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公开(公告)号：US10449271B2
公开(公告)日：2019-10-22
申请号：US15943163
申请日：2018-04-02
Applicant: Marsha Rolle , Fioleda Prifti , Christopher Malcuit , Terri Anne Camesano , Tanja Dominko , Denis Kole
Inventor： Marsha Rolle , Fioleda Prifti , Christopher Malcuit , Terri Anne Camesano , Tanja Dominko , Denis Kole
Abstract: The invention provides a scaffold of extracellular matrix polymers with recombinant chimeric peptides tethered thereto. The invention also provides recombinant chimeric peptides of antimicrobial peptides and extracellular matrix binding domains. The invention also provides methods for treating chronic wounds using the scaffold and/or recombinant chimeric peptides.
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2.发明申请METHODS OF PRODUCING HUMAN RPE CELLS AND PHARMACEUTICAL PREPARATIONS OF HUMAN RPE CELLS 审中-公开生产人RPE细胞的方法和人类RPE细胞的药物制备公开(公告)号：US20130149284A1
公开(公告)日：2013-06-13
申请号：US13510426
申请日：2010-11-17
Applicant: Christopher Malcuit , Linda Lemieux , William Holmes , Pedro Huertas , Lucy Vilner
Inventor： Christopher Malcuit , Linda Lemieux , William Holmes , Pedro Huertas , Lucy Vilner
IPC: A61K35/12
CPC classification number: A61K35/12 , C12N5/0621 , C12N2506/02
Abstract: The present invention provides improved methods for producing retinal pigmented epithelial (RPE) cells from human embryonic stem cells, human induced pluripotent stem (iPS), human adult stem cells, human hematopoietic stem cells, human fetal stem cells, human mesenchymal stem cells, human postpartum stem cells, human multipotent stem cells, or human embryonic germ cells. The RPE cells derived from embryonic stem cells are molecularly distinct from adult and fetal-derived RPE cells, and are also distinct from embryonic stem cells. The RPE cells described herein are useful for treating retinal degenerative conditions including retinal detachment and macular degeneration.
Abstract translation: 本发明提供了用于从人胚胎干细胞，人诱导多能干（iPS），人成体干细胞，人造血干细胞，人胎儿干细胞，人间充质干细胞，人类的人类胚胎干细胞中产生视网膜色素上皮（RPE）细胞的改进方法 产后干细胞，人多能干细胞或人胚胎生殖细胞。 衍生自胚胎干细胞的RPE细胞与成体和胎儿衍生的RPE细胞分子不同，并且也不同于胚胎干细胞。 本文所述的RPE细胞可用于治疗视网膜退行性疾病，包括视网膜脱离和黄斑变性。
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3.发明授权Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies 有权体细胞的转分化和再分化以及用于细胞治疗的细胞的产生公开(公告)号：US07621606B2
公开(公告)日：2009-11-24
申请号：US10228296
申请日：2002-08-27
Applicant: Raymond Page , Tanja Dominko , Christopher Malcuit
Inventor： Raymond Page , Tanja Dominko , Christopher Malcuit
CPC classification number: C12N5/0618 , A61K35/12 , C12N2501/70 , C12N2501/999 , C12N2506/1307
Abstract: The invention provides a method for effecting the trans-differentiation of a somatic cell, i.e., the conversion of a somatic cell of one cell type into a somatic cell of a different cell type. The method is practiced by culturing a somatic cell in the presence of at least one agent selected from the group consisting of (a) cytoskeletal inhibitors and (b) inhibitors of acetylation, and (c) inhibitors of methylation, and also culturing the cell in the presence of agents or conditions that induce differentiation to a different cell type. The method is useful for producing histocompatible cells for cell therapy.
