公开(公告)号：US20240262831A1

公开(公告)日：2024-08-08

申请号：US18257798

申请日：2021-12-17

Applicant: VOVA IDA THERAPEUTICS, INC. ,  THE SCRIPPS RESEARCH INSTITUTE

Inventor： Thomas D. BANNISTER ,  Corinne LASMEZAS ,  Minghai ZHOU ,  Anna Albertson

IPC: C07D487/04 ,  A61K31/4178 ,  A61K31/4365 ,  A61K31/4709 ,  A61K31/519 ,  C07D401/12 ,  C07D405/12 ,  C07D495/04

CPC classification number: C07D487/04 ,  A61K31/4178 ,  A61K31/4365 ,  A61K31/4709 ,  A61K31/519 ,  C07D401/12 ,  C07D405/12 ,  C07D495/04

Abstract: Provided are, inter alia, compounds having a structure of Formulae (X), (I) to (XIII) or a subordinate structure thereof, composition including the same and methods of use.

公开(公告)号：US20240150338A1

公开(公告)日：2024-05-09

申请号：US18261682

申请日：2022-01-14

Applicant: University of Florida Research Foundation, Incorporated ,  VOVA IDA THERAPEUTICS, INC.

Inventor： Thomas D. BANNISTER ,  Corinne LASMEZAS ,  Minghai ZHOU ,  Sultan ULLAH

IPC: C07D417/04 ,  C07D277/42

CPC classification number: C07D417/04 ,  C07D277/42

Abstract: Provided are, inter alia, compounds having a structure of Formulae (X) to (XVII), or a subordinate structure thereof, composition including the same and methods of use.

公开(公告)号：US20240124466A1

公开(公告)日：2024-04-18

申请号：US18256995

申请日：2021-12-10

Applicant: VOVA IDA THERAPEUTICS, INC. ,  SCRIPPS RESEARCH INSTITUTE, THE

Inventor： Thomas D. BANNISTER ,  Corinne LASMEZAS ,  Minghai ZHOU ,  Nicole KENNEDY

IPC: C07D487/04 ,  C07D213/34 ,  C07D213/61 ,  C07D213/74 ,  C07D231/12 ,  C07D231/56 ,  C07D233/64 ,  C07D237/30 ,  C07D249/08 ,  C07D271/06 ,  C07D285/08 ,  C07D333/18 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04 ,  C07D491/048 ,  C07D491/107 ,  C07D491/113 ,  C07D498/08

CPC classification number: C07D487/04 ,  C07D213/34 ,  C07D213/61 ,  C07D213/74 ,  C07D231/12 ,  C07D231/56 ,  C07D233/64 ,  C07D237/30 ,  C07D249/08 ,  C07D271/06 ,  C07D285/08 ,  C07D333/18 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04 ,  C07D491/048 ,  C07D491/107 ,  C07D491/113 ,  C07D498/08

Abstract: Provided are, inter alia, compounds having a structure of Formula (X), or a pharmaceutically acceptable salt thereof composition including the same and methods of use. Ring A, L1, L2, W, R2A, R2B, and R10 are as described herein.

公开(公告)号：US20240174651A1

公开(公告)日：2024-05-30

申请号：US18262409

申请日：2022-01-28

Applicant: THE SCRIPPS RESEARCH INSTITUTE ,  VOVA IDA THERAPEUTICS, INC.

Inventor： Thomas D. BANNISTER ,  Corinne LASMÉZAS ,  Minghai ZHOU ,  Ronald J. RAHAIM, Jr.

IPC: C07D405/14 ,  C07D401/06 ,  C07D401/14 ,  C07D413/14 ,  C07D491/107 ,  C07D493/08 ,  C07D498/08

CPC classification number: C07D405/14 ,  C07D401/06 ,  C07D401/14 ,  C07D413/14 ,  C07D491/107 ,  C07D493/08 ,  C07D498/08

Abstract: Provided are, inter alia, compounds having a structure of Formula (X), (XI), (XII), or (XIII), or a subordinate structure thereof, composition including the same and methods of use.

公开(公告)号：US20240003914A1

公开(公告)日：2024-01-04

申请号：US18252798

申请日：2021-11-12

Applicant: THE SCRIPPS RESEARCH INSTITUTE ,  VOVA IDA THERAPEUTICS, INC.

Inventor： Corinne LASMÉZAS ,  Minghai ZHOU

IPC: G01N33/68 ,  A61K31/455 ,  A61P3/00

CPC classification number: G01N33/6893 ,  A61K31/455 ,  A61P3/00

Abstract: Methods of preventing disease or treating a subject likely to develop or having a neurodegenerative, degenerative or metabolic disease include administration of nicotinamide dinucleotide (NAD) modulating agents. Compositions include one or more agents which increase or decrease NAD in vivo or in vitro.