hERG channel-expressing cell
    2.
    发明授权
    hERG channel-expressing cell 有权
    hERG通道表达细胞

    公开(公告)号:US07935526B2

    公开(公告)日:2011-05-03

    申请号:US10595858

    申请日:2004-11-17

    CPC classification number: G01N33/6872 C07K14/705

    Abstract: It is an object of the present invention to establish a method of establishing a cell with a remarkably high hERG channel expression level for use in predicting adverse effects based on hERG channel inhibition in research and development of drugs, and to thereby establish a highly sensitive and high throughput evaluation method.By inserting a hERG gene into a retrovirus vector plasmid or lentivirus vector plasmid to thereby prepare a virus vector, concentrating the vector by ultracentrifugation if necessary, transferring the hERG gene into cells and expressing hERG channels therein, it has become possible to secure an expression level effective in measurements using a fully automated high throughput patch clamp system or dyes.

    Abstract translation: 本发明的目的是建立一种建立具有非常高的hERG通道表达水平的细胞的方法,用于预测基于药物研发中的hERG通道抑制的不良反应,从而建立高度敏感和 高通量评估方法。 通过将hERG基因插入到逆转录病毒载体质粒或慢病毒载体质粒中,由此制备病毒载体,如果需要,通过超速离心浓缩载体,将hERG基因转移到细胞中并在其中表达hERG通道,已经可以确保表达水平 使用完全自动化的高通量膜片钳系统或染料测量有效。

    Process for producing olefin/aromatic vinyl copolymer
    3.
    发明授权
    Process for producing olefin/aromatic vinyl copolymer 失效
    烯烃/芳族乙烯基共聚物的制备方法

    公开(公告)号:US07022794B2

    公开(公告)日:2006-04-04

    申请号:US10477548

    申请日:2002-05-15

    Abstract: An olefin/aromatic vinyl compound copolymer which is excellent in transparency and which satisfies flexibility and heat resistance simultaneously can be produced by carrying out polymerization in such a manner that at least one of conditions: (a) the polymerization is carried out to an aromatic vinyl compound monomer conversion ratio of at least 50 mol % when the polymerization is completed, and (b) the polymer concentration is at least 10 mass % relative to the polymerization solution when the polymerization is completed, is satisfied, and the olefin partial pressure is changed so that the olefin partial pressure when the polymerization is completed is from 1.3 to 20 times the olefin partial pressure at the initiation of the polymerization.

    Abstract translation: 透明性优异并且同时满足柔软性和耐热性的烯烃/芳香族乙烯基化合物共聚物可以通过以下方式进行聚合来制造:使以下条件中的至少一个条件:(a)聚合进行芳族乙烯基 当聚合完成时,化合物单体转化率至少为50摩尔%,(b)当聚合完成时聚合物浓度相对于聚合溶液为至少10质量%,并且烯烃分压变化 使得当聚合完成时的烯烃分压是聚合开始时烯烃分压的1.3至20倍。

    Cross-copolymerized olefin/aromatic vinyl compound/diene copolymer and process for its production
    5.
    发明授权
    Cross-copolymerized olefin/aromatic vinyl compound/diene copolymer and process for its production 有权
    交联共聚烯烃/芳族乙烯基化合物/二烯共聚物及其生产方法

    公开(公告)号:US06803422B2

    公开(公告)日:2004-10-12

    申请号:US10078668

    申请日:2002-02-21

    Abstract: A highly uniform vinyl compound polymer-cross-copolymerized olefin/styrene/diene copolymer excellent in processability, mechanical properties, high temperature properties, compatibility and transparency, and its composition and a process for its production, are provided. This copolymer is a crossed polymer obtained by cross-copolymerizing an olefin/styrene/diene copolymer having a styrene content of from 0.03 mol % to 96 mol %, a diene content of from 0.0001 mol % to 3 mol % and the rest being an olefin, with an olefin/aromatic vinyl compound copolymer.

    Abstract translation: 提供了加工性,机械性能,高温性能,相容性和透明性优异的高度均匀的乙烯基化合物 - 交联共聚的烯烃/苯乙烯/二烯共聚物及其组成及其生产方法。 该共聚物是通过交联共聚苯乙烯含量为0.03摩尔%至96摩尔%,二烯含量为0.0001摩尔%至3摩尔%的烯烃/苯乙烯/二烯共聚物而得到的交叉聚合物,其余为烯烃 与烯烃/芳族乙烯基化合物共聚物。

    Flat core brushless motor
    6.
    发明授权
    Flat core brushless motor 失效
    平芯无刷电机

    公开(公告)号:US06762518B1

    公开(公告)日:2004-07-13

    申请号:US09587340

    申请日:2000-06-05

    CPC classification number: H02K11/00 H02K5/04 H02K21/22 Y10S310/06

    Abstract: A flat core brushless motor including a stator having a stator base with protruding poles, and a respective wound armature coil wrapped around each of the protruding poles, wherein the stator base includes at least one concave portion receiving the armature coils.

