公开(公告)号：US08822907B2

公开(公告)日：2014-09-02

申请号：US13288007

申请日：2011-11-02

Applicant: Ralph Joerger ,  Michael Hermann ,  Wolfgang Holzapfel ,  Walter Huber

Inventor： Ralph Joerger ,  Michael Hermann ,  Wolfgang Holzapfel ,  Walter Huber

IPC: G01D5/34 ,  G01B11/24 ,  G01D5/38

CPC classification number: G01D5/38 ,  G01B11/2441

Abstract: An optical position-measuring device includes a scanning bar extending in a first or second direction, and a scale extending in the other direction. The scale is offset by a scanning distance from the scanning bar in a third direction perpendicular to the first and second directions. The device has a light source whose light penetrates the scanning bar at an intersection point of the scanning bar and scale to fall on the scale and arrive back at the scanning bar. At a detector, the light is split by diffraction into different partial beams at optically effective structures of the scanning bar and scale and combined again. A periodic signal is obtained in the detector in response to: a shift between the scanning bar and scale in the first direction due to interference of combined partial beams, and a change in the scanning distance between the scanning bar and scale.

Abstract translation: 光学位置测量装置包括沿第一或第二方向延伸的扫描杆和沿另一个方向延伸的刻度。 在与第一和第二方向垂直的第三方向上，刻度尺距离扫描杆的扫描距离偏移。 该装置具有光源，其光在扫描条和刻度的交点处穿过扫描条，落在刻度上并返回扫描条。 在检测器处，通过衍射将光分解成不同的部分光束，在扫描条和刻度的光学有效结构上再次组合。 在检测器中响应于由于组合的部分光束的干扰而在第一方向上的扫描条和标尺之间的偏移以及扫描条和标尺之间的扫描距离的变化而在检测器中获得周期性信号。

公开(公告)号：US08797546B2

公开(公告)日：2014-08-05

申请号：US13423481

申请日：2012-03-19

Applicant: Walter Huber ,  Ralph Joerger

Inventor： Walter Huber ,  Ralph Joerger

IPC: G01B11/02

CPC classification number: G01B11/14 ,  G01B9/02061 ,  G01B9/02081 ,  G01B11/026 ,  G01B2290/30 ,  G01B2290/45 ,  G01B2290/70

Abstract: An interferometric distance measurement device that includes a light source that emits a beam of light and a scanning unit. The scanning unit includes a scanning plate having a splitter that splits the beam of light into a measurement beam and a reference beam, wherein the reference beam is propagated solely within the scanning plate before reaching interferential superposition with the measurement beam at a unification site. A reflector is provided, wherein the reflector is embodied such that the measurement beam striking the reflector undergoes retroreflection in a direction regardless of any possible relative tilting of the scanning unit and of the reflector downstream of the unification site. A detector arrangement is provided in which a distance signal relating to a distance between the scanning plate and the reflector is detectable from interference between the measurement beam and the reference beam.

Abstract translation: 一种干涉距离测量装置，包括发射光束的光源和扫描单元。 扫描单元包括具有分束器的扫描板，该分离器将光束分成测量光束和参考光束，其中参考光束在与测量光束在统一位置达到相互叠加之前仅在扫描板内传播。 提供反射器，其中反射器被实施为使得撞击反射器的测量光束在一个方向上经历逆向反射，而不管扫描单元和反射器在统一部位下游的任何可能的相对倾斜。 提供了一种检测器装置，其中可以从测量光束和参考光束之间的干涉检测与扫描板和反射器之间的距离相关的距离信号。

公开(公告)号：US20120225478A1

公开(公告)日：2012-09-06

申请号：US13472781

申请日：2012-05-16

Applicant: Michael Bardroff ,  Bernd Bohrmann ,  Manfred Brockhaus ,  Walter Huber ,  Titus Kretzschmar ,  Hansruedi Loetscher ,  Corinna Löhning ,  Christer Nordstedt ,  Christine Rothe

Inventor： Michael Bardroff ,  Bernd Bohrmann ,  Manfred Brockhaus ,  Walter Huber ,  Titus Kretzschmar ,  Hansruedi Loetscher ,  Corinna Löhning ,  Christer Nordstedt ,  Christine Rothe

IPC: C12N5/10 ,  C12N15/63 ,  C12N15/64 ,  C12N15/13

CPC classification number: C07K16/18 ,  A61K39/0007 ,  A61K2039/505 ,  C07K14/4711 ,  G01N33/6896

Abstract: The present invention relates to antibody molecules capable of specifically recognizing two regions of the β-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.

