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    2,N.sup.6 -disubstituted and 2,N.sup.6 -trisubstituted adenosine-3'-phosphoramidites
    2.
    发明授权
    2,N.sup.6 -disubstituted and 2,N.sup.6 -trisubstituted adenosine-3'-phosphoramidites 失效
    2，N6-二取代和2，N6-三取代的腺苷-3'-亚磷酰胺

    公开(公告)号：US4845205A

    公开(公告)日：1989-07-04

    申请号：US822639

    申请日：1986-01-08

    Applicant: Tam Huynh Dinh ,  Catherine Gouyette ,  Jean Igolen

    Inventor： Tam Huynh Dinh ,  Catherine Gouyette ,  Jean Igolen

    IPC: C07H19/20 ,  C07H21/00 ,  C12Q1/68

    CPC classification number: C07H21/00 ,  C07H19/20 ,  C12Q1/68

    Abstract: The invention concerns 2,N.sup.6 -disubstituted and 2,N.sup.6 -trisubstituted adenosine nucleosides in which the sugar component is substituted at position 3' or position 5' by a phosphite or phosphoramidite group of the formula: ##STR1## R.sub.1 representing a lower alkyl or --(CH.sub.2).sub.n --CN with n being an integer between 1 and 4, and X representing a halogen or an amine group. These nucleosides make it possible to prepare sequences of nucleotides usable, in particular, as probes in the field of analyses and biological extractions.

    Abstract translation: 本发明涉及2，N6-二取代和2，N6-三取代的腺苷核苷，其中糖组分在3'或5'位被亚磷酸酯或亚磷酰胺基团取代，其中R1表示低级烷基或 - （CH 2）n -CN，其中n是1和4之间的整数，X表示卤素或胺基。 这些核苷使得可以制备可用的核苷酸序列，特别是作为分析领域的探针和生物提取。

    Spool-type manual valve with position-adjustable lever
    3.
    发明申请
    Spool-type manual valve with position-adjustable lever 有权
    带位置可调杆的阀芯式手动阀

    公开(公告)号：US20070261747A1

    公开(公告)日：2007-11-15

    申请号：US11397217

    申请日：2006-04-04

    Applicant: Tam Huynh ,  Nathan French

    Inventor： Tam Huynh ,  Nathan French

    IPC: F15B13/04

    CPC classification number: F15B13/0401 ,  F15B2211/324 ,  F15B2211/7053 ,  Y10T137/86702 ,  Y10T137/8671

    Abstract: A manually actuated cartridge valve assembly (15) has a main body (31), a valve assembly (33), and an end assembly (35). Disposed within an internal cavity (107) of the end assembly (35) is a rotary member (109) that rotates about an axis (115) when a handle (29) is manually actuated. The axis (115) is substantially perpendicular to the axis (73) of the spool valve (49). The rotary member (109) has at least one axial end (117) that extends through the outer surface of the end assembly (35) and attaches to the handle (29). The movement of the handle (29) defines a plane of movement (147), which is selectively rotatable about the axis (73) to a desired orientation (149). A locking member (99) is selectively operably associated with the end assembly (35) to restrict rotation of the plane of movement (147).

    Abstract translation: 手动致动的盒式阀组件（15）具有主体（31），阀组件（33）和端部组件（35）。 设置在端部组件（35）的内部空腔（107）内的是当手动（29）被手动致动时围绕轴线（115）旋转的旋转构件（109）。 轴线（115）基本上垂直于滑阀（49）的轴线（73）。 旋转构件（109）具有延伸穿过端部组件（35）的外表面并附接到手柄（29）的至少一个轴向端部（117）。 手柄（29）的运动限定了运动平面（147），其可以围绕轴线（73）选择性地旋转到期望的取向（149）。 锁定构件（99）选择性地与端部组件（35）相关联以限制运动平面（147）的旋转。

    Cross-over relief valve assembly for use in bi-directional circuit
    4.
    发明申请
    Cross-over relief valve assembly for use in bi-directional circuit 失效
    用于双向电路的交叉溢流阀组件