    Abstract translation: 一种扁平芯型无刷电动机,其特征在于,具备具有带有突出极的定子基体的定子和缠绕在每个所述突出极上的绕组电枢线圈,其中,所述定子基座包括容纳所述电枢线圈的至少一个凹部。

    DC power supply apparatus for arc-utilizing apparatuses

    公开(公告)号:US06507004B2

    公开(公告)日:2003-01-14

    申请号:US09988434

    申请日:2001-11-20

    CPC classification number: B23K9/1056

    Abstract: A DC power supply apparatus has two power supply input terminals between which one of 100 V level, 200 V level and 400 V level AC power supply voltages or a 575 V AC power supply voltage is applied. A rectifying unit is connected between the two power supply input terminals, and a voltage-lowering converter is connected to the rectifying unit. A thyristor is connected between the input and output of the voltage-lowering converter. A series combination of two capacitors is connected between two output terminals of the voltage-lowering converter. A switch circuit is connected between the junction of the two capacitors and one input terminal of the rectifying unit. An inverter converts a DC voltage appearing across the series combination of the capacitors into a high-frequency voltage, which, in turn, is voltage transformed by a transformer. The voltage-transformed high-frequency voltage is converted into a DC voltage in a high-frequency-to-DC converter for application to a load. When a 100 V level voltage is applied between the power supply input terminals, the thyristor is turned on, the voltage-lowering converter is turned off and the switch circuit is turned on. When one of the 200 V level voltages is connected, the thyristor is turned on, the voltage-lowering converter is turned off, and the switch circuit is turned off. When one of the 400 V level voltages or the 575 V voltage is applied between the power supply input terminals, the thyristor is turned off, the voltage-lowering converter is turned on, and the switch circuit is turned off.

    Resin composition
    8.
    发明授权
    Resin composition 有权
    树脂组成

    公开(公告)号:US06410649B1

    公开(公告)日:2002-06-25

    申请号:US09646771

    申请日:2000-09-22

    Abstract: A resin composition characterized by comprising from 5 to 95 wt % of an aromatic vinyl compound/olefin random copolymer (A) which has an aromatic vinyl compound content of from 1 to 99 mol % and has a head-to-tail chain structure composed of two or more aromatic vinyl compound units, and from 95 to 5 wt % of an &agr;-olefin type polymer (B) and/or an aromatic vinyl compound type polymer (C) (provided that it is neither a medical material nor a medical device), which contains substantially no chlorine and is excellent in the impact resistance, moldability, weather resistance and chemical resistance and which is useful for an injection molded product, an extrusion molded product, a film, a sheet, etc. Further, it provides an excellent damping material.

    Abstract translation: 一种树脂组合物,其特征在于,含有5〜95重量%的芳香族乙烯基化合物/烯烃无规共聚物(A),其芳香族乙烯基化合物含量为1〜99摩尔%,并具有头 - 尾链结构, 两种或多种芳族乙烯基化合物单元和95至5重量%的α-烯烃型聚合物(B)和/或芳族乙烯基化合物型聚合物(C)(条件是它既不是医疗材料也不是医疗装置 ),其基本上不含氯,并且耐冲击性,成型性,耐候性和耐化学性优异,并且可用于注射成型产品,挤出成型产品,膜,片材等。此外,它提供了一种 优良的阻尼材料。

    Vibrator motor having nonmagnetic armature cores
    10.
    发明授权
    Vibrator motor having nonmagnetic armature cores 失效
    振动电机具有非磁性衔铁

    公开(公告)号:US6011333A

    公开(公告)日:2000-01-04

    申请号:US298227

    申请日:1999-04-22

    CPC classification number: H02K7/063 H02K21/26

    Abstract: A vibrator motor has a generally sector-shaped eccentric armature rotor that has a nonmagnetic body including core parts, around which armature coils are individually wound. The core parts are disposed at an even pitch angle, but within a 180.degree. angular range, about the rotational axis of the rotor. A rotor body of one embodiment consists of a first part and a second part that includes the core parts and the first part is made of a synthetic resin and the second part is made of a synthetic resin or a nonmagnetic but electrically-conductive metal. A rotor of an additional embodiment has a single-piece body of a synthetic resin that integrally has the core parts.

    Abstract translation: 振动电动机具有大致扇形的偏心电枢转子,该转子具有包括铁芯部分的非磁性体,电枢线圈围绕该磁芯单独缠绕。 芯部分以相对于转子的旋转轴线的均匀角度设置在180度角范围内。 一个实施方式的转子体由包括芯部的第一部分和第二部分构成,第一部分由合成树脂制成,第二部分由合成树脂或非磁性但导电的金属制成。 附加实施例的转子具有整体地具有芯部的合成树脂的单件本体。

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