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公开(公告)号：US12054458B2
公开(公告)日：2024-08-06
申请号：US18186043
申请日：2023-03-17
发明人： Jens Cardinale , Martin Schaefer , Klaus Kopka , Matthias Eder , Ulrike Bauder-Wuest , Michael Eisenhut , Martina Benesova , Uwe Haberkorn , Frederik L. Giesel
IPC分类号： C07D213/61 , A61K38/00 , A61K51/04 , A61P35/00 , C07B59/00 , C07K7/02 , G01N33/574
CPC分类号： C07D213/61 , A61K51/04 , A61K51/0455 , A61P35/00 , C07B59/002 , C07K7/02 , G01N33/57434 , A61K38/00 , C07B2200/05
摘要： The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers and imaging agents for various disease states of prostate cancer.
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公开(公告)号：US20240240190A1
公开(公告)日：2024-07-18
申请号：US18562167
申请日：2022-05-20
IPC分类号： C12N15/113 , A61P35/00 , G01N33/50
CPC分类号： C12N15/1138 , A61P35/00 , G01N33/5026 , C12N2310/14 , G01N2500/10
摘要： The present invention relates to an inhibitor of mitoferrin-2 for use in treating a cancer with reduced activity of mitoferrin-1 in a subject. The present invention also relates to a method for identifying an inhibitor of mitoferrin-2 comprising (a) contacting a (i) host cell with a reduced mitoferrin-1 activity and (ii) a host cell with a non-reduced mitoferrin-1 activity with a candidate inhibitor of mitoferrin-2. (b) determining growth and/or morphology of the host cells of step (a): (c) identifying an inhibitor of mitoferrin-2 if a growth arrest and/or abnormal morphology is/are detected in step (b) in the host cell having the reduced activity of mitoferrin-1 but not in the host cell with the non-reduced activity of mitoferrin-1. The present invention further relates to a method for identifying a subject susceptible to cancer treatment by an inhibitor of mitoferrin-2, comprising (A) determining mitoferrin-1 activity in a sample of said subject, preferably a sample of cancer cells, and (B) identifying a patient susceptible to cancer treatment by an inhibitor of mitoferrin-2 based on determining step (A).
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3.发明授权公开(公告)号：US11835405B2
公开(公告)日：2023-12-05
申请号：US17638961
申请日：2020-08-16
IPC分类号： G01L1/24 , G01N33/483
CPC分类号： G01L1/24 , G01N33/4833
摘要： A force measuring plate having a planar regular arrangement of force measuring cells. A force measuring cell is formed in a hole in the force measuring plate, in which hole precisely one planar element which is secured by springs in a self-supporting fashion is arranged and is oriented so as to run parallel to the force measuring plate. Each spring is connected in a materially joined fashion at a first end to the edge of a hole and at a second end to the edge of a planar element. The force measuring plate, the springs and the planar elements are formed from the same material. Each planar element can be elastically deflected in three spatial directions under the effect of a force. There is a linear relationship between the deflection and the force. In addition, the invention relates to a device for determining forces in the piconewton to nanonewton ranges.
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公开(公告)号：US11426491B2
公开(公告)日：2022-08-30
申请号：US16094553
申请日：2017-03-23
摘要： A layer having individual elements made of an elastic material, with the length thereof exceeding the diameter thereof, which are secured on a carrier at a distance to one another, wherein the elements can be moved towards and away from one another, the elements can contact when moving towards one another, the outer surfaces of the elements provided with a surface modification, and the surface modification containing substances that can form reversible, non-covalent bonds. Also, a method for producing the layer, and the use of the layer.
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公开(公告)号：US10967044B2
公开(公告)日：2021-04-06
申请号：US16270293
申请日：2019-02-07
发明人： Volker Cleeves , Stephan Urban , Ralf Kubitz
IPC分类号： A61K38/00 , A61K38/16 , C07K14/705 , A61K38/17 , G01N33/50 , G01N33/68 , A61K31/00 , A61K31/575 , G01N33/92 , C07K14/005 , C12N7/00
摘要： The present invention relates to lipopeptide-based compounds for use in the diagnosis, prevention and/or treatment of a liver disease or condition, preferably liver involved metabolic diseases, as well as in the control or modification of the cholesterol level or cholesterol uptake and, thus, diagnosis, prevention and/or treatment of a cardiovascular disease. The present invention furthermore relates to an in vitro or in vivo assay or method for testing or measuring the NTCP-mediated transport of test compound(s). The present invention furthermore relates to a method for the diagnosis, prevention and/or treatment of a liver disease or condition, comprising administering a therapeutically effective amount of a lipopeptide-based compound to a patient. The present invention furthermore relates to a method for the diagnosis, prevention and/or treatment of a cardiovascular disease.
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公开(公告)号：US20200368211A1
公开(公告)日：2020-11-26
申请号：US16613514
申请日：2018-05-15
发明人： Aleksandar RADUJKOVIC , Thomas LUFT
IPC分类号： A61K31/433 , A61K31/42 , A61K31/275 , A61K31/44 , A61K31/45 , A61P35/00
摘要： The present invention relates to compositions for the treatment of a malignant disease and in particular to compositions comprising an NF-κB inhibitor and a γ-glutamyltransferase (γ-GT) inhibitor and therapeutic uses thereof. The invention further relates to in vitro methods of testing putative anti-tumour agents for their potential to act as therapeutically effective anti-tumour agents in vivo. Embodiments of the invention have been particularly developed for bringing NF-κB inhibitors to the clinic such as to provide alternative therapeutic options in the treatment of malignant diseases and will be described hereinafter with reference to this application. However, it will be appreciated that the invention is not limited to this particular field of use.
