公开(公告)号：US20250051403A1

公开(公告)日：2025-02-13

申请号：US18720105

申请日：2022-12-16

Applicant: UNIVERSITE DE LILLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITE D'AIX MARSEILLE ,  SORBONNE UNIVERSITE ,  ECOLE CENTRALE DE MARSEILLE

Inventor： Aurélie TASIEMSKI ,  Céline WICHLACZ ,  Marc MARESCA ,  Stéphane CANAAN ,  Jean-François CAVALIER ,  Kamel MABROUK ,  Stéphane HOURDEZ

IPC: C07K14/435 ,  A61K38/00 ,  A61P31/04

Abstract: The present invention relates to antimicrobial peptides, variants and chemical analogues thereof; in particular, a peptide of 20 amino acids, named Michelicin, having the sequence RVCVRICRNGRCYRRCWNT, derived from a longer precursor with a BRICHOS domain from the marine worm Capitella. The peptide has several cysteines which form disulfide bridges and provide stability in salt conditions. Several derivatives and analogues were produced. The peptide and the derivatives show antimicrobial activity against a wide range of bacteria. The application also concerns nucleic acid sequences encoding these, pharmaceutical composition and to their use as a drug, preservative and disinfectant.

公开(公告)号：US20240409769A1

公开(公告)日：2024-12-12

申请号：US18719893

申请日：2022-12-16

Applicant: UNIVERSITE DE HAUTE-ALSACE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE D'AIX-MARSEILLE

Inventor： OLIVIER SOPPERA ,  YOHANN GUILLANEUF ,  CONSTANCE THOMAS ,  NOÉMIE GIL ,  CATHERINE LEFAY

IPC: C09D135/02 ,  B29C64/124 ,  B29K33/00 ,  B33Y10/00 ,  B33Y70/00 ,  C08F222/10 ,  C09D4/00

Abstract: The present invention relates to a light-activated resin composition comprising a multi-functional acrylate or methacrylate monomer, a cyclic monomer comprising a cleavable or pre-cleavable group and a photo-initiator. It also relates to a degradable polymer, a degradable 3D-printed article, and to a process for preparing such polymer and article. It further relates to the use of a monomer comprising a thionolactone or sulfide cyclic methacrylate for preparing a degradable 3D-printed article.

公开(公告)号：US12030333B2

公开(公告)日：2024-07-09

申请号：US17297138

申请日：2019-11-28

Applicant: OBERTHUR FIDUCIAIRE SAS ,  Centre National de la Recherche Scientifique (CNRS) ,  ECOLE CENTRALE DE MARSEILLE ,  Universite D'Aix Marseille

Inventor： Julien Lumeau ,  Fabien Lemarchand ,  Antonin Moreau ,  Thomas Begou ,  Julien Gillot ,  Xavier Borde

IPC: B42D25/373 ,  B42D25/29 ,  B42D25/405 ,  C23C14/04 ,  C23C14/22 ,  C23C14/54

CPC classification number: B42D25/373 ,  B42D25/29 ,  B42D25/405 ,  C23C14/044 ,  C23C14/225 ,  C23C14/542

Abstract: The present invention particularly relates to a method for physical vacuum deposition of a coating (R) comprising at least one material (M) on at least a portion of a front face (10) of a support (1), said at least one material (M) originating from an evaporation source or an atomisation source (2), wherein: —use is made of a support (1), at least a portion of the front face (10) of which is smooth, that is to say, does not have any roughness and/or reliefs and/or recesses; —said vacuum deposition is carried out while varying the thickness distribution of the material (M) on said front face (10), that is, while progressively varying the thickness deposited, from a central region (11) in the direction of at least one lateral region (12) contiguous to the central region (11), without modifying the position of the evaporation source or atomisation source (2) of the material particles (M).

