公开(公告)号：US5952450A

公开(公告)日：1999-09-14

申请号：US127075

申请日：1998-07-31

申请人： Jiro Ishihara ,  Hiroki Kuyama ,  Eiichi Ozeki ,  Takeshi Ishitoku ,  Masahide Tanaka ,  Naoya Sakamoto

发明人： Jiro Ishihara ,  Hiroki Kuyama ,  Eiichi Ozeki ,  Takeshi Ishitoku ,  Masahide Tanaka ,  Naoya Sakamoto

IPC分类号： C08G64/02 ,  C08G64/22 ,  C08G64/30 ,  C08G64/00

CPC分类号： C08G64/0216 ,  C08G64/226 ,  C08G64/305

摘要： A crosslinked polycarbonate is obtained by polycondensation of diol (A), trivalent or more polyhydric alcohol (B) whose arbitrary two hydroxy groups are not in the positional relationship of 1,2-disubstitution or 1,3-disubstitution, and carbonyl component (C) such as carbonic acid diesters. In the polycondensation step, no side reaction does not occur.This crosslinked polycarbonate is used as a modifier for polylactic acids. The brittleness of the polylactic acid is improved while maintaining mechanical strength, thermostability, and transparency.

摘要翻译： 交联聚碳酸酯通过二醇（A），任意两个羟基不具有1,2-取代或1,3-取代的位置关系的三价以上的多元醇（B）和羰基成分（C ）如碳酸二酯。 在缩聚步骤中，不会发生副反应。 该交联聚碳酸酯用作聚乳酸的改性剂。 改善聚乳酸的脆性，同时保持机械强度，热稳定性和透明度。

公开(公告)号：US4973703A

公开(公告)日：1990-11-27

申请号：US267379

申请日：1988-11-04

申请人： Junichi Imuta ,  Noriaki Kihara ,  Takeshi Ishitoku

发明人： Junichi Imuta ,  Noriaki Kihara ,  Takeshi Ishitoku

IPC分类号： C07D233/54 ,  C07D233/64

CPC分类号： C07D233/64

摘要： A process for the purification of N-cyano-N'-methyl-N"-[2-{(5-methyl-1H-imidazol-4-yl)methylthio}-ethyl]guanidine, which comprises bringing a crude product of N-cyano-N'-methyl-N"-[2-{(5-methyl-1H-imidazol-4-yl)-methylthio}ethyl]guanidine into contact with activated carbon in water in the presence of an organic acid.

公开(公告)号：US5072007A

公开(公告)日：1991-12-10

申请号：US547132

申请日：1990-07-03

申请人： Daisuke Fukuoka ,  Takeshi Ishitoku ,  Katsuya Takahashi ,  Takashi Tashiro ,  Junichi Imuta ,  Hiroaki Tan ,  Masaharu Ishiguro ,  Noriaki Kihara ,  Teruaki Mukaiyama

发明人： Daisuke Fukuoka ,  Takeshi Ishitoku ,  Katsuya Takahashi ,  Takashi Tashiro ,  Junichi Imuta ,  Hiroaki Tan ,  Masaharu Ishiguro ,  Noriaki Kihara ,  Teruaki Mukaiyama

IPC分类号： C07D311/20

CPC分类号： C07D311/20

摘要： Process for preparing polyalkyl-2-alkoxy-7-hydroxychroman derivative of the general formula (V): ##STR1## wherein R.sup.1 denotes lower primary alkyl, R.sup.2 denotes hydrogen or lower primary alkyl and R.sup.3 denotes loweralkyl, by reacting resorcin with either an aliphatic ketone of the general formula (I): ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, and an alcohol of the formula (II):R.sup.3 OH (II)wherein R.sup.3 is as defined above, in the presence of an acid catalyst, or an aliphatic ketone acetal of the general formula (III): ##STR3## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined above, in the presence of an acid catalyst.

公开(公告)号：US5037977A

公开(公告)日：1991-08-06

申请号：US390903

申请日：1989-08-08

申请人： Hiroaki Tan ,  Naoya Sakamoto ,  Eiichiro Hata ,  Takeshi Ishitoku ,  Noriaki Kihara

发明人： Hiroaki Tan ,  Naoya Sakamoto ,  Eiichiro Hata ,  Takeshi Ishitoku ,  Noriaki Kihara

IPC分类号： C07D519/04

CPC分类号： C07D519/04

摘要： This invention concerns a method for the production of dimeric alkaloids, characterized by reacting of catharanthine with vindoline in the presence of Fe.sup.3+ and (1) removing or inactivating the Fe.sup.3+ and allowing the reaction product to react with a reducing agent or (2) allowing presence of oxygen and a dicarboxylic acid or a derivative thereof in the reaction system and allowing the reaction product to react with a hydride source.In accordance with this invention, such dimeric alkaloid as vinblastine, leurosidin, and 3',4'-anhydrovinblastine which are useful as antineoplastic drugs can be produced in high yields.

