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    Trans-Differentiation And Re-Differentiation Of Somatic Cells And Production Of Cells For Cell Therapies
    2.
    发明申请
    Trans-Differentiation And Re-Differentiation Of Somatic Cells And Production Of Cells For Cell Therapies 审中-公开
    体细胞细胞的转分化和再分化以及细胞治疗细胞的产生

    公开(公告)号：US20100120079A1

    公开(公告)日：2010-05-13

    申请号：US12609439

    申请日：2009-10-30

    Applicant: Raymond Page ,  Tanja Dominko ,  Christopher Malcuit

    Inventor： Raymond Page ,  Tanja Dominko ,  Christopher Malcuit

    IPC: C12N5/071 ,  C12N5/00 ,  C12Q1/02

    CPC classification number: C12N5/0618 ,  A61K35/12 ,  C12N2501/70 ,  C12N2501/999 ,  C12N2506/1307

    Abstract: The invention provides a method for effecting the trans-differentiation of a somatic cell, i.e., the conversion of a somatic cell of one cell type into a somatic cell of a different cell type. The method is practiced by culturing a somatic cell in the presence of at least one agent selected from the group consisting of (a) cytoskeletal inhibitors and (b) inhibitors of acetylation, and (c) inhibitors of methylation, and also culturing the cell in the presence of agents or conditions that induce differentiation to a different cell type. The method is useful for producing histocompatible cells for cell therapy.

    Abstract translation: 本发明提供了一种用于实现体细胞的转分化的方法，即将一种细胞类型的体细胞转化成不同细胞类型的体细胞。 所述方法是通过在至少一种选自（a）细胞骨架抑制剂和（b）乙酰化抑制剂）的药剂存在下培养体细胞来实施的，和（c）甲基化抑制剂，并且还将细胞培养 诱导分化成不同细胞类型的药剂或病症的存在。 该方法可用于生产用于细胞治疗的组织相容性细胞。

    METHODS AND COMPOSITIONS FOR CELL THERAPY
    5.
    发明申请
    METHODS AND COMPOSITIONS FOR CELL THERAPY 审中-公开
    细胞治疗方法与组合物

    公开(公告)号：US20120201788A1

    公开(公告)日：2012-08-09

    申请号：US13339614

    申请日：2011-12-29

    Applicant: Jose Cibelli ,  Tanja Dominko

    Inventor： Jose Cibelli ,  Tanja Dominko

    IPC: A61K35/12 ,  A61P25/16 ,  A61P25/28 ,  A61P25/00

    CPC classification number: A01K67/0271 ,  A01K2217/05 ,  A61K35/12 ,  A61K48/00 ,  C12N15/873 ,  C12N2517/02 ,  C12N2517/04

    Abstract: Improved methods of cell therapy are provided using cells and tissues that are histocompatible with a human or non-human transplant recipient. The cells and tissues for transplant produced by the present invention exhibit a youthful state and can be committed to specific cell lineages to better infiltrate and proliferate at a desired target, e.g., a tissue, or organ in need of cell replacement therapy. For providing cells and tissues for transplant to a non-human mammal, the cells and tissues can be isolated from a gastrulating embryo produced by same-species nuclear transfer.

    Abstract translation: 使用与人或非人类移植受体组织相容的细胞和组织提供改进的细胞治疗方法。 本发明生产的用于移植的细胞和组织表现出年轻状态，并且可以致力于特定的细胞谱系，以在期望的靶，例如需要细胞替代疗法的组织或器官中更好地渗透和增殖。 为了提供用于移植到非人哺乳动物的细胞和组织，细胞和组织可以从通过相同种类的核转移产生的诱导胚胎中分离出来。

    De-differentiation and re-differentiation of somatic cells and production of cells for cell therapies
    6.
    发明申请
    De-differentiation and re-differentiation of somatic cells and production of cells for cell therapies 审中-公开
    体细胞的分化和再分化以及用于细胞治疗的细胞的产生

    公开(公告)号：US20080076176A1

    公开(公告)日：2008-03-27

    申请号：US11842074

    申请日：2007-08-20

    Applicant: Tanja Dominko ,  Raymond Page

    Inventor： Tanja Dominko ,  Raymond Page

    IPC: C12N5/00 ,  C12N5/08

    CPC classification number: C12N5/0618 ,  C12N5/16 ,  C12N2500/25 ,  C12N2500/80 ,  C12N2500/90 ,  C12N2501/13 ,  C12N2502/13 ,  C12N2506/1307