Abstract translation: 本发明涉及能够特异性识别β-A4肽的两个区域的抗体分子，其中第一区域包含如SEQ ID NO：1所示的氨基酸序列AEFRHDSGY或其片段，其中第二区域包含 如SEQ ID NO：2所示的氨基酸序列VHHQKLVFFAEDVG或其片段。 此外，公开了编码本发明抗体分子的核酸分子和包含所述核酸分子的载体和宿主。 此外，本发明提供包含本发明化合物以及本发明的抗体分子，核酸分子，载体或宿主的特定用途的组合物，优选药物或诊断组合物。

公开(公告)号：US08216577B2

公开(公告)日：2012-07-10

申请号：US12462119

申请日：2009-07-28

Applicant: Michael Bardroff ,  Bernd Bohrmann ,  Manfred Brockhaus ,  Walter Huber ,  Titus Kretzschmar ,  Hansruedi Loetscher ,  Corinna Löhning ,  Christer Nordstedt ,  Christine Rothe

Inventor： Michael Bardroff ,  Bernd Bohrmann ,  Manfred Brockhaus ,  Walter Huber ,  Titus Kretzschmar ,  Hansruedi Loetscher ,  Corinna Löhning ,  Christer Nordstedt ,  Christine Rothe

IPC: A61K39/395 ,  C07K16/18

CPC classification number: C07K16/18 ,  A61K39/0007 ,  A61K2039/505 ,  C07K14/4711 ,  G01N33/6896

Abstract: The present invention relates to antibody molecules capable of specifically recognizing two regions of the β-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.

Abstract translation: 本发明涉及能够特异性识别β-A4肽的两个区域的抗体分子，其中第一区域包含如SEQ ID NO：1所示的氨基酸序列AEFRHDSGY或其片段，其中第二区域包含 如SEQ ID NO：2所示的氨基酸序列VHHQKLVFFAEDVG或其片段。 此外，公开了编码本发明抗体分子的核酸分子和包含所述核酸分子的载体和宿主。 此外，本发明提供包含本发明化合物以及本发明的抗体分子，核酸分子，载体或宿主的特定用途的组合物，优选药物或诊断组合物。

公开(公告)号：US20090252724A1

公开(公告)日：2009-10-08

申请号：US12086309

申请日：2006-12-11

Applicant: Hansruedi Loetscher ,  Walter Huber ,  Diana Schuhbauer ,  Karl Weyer ,  Manfred Brockhaus ,  Bernd Bohrmann ,  Hans Koll ,  Andreas Schaubmar ,  Kurt Lang

Inventor： Hansruedi Loetscher ,  Walter Huber ,  Diana Schuhbauer ,  Karl Weyer ,  Manfred Brockhaus ,  Bernd Bohrmann ,  Hans Koll ,  Andreas Schaubmar ,  Kurt Lang

IPC: A61K39/395 ,  C07K16/00 ,  A61P25/28

CPC classification number: A61K39/3955 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/77

Abstract: The present invention relates to a purified antibody molecule preparation being characterized in that at least one antigen binding site comprises a glycosylated asparagine (Asn) in the variable region of the heavy chain (VH). More specifically, a pharmaceutical and a diagnostic composition comprising said antibody molecule and antibody mixtures are provided which is/are capable of specifically recognizing the β-A4 peptide/Aβ4. The present invention relates in particular to a mixture of antibodies comprising one or two glycosylated antigen binding sites with a glycosylated asparagine (Asn) in the variable region of the heavy chain, i.e. mixtures of isoforms of antibodies which comprise a glycosylated Asn in the variable region of the heavy chain (VH). Also disclosed are compositions or antibody preparations comprising the specifically glycosylated antibody isoforms. Furthermore, the pharmaceutical and diagnostic uses for these antibodies are provided. The antibody isoforms may for example be used in the pharmaceutical intervention of amyloidogenesis or amyloid-plaque formation and/or in the diagnosis of the same.

Abstract translation: 本发明涉及纯化的抗体分子制剂，其特征在于至少一个抗原结合位点包含重链可变区（VH）中的糖基化天冬酰胺（Asn）。 更具体地，提供了包含所述抗体分子和抗体混合物的药物和诊断组合物，其能够特异性识别β-A4肽/Aβ4。 本发明特别涉及包含一个或两个糖基化抗原结合位点与重链可变区中的糖基化天冬酰胺（Asn）的抗体的混合物，即包含可变区中的糖基化Asn的抗体同种型的混合物 的重链（VH）。 还公开了包含特异性糖基化抗体同种型的组合物或抗体制剂。 此外，提供了这些抗体的药物和诊断用途。 抗体同种型可以例如用于淀粉样变形或淀粉样蛋白斑形成的药物干预和/或其诊断。