    公开(公告)号：US20060213562A1

    公开(公告)日：2006-09-28

    申请号：US11091187

    申请日：2005-03-28

    Applicant: Robert Jacobson ,  Nathan French ,  Tam Huynh ,  Christopher Lodermeier ,  Brian Behm

    Inventor： Robert Jacobson ,  Nathan French ,  Tam Huynh ,  Christopher Lodermeier ,  Brian Behm

    IPC: F16K17/18

    CPC classification number: F16K17/196 ,  F15B13/024 ,  Y10T137/777 ,  Y10T137/7771 ,  Y10T137/7773 ,  Y10T137/7778

    Abstract: A relief valve assembly (27) for use with first (15) and second (21) conduits, one communicating high pressure. The assembly comprises a housing (29,33) defining first (45) and second (47) ports, and a poppet seat (49). A poppet member (43) and the housing define a spring chamber (55), and a spring (39) is disposed to bias the poppet member toward the seat. The poppet member defines a shuttle cavity (51), a shuttle passage (53) communicating from the cavity to the spring chamber, and the poppet defining a seat (57), and a fluid passage (61P) communicating with the first port, and a seat (59), and a second fluid passage (63) communicating with the second port. A shuttle valve assembly (71,73,75) is provided, whereby the fluid pressure in whichever of the ports is at lower pressure is communicated to the spring chamber and adds to the force of the biasing spring.

    Abstract translation: 一种用于与第一（15）和第二（21）导管一起使用的安全阀组件（27），一个连通高压。 组件包括限定第一（45）和第二（47）端口的壳体（29,33）和提升阀座（49）。 提升构件（43）和壳体限定弹簧室（55），并且弹簧（39）被设置成朝向座椅偏置提升阀构件。 提升构件限定梭腔（51），从空腔连通到弹簧室的梭通道（53）和限定座（57）的提升阀以及与第一端口连通的流体通道（61P） 和座（59），以及与第二端口连通的第二流体通道（63）。 提供了梭阀组件（71,73,75），由此无论哪个端口处于较低压力的流体压力都连通到弹簧室，并增加了偏置弹簧的力。

    Gantry for medical imaging system
    5.
    发明授权
    Gantry for medical imaging system 失效
    龙门架用于医学影像系统

    公开(公告)号：US6150662A

    公开(公告)日：2000-11-21

    申请号：US71367

    申请日：1998-04-30

    Applicant: Paul Hug ,  Ottavio T. Rotondale ,  Caleb J. L. Zhang ,  Tam Huynh

    Inventor： Paul Hug ,  Ottavio T. Rotondale ,  Caleb J. L. Zhang ,  Tam Huynh

    IPC: G01T1/164 ,  G01T1/166

    CPC classification number: G01T1/1642 ,  G01T1/166

    Abstract: A nuclear medicine imaging system provides three-axis linear and rotary detector motion. The imaging system includes an overhead gantry, which includes a carriage supported above the object and movable in translation along a first horizontal axis. Support arms are suspended downward from the carriage and are movable along a second horizontal axis perpendicular to the first horizontal axis. A detector is coupled to a lower end of each support arm. Each support arm is retractably extendible along a substantially vertical axis, and each detector is pivotable about a horizontal axis parallel to the first horizontal axis. Each support arm cooperates with the carriage to enable the corresponding detector to be positioned at multiple angular positions about a longitudinal axis corresponding to multiple projection angles by using combinations of independent linear movements of the detectors along any of three perpendicular axes.

    Abstract translation: 核医学成像系统提供三轴线性和旋转检测器运动。 该成像系统包括架式架架，其包括支撑在物体上方并可沿第一水平轴线平移移动的滑架。 支撑臂从滑架向下悬挂并且可沿垂直于第一水平轴线的第二水平轴线移动。 检测器联接到每个支撑臂的下端。 每个支撑臂可沿着基本上垂直的轴线可缩回地延伸，并且每个检测器可围绕平行于第一水平轴线的水平轴线枢转。 每个支撑臂与托架配合，以使得相应的检测器能够通过使用三个垂直轴中任何一个上的检测器的独立线性运动的组合来定位在与多个投影角度对应的纵向轴线的多个角度位置处。

