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    Treatment of women affected with polycystic ovary syndrome
    1.
    发明授权
    Treatment of women affected with polycystic ovary syndrome 有权

    公开(公告)号：US12208130B2

    公开(公告)日：2025-01-28

    申请号：US16490228

    申请日：2018-03-14

    Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITÉ DE LILLE ,  CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE

    Inventor： Paolo Giacobini ,  Vincent Prevot

    IPC: A61K38/09 ,  A61K31/7105 ,  A61K45/06

    Abstract: The present invention relates to the field of therapeutic treatment of polycystic ovary syndrome (PCOS). Polycystic ovary syndrome, PCOS, is the most common female reproductive disorder against which no therapeutic solution is available, beyond changes in the lifestyle. The inventors have now shown by using in vivo preclinical models, that individuals affected with PCOS have an abnormal elevated production of GnRH and that this elevated production of GnRH was transmitted to their offspring that also develop PCOS. Further, by examining AMH levels in a cohort of pregnant PCOS and control women, the inventors have found that AMH concentrations are significantly higher in PCOS women as compared to healthy women during the second trimester of gestation. These unexpected findings has allowed conceiving both prevention and treatment therapeutic strategies based on the administration of GnRH antagonists. Especially, the present invention relates to a gonadotropin-releasing hormone (GnRH) antagonist for its use in a woman affected with polycystic ovary syndrome (PCOS) for preventing the occurrence of PCOS in the offspring of the said woman. Even more interestingly, the present invention relates to a gonadotropin-releasing hormone (GnRH) antagonist for its use to rescue ovulation and fertility in postpuberal PCOS affected individuals.

    TEMPORO-MANDIBULAR PROSTHESIS
    4.
    发明申请
    TEMPORO-MANDIBULAR PROSTHESIS 审中-公开

    公开(公告)号：US20200008945A1

    公开(公告)日：2020-01-09

    申请号：US16486594

    申请日：2018-02-14

    Applicant: Institut National De La Sante De La Recherche Medicale (INSERM) ,  Centre Hospitalier Regional Universitaire De Lille ,  Universite De Lille

    Inventor： Joel Ferri

    IPC: A61F2/30

    Abstract: A temporo-mandibular prosthesis including a glenoid part and a condylar part intended to be articulated relative to the glenoid part. The glenoid part including a glenoid support made in a metallic material; and a glenoid insert made in a non-metal lie material, and defining a scat for a head of said condylar part to define said articulation, wherein the glenoid support defines a housing having an opening through which said glenoid insert is insertable into said housing, said opening opening on an external side (E) of said glenoid support, the glenoid support comprising a tab configurable in a passive position and in an active position in which said tab allows and forbids, respectively, the insertion and the extraction, respectively, of said glenoid insert into and out of said housing, respectively.

    Device enabling flow of food bolus between two stomas
    6.
    发明授权
    Device enabling flow of food bolus between two stomas 有权

    公开(公告)号：US10166139B2

    公开(公告)日：2019-01-01

    申请号：US14759885

    申请日：2014-01-27

    Applicant: CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE

    Inventor： Régis Logier ,  Jean-Pierre Sozanski ,  Jean-Robert Nzamushe Lepan Mabla

    IPC: A61F5/445 ,  A61M1/00 ,  A61F5/44 ,  A61M39/10

    Abstract: A device enabling food bolus flow between two stomas, said device having a pump forming means (3), said pump forming means (3) having an entry opening and an exit opening and being suitable for sucking food bolus through said entry opening and releasing it through said exit opening. The device further includes: —first watertight connection means (11) suitable for connecting said entry opening to a upstream stoma (S1) located on a patient's abdominal wall; —second watertight connection means (1) suitable for connecting said exit opening to a downstream stoma (S2), located on said patient's abdominal wall; said pump forming means being able to be activated by a user and suitable for being mounted on a patient's body, particularly on said patient's abdomen, in such a manner that once said device is mounted onto said patient's abdomen, food bolus flow can circulate from said upstream stoma (S1) to said downstream stoma (S2) outside of said patient's abdomen.

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