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    FUNCTIONAL OPTICAL COHERENT IMAGING
    3.
    发明申请
    FUNCTIONAL OPTICAL COHERENT IMAGING 有权
    功能光学相干成像

    公开(公告)号：US20110169978A1

    公开(公告)日：2011-07-14

    申请号：US13057593

    申请日：2008-07-10

    申请人： Theo Lasser ,  Dimitri Van De Ville ,  Erica Martin-Williams ,  Marcel Leutenegger ,  Iwan Maerki ,  Michael Friedrich ,  Martin Villiger

    发明人： Theo Lasser ,  Dimitri Van De Ville ,  Erica Martin-Williams ,  Marcel Leutenegger ,  Iwan Maerki ,  Michael Friedrich ,  Martin Villiger

    IPC分类号： H04N5/228

    CPC分类号： A61B5/0066 ,  A61B3/102 ,  A61B3/1233 ,  A61B5/0048 ,  A61B5/0059 ,  A61B5/02028 ,  A61B5/413 ,  A61B5/7203 ,  A61B5/726 ,  A61B5/7278 ,  A61B5/742

    摘要： The present invention relates to a functional optical coherent imaging (fOCI) platform comprising at least one active camera unit (ACU) comprising a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit, SAU); and an operator interface (HOD. Further the invention relates to a process for acquiring stimuli activated subject data comprising the steps of aligning a body function unit at a subject and monitoring pre-selected body function; selecting a stimulus or stimuli; imaging a body area of interest; exerting one or a series of stimuli on the subject; imaging the body area of interest synchronous with said stimuli and the preselected body functions; and transferring said synchronized image, stimuli and body function data to a statistical analysis unit (SAU) and performing calculations to generate results pertaining to body functions.

    摘要翻译： 功能性光学相干成像（fOCI）平台本发明涉及包括至少一个包括相干和/或部分相干光源的有源相机单元（ACU）的功能性光学相干成像（fOCI）平台，以及用于对感兴趣的所选择的身体区域进行频谱滤波和成像的装置; 用于预处理从ACU接收的数据的图像处理单元（IPU）; 向受试者传送刺激的至少一个刺激单元（STU）; 至少一个身体功能参考测量单元（BFMU）; 中央时钟和处理单元（CCU），与ACU，IPU，STU的互连，用于从IPU收集预处理的数据，以同步方式从BFMU的STU主体功能参考数据的刺激; 后处理单位（统计分析单位，SAU）; 另外本发明涉及一种用于获取刺激激活的被摄体数据的处理，包括以下步骤：对准对象的身体功能单元并监视预先选择的身体功能;选择刺激或刺激;对身体区域进行成像 对所述受试者施加一个或一系列刺激;对与所述刺激和预选身体功能同步的感兴趣体部成像;将所述同步图像，刺激和身体功能数据传送到统计分析单元（SAU）和 执行计算以生成与身体功能相关的结果。

    Microscopy imaging apparatus and method for generating an image
    4.
    发明授权
    Microscopy imaging apparatus and method for generating an image 有权
    显微镜成像装置和产生图像的方法

    公开(公告)号：US07385709B2

    公开(公告)日：2008-06-10

    申请号：US10501637

    申请日：2003-01-15

    申请人： Karsten Plamann ,  Stéphane Bourquin ,  Mathieu Ducros ,  Jelena Mitic ,  Francois Vuille ,  Theo Lasser ,  Tiemo Anhut

    发明人： Karsten Plamann ,  Stéphane Bourquin ,  Mathieu Ducros ,  Jelena Mitic ,  Francois Vuille ,  Theo Lasser ,  Tiemo Anhut

    IPC分类号： G01B11/24

    CPC分类号： G02B21/06 ,  G02B21/002 ,  G02B21/367 ,  G02B27/58

    摘要： A method and a microscopy imaging apparatus for generating an optically sectioned image of a specimen are provided. The method comprises the steps of: illuminating the specimen with a modulating, spatially periodic illumination pattern; imaging said specimen on a conjugate image plane; acquiring a plurality of signals at respective positions on said image plane, each signal corresponding to the incident light intensity at that position and having an oscillatory component caused by the modulation of the illumination pattern; and measuring a characteristic of the oscillatory component of each of the signals, whereby the measured characteristics when combined in their relative positions generate an optically sectioned image of the specimen.

    摘要翻译： 提供了一种用于产生样本的光学截面图像的方法和显微镜成像设备。 该方法包括以下步骤：用调制的空间周期照明图案照射样本; 在共轭图像平面上成像所述样本; 在所述图像平面上的各个位置处获取多个信号，每个信号对应于该位置处的入射光强度并且具有由照明图案的调制引起的振荡分量; 并且测量每个信号的振荡分量的特性，由此当在其相对位置中组合时的测量特性产生样本的光学截面图像。

    Method and device for identifying luminescent molecules according to the fluorescence correlation spectroscopy method
    5.
    发明申请
    Method and device for identifying luminescent molecules according to the fluorescence correlation spectroscopy method 审中-公开
    根据荧光相关光谱法鉴定发光分子的方法和装置

    公开(公告)号：US20060226374A1

    公开(公告)日：2006-10-12

    申请号：US10567427

    申请日：2004-08-06

    申请人： Rudolf Rigler ,  Theo Lasser ,  Pierre-Andre Besse ,  Alexis Rochas ,  Alexandre Serov ,  Michael Gosch ,  Radivoje Popovic

