开(公告)日：1997-04-15

申请号：US95760

申请日：1993-07-21

Applicant: William McBride ,  Richard T. Dean

Inventor： William McBride ,  Richard T. Dean

IPC: A61K51/00 ,  A61K38/00 ,  A61K51/08 ,  C07F7/22 ,  C07F13/00 ,  C07K1/04 ,  C07K5/083 ,  C07K5/10 ,  C07K7/06 ,  C07K7/08 ,  C07K14/655 ,  A61K38/31

CPC classification number: C07K14/6555 ,  A61K51/083 ,  A61K51/088 ,  A61K2121/00 ,  A61K2123/00 ,  A61K38/00

Abstract: This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing label radiodiagnostic agents. Specifically, the invention relates to linear peptide derivatives and analogs of somatostatin, and embodiments of such peptides radiolabeled with a radioisotope, as well as methods and kits for making, radiolabeling and using such peptides for radiodiagnostic and radiotherapeutic purposes. The invention specifically relates to linear peptide derivatives and analogues of somatostatin radiolabeled with technetium-99m and uses thereof as scintigraphic imaging agents. The invention so specifically relates to liner peptide derivatives and analogues of somatostatin radiolabeled with cytotoxic radioisotopes such as rhenium-186 (.sup.186 Re) and rhenium-188 (.sup.188 Re) for use as radiotherapeutic agents. Methods and kits for making, radiolabeling and using such peptides diagnostically and therapeutically in a mammalian body are also provide.

Abstract translation: 本发明涉及治疗试剂和肽，放射诊断试剂和肽，以及用于制备标记物放射诊断剂的方法。 具体地，本发明涉及生长抑素的线性肽衍生物和类似物，以及用放射性同位素放射性标记的这些肽的实施方案，以及用于制备放射性标记和用于放射诊断和放射治疗目的的这些肽的方法和试剂盒。 本发明具体涉及用锝-99m放射性标记的生长抑素的线性肽衍生物和类似物及其作为闪烁照相成像剂的用途。 本发明具体涉及用作放射性治疗剂放射性标记的细胞毒性放射性同位素如铼-186（186Re）和铼-188（188Re）的生长抑素的衬垫肽衍生物和类似物。 还提供了用于在哺乳动物体内制造，放射性标记和诊断和治疗使用这些肽的方法和试剂盒。

公开(公告)号：US20100088337A1

公开(公告)日：2010-04-08

申请号：US12572544

申请日：2009-10-02

Applicant: William McBride Fesq ,  Michael Emil Ogrinz

Inventor： William McBride Fesq ,  Michael Emil Ogrinz

IPC: G06F17/30

CPC classification number: G06F17/30241 ,  G06Q10/10

Abstract: The instant invention presents a system and method for performing local searches across one or more events created by one or more users. The system of the present invention comprises an event data structure comprising one or more user defined events, each event associated with a zip code. A zip list processor is provided to receive a zip code and a distance value, e.g., from user defined input, which are used to calculate a zip list comprising all zip codes geographically located with the distance value from the zip code. An event list generator to receives the zip list and queries the event data structure to retrieve events associated with zip codes contained in the zip list. The method of the present invention comprises creating an event data structure comprising one or more user defined events, each event associated with a zip code, calculating a zip list comprising all zip codes geographically located within a distance equal to a received distance value from a received zip code, and querying the event data structure to retrieve events associated with zip codes contained in the zip list.

Abstract translation: 本发明提出了一种用于在由一个或多个用户创建的一个或多个事件上执行本地搜索的系统和方法。 本发明的系统包括包括一个或多个用户定义的事件的事件数据结构，每个事件与邮政编码相关联。 提供压缩列表处理器以接收例如用户定义的输入的邮政编码和距离值，所述距离值用于计算包含地理位置上与邮政编码的距离值的所有邮政编码的邮政编码。 一个事件列表生成器，用于接收zip列表，并查询事件数据结构以检索与zip列表中包含的邮​​政编码相关联的事件。 本发明的方法包括创建包括一个或多个用户定义的事件的事件数据结构，与邮政编码相关联的每个事件，计算一个zip列表，该列表包括地理上位于等于从接收到的接收到的距离值的距离内的所有邮政编码 邮政编码，并查询事件数据结构，以检索与zip列表中包含的邮​​政编码相关联的事件。

