Invention Application
US20110274662A1 Methods of Producing RPE Cells and Compositions of RPE Cells
审中-公开
RPE细胞的产生方法及RPE细胞的组成
- Patent Title: Methods of Producing RPE Cells and Compositions of RPE Cells
- Patent Title (中): RPE细胞的产生方法及RPE细胞的组成
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Application No.: US12682712Application Date: 2008-10-10
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Publication No.: US20110274662A1Publication Date: 2011-11-10
- Inventor: Christopher Malcuit , Linda Lemieux , William Holmes , Pedro Huertas , Lucy Vilner
- Applicant: Christopher Malcuit , Linda Lemieux , William Holmes , Pedro Huertas , Lucy Vilner
- International Application: PCT/US08/11669 WO 20081010
- Main IPC: A61K35/12
- IPC: A61K35/12 ; C12N5/071 ; A61P27/02 ; C12Q1/02
Abstract:
The present invention provides improved methods for producing RPE cells from human embryonic stem cells or from other human pluripotent stem cells. The invention also relates to human retinal pigmented epithelial cells derived from human embryonic stem cells or other human multipotent or pluripotent stem cells. hRPE cells derived from embryonic stem cells are molecularly distinct from adult and fetal-derived RPE cells, and are also distinct from embryonic stem cells. The hRPE cells described herein are useful for treating retinal degenerative diseases.
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