Abstract translation: 本发明提供了一种用于实现体细胞的转分化的方法，即将一种细胞类型的体细胞转化成不同细胞类型的体细胞。 所述方法是通过在至少一种选自（a）细胞骨架抑制剂和（b）乙酰化抑制剂）的药剂存在下培养体细胞来实施的，和（c）甲基化抑制剂，并且还将细胞培养 诱导分化成不同细胞类型的药剂或病症的存在。 该方法可用于生产用于细胞治疗的组织相容性细胞。
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4.发明公开公开(公告)号：US20240307436A2
公开(公告)日：2024-09-19
申请号：US18504238
申请日：2023-11-08
Applicant: Christopher Malcuit , Linda Lemieux , William Holmes , Pedro Huertas , Lucy Vilner
Inventor： Christopher Malcuit , Linda Lemieux , William Holmes , Pedro Huertas , Lucy Vilner
CPC classification number: A61K35/12 , C12N5/0621 , C12N2506/02
Abstract: The present invention provides improved methods for producing retinal pigmented epithelial (RPE) cells from human embryonic stem cells, human induced pluripotent stem (iPS), human adult stem cells, human hematopoietic stem cells, human fetal stem cells, human mesenchymal stem cells, human postpartum stem cells, human multipotent stem cells, or human embryonic germ cells. The RPE cells derived from embryonic stem cells are molecularly distinct from adult and fetal-derived RPE cells, and are also distinct from embryonic stem cells. The RPE cells described herein are useful for treating retinal degenerative conditions including retinal detachment and macular degeneration.
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公开(公告)号：US20130095078A1
公开(公告)日：2013-04-18
申请号：US13634075
申请日：2011-03-11
Applicant: Christopher Malcuit , Tanja Dominko , Raymond Lynn Page , George D. Pins , Jennifer Makridakis
Inventor： Christopher Malcuit , Tanja Dominko , Raymond Lynn Page , George D. Pins , Jennifer Makridakis
CPC classification number: A61K38/39 , A61K35/33 , A61K35/34 , A61K35/44 , A61L27/225 , A61L27/24 , A61L27/38 , A61M37/00
Abstract: An engineered muscle construct in the form of a braided collagen microthread scaffold is provided. The microthread scaffold can be used with or without cells as engineered skeletal muscle. The microthread scaffold can also be used to promote cell attachment and growth to deliver cells to a large muscle defect to stimulate muscle regeneration. Methods for making a muscle construct, seeding cells onto microthread scaffolds and treating muscle defects are also provided.
Abstract translation: 提供了一种以编织胶原微结构支架形式的工程肌肉构造。 微型支架可用于或不使用细胞作为工程骨骼肌。 微观支架也可用于促进细胞附着和生长，以将细胞递送至大的肌肉缺陷以刺激肌肉再生。 还提供了制备肌肉构造物，将细胞接种到微型支架上并治疗肌肉缺陷的方法。
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Patent Agency Ranking
6.发明申请Genetically Intact Induced Pluripotent Cells Or Transdifferentiated Cells And Methods For The Production Thereof 审中-公开基因完整诱导多能细胞或转分化细胞及其生产方法公开(公告)号：US20110286978A1
公开(公告)日：2011-11-24
申请号：US12787175
申请日：2010-05-25
Applicant: Irina V. Klimanskaya , Shi-Jiang Lu , Robert Lanza , Michael D. West , Karen B. Chapman , Roy Geoffrey Sargent , Raymond Page , Tanja Dominko , Christopher Malcuit
Inventor： Irina V. Klimanskaya , Shi-Jiang Lu , Robert Lanza , Michael D. West , Karen B. Chapman , Roy Geoffrey Sargent , Raymond Page , Tanja Dominko , Christopher Malcuit
CPC classification number: C12N5/0696 , C07K2319/10 , C07K2319/60 , C07K2319/71 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608
Abstract: The present disclosure relates to methods for dedifferentiating and transdifferentiating recipient cells, preferably human somatic cells. These methods minimize the risk of undesired genome sequence alteration. These methods employ reprogramming factors, which may be used alone or in certain combinations with one another. These methods have application especially in the context of cell-based therapies, establishment of cell lines, and the production of genetically modified cells.
Abstract translation: 本公开涉及用于去分化和转分化受体细胞，优选人体细胞的方法。 这些方法使不希望的基因组序列改变的风险最小化。 这些方法采用重编程因子，其可以单独使用或以某种组合使用。 这些方法特别适用于基于细胞的疗法，细胞系的建立以及转基因细胞的生产。
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7.发明申请Trans-Differentiation And Re-Differentiation Of Somatic Cells And Production Of Cells For Cell Therapies 审中-公开体细胞细胞的转分化和再分化以及细胞治疗细胞的产生公开(公告)号：US20100120079A1
公开(公告)日：2010-05-13
申请号：US12609439
申请日：2009-10-30
Applicant: Raymond Page , Tanja Dominko , Christopher Malcuit
Inventor： Raymond Page , Tanja Dominko , Christopher Malcuit
CPC classification number: C12N5/0618 , A61K35/12 , C12N2501/70 , C12N2501/999 , C12N2506/1307
Abstract: The invention provides a method for effecting the trans-differentiation of a somatic cell, i.e., the conversion of a somatic cell of one cell type into a somatic cell of a different cell type. The method is practiced by culturing a somatic cell in the presence of at least one agent selected from the group consisting of (a) cytoskeletal inhibitors and (b) inhibitors of acetylation, and (c) inhibitors of methylation, and also culturing the cell in the presence of agents or conditions that induce differentiation to a different cell type. The method is useful for producing histocompatible cells for cell therapy.
