公开(公告)号：US20120188874A1

公开(公告)日：2012-07-26

申请号：US13357927

申请日：2012-01-25

申请人： TAKESHI KUMAGAI ,  Nobuhito Matsuyama ,  Takeshi Aimoto ,  Toshio Doi ,  Kazuo Sugai

发明人： TAKESHI KUMAGAI ,  Nobuhito Matsuyama ,  Takeshi Aimoto ,  Toshio Doi ,  Kazuo Sugai

IPC分类号： H04L12/26 ,  H04L12/56

CPC分类号： H04L47/6275 ,  H04L47/2441 ,  H04L47/60 ,  H04L49/9036

摘要： A relay device of relaying a communication packet is disclosed, which comprises: an input module configured to receive the communication packet as an input; a buffer configured to have a plurality of queues and temporarily accumulated the received communication packet; a sorter configured to sort the received communication packet to one of the plurality of queues, depending on a specific value obtained by a predetermined function that gives an aggregate output from an input which is transfer information regarding transfer of the communication packet; and a band controller configured to control a bandwidth for each of the plurality of queues and output communication packets accumulated in the plurality of queues for transmission of the communication packets. This ensures the quality of service, while saving the capacity of the buffer used for the queues.

摘要翻译： 公开了一种中继通信分组的中继装置，包括：输入模块，用于接收通信分组作为输入; 配置为具有多个队列并临时累积所接收的通信分组的缓冲器; 分拣机，被配置为根据通过给出来自关于通信分组的传送的传输的信息的输入的聚合输出的预定功能获得的特定值，将接收到的通信分组排序到多个队列中的一个队列; 以及频带控制器，被配置为控制所述多个队列中的每一个的带宽，并且输出在所述多个队列中累积的通信分组，以发送所述通信分组。 这确保了服务质量，同时节省了用于队列的缓冲区的容量。

公开(公告)号：US07764599B2

公开(公告)日：2010-07-27

申请号：US11672152

申请日：2007-02-07

申请人： Toshio Doi ,  Yukimasa Komahara

发明人： Toshio Doi ,  Yukimasa Komahara

IPC分类号： G01R31/08

CPC分类号： H04L45/22 ,  H04L45/00 ,  H04L45/02 ,  H04L45/28 ,  H04L45/54

摘要： A network routing device according to the invention transmits a packet via a second port based upon destination information included in the packet received via a first port referring to a routing table. In addition, the network routing device calculates beforehand a third port which is a transfer destination when a fault occurs in a destination connected to the second port. Further, the network routing device holds scenario information including a combination of the second port and the third port and updates the routing table based upon the scenario information when a fault is detected in either of the ports.

摘要翻译： 根据本发明的网络路由设备基于参考路由表经由第一端口接收的分组中包括的目的地信息经由第二端口发送分组。 此外，网络路由装置在连接到第二端口的目的地中发生故障时，预先计算作为传送目的地的第三端口。 此外，网络路由设备保存包括第二端口和第三端口的组合的场景信息，并且当在任一端口中检测到故障时，基于场景信息来更新路由表。

公开(公告)号：US06864247B2

公开(公告)日：2005-03-08

申请号：US10314389

申请日：2002-12-09

申请人： Toshio Doi

发明人： Toshio Doi

IPC分类号： A61K31/593 ,  A61P13/12 ,  A01N45/00

CPC分类号： A61K31/593

摘要： An object of the present invention is to provide pharmaceutical compositions for inhibiting mesangial cell proliferation or mesangial matrix production without causing hypercalcemia.According to the present invention, therapeutic agents for glomerulosclerosis containing 1α,3β-dihydroxy-20α-(3-hydroxy-3-methylbutyloxy)-9,10-seco-5,7,10 (19)-pregnatriene as an active ingredient are provided.

