公开(公告)号：US11773138B2

公开(公告)日：2023-10-03

申请号：US17506523

申请日：2021-10-20

Applicant: Theradaptive, Inc.

Inventor： Luis Alvarez

IPC: C07K7/08 ,  C07K14/51 ,  C07K14/00 ,  A61P19/00 ,  C07K14/475 ,  A61K38/18 ,  A61K38/04 ,  A61K38/16

CPC classification number: C07K7/08 ,  A61K38/04 ,  A61K38/16 ,  A61K38/1875 ,  A61P19/00 ,  C07K14/001 ,  C07K14/475 ,  C07K14/51

Abstract: Provided herein are polypeptides that include one or more β-tricalcium phosphate (βTCP)-binding sequence(s) and uses thereof.

公开(公告)号：US20220395610A1

公开(公告)日：2022-12-15

申请号：US17871734

申请日：2022-07-22

Applicant: ORTHOREBIRTH CO., LTD. ,  Theradaptive, Inc.

Inventor： Hiroyuki TAIRA ,  Luis ALVAREZ

IPC: A61L27/36 ,  A61L27/44 ,  A61L27/54 ,  A61L27/58 ,  C08L67/04 ,  D01D5/00

Abstract: A bone regeneration material has a cotton-wool like structure formed of a plurality of electrospun fibers that contain bound BMP-2 through β-TCP binding peptide. The electrospun biodegradable fiber contains 25-65 vol % of β-TCP particles distributed in the fiber such that a portion of the β-TCP particles is exposed on a surface of the electrospun fiber and the remaining portion of the β-TCP particles is buried in the fiber. β-TCP binding peptides that are fused with BMP-2 are bound to the β-TCP particles so that BMP-2 is tethered to β-TCP particles on the surface of the fibers. Upon implantation of the bone regeneration material in a bone defect site of a human body, BMP-2 that are tethered to β-TCP particles on the surface of the bone regeneration material promotes proliferation and differentiation of cells at the bone defect site.

公开(公告)号：US20220323641A1

公开(公告)日：2022-10-13

申请号：US17636527

申请日：2020-08-19

Applicant: Theradaptive, Inc.

Inventor： Luis ALVAREZ ,  Todd HEIL

IPC: A61L27/10 ,  A61L27/42 ,  A61L27/54 ,  A61L27/56 ,  A61K38/08 ,  A61K38/10 ,  A61K38/17 ,  A61K38/18

Abstract: The present disclosure provides devices comprising a therapeutic agent bound to a printed three-dimensional structure. The printed three-dimensional structure comprises about 50% to about 100% by weight ceramic and about 0% to about 50% by weight N polymer. Ink formulations for three-dimensional printing are also disclosed. Additionally, provided herein are methods for manufacturing devices and uses thereof, e.g., in treating a condition in a subject in need thereof.

公开(公告)号：US20240226383A9

公开(公告)日：2024-07-11

申请号：US18547668

申请日：2022-02-23

Applicant: Theradaptive, Inc.

Inventor： Luis ALVAREZ ,  Todd HEIL

IPC: A61L27/56 ,  A61K47/52 ,  A61K47/59 ,  A61L27/12 ,  A61L27/26 ,  A61L27/54 ,  B33Y70/10 ,  B33Y80/00

CPC classification number: A61L27/56 ,  A61K47/52 ,  A61K47/593 ,  A61L27/12 ,  A61L27/26 ,  A61L27/54 ,  B33Y70/10 ,  B33Y80/00 ,  A61L2300/414 ,  A61L2430/02 ,  A61L2430/38

Abstract: The present disclosure provides devices comprising a therapeutic agent bound to a printed three-dimensional structure. Ink formulations for three-dimensional printing are also disclosed. Additionally, provided herein are methods for manufacturing devices and uses there e.g., in treating a condition in a subject in need thereof. The devices may be coated with therapeutic agents, such as those that promo bone growth, and/or seeded with cells to generate devices for use in tissue replacement and grafting.

公开(公告)号：US20240131228A1

公开(公告)日：2024-04-25

申请号：US18547668

申请日：2022-02-23

Applicant: Theradaptive, Inc.

Inventor： Luis ALVAREZ ,  Todd HEIL

IPC: A61L27/56 ,  A61K47/52 ,  A61K47/59 ,  A61L27/12 ,  A61L27/26 ,  A61L27/54 ,  B33Y70/10 ,  B33Y80/00

CPC classification number: A61L27/56 ,  A61K47/52 ,  A61K47/593 ,  A61L27/12 ,  A61L27/26 ,  A61L27/54 ,  B33Y70/10 ,  B33Y80/00 ,  A61L2300/414 ,  A61L2430/02 ,  A61L2430/38

Abstract: The present disclosure provides devices comprising a therapeutic agent bound to a printed three-dimensional structure. Ink formulations for three-dimensional printing are also disclosed. Additionally, provided herein are methods for manufacturing devices and uses there e.g., in treating a condition in a subject in need thereof. The devices may be coated with therapeutic agents, such as those that promo bone growth, and/or seeded with cells to generate devices for use in tissue replacement and grafting.