Abstract translation: 本发明提供了一种用于实现体细胞的转分化的方法，即将一种细胞类型的体细胞转化成不同细胞类型的体细胞。 所述方法是通过在至少一种选自（a）细胞骨架抑制剂和（b）乙酰化抑制剂）的药剂存在下培养体细胞来实施的，和（c）甲基化抑制剂，并且还将细胞培养 诱导分化成不同细胞类型的药剂或病症的存在。 该方法可用于生产用于细胞治疗的组织相容性细胞。
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公开(公告)号：US20110274662A1
公开(公告)日：2011-11-10
申请号：US12682712
申请日：2008-10-10
Applicant: Christopher Malcuit , Linda Lemieux , William Holmes , Pedro Huertas , Lucy Vilner
Inventor： Christopher Malcuit , Linda Lemieux , William Holmes , Pedro Huertas , Lucy Vilner
Abstract: The present invention provides improved methods for producing RPE cells from human embryonic stem cells or from other human pluripotent stem cells. The invention also relates to human retinal pigmented epithelial cells derived from human embryonic stem cells or other human multipotent or pluripotent stem cells. hRPE cells derived from embryonic stem cells are molecularly distinct from adult and fetal-derived RPE cells, and are also distinct from embryonic stem cells. The hRPE cells described herein are useful for treating retinal degenerative diseases.
Abstract translation: 本发明提供了用于从人胚胎干细胞或其他人多能干细胞产生RPE细胞的改进方法。 本发明还涉及源自人胚胎干细胞或其他人多能或多能干细胞的人视网膜色素上皮细胞。 衍生自胚胎干细胞的hRPE细胞与成体和胎儿衍生的RPE细胞分子不同，并且也不同于胚胎干细胞。 本文所述的hRPE细胞可用于治疗视网膜退行性疾病。
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公开(公告)号：US20180280579A1
公开(公告)日：2018-10-04
申请号：US15943163
申请日：2018-04-02
Applicant: Marsha Rolle , Fioleda Prifti , Christopher Malcuit , Terri Anne Camesano , Tanja Dominko , Denis Kole
Inventor： Marsha Rolle , Fioleda Prifti , Christopher Malcuit , Terri Anne Camesano , Tanja Dominko , Denis Kole
CPC classification number: A61L27/54 , A61L2300/404 , C07K14/4723 , C07K14/78 , C07K2319/00 , C12N15/62
Abstract: The invention provides a scaffold of extracellular matrix polymers with recombinant chimeric peptides tethered thereto. The invention also provides recombinant chimeric peptides of antimicrobial peptides and extracellular matrix binding domains. The invention also provides methods for treating chronic wounds using the scaffold and/or recombinant chimeric peptides.
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公开(公告)号：US09931437B2
公开(公告)日：2018-04-03
申请号：US14613767
申请日：2015-02-04
Applicant: Marsha Rolle , Fioleda Prifti , Christopher Malcuit , Terri Anne Camesano , Tanja Dominko , Denis Kole
Inventor： Marsha Rolle , Fioleda Prifti , Christopher Malcuit , Terri Anne Camesano , Tanja Dominko , Denis Kole
CPC classification number: A61L27/54 , A61L2300/404 , C07K14/4723 , C07K14/78 , C07K2319/00 , C12N15/62
Abstract: The invention provides a scaffold of extracellular matrix polymers with recombinant chimeric peptides tethered thereto. The invention also provides recombinant chimeric peptides of antimicrobial peptides and extracellular matrix binding domains. The invention also provides methods for treating chronic wounds using the scaffold and/or recombinant chimeric peptides.
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