公开(公告)号：US20070086942A1

公开(公告)日：2007-04-19

申请号：US11478021

申请日：2006-06-29

Applicant: Chien Chang ,  David Goldenberg ,  William McBride ,  Edmund Rossi

Inventor： Chien Chang ,  David Goldenberg ,  William McBride ,  Edmund Rossi

IPC: A61K51/00 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/554 ,  C07K16/46

CPC classification number: A61K47/48438 ,  A61K31/00 ,  A61K38/00 ,  A61K47/48415 ,  A61K47/48484 ,  A61K47/485 ,  A61K47/48538 ,  A61K47/48546 ,  A61K47/48561 ,  A61K47/48569 ,  A61K47/6811 ,  A61K47/6817 ,  A61K47/6829 ,  A61K47/6833 ,  A61K47/6843 ,  A61K47/6845 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y15/00 ,  C07K14/475 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/2833 ,  C07K16/2851 ,  C07K16/2863 ,  C07K16/2881 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/3007 ,  C07K16/3092 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/35 ,  C07K2319/70 ,  C07K2319/74 ,  C12N9/12 ,  C12N9/22 ,  C12N9/96 ,  C12Y207/11001 ,  G01N33/54353 ,  G01N33/588 ,  Y02A50/491

Abstract: The present invention concerns methods and compositions for making and using bioactive assemblies of defined compositions, which may have multiple functionalities and/or binding specificities. In particular embodiments, the bioactive assembly is formed using dock-and-lock (DNL) methodology, which takes advantage of the specific binding interaction between dimerization and docking domains (DDD) and anchoring domains (AD) to form the assembly. In various embodiments, one or more effectors may be attached to a DDD or AD sequence. Complementary AD or DDD sequences may be attached to an adaptor module that forms the core of the bioactive assembly, allowing formation of the assembly through the specific DDD/AD binding interactions. Such assemblies may be attached to a wide variety of effector moieties for treatment, detection and/or diagnosis of a disease, pathogen infection or other medical or veterinary condition.

Abstract translation: 本发明涉及用于制备和使用具有多种功能和/或结合特异性的限定组合物的生物活性组合物的方法和组合物。 在特定的实施方案中，生物活性组件使用对接和锁定（DNL）方法形成，其利用二聚化和对接结构域（DDD）和锚定结构域（AD）之间的特异性结合相互作用形成组件。 在各种实施方案中，一个或多个效应物可以连接到DDD或AD序列。 互补AD或DDD序列可以连接到形成生物活性组件核心的适配器模块，从而允许通过特定的DDD / AD结合相互作用形成组装体。 这些组合物可以连接到各种各样的效应部分，用于治疗，检测和/或诊断疾病，病原体感染或其他医学或兽医病症。

公开(公告)号：US20060140858A1

公开(公告)日：2006-06-29

申请号：US10514632

申请日：2003-05-16

Applicant: David Goldenberg ,  Hans Hansen ,  Shui-on Leung ,  William McBride ,  Zhengxing Gu

Inventor： David Goldenberg ,  Hans Hansen ,  Shui-on Leung ,  William McBride ,  Zhengxing Gu

IPC: A61K49/14 ,  A61K51/00 ,  C07K7/06

CPC classification number: A61K51/1048 ,  A61K47/665 ,  A61K47/6879 ,  A61K51/1063 ,  A61K2039/505 ,  B82Y5/00 ,  C07K5/0215 ,  C07K5/1016 ,  C07K5/1019 ,  C07K7/06 ,  C07K16/18 ,  C07K16/3007 ,  C07K16/3046 ,  C07K16/44 ,  C07K16/468 ,  C07K2317/12 ,  C07K2317/13 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2319/00

Abstract: The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds the targetable construct. The targetable construct comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable construct further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the targetable constructs and bi-specific antibodies or antibody fragments, as well as methods for using them.

Abstract translation: 本发明涉及可靶向的构建体，其可以由具有特异性结合靶组织的至少一个臂的双特异性抗体或抗体片段和至少一个特异性结合可靶向构建体的其它臂结合。 可靶向构建体包含载体部分，其包含或携带至少一个可被所述双特异性抗体或抗体片段的至少一个臂识别的表位。 可靶向构建物还包含一种或多种治疗剂或诊断剂或酶。 本发明提供用于产生可靶向构建体和双特异性抗体或抗体片段的构建体和方法，以及使用它们的方法。