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公开(公告)号：US10525091B2
公开(公告)日：2020-01-07
申请号：US15617265
申请日：2017-06-08
发明人： Jean Rommelaere , Jeannine Lacroix , Joerg Schlehofer , Olaf Witt , Elisabeth Hedwig Deubzer , Sonja Kern , Christel Herold-Mende , Karsten Geletneky , Barbara Leuchs
IPC分类号： A61K39/23 , A61K35/768
摘要： Described is the use of a parvovirus, preferably H-1PV, for the therapeutical elimination of cancer stem cells (CSCs), preferably neuroblastoma stem cells and glioblastoma stem cells.
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公开(公告)号：US20170204450A1
公开(公告)日：2017-07-20
申请号：US15312780
申请日：2015-05-28
发明人： Stefan KRIENKE , Michael HUNDEMER
CPC分类号： C12Q1/37 , C12N9/50 , C12N9/52 , C12N9/6416 , C12N9/6427 , C12Y304/21004 , C12Y304/24021 , C12Y304/24024 , G01N15/1404 , G01N33/5047 , G01N2333/96433 , G01N2333/96486
摘要： The invention relates to an enzyme solution, which is used preferably for pre-treating mammalian cells for flow-cytometric detection of light chain restriction of the cells, the enzyme solution comprising at least two proteases, which are proteolytic and also collagenolytic, in a buffer. Preferably, the enzyme solution comprises trypsin, collagenase 4, dispase and astacin. The invention also relates to uses of the enzyme solution and methods for flow-cytometric detection of light chain restriction of cells.
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公开(公告)号：US09464995B2
公开(公告)日：2016-10-11
申请号：US14339691
申请日：2014-07-24
IPC分类号： G01N23/00 , G01N21/17 , G01N23/225 , G02B21/34 , G02B21/00
CPC分类号： G01N23/00 , G01N21/17 , G01N23/2251 , G01N23/2255 , G01N2223/612 , G02B21/002 , G02B21/34
摘要： Methods and devices for magnified imaging of three-dimensional samples are disclosed. The methods include imaging sample sections of a sample section series using a first particle-optical device. Coordinates of the imaged sample point are acquired and stored in such a way that the coordinates of the imaged sample point can be associated with the respective image of this sample point. The method also includes selecting a volume of interest (VOI), and transmitting the coordinates of the selected VOI to a second particle-optical device. In addition, the method includes imaging the selected VOI by means of the second particle-optical device. A plurality of planes of a sample section are imaged in order to obtain a 3D image of the selected VOI.
摘要翻译： 公开了用于三维样品的放大成像的方法和装置。 该方法包括使用第一粒子 - 光学装置成像样品部分序列的样品部分。 获取并存储成像采样点的坐标，使得成像采样点的坐标可以与该采样点的相应图像相关联。 该方法还包括选择感兴趣的体积（VOI），以及将所选择的VOI的坐标传输到第二粒子光学装置。 此外，该方法包括通过第二粒子光学装置对所选择的VOI进行成像。 对样本部分的多个平面进行成像以获得所选择的VOI的3D图像。
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公开(公告)号：US20150140067A1
公开(公告)日：2015-05-21
申请号：US14402586
申请日：2013-05-15
发明人： Marcus Mall , Raman Agrawal , Martina Muckenthaler
IPC分类号： C12N15/113 , C12Q1/68 , A61K47/48 , A61K45/06 , A61K31/713
CPC分类号： C12N15/113 , A61K31/713 , A61K45/06 , A61K47/543 , C12N2310/113 , C12N2310/141 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12Q1/6883 , C12Q2600/178 , C12N2310/3521
摘要： The present invention relates to the identification of microRNAs of the miR-148 family that are involved in the pathogenesis of chronic pulmonary diseases. The present invention relates to micro RNA of the miR-148 family selected from miR-148a, miR-148b and miR-152 for use in the diagnosis, prognosis, prevention and/or therapy of a chronic pulmonary disease. The present invention further relates to miR-148 inhibitors, pharmaceutical compositions comprising such inhibitors, their use in preventing and/or treating chronic pulmonary diseases, and methods for preventing and/or treating chronic pulmonary diseases. The present invention further relates to transgenic, non-human mammals and methods for identifying modulators of miR-148 and methods for diagnosis and/or prognosis of chronic pulmonary diseases.
摘要翻译： 本发明涉及参与慢性肺部疾病发病机理的miR-148家族的微小RNA的鉴定。 本发明涉及用于诊断，预后，预防和/或治疗慢性肺部疾病的miR-148家族的miR-148家族的微RNA，其用于miR-148a，miR-148b和miR-152。 本发明进一步涉及miR-148抑制剂，包含这些抑制剂的药物组合物，其用于预防和/或治疗慢性肺部疾病，以及预防和/或治疗慢性肺部疾病的方法。 本发明还涉及用于鉴定miR-148的调节剂的转基因，非人哺乳动物和用于诊断和/或预后的慢性肺部疾病的方法。
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