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公开(公告)号：US10413585B2
公开(公告)日：2019-09-17
申请号：US14442304
申请日：2013-11-12
发明人： Volker Cleeves , Stephan Urban , Ralf Kubitz
IPC分类号： A61K38/16 , C07K14/705 , A61K38/17 , G01N33/50 , G01N33/68 , A61K31/00 , A61K31/575 , G01N33/92 , C07K14/005 , C12N7/00
摘要： The present invention relates to lipopeptide-based compounds for use in the diagnosis, prevention and/or treatment of a liver disease or condition, preferably liver involved metabolic diseases, as well as in the control or modification of the cholesterol level or cholesterol uptake and, thus, diagnosis, prevention and/or treatment of a cardiovascular disease. The present invention furthermore relates to an in vitro or in vivo assay or method for testing or measuring the NTCP-mediated transport of test compound(s). The present invention furthermore relates to a method for the diagnosis, prevention and/or treatment of a liver disease or condition, comprising administering a therapeutically effective amount of a lipopeptide-based compound to a patient. The present invention furthermore relates to a method for the diagnosis, prevention and/or treatment of a cardiovascular disease.
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公开(公告)号：US20240123025A1
公开(公告)日：2024-04-18
申请号：US18330135
申请日：2023-06-06
发明人： Volker Cleeves , Stephan Urban , Ralf Kubitz
IPC分类号： A61K38/16 , A61K31/00 , A61K31/575 , A61K38/17 , C07K14/005 , C07K14/705 , C12N7/00 , G01N33/50 , G01N33/68 , G01N33/92
CPC分类号： A61K38/162 , A61K31/00 , A61K31/575 , A61K38/1709 , C07K14/005 , C07K14/705 , C12N7/00 , G01N33/5023 , G01N33/5067 , G01N33/6893 , G01N33/92 , C12N2730/10122 , C12N2730/10132 , G01N2333/705 , G01N2500/04 , G01N2500/10 , G01N2800/085
摘要： The present invention relates to lipopeptide-based compounds for use in the diagnosis, prevention and/or treatment of a liver disease or condition, preferably liver involved metabolic diseases, as well as in the control or modification of the cholesterol level or cholesterol uptake and, thus, diagnosis, prevention and/or treatment of a cardiovascular disease. The present invention furthermore relates to an in vitro or in vivo assay or method for testing or measuring the NTCP-mediated transport of test compound(s). The present invention furthermore relates to a method for the diagnosis, prevention and/or treatment of a liver disease or condition, comprising administering a therapeutically effective amount of a lipopeptide-based compound to a patient. The present invention furthermore relates to a method for the diagnosis, prevention and/or treatment of a cardiovascular disease.
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公开(公告)号：US10967044B2
公开(公告)日：2021-04-06
申请号：US16270293
申请日：2019-02-07
发明人： Volker Cleeves , Stephan Urban , Ralf Kubitz
IPC分类号： A61K38/00 , A61K38/16 , C07K14/705 , A61K38/17 , G01N33/50 , G01N33/68 , A61K31/00 , A61K31/575 , G01N33/92 , C07K14/005 , C12N7/00
摘要： The present invention relates to lipopeptide-based compounds for use in the diagnosis, prevention and/or treatment of a liver disease or condition, preferably liver involved metabolic diseases, as well as in the control or modification of the cholesterol level or cholesterol uptake and, thus, diagnosis, prevention and/or treatment of a cardiovascular disease. The present invention furthermore relates to an in vitro or in vivo assay or method for testing or measuring the NTCP-mediated transport of test compound(s). The present invention furthermore relates to a method for the diagnosis, prevention and/or treatment of a liver disease or condition, comprising administering a therapeutically effective amount of a lipopeptide-based compound to a patient. The present invention furthermore relates to a method for the diagnosis, prevention and/or treatment of a cardiovascular disease.
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