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    Devices, systems, and methods for reshaping a heart valve annulus, including the use of a bridge implant having an adjustable bridge stop
    1.
    发明申请
    Devices, systems, and methods for reshaping a heart valve annulus, including the use of a bridge implant having an adjustable bridge stop 审中-公开
    用于重塑心脏瓣膜环的装置，系统和方法，包括使用具有可调节桥接止挡件的桥式植入物

    公开(公告)号：US20080091059A1

    公开(公告)日：2008-04-17

    申请号：US11903407

    申请日：2007-09-21

    申请人： Timothy Machold ,  David Scott ,  David Rahdert ,  David Tholfsen ,  Robert Chang

    发明人： Timothy Machold ,  David Scott ,  David Rahdert ,  David Tholfsen ,  Robert Chang

    IPC分类号： A61F2/02

    CPC分类号： A61B17/0401 ,  A61B17/0057 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00606 ,  A61B2017/00619 ,  A61B2017/00623 ,  A61B2017/00876 ,  A61F2/2451 ,  A61F2/2466 ,  A61F2/2487

    摘要： Implants or systems of implants and methods apply a selected force vector or a selected combination of force vectors within or across the left atrium, which allow mitral valve leaflets to better coapt. The implants or systems of implants and methods make possible rapid deployment, facile endovascular delivery, and full intra-atrial adjustability and retrievability years after implant. The implants or systems of implants and methods also make use of strong fluoroscopic landmarks. The implants or systems of implants and methods make use of an adjustable implant and a fixed length implant. The implants or systems of implants and methods may also utilize an adjustable bridge stop to secure the implant, and the methods of implantation employ various tools.

    摘要翻译： 植入物或植入物和方法的系统在左心房内或横过左心房施加选定的力向量或力向量的选择组合，这允许二尖瓣小叶更好地适应。 植入物和植入物和方法的植入物或系统使得植入后几年可以快速部署，容易的血管内递送和完全的心房内可调节性和可追溯性。 植入物或植入物和方法的植入物或系统也利用强荧光检查标志。 植入物和植入物和植入物的系统利用可调植入物和固定长度植入物。 植入物和植入物和方法的植入物或系统还可以利用可调节的桥接止挡来固定植入物，并且植入方法使用各种工具。

    Devices, systems, and methods for supplementing, repairing, or replacing a native heart valve leaflet
    4.
    发明申请
    Devices, systems, and methods for supplementing, repairing, or replacing a native heart valve leaflet 有权
    用于补充，修复或更换天然心脏瓣膜小叶的装置，系统和方法

    公开(公告)号：US20080065204A1

    公开(公告)日：2008-03-13

    申请号：US11981025

    申请日：2007-10-31

    申请人： John Macoviak ,  Robert Chang ,  David Rahdert ,  Timothy Machold ,  Rick Soss

    发明人： John Macoviak ,  Robert Chang ,  David Rahdert ,  Timothy Machold ,  Rick Soss

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2445 ,  A61F2/2418 ,  A61F2/2454

    摘要： An implant for supplementing, repairing, or replacing a native heart valve leaflet or leaflets provides a scaffold, which defines a pseudo-annulus. The implant further has at least two struts in generally oppositely spaced apart positions on the scaffold. The scaffold can be placed in an elastically loaded condition in a heart with the struts engaging tissue at or near the leaflet commissures of a heart valve annulus, to reshape the annulus for leaflet coaptation. The implant further provides a neoleaflet element coupled to the scaffold within pseudo-annulus, to provide a one-way valve function.

    摘要翻译： 用于补充，修复或更换天然心脏瓣膜小叶或小叶的植入物提供了一种支架，其限定了假环形瓣。 植入物还具有至少两个在支架上相对间隔开的位置的支柱。 支架可以放置在心脏中的弹性加载状态，其中支柱将组织接合在心脏瓣膜环的小叶连接处或附近，以重新形成瓣膜以进行小叶接合。 植入物还提供在假环形空间内连接到支架的新翼元件，以提供单向阀功能。

    Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter
    5.
    发明申请
    Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter 有权
    通过可插入热交换导管来控制患者体温的方法和系统

    公开(公告)号：US20070191918A1

    公开(公告)日：2007-08-16

    申请号：US10645755

    申请日：2003-08-20

    申请人： Timothy MacHold ,  Wade Keller ,  Alex Roth ,  Nicole Bloom

    发明人： Timothy MacHold ,  Wade Keller ,  Alex Roth ,  Nicole Bloom

    IPC分类号： A61F7/00 ,  A61F7/12

    CPC分类号： A61F7/0085 ,  A61B2017/00092 ,  A61B2017/00119 ,  A61B2017/00123 ,  A61B2017/00199 ,  A61B2017/22051 ,  A61F7/0097 ,  A61F7/10 ,  A61F7/123 ,  A61F2007/0054 ,  A61F2007/0096 ,  A61F2007/126 ,  A61M25/10 ,  A61M25/1011 ,  A61M2025/1072 ,  A61M2025/1086 ,  A61M2205/12 ,  A61M2205/127

    摘要： Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory flow lines of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.