摘要翻译： 本发明的目的是提供用于抑制肾小球系膜细胞增殖或肾小球系膜基质产生而不引起高钙血症的药物组合物。根据本发明，含有1α，3β-二羟基-20α-（3-羟基-3- 甲基丁氧基）-9,10-仲-5,7,10（19） - 三孕烯作为活性成分。

公开(公告)号：US06506741B1

公开(公告)日：2003-01-14

申请号：US09959898

申请日：2001-11-13

申请人： Toshio Doi

发明人： Toshio Doi

IPC分类号： A01N4500

CPC分类号： A61K31/593

摘要： An object of the present invention is to provide pharmaceutical compositions for inhibiting mesangial cell proliferation or mesangial matrix production without causing hypercalcemia. According to the present invention, therapeutic agents for glomerulosclerosis containing 1&agr;,3&bgr;-dihydroxy-20&agr;-(3-hydroxy-3-methylbutyloxy)-9,10-seco-5,7,10 (19)-pregnatriene as an active ingredient are provided.

摘要翻译： 本发明的目的是提供用于抑制肾小球系膜细胞增殖或肾小球系膜基质产生而不引起高钙血症的药物组合物。根据本发明，含有1α，3β-二羟基-20α-（3-羟基-3- 甲基丁氧基）-9,10-仲-5,7,10（19） - 三孕烯作为活性成分。

公开(公告)号：US5669012A

公开(公告)日：1997-09-16

申请号：US720455

申请日：1996-09-30

申请人： Toru Shimizu ,  Shunichi Iwata ,  Toshio Doi ,  Shigeo Mizugaki

发明人： Toru Shimizu ,  Shunichi Iwata ,  Toshio Doi ,  Shigeo Mizugaki

IPC分类号： G06F7/00 ,  G06F9/30 ,  G06F9/305 ,  G06F9/308 ,  G06F9/315 ,  G06F9/34 ,  G06F9/35

CPC分类号： G06F9/30018 ,  G06F9/30032 ,  G06F9/30167

摘要： A data processor being provided with a microdecoder which decodes instruction codes comprising two operation code parts, a source operand specifying part and a destination operand specifying part, wherein an optional bit area of source data (a register of a general register file or a memory) is inserted in an optional bit area (determined by the value of the first operation code part) of a destination register according to the decoding result, and an optional bit area (determined by the value of the second operation code part) of a source register is extracted and stored in an optional bit area of destination (a register of the general register file or the memory), thereby making it possible to "process the insertion and extraction operations to and from optional byte positions of registers" at a high speed with short instruction code size.

摘要翻译： 一种数据处理器，其具有对包括两个操作码部分的指令代码，源操作数指定部分和目的地操作数指定部分进行解码的微解码器，其中源数据的可选位区（通用寄存器文件或存储器的寄存器） 根据解码结果插入到目的地寄存器的可选位区域（由第一操作码部分的值确定）和源寄存器的可选位区域（由第二操作码部分的值确定） 被提取并存储在目的地的可选位区（通用寄存器文件或存储器的寄存器）中，从而使得可以以高速“处理到寄存器的可选字节位置的插入和提取操作”成为可能， 短指令代码大小。

公开(公告)号：US5223733A

公开(公告)日：1993-06-29

申请号：US793296

申请日：1991-11-14

申请人： Toshio Doi ,  Takehisa Hayashi ,  Kenichi Ishibashi ,  Mitsuo Asai

发明人： Toshio Doi ,  Takehisa Hayashi ,  Kenichi Ishibashi ,  Mitsuo Asai

IPC分类号： H01L23/522 ,  H01L27/02

CPC分类号： H01L23/5225 ,  H01L27/0207 ,  H01L2924/0002 ,  H01L2924/3011

摘要： A semiconductor integrated circuit device is provided which include a plurality of cell columns each having a number of unit cells previously fabricated on a semiconductor substrate selected from the plural kinds of unit cells which are formed in desired circuits by electrically connecting circuit devices previously arranged. Each column includes at least one kind of unit cell of a dynamic circuit which has a node in a floating state during the operation of the cell unit. A fixed potential shield layer is also provided on the cell columns so as to cover the nodes of the dynamic circuits. By virtue of this, a wiring area for electrically connecting the desired cell units can be located between the cell columns and above the shield layer. In other words, signal wirings in the wiring area can pass over the nodes of the dynamic circuits. without adverse parasitic effects. The unit cell can also be provided with a precharge circuit comprising a standard cell and an in-cell wiring layer. Further, clock input terminals of the unit cells which are provided with a precharge circuit can be divided into plural groups, with all of said clock input terminals belonging to the same group and having equal load capacitances being connected. Clock buffer cells can be provided for supplying clock signals to the clock signal wirings for each group.

