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公开(公告)号:US11617730B2
公开(公告)日:2023-04-04
申请号:US16489378
申请日:2018-02-28
发明人: Eric Goupil
IPC分类号: A61K9/00 , A61K31/167 , A61K47/02 , A61K47/10
摘要: The present invention concerns a pharmaceutical formulation for administering paracetamol by buccal/gingival route consisting of a hydroalcoholic solution comprising dissolved paracetamol, characterised in that: #the mass of paracetamol is between 95 mg and 190 mg, #the volume of said hydroalcoholic solution is between 1.0 ml and 2.0 ml, #the degree of alcohol of said hydroalcoholic solution is between 48.5° and 52.5°, and #the concentration of paracetamol in said hydroalcoholic solution is between 85 mg/ml and 110 mg/ml. The present invention also concerns said pharmaceutical formulation for the use of same for accelerating the speed at which paracetamol passes through the blood-brain barrier, and the use thereof as a drug, in particular for the symptomatic treatment of pain or fever.
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公开(公告)号:US20210008293A1
公开(公告)日:2021-01-14
申请号:US16979399
申请日:2019-03-11
发明人: Marc Maury
摘要: The invention concerns a device for preparing a dose of medicament on demand, comprising at least one receptacle (10), at least one cartridge (12) of a medicinal composition intended to enter said at least one receptacle, the medicinal composition being in liquid or solid powder form, as well as dosing means (14) for dosing said medicinal composition, monitoring means (16) for monitoring the dose of the medicinal composition delivered and control means (18) for controlling the at least one cartridge (12), the dosing means (14) and the monitoring means (16).
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公开(公告)号:US20170081270A1
公开(公告)日:2017-03-23
申请号:US15312262
申请日:2015-05-28
发明人: THIERRY ARNAL
IPC分类号: C07C67/28 , C07C67/52 , C07C227/42 , C07C227/16
CPC分类号: C07C67/28 , C07C67/52 , C07C69/157 , C07C227/16 , C07C227/42 , C07C229/26
摘要: A method for preparing a salt of acetylsalicylic acid and a basic amino acid. A solution of acetylsalicylic acid and a solution of said basic amino acid are mixed in a reactor, at a temperature lower than or equal to 30° C. at atmospheric pressure. The mixture is created by simultaneously and progressively introducing the acetylsalicylic acid and the basic amino acid into the reactor in amounts that are always equimolar.
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公开(公告)号:US20170189272A1
公开(公告)日:2017-07-06
申请号:US14984675
申请日:2015-12-30
发明人: Eric Goupil , Marc Maury
IPC分类号: A61J7/00
CPC分类号: A61J7/0038 , A61J2205/20
摘要: A device for delivering a soluble product (28) that includes a straw (10), includes a body (12), element (14) for accommodating at least one cartridge (16) that contains the soluble product, in solid form. The adapted cartridges (16) as well as a particular packaging are also described.
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公开(公告)号:US20220211644A1
公开(公告)日:2022-07-07
申请号:US17608207
申请日:2020-04-30
发明人: Pierre-Louis DESTRUEL , Vincent BOUDY , Ni ZENG , Nathalie MIGNET , Marc MAURY
IPC分类号: A61K31/137 , A61K47/36 , A61K9/08 , A61K47/38 , A61P27/08
摘要: The invention relates to a specific composition comprising in particular at least gellan gum and phenylephrine. It also relates to a particular method for manufacturing such a composition and its uses in particular as a mydriatic ophthalmic product.
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公开(公告)号:US20190201343A1
公开(公告)日:2019-07-04
申请号:US16330288
申请日:2017-09-15
发明人: Jean-Luc Pougnas
IPC分类号: A61K9/16 , A61K9/00 , A61K31/167 , A61K36/324 , A61K36/81 , A61K36/9066 , A61K31/192 , A61K31/606 , A61K36/05 , A61K36/28 , A61K36/9068
CPC分类号: A61K9/1623 , A61K9/0056 , A61K9/009 , A61K9/145 , A61K31/167 , A61K31/192 , A61K31/606 , A61K36/05 , A61K36/28 , A61K36/324 , A61K36/81 , A61K36/9066 , A61K36/9068
摘要: A solid composition with rapid ingestion and facilitated swallowing, in the form of non-agglomerated solid particles, said composition comprising the following two different types of particle: Pa particles, with very low solubility in saliva and comprising at least one active ingredient, and Ps particles, rapidly soluble in saliva, characterised by an apparent density equal to or greater than approximately 0.6 g.cm−3, advantageously equal to or greater than approximately 0.7 g.cm−3, and preferably between 0.7 and 1.5 g.cm−3 inclusive.