    摘要翻译： 包括诱导低温的状态的患者的温度改变方法和装置，或其选定区域。 使用在其中流体热交换介质循环的内部热交换导管来实现温度改变。 几个公开的变型中的任何一个的热交换盒附接到导管的循环流动管线，热交换盒的尺寸适于接合各种所描述的可重复使用的控制单元之一内的空腔。 控制单元包括加热器/冷却器装置，用户输入装置和连接以接收来自身体和系统周围的各种传感器的输入的处理器。 加热器/冷却器装置可以是热电，以使得能够基于极性进行加热和冷却。 提供了一种用于使体温上升或下降而没有过冲的温度控制方案。 一次性热交换盒可以包括与可再使用的控制单元内的泵驱动机构接合的整体泵头。 可以设置多个控制单元以接收相同的热交换盒，使得最初可以使用大容量控制单元，并且一旦患者达到期望的目标温度，可以取代较小的电池供电的单元。

    Inhibition of platelet activation, aggregation and/or adhesion by hypothermia
    6.
    发明申请
    Inhibition of platelet activation, aggregation and/or adhesion by hypothermia 有权
    通过低温抑制血小板活化，聚集和/或粘附

    公开(公告)号：US20070038277A1

    公开(公告)日：2007-02-15

    申请号：US11501442

    申请日：2006-08-08

    申请人： Michael Dae ,  Timothy Machold ,  Wade Keller

    发明人： Michael Dae ,  Timothy Machold ,  Wade Keller

    IPC分类号： A61F7/00 ,  A61F7/12

    CPC分类号： A61F7/12 ,  A61F7/123 ,  A61F2007/126

    摘要： A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient's vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36° C.) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient's shivering threshold (typically approximately 35.5 C). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient's body to normothermia or near normothermia.

    摘要翻译： 一种通过将热交换装置放置在患者的脉管系统中并使用该热交换装置来冷却患者来治疗人或动物患者的急性冠状动脉综合征（即不稳定型心绞痛或非Q波MI）或短暂性脑缺血发作的方法 达到血小板抑制（即，抑制血小板活化和/或聚集和/或粘附）的温度（例如30-36℃）。 可以向体温冷却到患者发抖阈值以下（通常约35.5℃）的患者施用抗发抖药物或麻醉。 如果确定不再需要血小板抑制，例如当患者即将进行其中出血可能有问题的手术或介入手术时，通过使用血管内热交换装置可以快速逆转低体温诱导的血小板抑制 将患者的身体重温为正常体温或接近正常体温。

    Intra-aortic balloon counterpulsation with concurrent hypothermia
    9.
    发明申请
    Intra-aortic balloon counterpulsation with concurrent hypothermia 有权
    主动脉内气囊反搏与并发低温

    公开(公告)号：US20050043579A1

    公开(公告)日：2005-02-24

    申请号：US10933970

    申请日：2004-09-02

    申请人： Michael Dae ,  Timothy Machold

    发明人： Michael Dae ,  Timothy Machold

    IPC分类号： A61B17/00 ,  A61F7/00 ,  A61F7/10 ,  A61F7/12 ,  A61M1/10 ,  A61M19/00 ,  A61M25/00 ,  A61N1/362

    CPC分类号： A61M1/1086 ,  A61F7/10 ,  A61F7/123 ,  A61F2007/0056 ,  A61F2007/0095 ,  A61F2007/126 ,  A61M1/106 ,  A61M1/107 ,  A61M1/1072 ,  A61M1/1074 ,  A61M1/125 ,  A61M19/00 ,  A61M2205/3606 ,  A61M2230/04

    摘要： Devices, systems and methods for treating disorders characterized by low cardiac output. The devices, systems and methods use intra-aortic balloon counterpulsation in combination with hypothermia of all or a portion of a human or veterinary patient's body to improve coronary perfusion and cardiac output. To effect the hypothermia, a heat exchange catheter may be positioned in the a patient's vasculature separately from the intra-aortic balloon counterpulsation catheter. Alternatively, a combination Intra-aortic balloon counterpulsation/heat exchange catheter may be utilized. Such combination catheter comprises a) a catheter sized for insertion into the aorta, b) a counterpulsation balloon and c) a heat exchanger. A drive/control system receives temperature and electrocardiograph signals and drives the inflation/deflation of the counterpulsation balloon as well as the heating/cooling of the heat exchanger.

    摘要翻译： 用于治疗以低心输出量为特征的疾病的装置，系统和方法。 装置，系统和方法使用主动脉内气囊反搏与人或兽医患者身体的全部或一部分的低体温结合以改善冠状动脉灌注和心输出量。 为了降低体温，可以将热交换导管与主动脉内气囊反搏导管分开设置在患者的脉管系统中。 或者，可以使用主动脉内球囊反搏/热交换导管的组合。 这种组合导管包括a）尺寸适于插入主动脉的导管，b）反力气囊和c）热交换器。 驱动/控制系统接收温度和心电图仪信号并驱动反力气囊的充气/放气以及热交换器的加热/冷却。