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公开(公告)号：US11521745B2
公开(公告)日：2022-12-06
申请号：US16763815
申请日：2018-11-14
申请人： Universite Paris-SUD , Universite De Paris , Institut National De Sport De L'Expertise Et De La Performance , Centre National de la Recherche Scientifique (CNRS)
摘要： The invention proposes a new method for monitoring a health event in a mammal, comprising detecting at least one abnormal value within a series of values related to at least one biomarker, based on appropriate Z-scores.
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公开(公告)号：US20220326414A1
公开(公告)日：2022-10-13
申请号：US17638305
申请日：2020-08-20
发明人： Thomas LOPEZ , David BARAT , Laetitia PRADERE , Béatrice DAGENS
摘要： A dust-proof covering element is provided to close a projection aperture located in the dashboard of a vehicle and through which the information-carrying source light beam projected by the projecting module of a head-up display device passes on its way to a partially reflective return element. The covering element comprises a transparent carrier and an optical coating placed on one of the faces of the carrier; wherein, the optical coating comprises a metal layer with plasmonic properties, said metal layer being endowed with an array of subwavelength nanoperforations, and being configured to allow the extraordinary transmission of one or more restricted bands of wavelengths of the visible spectrum that are centered on the one or more wavelengths of the light beam projected by the projecting module.
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公开(公告)号：US11066649B2
公开(公告)日：2021-07-20
申请号：US15125596
申请日：2015-03-19
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITE PARIS—SUD , UNIVERSITÉ DE RENNES
IPC分类号： C12N5/071 , A61K35/407
摘要： The invention relates to a method for inducing human cholangiocyte differentiation of progenitor cells called hepatoblasts. More specifically, the invention relates to a method for differentiating hepatoblasts to cholangiocytes by culturing said hepatoblasts with a particular medium having interleukin-6 (IL-6) activity. The differentiation method can specifically induce cholangiocyte differentiation from hepatoblasts, and the human cholangiocytes differentiated according to the invention may be useful for drug discovery for treatment of cholangiopathies and bioengineered livers.
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公开(公告)号：US11014871B2
公开(公告)日：2021-05-25
申请号：US16068097
申请日：2017-01-05
发明人： Mouâd Alami , Abdallah Hamze , Jean-Daniel Brion , Jérôme Bignon , Joëlle Dubois
IPC分类号： C07C69/734 , C07C235/64 , C07D209/42 , C07D213/65 , A61K45/06 , C07D239/74 , C07C235/38 , C07D215/14 , C07C259/06 , C07D213/81 , C07C259/10 , C07D209/86 , A61K47/68 , A61P35/00 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/192 , A61K31/216 , A61K31/404 , A61K31/44 , C07C59/68 , C07C235/34 , C07C235/60 , C07D209/18
摘要： The present invention relates to the design of novel molecules, referred to as “multi-target” molecules, having a double pharmacophore and acting both as inhibitors of histone deacetylases (HDACs) and as inhibitors of tubulin polymerisation. The invention also describes the method for synthesising the “multi-target” molecules and their use in the treatment of cancer, a pharmaceutical composition comprising at least one “multi-target” molecule, and the use of such compositions in the treatment of cancer.
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公开(公告)号：US11008582B2
公开(公告)日：2021-05-18
申请号：US15120829
申请日：2015-02-24
发明人： Linda De Bont , Bertrand Gakiere
IPC分类号： C12N15/82 , C07K14/415 , A01H1/02 , A01H1/04 , C12N9/06 , C12Q1/6895
摘要： The invention relates to a method for increasing the yield and biomass of a plant, by means of an increase in the expression of the L-aspartate oxidase in the plant. The method according to the invention allows an increase in the photosynthetic capacities of the plants as a result of an increase in the quantities of NAD and the derivatives thereof in said plants. The invention relates to the plants produced by such a method.
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公开(公告)号：US10895551B2
公开(公告)日：2021-01-19
申请号：US15773517
申请日：2016-11-14
发明人： Hafsa Korri-Youssoufi , Anna Miodek , Nawel Mejri
IPC分类号： G01N27/327 , C12Q1/6825 , G01N33/543
摘要： A system for “signal-on” electrochemical detection of molecules of interest and to a method implementing said system.