    发明人： Rudolf Rigler ,  Theo Lasser ,  Pierre-Andre Besse ,  Alexis Rochas ,  Alexandre Serov ,  Michael Gosch ,  Radivoje Popovic

    IPC分类号： G01J1/58

    CPC分类号： G01J3/2803 ,  G01J3/4406 ,  G01N21/645 ,  G01N21/6458 ,  G01N2021/6417 ,  G01N2021/6463 ,  G02B21/0024

    摘要： The invention relates to a method and device for identifying luminescent molecules according to the fluorescence correlation spectroscopy method. The inventive method comprising the following steps: a) preparing a sample (12) containing luminescent molecules; b) illuminating the sample (12) using an optical excitation device (2,4,6,8) comprising at least one light source, at least one, in particular, diffractive optical element (7) for splitting light passing therethrough into multiple beams, and a focusing optics (8) for focusing multiple light beams passing therethrough into multiple confocal volume elements: c) capturing emission radiation from the multiple confocal volume elements by means of a locally resolving sensor matrix arrangement (20), whereby the sensor matrix arrangement is a sensor matrix, which is comprised of avalanche photodiodes AD is produced using IC technology, particularly CMOS technology, and is integrated in a sensor chip (20) with Greiger-mode wiring, and; d) processing the signals, which are provided by the avalanche photodiode matrix, by means of a signal processing and evaluation device preferably integrated in the sensor chip.

    摘要翻译： 本发明涉及根据荧光相关光谱法鉴定发光分子的方法和装置。 本发明的方法包括以下步骤：a）制备含有发光分子的样品（12） b）使用包括至少一个光源的光学激发装置（2,4,6,8）照亮样品（12），至少一个特别是衍射光学元件（7），用于将穿过其中的光分成多个光束 以及用于将通过其中的多个光束聚焦成多个共焦体积元件的聚焦光学器件（8）：c）通过局部分辨传感器矩阵布置（20）捕获来自多个共焦体积元件的发射辐射，由此传感器矩阵布置 是由雪崩光电二极管组成的传感器矩阵，AD采用IC技术，特别是CMOS技术制造，并集成在具有Greiger模式布线的传感器芯片（20）中; d）通过优选地集成在传感器芯片中的信号处理和评估装置处理由雪崩光电二极管矩阵提供的信号。

    Instrument and method for high-speed perfusion imaging
    8.
    发明授权
    Instrument and method for high-speed perfusion imaging 有权
    用于高速灌注成像的仪器和方法

    公开(公告)号：US08480579B2

    公开(公告)日：2013-07-09

    申请号：US11912224

    申请日：2006-04-20

    申请人： Alexandre Serov ,  Theo Lasser

    发明人： Alexandre Serov ,  Theo Lasser

    IPC分类号： A61B5/05

    CPC分类号： A61B5/0059 ,  A61B5/0261 ,  A61B5/413

    摘要： A high-speed laser perfusion imaging instrument including a laser source, a detector, a signal-processing unit, data memory, and a screen to display results. A section of a sample surface is illuminated with laser light; reemitted light from the irradiated surface is collected by focusing optics on a 2D array of integrating photodetectors having elements that can be accessed individually or in a pre-defined selection of pixels at high speed. This 2D array measures intensity variations at each individual pixel. Average amplitude and mean frequency of the measured signal contain information about concentration and speed of moving blood cells. For real-time imaging, exposure time is used as a parameter to measure relative perfusion changes. These data are stored and processed with the signal-processing unit to deliver 2D flow maps of the illuminated sample section, and allow a simple overlay between a conventional image and processed flow maps.

    摘要翻译： 一种高速激光灌注成像仪器，包括激光源，检测器，信号处理单元，数据存储器和显示结果的屏幕。 用激光照射样品表面的一部分; 通过将光学器件聚焦在具有可以单独访问的元素的集成光电检测器的2D阵列上或以高速度的预定义的像素选择来收集来自被照射的表面的光。 该2D阵列测量各个像素处的强度变化。 测量信号的平均振幅和平均频率包含关于移动血细胞的浓度和速度的信息。 对于实时成像，暴露时间用作测量相对灌注变化的参数。 这些数据与信号处理单元一起存储和处理，以提供照明样本部分的2D流程图，并允许传统图像和处理流程图之间的简单覆盖。

    APPARATUS AND METHOD FOR DETECTING AND MEASURING BIOMOLECULAR INTERACTIONS
    10.
    发明申请
    APPARATUS AND METHOD FOR DETECTING AND MEASURING BIOMOLECULAR INTERACTIONS 有权
    用于检测和测量生物分子相互作用的装置和方法

    公开(公告)号：US20130016887A1

    公开(公告)日：2013-01-17

    申请号：US13581761

    申请日：2011-02-25

    申请人： Nicolas Durand ,  Iwan Märki ,  Theo Lasser

    发明人： Nicolas Durand ,  Iwan Märki ,  Theo Lasser

    IPC分类号： G06K9/62

    CPC分类号： G01N21/6452 ,  G01N21/6428 ,  G01N2035/00158

    摘要： A method and system for the rapid detection of biomolecular interactions, the system comprising a sensing platform which comprises a primary support structure including recesses designed to be located in front of a detection unit, said recesses containing one or several arrays of biosensors, said system furthermore comprising a reader unit for optical excitation and detection.

    摘要翻译： 一种用于快速检测生物分子相互作用的方法和系统，该系统包括感测平台，该感测平台包括主要支撑结构，其包括设计成位于检测单元前面的凹槽，所述凹部包含一个或多个生物传感器阵列，所述系统进一步 包括用于光学激发和检测的读取器单元。