摘要翻译： 提供了一种半导体集成电路器件，其包括多个单元列，每个单元列具有预先制造在半导体衬底上的多个单元电池，半导体衬底选自通过电连接先前布置的电路元件而形成在期望电路中的多种单元电池。 每列包括在单元单元的操作期间具有处于浮置状态的节点的动态电路的至少一种单元。 固定电位屏蔽层也设置在单元列上，以覆盖动态电路的节点。 由此，用于电连接所需单元单元的布线区域可以位于单元列之间并且位于屏蔽层之上。 换句话说，布线区域中的信号布线可以通过动态电路的节点。 无不良寄生效应。 单元电池还可以设置有包括标准单元和单元内布线层的预充电电路。 此外，设置有预充电电路的单元电池的时钟输入端子可以被分成多组，所有的所述时钟输入端子都属于同一组并具有相等的负载电容。 可以提供时钟缓冲单元，用于将时钟信号提供给每个组的时钟信号布线。

公开(公告)号：US4114243A

公开(公告)日：1978-09-19

申请号：US775618

申请日：1977-03-08

申请人： Ko Soeno ,  Toshio Doi ,  Tomio Iizuka ,  Hiroshi Sakamoto ,  Hisashi Ando ,  Tetsuo Oyama ,  Akira Misumi

发明人： Ko Soeno ,  Toshio Doi ,  Tomio Iizuka ,  Hiroshi Sakamoto ,  Hisashi Ando ,  Tetsuo Oyama ,  Akira Misumi

IPC分类号： H01J1/14 ,  H01J9/04

CPC分类号： H01J9/04

摘要： In a process for producing a cathode for a cathode ray tube of directly heating type, which comprises shaping a heat-resistant and electro-conductive, flat metal plate, into a cathode substrate body having two leg pieces extended in the same direction and a flat part connected to one end of each leg piece, forming a heat-diffusible metal powder layer having a good affinity to said flat metal plate and on an outer surface of said flat part, heating the powder layer, thereby diffusion bonding the powder layer to the flat part and forming a bonding layer having an uneven surface, to which a thermionic emission layer is to be bonded, and forming the thermionic emission layer on the surface of the bonding layer, the process is characterized by forming on said flat metal plate a metal layer having a good affinity to the flat metal plate, by diffusion bonding, thereby forming a compound plate, and shaping the resulting compound plate into the shape of said cathode substrate body. A cathode having less thermal deformation and a longer life can be produced thereby.Furthermore, the process is characterized by applying a plastic working to the compound plate to a desired thickness and shaping the resulting compound plate into the shape of the cathode substrate body, and a cathode having much less thermal deformation and much longer life can be produced thereby.

摘要翻译： 在直接加热型阴极射线管用阴极的制造方法中，包括将耐热导电平板状金属板成形为具有沿相同方向延伸的两个支腿的阴极基板主体， 形成与所述平板状金属板和所述平坦部的外表面具有良好亲和性的热扩散性金属粉末层，加热所述粉末层，从而将所述粉末层扩散到 并且形成具有不平坦表面的接合层，热电子发射层将被结合到其上，并且在接合层的表面上形成热离子发射层，其特征在于在所述平坦金属板上形成金属 通过扩散接合对平板状金属板具有良好的亲和性，从而形成复合板，并将得到的化合物板成形为所述阴极基体的形状。 因此可以产生具有较少热变形和较长寿命的阴极。

公开(公告)号：US08774001B2

公开(公告)日：2014-07-08

申请号：US13357927

申请日：2012-01-25

申请人： Takeshi Kumagai ,  Nobuhito Matsuyama ,  Takeshi Aimoto ,  Toshio Doi ,  Kazuo Sugai

发明人： Takeshi Kumagai ,  Nobuhito Matsuyama ,  Takeshi Aimoto ,  Toshio Doi ,  Kazuo Sugai

IPC分类号： H04L12/26

CPC分类号： H04L47/6275 ,  H04L47/2441 ,  H04L47/60 ,  H04L49/9036

摘要： A relay device of relaying a communication packet is disclosed, which comprises: an input module configured to receive the communication packet as an input; a buffer configured to have a plurality of queues and temporarily accumulated the received communication packet; a sorter configured to sort the received communication packet to one of the plurality of queues, depending on a specific value obtained by a predetermined function that gives an aggregate output from an input which is transfer information regarding transfer of the communication packet; and a band controller configured to control a bandwidth for each of the plurality of queues and output communication packets accumulated in the plurality of queues for transmission of the communication packets. This ensures the quality of service, while saving the capacity of the buffer used for the queues.