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公开(公告)号：US10890583B2
公开(公告)日：2021-01-12
申请号：US15300309
申请日：2015-04-01
申请人： INSTITUT PASTEUR , UNIVERSITE PARIS-SUD , CENTRE HOSPITALIER DE VERSAILLES , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS
IPC分类号： G01N33/569 , A61K39/08 , G01N33/564
摘要： The present invention relates to the field of Clostridium difficile infections. Methods of diagnosing, treating and preventing Clostridium difficile-associated disease and recurrent CDAD are disclosed herein.
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公开(公告)号：US10662482B2
公开(公告)日：2020-05-26
申请号：US15177055
申请日：2016-06-08
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , INSTITUT GUSTAVE-ROUSSY , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS , CENTRE HENRI BECQUEREL , UNIVERSITE PARIS DESCARTES , UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , UNIVERSITE PARIS-SUD
发明人： Franck Viguie , Olivier Bernard , Michaela Fontenay , Christian Bastard , Francois Delhommeau , William Vainchenker
IPC分类号： C12Q1/6886 , G01N33/574 , A61K31/7068
摘要： The present invention concerns an in vitro method for diagnosing a myeloid tumour or a lymphoid tumour in a subject, which comprises the step of analyzing a biological sample from said subject by (i) detecting the presence of a mutation in the Ten Eleven Translocation protein family member 2 gene (TET2) coding for the polypeptide having the sequence SEQ ID NO: 2, and/or (ii) analyzing the expression of the TET2 gene; wherein the detection of such a TET2 mutation, of the absence of expression of TET2 or of the expression of a truncated TET2 is indicative of a subject developing or predisposed to develop a myeloid tumour or a lymphoid tumour.
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公开(公告)号：US10653694B2
公开(公告)日：2020-05-19
申请号：US15303157
申请日：2015-04-09
发明人： Mouad Alami , Jean-Daniel Brion , Samir Messaoudi , Olivier Provot , Mohamed-Ali Soussi , Jerome Bignon , Joelle Dubois , Joanna Bakala-Wdzieczak
IPC分类号： C07D403/06 , A61K31/517 , C07D235/02 , A61K47/68 , A61K31/47 , A61K31/472 , A61K45/06 , C07D215/14 , C07D215/18 , C07D217/02 , C07D239/74 , C07D239/78
摘要： The invention relates to compounds which are inhibitors of the polymerization of tubulin, to the methods for the production thereof, and to the uses of same.
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公开(公告)号：US10544231B2
公开(公告)日：2020-01-28
申请号：US15303889
申请日：2015-04-16
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , UNIVERSITE PARIS—SUD , CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE , UNIVERSITÉ DE DROIT ET DE LA SANTÉ DE LILLE 2
发明人： Petrus Lenting , Cécile Denis , Olivier Christophe , Paulette Legendre , Antoine Rauch , Sophie Susen
IPC分类号： C07K16/36 , A61K39/395
摘要： The invention relates to an isolated monoclonal antibody that specifically binds to the D4 domain of VWF, competes for binding to VWF D4 domain with ADAMTS13 and partially inhibits ADAMTS 13-mediated degradation of VWF. More particularly, the invention relates to an isolated monoclonal antibody comprising a heavy chain wherein the variable domain comprises at least one CDR having a sequence selected from the group consisting of SEQ ID NO: 3 for H-CDR1, SEQ ID NO: 4 for H-CDR2 and SEQ ID NO: 5 for H-CDR3 and a light chain wherein the variable domain comprises at least one CDR having a sequence selected from the group consisting of SEQ ID NO: 7 for L-CDR1, SEQ ID NO: 8 for L-CDR2 and SEQ ID NO: 9 for L-CDR3. Antibodies of the invention are presented to be useful in for the prevention or the treatment of bleeding episodes, such as bleeding episodes occurring in patients with aortic stenosis or patients with ventricular assist devices (VAD).
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