公开(公告)号：US07271920B2

公开(公告)日：2007-09-18

申请号：US10946872

申请日：2004-09-21

Applicant: Sebastian Tondorf ,  Walter Huber

Inventor： Sebastian Tondorf ,  Walter Huber

IPC: G01B11/14 ,  G01B11/02 ,  G01N21/86 ,  G01V8/00 ,  G01D5/34 ,  G01D5/36

CPC classification number: G01D5/26 ,  G01D5/34707 ,  G01D5/38

Abstract: A position-measuring device includes: a measuring graduation provided on a material measure going around in ring-like fashion; a scanning unit for optically scanning the measuring graduation using electromagnetic radiation; a scanning plate with a periodic scanning graduation which is arranged in the beam path of the electromagnetic radiation used for scanning the measuring graduation, so that the radiation interacts both with the scanning graduation and with the measuring graduation; and a detector of the scanning unit, the detector surface of which is used for detecting the electromagnetic radiation after interaction with the scanning graduation and the measuring graduation and which is arranged with a period (PD) for detecting electromagnetic radiation in the form of a stripe pattern. The period PM of the measuring graduation and the period PA of the scanning graduation may be coordinated so that 1/(1/PA−1/PM)

Abstract translation: 位置测量装置包括：以环状方式围绕的材料测量提供的测量刻度; 扫描单元，用于使用电磁辐射光学扫描测量刻度; 具有定期扫描刻度的扫描板，其布置在用于扫描测量刻度的电磁辐射的光束路径中，使得辐射与扫描刻度和测量刻度相互作用; 以及扫描单元的检测器，其检测器表面用于在与扫描刻度和测量刻度相互作用之后检测电磁辐射，并且被布置成具有用于检测的周期（P> D ） 条纹图案形式的电磁辐射。 扫描刻度的测量刻度的周期P＆gt; M＆lt; / SUB＆gt;可以协调使得1 /（1 / P> A < -1 / P M M）

D。

公开(公告)号：US20060186206A1

公开(公告)日：2006-08-24

申请号：US11357596

申请日：2006-02-16

Applicant: Walter Huber ,  Volker Hoefer

Inventor： Walter Huber ,  Volker Hoefer

IPC: G06K7/10

CPC classification number: G01D5/24438 ,  G01D5/34746

Abstract: A scanning unit for a position measuring device for scanning a measuring graduation of the position measuring device, includes a scanning structure that is provided on a carrier and is formed such that, by interaction of an electromagnetic radiation, used for scanning the measuring graduation, with the measuring graduation on one hand and with the scanning structure on the other hand, a periodic stripe pattern is generated. A detector arrangement is provided for detecting the stripe pattern, which is made up of a plurality of detector elements of different phases, arranged one after another, that generate output signals having a phase shift represented by those phases, the arrangement of detector elements of different phases one after another forming a periodic pattern, and each of the detector elements being assigned exactly one region of the scanning structure referred to as a bar, and the detector elements being combined to form two detector groups such that at least detector elements of the same phase belong to the same detector group, and the detector elements within one detector group being interconnected for generating a detector signal. The bars of the scanning structure are formed and arranged such that the totality of the bars assigned to the first detector group and the totality of the bars assigned to the second detector group in each case cover an active area of equal size on the carrier of the scanning structure. The area center of gravity of the area covered by the totality of the bars assigned to the first detector group on one hand, and the area center of gravity of the area covered by the totality of the bars assigned to the second detector group on the other hand coincide.

Abstract translation: 一种用于扫描位置测量装置的测量刻度的位置测量装置的扫描装置，包括一个扫描结构，该扫描结构设置在载体上，并形成为使得用于扫描测量刻度的电磁辐射与扫描测量刻度的相互作用与 另一方面，一方面测量刻度和扫描结构产生周期性条纹图案。 提供一种检测器装置，用于检测由多个不同相位的检测器元件组成的条纹图案，该多个检测器元件依次布置，产生具有由这些相位表示的相移的输出信号，不同的检测器元件的布置 相位形成周期性图案，并且每个检测器元件被精确地分配为被称为条的扫描结构的一个区域，并且检测器元件被组合以形成两个检测器组，使得至少相同的检测器元件 相位属于相同的检测器组，并且一个检测器组内的检测器元件互连用于产生检测器信号。 扫描结构的条形成并布置成使得分配给第一检测器组的条的总数和分配给第二检测器组的条的总数在每种情况下都覆盖相同尺寸的有效区域 扫描结构。 一方面由分配给第一检测器组的条的总面积覆盖的区域的区域重心以及由另一方分配给第二检测器组的条的总数所覆盖的区域的区域重心 手重合。