摘要翻译： 公开了一种中继通信分组的中继装置，包括：输入模块，用于接收通信分组作为输入; 配置为具有多个队列并临时累积所接收的通信分组的缓冲器; 分拣机，被配置为根据通过给出来自关于通信分组的传送的传输的信息的输入的聚合输出的预定功能获得的特定值，将接收到的通信分组排序到多个队列中的一个队列; 以及频带控制器，被配置为控制所述多个队列中的每一个的带宽，并且输出在所述多个队列中累积的通信分组，以发送所述通信分组。 这确保了服务质量，同时节省了用于队列的缓冲区的容量。

公开(公告)号：US08025881B2

公开(公告)日：2011-09-27

申请号：US12374473

申请日：2007-07-19

申请人： Toshio Doi ,  Hideharu Abe ,  Naoshi Fukushima ,  Hitoshi Tai ,  Takakazu Mizuno ,  Masahiko Kinosaki

发明人： Toshio Doi ,  Hideharu Abe ,  Naoshi Fukushima ,  Hitoshi Tai ,  Takakazu Mizuno ,  Masahiko Kinosaki

IPC分类号： A61K39/395 ,  C12N5/12 ,  C07K16/00 ,  C07K16/18 ,  C07K16/22

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/76

摘要： When an anti-human BMP antibody was added to cells of an immortalized human mesangial cell line cultured in the presence of human BMP, the anti-human BMP antibody significantly suppressed the production of type IV collagen in mesangial cells. A number of signaling pathways are involved in abnormal proliferation of type IV collagen. It was therefore completely unpredictable whether merely blocking the BMP signal would indeed suppress the abnormal proliferation of type IV collagen. However, for the first time, the present inventors demonstrated that anti-BMP antibodies are very effective in suppressing the abnormal proliferation of type IV collagen. Thus, anti-BMP antibodies can be used as novel therapeutic agents for kidney diseases associated with abnormal proliferation of the mesangial matrix.

摘要翻译： 当将抗人BMP抗体加入到在人BMP存在下培养的永生化人肾小球系膜细胞的细胞中时，抗人BMP抗体显着抑制肾小球系膜细胞中IV型胶原的产生。 许多信号通路涉及IV型胶原异常增殖。 因此，完全不可预测的是，只是阻断BMP信号将确实抑制IV型胶原蛋白的异常增殖。 然而，本发明人第一次证明抗BMP抗体在抑制IV型胶原蛋白的异常增殖方面非常有效。 因此，抗BMP抗体可用作与肾小球系膜基质异常增殖相关的肾脏疾病的新型治疗剂。

公开(公告)号：US07862993B2

公开(公告)日：2011-01-04

申请号：US10571511

申请日：2004-09-09

申请人： Toshio Doi ,  Hideharu Abe

发明人： Toshio Doi ,  Hideharu Abe

IPC分类号： G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  G01N33/68

摘要： A method of detecting proliferative diseases causing sclerosis, comprising measuring the expression of at least one substance selected from the group consisting of STAT3, phosphorylated STAT3, Smad1, phosphorylated Smad1, activin receptor-like kinase 1, activin receptor-like kinase 3 and bone morphogenetic proteins in a biological sample. A kit therefor. A prophylactic and/or therapeutic agent for proliferative diseases causing sclerosis, comprising as an active ingredient a substance having an inhibitory effect on the expression of at least one substance selected from the group consisting of STAT3, phosphorylated STAT3, Smad1 and phosphorylated Smad1. A method of identifying substances effective in preventing and/or treating proliferative diseases causing sclerosis, comprising judging whether or not a test substance inhibits the expression of at least one substance selected from the group consisting of STAT3, phosphorylated STAT3, Smad1 and phosphorylated Smad1. A kit therefor.