    Abstract: The invention provides a method for effecting the de-differentiation of a somatic cell by culturing the cell in the absence of growth factors, cytokines, or other differentiation-inducing agents, and introducing components of cytoplasm of plutipotent cells into the somatic cell and allowing the cell to de-differentiate. The method can be used with somatic cells of any type, from any species of animal. The pluripotent cells may be oocytes, blastomeres, inner cell mass cells, embryonic stem cells, embryonic germ cells, embryos consisting of one or more cells, embryoid body (embryoid) cells, moruia-derived cells, teratoma (teratocarcinoma) cells, as well as multipotent partially differentiated embryonic stem cells taken from later in the embryonic development process. After being de-differentiated, the cell can be induced to re-differentiate into a different somatic cell type. A method for de-differentiating a somatic cell and inducing it to re-differentiate into a cell of neural lineage is disclosed.

    Abstract translation: 本发明提供了一种通过在不存在生长因子，细胞因子或其它分化诱导剂的情况下培养细胞来实现体细胞去分化的方法，并将多能细胞的细胞质成分引入体细胞，并允许 细胞去分化。 该方法可以与来自任何动物种类的任何类型的体细胞一起使用。 多能细胞可以是卵母细胞，卵裂球细胞，内细胞大量细胞，胚胎干细胞，胚胎生殖细胞，由一种或多种细胞组成的胚胎，胚状体（胚状体）细胞，蚕源性细胞，畸胎瘤（畸胎癌）细胞，以及 作为从胚胎发育过程后期获取的多能部分分化胚胎干细胞。 在被分化后，可诱导细胞重新分化成不同的体细胞类型。 公开了一种使体细胞去分化并诱导其重新分化成神经谱系的细胞的方法。

    Pluripotent mammalian cells
    7.
    发明申请
    Pluripotent mammalian cells 审中-公开
    多能哺乳动物细胞

    公开(公告)号：US20050210537A1

    公开(公告)日：2005-09-22

    申请号：US11131703

    申请日：2005-05-18

    Applicant: Tanja Dominko ,  Raymond Page ,  Alan Colman ,  Todd Vaught ,  Vivienne Marshall

    Inventor： Tanja Dominko ,  Raymond Page ,  Alan Colman ,  Todd Vaught ,  Vivienne Marshall

    IPC: A61K48/00 ,  C12N5/16 ,  C12N15/873 ,  A01K67/027 ,  C12N5/06 ,  C12N5/08

    CPC classification number: C12N15/873 ,  A61K48/00 ,  C12N5/16 ,  C12N2506/04 ,  C12N2517/04 ,  C12N2517/10

    Abstract: The invention relates to a method of making pluripotent stem cells that does not involve the formation of early preimplantation embryos or fetal tissue. The method has general utility in the production of pluripotent stem cells from many mammalian species but has particular application in man where pluripotent stem cell production can be customized to particular human individual. The method involves the fusion of donor somatic or stem cells (or their karyoplasts) with cytoplasmic, membrane-delimited fragments of mammalian oocytes or zygotes. After the initial genomic reprogramming occurs, the cells can proliferate and thus multiply in vitro yielding a large number of autologous cells for cell therapy application. The result of this process is a cell population genomically identical to the somatic, differentiated cells derived from an individual patient. However, these cells are pluripotent in that upon application of specific growth factors, the cells are capable of differentiating into specific cell types as required by the sought clinical indication.

    Abstract translation: 本发明涉及一种制造不涉及早期植入前胚胎或胎儿组织的形成的多能干细胞的方法。 该方法在许多哺乳动物物种的多能干细胞的生产中具有普遍的用途，但在人类中具有特殊应用，其中多能干细胞的生产可以根据具体的个体进行定制。 该方法涉及供体体细胞或干细胞（或它们的核型）与哺乳动物卵母细胞或合子的细胞质膜分离的片段的融合。 在初始基因组重编程发生后，细胞可以增殖并因此在体外繁殖产生大量用于细胞治疗应用的自体细胞。 该过程的结果是与来自个体患者的体细胞分化细胞基因相同的细胞群体。 然而，这些细胞是多能的，因为在应用特定生长因子时，细胞能够根据寻求的临床适应症的要求将其分化成特定的细胞类型。

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