公开(公告)号：US20240108787A1

公开(公告)日：2024-04-04

申请号：US18542059

申请日：2023-12-15

Applicant: ORTHOREBIRTH CO., LTD. ,  Theradaptive, Inc.

Inventor： Hiroyuki Taira ,  Luis Alvarez

IPC: A61L27/36 ,  A61L27/44 ,  A61L27/54 ,  A61L27/58 ,  C08L67/04 ,  D01D5/00

CPC classification number: A61L27/3608 ,  A61L27/365 ,  A61L27/446 ,  A61L27/54 ,  A61L27/58 ,  C08L67/04 ,  D01D5/003 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2430/02

Abstract: A bone regeneration material has a cotton-wool like structure formed of a plurality of electrospun fibers that contain bound BMP-2 through β-TCP binding peptide. The electrospun biodegradable fiber contains 25-65 vol % of β-TCP particles distributed in the fiber such that a portion of the β-TCP particles is exposed on a surface of the electrospun fiber and the remaining portion of the β-TCP particles is buried in the fiber. β-TCP binding peptides that are fused with BMP-2 are bound to the β-TCP particles so that BMP-2 is tethered to β-TCP particles on the surface of the fibers. Upon implantation of the bone regeneration material in a bone defect site of a human body, BMP-2 that are tethered to β-TCP particles on the surface of the bone regeneration material promotes proliferation and differentiation of cells at the bone defect site.

公开(公告)号：US20240018187A1

公开(公告)日：2024-01-18

申请号：US18451003

申请日：2023-08-16

Applicant: THERADAPTIVE, INC.

Inventor： Luis ALVAREZ

IPC: C07K7/08 ,  C07K14/00 ,  A61P19/00 ,  C07K14/51 ,  C07K14/475 ,  A61K38/18 ,  A61K38/04 ,  A61K38/16

CPC classification number: C07K7/08 ,  C07K14/001 ,  A61P19/00 ,  C07K14/51 ,  C07K14/475 ,  A61K38/1875 ,  A61K38/04 ,  A61K38/16

Abstract: Provided herein are polypeptides that include one or more β-tricalcium phosphate (βTCP)-binding sequence(s) and uses thereof.

公开(公告)号：US20220220154A1

公开(公告)日：2022-07-14

申请号：US17506523

申请日：2021-10-20

Applicant: Theradaptive, Inc.

Inventor： Luis ALVAREZ

IPC: C07K7/08 ,  C07K14/00 ,  A61P19/00 ,  C07K14/51 ,  C07K14/475 ,  A61K38/18 ,  A61K38/04 ,  A61K38/16

Abstract: Provided herein are polypeptides that include one or more β-tricalcium phosphate (βTCP)-binding sequence(s) and uses thereof.

公开(公告)号：US20230235002A1

公开(公告)日：2023-07-27

申请号：US18046810

申请日：2022-10-14

Applicant: Theradaptive, Inc.

Inventor： Luis ALVAREZ ,  David STEWART ,  Hyeon PARK ,  Todd HEIL

IPC: C07K14/51 ,  C12N15/63 ,  A61P19/00

CPC classification number: C07K14/51 ,  C12N15/63 ,  A61P19/00

Abstract: Provided herein are polypeptides comprising a therapeutic targeted for delivery to an organ or tissue, and uses thereof.

公开(公告)号：US20230233740A1

公开(公告)日：2023-07-27

申请号：US18002608

申请日：2021-06-18

Applicant: ORTHOREBIRTH CO., LTD. ,  THERADAPTIVE, INC.

Inventor： Luis ALVAREZ ,  Yasutoshi NISHIKAWA ,  Hiroyuki TAIRA

IPC: A61L27/46

CPC classification number: A61L27/46 ,  A61L2430/02

Abstract: A method of producing an osteoinductive bone graft formed of a plurality of electrospun biodegradable fibers is disclosed. The method includes preparing a fibrous scaffold material formed of the plurality of electrospun biodegradable fibers, wherein the plurality of electrospun biodegradable fibers are entangled with each other to form a cotton-wool like structure having inter-fiber spaces forming a microenvironment for cell growth therein, and immersing the fibrous scaffold in a solution containing BMP-2 so that the BMP-2 is bound to the calcium particles exposed on the surface of the fibers. Area of binding site for BMP-2 on calcium particles exposed on a surface of the electrospun biodegradable fibers is adjusted by an amount of the calcium particles contained in the electrospun biodegradable fibers.