公开(公告)号：US11904004B2

公开(公告)日：2024-02-20

申请号：US16896556

申请日：2020-06-09

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITE D'AIX-MARSEILLE ,  INSTITUT JEAN PAOLI & IRENE CALMETTES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITE DE NANTES

Inventor： Daniel Olive ,  Marc Bonneville ,  Emmanuel Scotet ,  Christelle Harly ,  Yves Guillaume

IPC: A61K39/00 ,  C07K16/28

CPC classification number: A61K39/001129 ,  C07K16/2818 ,  C07K16/2827 ,  A61K39/00 ,  C07K2317/55 ,  C07K2317/74 ,  C07K2317/75

Abstract: Described herein are anti-CD277 antibodies which: activates or inhibit the cytolytic function of Vγ9/Vδ2 T cells, and/or costimulates T cells together with CD3-TCR, and/or costimulates T cells in addition to CD28-B7 costimulation, and/or increases the activity and/or survival of monocytes and dendritic cells. The use of said antibodies in therapy is also described.

公开(公告)号：US20230295103A1

公开(公告)日：2023-09-21

申请号：US18014762

申请日：2021-07-08

Applicant: UNIVERSITE D'AIX-MARSEILLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  ECOLE CENTRALE DE MARSEILLE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ,  Etat Francais Représenté Par La Direction Centrale Du Service De Santé Des Armées

Inventor： MAXIME ROBIN ,  MARC MARESCA ,  HAMZA OLLEIK ,  VALÉRIE PIQUE ,  JOSETTE PERRIER-VIRET ,  JEAN-MICHEL BOLLA ,  FABIENNE NEULAT-RIPOLL

IPC: C07D307/83 ,  C07D407/12 ,  C07D455/03 ,  A01P1/00 ,  A01P3/00 ,  A61P31/04 ,  A61P31/10 ,  A01N43/12 ,  A01N43/16 ,  A01N43/42

CPC classification number: C07D307/83 ,  C07D407/12 ,  C07D455/03 ,  A01P1/00 ,  A01P3/00 ,  A61P31/04 ,  A61P31/10 ,  A01N43/12 ,  A01N43/16 ,  A01N43/42

Abstract: The present invention relates to aurones compounds of formula (I) and their uses for controlling a bacterium and/or a fungus. The invention also relates to the use of such compounds as phytoprotective and/or decontaminating and/or disinfectant agent and compositions comprising them.

公开(公告)号：US11712486B2

公开(公告)日：2023-08-01

申请号：US16479234

申请日：2018-01-30

Applicant: VECT-HORUS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE D'AIX-MARSEILLE

Inventor： Cédric Malicet ,  Pascaline Lecorche ,  Jonathan Nowak ,  Marion David ,  Jamal Temsamani ,  Michel Khrestchatisky

IPC: A61K51/08 ,  A61K51/04 ,  C07K7/06 ,  G01N33/574 ,  G01N33/60 ,  G01N33/92

CPC classification number: A61K51/088 ,  A61K51/048 ,  C07K7/06 ,  G01N33/57438 ,  G01N33/60 ,  G01N33/92 ,  A61K2121/00 ,  A61K2123/00

Abstract: The present invention relates to a conjugated compound comprising a marker M pharmaceutically acceptable, and a peptide or pseudo-peptide P having at most 30 amino acid residues and able to bind the Low-Density Lipoprotein Receptor (LDLR) and to its use in a method of labelling and/or detecting and/or treating cancerous cells in a subject by administration of the conjugated compound to the subject an analysis of the presence and/or the amount of marker.

公开(公告)号：US20230226231A1

公开(公告)日：2023-07-20

申请号：US18010498

申请日：2021-06-18

Applicant: UNIVERSITE D'AIX MARSEILLE ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE

Inventor： BENJAMIN GUILLET ,  AHLEM BOUHLEL ,  ANAÏS MOYON ,  BÉATRICE MARIE FLORENCE LOUIS ,  FRANÇOISE DIGNAT-GEORGE ,  LAURE BALASSE ,  PHILIPPE GARRIGUE ,  SAMANTHA FERNANDEZ