    Glycosyl phospholipid derivatives of nucleosides and their use as medicines
    6.
    发明授权
    Glycosyl phospholipid derivatives of nucleosides and their use as medicines 失效
    核苷的糖基磷脂衍生物及其作为药物的用途

    公开(公告)号：US5358937A

    公开(公告)日：1994-10-25

    申请号：US947991

    申请日：1992-09-21

    Applicant: Tam Huynh Dinh ,  Catherine Gouyette ,  Jean Igolen ,  Robert Fauve ,  Luc Montagnier ,  Yvette Henin ,  Olivier Schwartz

    Inventor： Tam Huynh Dinh ,  Catherine Gouyette ,  Jean Igolen ,  Robert Fauve ,  Luc Montagnier ,  Yvette Henin ,  Olivier Schwartz

    IPC: C07H19/10 ,  A61K31/70

    CPC classification number: C07H19/10 ,  Y10S514/934

    Abstract: The glycosylphospholipid nucleoside derivatives of the invention are based on the formula: ##STR1## wherein: R.sub.1 is a nucleoside derivative selected from the group consisting of 3'-azidothymidine (AZT); 2', 3'-dideoxythymidine (ddT); and 2'-deoxy-5-fluorouridine (dFU);R.sub.2 is a hexose or pentose sugar, with the exception of glucose when x is 1;A is a hydrogen atom or an alkyl or alkoxy chain containing from 5 to 20 carbon atoms, said alkyl or alkoxy chain having at its extremity a group selected from the group consisting of a hydrogen atom and an NR'R" group, wherein R' and R" represent hydrogen or an alkyl group of 1 to 4 carbon atoms;x is a number from 1 to 12;y is a number from 1 to 4; andz is 0 or 1; and further wherein:attachment of said hexose sugar is at position 1 or position 6 of said hexose sugar, and attachment of said pentose sugar is at position 1 or position 5 of said pentose sugar. The derivatives of the invention are useful for producing pharmaceutical compositions having, in particular, anti-vital properties.

    Abstract translation: 本发明的糖基磷脂核苷衍生物基于下式：其中：R1是选自3'-叠氮胸苷（AZT）的核苷衍生物; 2'，3'-二脱氧胸苷（ddT）; 和2'-脱氧-5-氟尿苷（dFU）; R2是己糖或戊糖，当x为1时除葡萄糖外; A是氢原子或含有5至20个碳原子的烷基或烷氧基链，所述烷基或烷氧基链在其末端具有选自氢原子和NR'R“基团的基团，其中R '和R“表示氢或1至4个碳原子的烷基; x是从1到12的数字; y是从1到4的数字; z为0或1; 并且其中：所述己糖的附着在所述己糖的位置1或位置6，并且所述戊糖连接在所述戊糖的位置1或位置5。 本发明的衍生物可用于生产具有特别是抗重要性质的药物组合物。

    Probes comprising modified adenine groups, their preparation and their uses
    8.
    发明授权
    Probes comprising modified adenine groups, their preparation and their uses 失效
    包含修饰腺嘌呤基团的探针，其制备及其用途

    公开(公告)号：US4842996A

    公开(公告)日：1989-06-27

    申请号：US768042

    申请日：1985-08-22

    Applicant: Tam Huynh-Dinh ,  Jean Igolen

    Inventor： Tam Huynh-Dinh ,  Jean Igolen

    IPC: G01N33/53 ,  C07H21/00 ,  C07H21/04 ,  C12N15/09 ,  C12Q1/68

    CPC classification number: C07H21/00 ,  C12Q1/6813

    Abstract: The invention relates to a probe constituted by an oligonucleotide fragment of structure predetermined by the application envisaged, wherein at least a part of the adenine groups therein is replaced by modified adenine groups so that they can form three hydrogen bonds with the reactive groups of thymine or uracil. This probe is useful in the field of biological analyses and extractions.

    Abstract translation: 本发明涉及由所设想的应用预定的结构的寡核苷酸片段构成的探针，其中至少一部分腺嘌呤基团被修饰的腺嘌呤基团代替，使得它们可与胸腺嘧啶的反应性基团形成三个氢键或 尿嘧啶 该探针在生物分析和提取领域是有用的。

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