发明申请
US20060140858A1 Drug pre-targeting by means of bi-specific antibodies and hapten constructs comprising a carrier peptide and the active agent(s)
审中-公开
通过双特异性抗体和包含载体肽和活性剂的半抗原构建体的药物预靶向，
- 专利标题： Drug pre-targeting by means of bi-specific antibodies and hapten constructs comprising a carrier peptide and the active agent(s)
- 专利标题（中）： 通过双特异性抗体和包含载体肽和活性剂的半抗原构建体的药物预靶向，
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申请号： US10514632申请日： 2003-05-16
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公开(公告)号： US20060140858A1公开(公告)日： 2006-06-29
- 发明人: David Goldenberg , Hans Hansen , Shui-on Leung , William McBride , Zhengxing Gu
- 申请人： David Goldenberg , Hans Hansen , Shui-on Leung , William McBride , Zhengxing Gu
- 申请人地址： US NJ Morris Plains
- 专利权人： Immunomedics, Inc.
- 当前专利权人： Immunomedics, Inc.
- 当前专利权人地址： US NJ Morris Plains
- 优先权： US10/150,654 20020517
- 国际申请： PCT/GB03/02110 WO 20030516
- 主分类号： A61K49/14
- IPC分类号： A61K49/14 ; A61K51/00 ; C07K7/06
摘要：
The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds the targetable construct. The targetable construct comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable construct further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the targetable constructs and bi-specific antibodies or antibody fragments, as well as methods for using them.
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