公开(公告)号：US20060060213A1

公开(公告)日：2006-03-23

申请号：US11128215

申请日：2005-05-13

Applicant: Walter Huber ,  John Krueger ,  Yoram Uziel ,  Amir Wachs

Inventor： Walter Huber ,  John Krueger ,  Yoram Uziel ,  Amir Wachs

IPC: C23G1/00

CPC classification number: H01L21/02043 ,  B08B7/0042 ,  H01L21/67051

Abstract: A method and apparatus for removing surface impurities from a surface of a material, particularly silicon wafers, includes identifying the location of at least one impurity particle on a surface of the material and applying a liquid to the surface in the vicinity of the at least one impurity particle. The liquid is explosively evaporated to remove the surface particle as part of the evaporation of the liquid. The apparatus can include a source of humidified gas for the liquid and a laser apparatus to provide the heat for liquid evaporation.

Abstract translation: 一种用于从材料表面特别是硅晶片表面去除表面杂质的方法和装置包括：鉴定至少一种杂质颗粒在该材料表面上的位置，并向该表面附近的至少一个 杂质颗粒。 液体被爆炸性蒸发以除去作为液体蒸发的一部分的表面颗粒。 该装置可以包括用于液体的加湿气体源和用于提供用于液体蒸发的热量的激光装置。

公开(公告)号：US06541761B1

公开(公告)日：2003-04-01

申请号：US09652220

申请日：2000-08-30

Applicant: Wolfgang Holzapfel ,  Walter Huber

Inventor： Wolfgang Holzapfel ,  Walter Huber

IPC: G01D534

CPC classification number: G01D5/38

Abstract: An optical position measuring system that includes a light source, a measuring graduation, a scanning unit movable relative to the measuring graduation in at least one measurement direction. A projection graduation has periodic amplitude and phase structures disposed in alternation in the measurement direction. The arrangement further includes a detection graduation and a plurality of optoelectronic detector elements, wherein light from the light source interacts with the projection graduation so as to project a fringe pattern onto the detection graduation, so that via the plurality of optoelectronic detector elements, displacement-dependent output signals are detectable, and wherein the projection graduation has a structure such that in addition to even orders of diffraction and the zero order of diffraction, at least some of the (2n+1)th orders of diffraction are suppressed, where n=1, 2, 3, . . . , as a result of which essentially only the ±1st orders of diffraction contribute to generating the output signals.

Abstract translation: 一种光学位置测量系统，包括光源，测量刻度，在至少一个测量方向上相对于测量刻度移动的扫描单元。 投影刻度具有在测量方向上交替设置的周期性幅度和相位结构。 该布置还包括检测刻度和多个光电检测器元件，其中来自光源的光与投影刻度相互作用以将条纹图案投影到检测刻度上，使得经由多个光电检测器元件， 依赖输出信号是可检测的，并且其中投影刻度具有这样的结构，使得除了衍射的偶数阶和衍射的零级之外，抑制衍射的第（2n + 1）阶中的至少一些，其中n = 1，2，3，。 。 。 ，其结果基本上只有±1级的衍射有助于产生输出信号。

公开(公告)号：US06198534B1

公开(公告)日：2001-03-06

申请号：US09130702

申请日：1998-08-07

Applicant: Volker Höfer ,  Wolfgang Holzapfel ,  Walter Huber ,  Elmar Mayer

Inventor： Volker Höfer ,  Wolfgang Holzapfel ,  Walter Huber ,  Elmar Mayer

IPC: G01N1100

CPC classification number: G01D5/366 ,  G01D5/2457

Abstract: A scanning unit for an optical position measuring system is disclosed which, besides periodic incremental signals, also provides at least one reference pulse signal at a defined reference position of a scale and a scanning unit which is movable relative to it. For scanning a reference mark on the scale, the scanning unit comprises a scanning plate with at least one reference mark scanning field and/or at least one reference pulse detector element. A filtering effect results either from the design of the reference mark scanning field or by the design of one or several reference mark detector elements in such a way that the periodic incremental signal portion of the reference pulse signal next to the reference position can be eliminated to a great extent.

Abstract translation: 公开了一种用于光学位置测量系统的扫描单元，除了周期性增量信号之外，还提供了在刻度的限定的参考位置处的至少一个参考脉冲信号和可相对于其移动的扫描单元。 为了扫描标尺上的参考标记，扫描单元包括具有至少一个参考标记扫描场的扫描板和/或至少一个参考脉冲检测器元件。 滤波效果可以从参考标记扫描场的设计或一个或几个参考标记检测器元件的设计得到，使得可以消除与参考位置相邻的参考脉冲信号的周期性增量信号部分到 在很大程度上