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公开(公告)号:US11304905B2
公开(公告)日:2022-04-19
申请号:US16330288
申请日:2017-09-15
发明人: Jean-Luc Pougnas
IPC分类号: A61K9/14 , A61K9/16 , A61K9/00 , A61K31/167 , A61K31/192 , A61K31/606 , A61K36/05 , A61K36/28 , A61K36/324 , A61K36/81 , A61K36/9066 , A61K36/9068
摘要: A solid composition with rapid ingestion and facilitated swallowing, in the form of non-agglomerated solid particles, said composition comprising the following two different types of particle: Pa particles, with very low solubility in saliva and comprising at least one active ingredient, and Ps particles, rapidly soluble in saliva, characterised by an apparent density equal to or greater than approximately 0.6 g.cm−3, advantageously equal to or greater than approximately 0.7 g.cm−3, and preferably between 0.7 and 1.5 g.cm−3 inclusive.
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公开(公告)号:US09745246B2
公开(公告)日:2017-08-29
申请号:US15312262
申请日:2015-05-28
发明人: Thierry Arnal
IPC分类号: C07C67/52 , C07C67/28 , C07C227/16 , C07C227/42 , C07C69/157
CPC分类号: C07C67/28 , C07C67/52 , C07C69/157 , C07C227/16 , C07C227/42 , C07C229/26
摘要: A method for preparing a salt of acetylsalicylic acid and a basic amino acid. A solution of acetylsalicylic acid and a solution of said basic amino acid are mixed in a reactor, at a temperature lower than or equal to 30° C. at atmospheric pressure. The mixture is created by simultaneously and progressively introducing the acetylsalicylic acid and the basic amino acid into the reactor in amounts that are always equimolar.
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公开(公告)号:US20170169187A1
公开(公告)日:2017-06-15
申请号:US15359258
申请日:2016-11-22
CPC分类号: G06F19/3462 , A61J1/03 , A61J7/04 , A61J2205/60 , B65D65/40 , B65D75/06 , B65D75/52 , B65D75/5811 , B65D79/00 , B65D2203/10 , B65D2215/04
摘要: A stick pack having a top sealed portion with a top edge, a horizontal notch parallel with the top edge and passing through the stick pack, and further including a horizontal perforation line parallel with the top edge. The stick pack also has a bottom edge portion with a bottom sealed edge, a longitudinal seal extending from the top sealed edge to the bottom edge; an integrated RLC circuit; and a spout formed at least partially in the top sealed portion but not extending past the top sealed edge. The stick pack is configured to be folded along its longitudinal axis to fold the notch, and only when the notch is folded can a user easily tear the top sealed edge along the horizontal perforation line to expose the spout.
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公开(公告)号:US20170166380A1
公开(公告)日:2017-06-15
申请号:US15359110
申请日:2016-11-22
IPC分类号: B65D75/58 , B65B61/18 , B65D75/06 , B65D81/20 , B65D35/08 , B65B31/00 , B65B9/10 , B65D65/40
CPC分类号: B65D75/5811 , B31B70/14 , B31B2155/00 , B31B2160/10 , B65B9/10 , B65B31/00 , B65B61/18 , B65D35/08 , B65D65/40 , B65D75/06 , B65D75/52 , B65D81/2084 , B65D2215/04
摘要: A stick pack having a top sealed portion with a top edge, a horizontal notch parallel with the top edge and passing through the stick pack, and further including a horizontal perforation line parallel with the top edge. The stick pack also has a bottom edge portion with a bottom sealed edge, a longitudinal seal extending from the top sealed edge to the bottom edge; and a spout formed at least partially in the top sealed portion but not extending past the top sealed edge. The stick pack is configured to be folded along its longitudinal axis to fold the notch, and only when the notch is folded can a user easily tear the top sealed edge along the horizontal perforation line to expose the spout.
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