IPC: A61K51/08 ,  A61K49/00 ,  A61P35/00

CPC classification number: A61K51/088 ,  A61K49/0004 ,  A61P35/00

Abstract: The invention relates to the field of imaging, diagnostic, internal vectorized radiotherapy and nuclear medicine. Inventors herein describe new products for use for labelling, detecting and/or imaging angiogenesis, vasculogenesis or a tissue or organ expressing the APJ receptor; for use for detecting, measuring, diagnosing, staging and/or monitoring angiogenesis, vasculogenesis, an angiogenesis- and/or vasculogenesis-related disease or disorder, and/or a disease or disorder inducing or modulating the expression of a APJ receptor in a tissue or organ; for use for preventing or treating angiogenesis, vasculogenesis, an angiogenesis- and/or vasculogenesis-related disease or disorder, and/or a disease or disorder inducing or modulating the expression of a APJ receptor in a tissue or organ; or for use for evaluating or monitoring the therapeutic effect of an angiogenic or antiangiogenic treatment or of an APJ receptor-targeted treatment. Compositions and kits comprising such products are also herein described as well as uses thereof.

公开(公告)号：US11384167B2

公开(公告)日：2022-07-12

申请号：US16770342

申请日：2018-12-20

Applicant: Universite de Haute-Alsace ,  Universite d'Aix-Marseille ,  Centre National de la Recherche Scientifique

Inventor： Aude-Heloise Bonardi ,  Jacques Lalevee ,  Fabrice Morlet-Savary ,  Celine Dietlin ,  Didier Gigmes ,  Frederic Dumur

IPC: C08F2/46 ,  C08F222/10 ,  C08F222/20 ,  C08F222/22 ,  C08K3/30 ,  C08K5/14 ,  C08K5/315 ,  C08K5/5353 ,  C09B23/04 ,  C09B47/04 ,  C09B57/00 ,  C09B57/10 ,  B41M5/46

Abstract: The present invention relates to compositions thermally curable on demand by red to near infrared irradiation, method of using same for thermal amplification of free radical polymerizations, and articles obtained by such method. The invention also relates to the use of a heat-generating dye in association with a thermal initiator for controlling the onset of thermal free radical polymerization.

公开(公告)号：US11274160B2

公开(公告)日：2022-03-15

申请号：US16490388

申请日：2018-03-01

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  INSTITUT JEAN PAOLI & IRENE CALMETTES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITE D'AIX MARSEILLE

Inventor： Marc Lopez

IPC: C07K16/30 ,  A61P35/00 ,  A61K47/68 ,  A61K45/06 ,  A61K39/00

Abstract: The present invention relates to a new antibody anti-nectin-4. Nectin-4 is a tumor-associated antigen overexpressed in several cancers and notably in 30%, 49% and 86% of breast, ovarian and lung carcinomas, respectively, which are tumors of bad prognosis. Treatments remain still elusive. That's why the inventors developed a new targeted therapy based on an antibody having specificity to nectin-4 (called 14A5.2 mab). Indeed, the inventors selected this antibody for its intrinsic prophylactic anti-metastatic properties and also for the treatment of localized primary and metastatic cancer. More, the 14A5.2 mab could be indicated for the treatment of cancer resistant to ASG-22ME (from Astellas company). Thus, the invention relates to the 14A5.2 mab and its uses thereof.

公开(公告)号：US11191476B2

公开(公告)日：2021-12-07

申请号：US16316803

申请日：2016-07-18

Applicant: UNIVERSITE D'AIX MARSEILLE (AMU) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  ASSISTANCE PUBLIQUE—HOPITAUX DE MARSEILLE (AP-HM) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Inventor： Viktor Jirsa ,  Christophe Bernard ,  Fabrice Bartolomei ,  Maxime Guye

IPC: A61B5/00 ,  G16H50/50 ,  A61B34/10 ,  A61B5/0478 ,  A61B5/291 ,  A61B5/369 ,  G16H10/60

Abstract: The method of modulating epileptogenicity in a brain of an epileptic patient includes: providing a virtual brain; providing a model of an epileptogenic and of a propagation zones and loading the model in the virtual brain to create a virtual epileptic brain; acquiring data of the brain of the epileptic patient; identifying, in the data, a location of at least one possible epileptogenic zone; fitting the virtual epileptic brain against the data acquired from the epileptic patient and parametrizing the at least one possible epileptogenic zone in the virtual epileptic brain as an epileptogenic zone; and simulating, within the virtual epileptic brain, the effect of a network modulation mimicking a clinical intervention of the brain of the patient.