公开(公告)号：US4814500A

公开(公告)日：1989-03-21

申请号：US91850

申请日：1987-09-01

申请人： Noriaki Kihara ,  Teruaki Mukaiyama ,  Takeshi Ishitoku ,  Katsuya Takahashi

发明人： Noriaki Kihara ,  Teruaki Mukaiyama ,  Takeshi Ishitoku ,  Katsuya Takahashi

IPC分类号： C07C319/18 ,  C07C319/20 ,  C07C323/44 ,  C07C129/08

CPC分类号： C07C323/44

摘要： A novel cyanoguanidine derivative represented by the following general formula (I): ##STR1## wherein X stands for a hydrogen atom, a chlorine atom or a bromine atom, and R stands for a lower alkyl group, is an effective precursor for the synthesis of N-cyano-N'-methyl-N"-(2-(5-methyl-4-imidazolylmethylthio(ethyl)-guanidine (Cimetidine) which has an action of controlling secretion of gastric acid and is valuable as an agent for the remedy of a gastric ulcer.This cyanoguanidine derivative is prepared by reacting a methylvinylketone derivative with a mercaptoguanidine derivative or by reacting an amidinoketone derivative with a halogenating agent.

公开(公告)号：US06569572B1

公开(公告)日：2003-05-27

申请号：US09529273

申请日：2000-04-11

申请人： Seijiro Ochiai ,  Syuichi Izuchi ,  Takeshi Ishitoku ,  Masaharu Shindo ,  Hidenobu Nogi

发明人： Seijiro Ochiai ,  Syuichi Izuchi ,  Takeshi Ishitoku ,  Masaharu Shindo ,  Hidenobu Nogi

IPC分类号： H01M1040

CPC分类号： H01M10/0565 ,  C07C69/96 ,  C08F20/28 ,  C08F22/20 ,  H01B1/122 ,  H01M6/22 ,  H01M10/052 ,  H01M2300/0085

摘要： In a lithium battery comprising a positive electrode, a negative electrode and a gel electrolyte; the gel electrolyte is composed of at least an ester-group or ether-group aprotic polar solvent, a lithium salt and a polymeric compound, and the polymeric compound comprises a polymer of at least one compound among those expressed by an equation (I) and an equation (II). (k: zero or number of 1 or more, m: number of 1 or more, R1:CpH2p, R2:CqH2q, p≠q, p & q: integer of 1 or more, A: CH2═CH—CO— or CH2═C(CH3)—CO—, X: n-valent combination group (n: integer ranging from 1 to 4), r: zero or number of 1 or more, s: number of 1 or more, R3: CtH2t, R4: CuH2u, t≠u, t & u: integer of 1 or more).

摘要翻译： 在包含正极，负极和凝胶电解质的锂电池中; 凝胶电解质由至少一种酯基或醚基非质子极性溶剂，锂盐和高分子化合物组成，并且该聚合物包含由式（I）表示的那些化合物和 式（II）（k：0或1以上的数，m：1以上的数，R1：CpH2p，R2：CqH2q，pq，p＆q：1以上的整数，A： CH 2 = CH-CO-或CH 2 = C（CH 3）-CO-，X：n价组合基团（n为1〜4的整数），r为0或1以上数，s为1 或更多，R3：CtH2t，R4：CuH2u，t

公开(公告)号：US06384241B2

公开(公告)日：2002-05-07

申请号：US09820674

申请日：2001-03-30

申请人： Satoru Nakatani ,  Takuji Matsumoto ,  Yoshinori Nakahara ,  Hideyuki Akieda ,  Takeshi Ishitoku

发明人： Satoru Nakatani ,  Takuji Matsumoto ,  Yoshinori Nakahara ,  Hideyuki Akieda ,  Takeshi Ishitoku

IPC分类号： C07D40700

CPC分类号： C07D319/12 ,  C07C51/43 ,  C07C51/47 ,  C07C59/125

摘要： A purified salt of &bgr;-hydroxyethoxy acetic acid of formula (1) having a fusion peak-top temperature detected by differential scanning calorimetry (DSC) and a purified 2-p-dioxanone of formula (2) derived from the purified salt of &bgr;-hydroxyethoxy acetic acid of formula (1). (wherein in formula (1), n=1-2, and if n=1, M is Na and/or K, and, if n=2, M is Ca and/or Mg.)

摘要翻译： 具有通过差示扫描量热法（DSC）检测的融合峰顶温度的式（1）的纯化的β-羟基乙氧基乙酸盐和由纯化的β- （1）的羟基乙氧基乙酸（其中在式（1）中n = 1-2，如果n = 1，M是Na和/或K，如果n = 2，M是Ca和/或 镁）

公开(公告)号：US06315918B1

公开(公告)日：2001-11-13

申请号：US09151663

申请日：1998-09-11

申请人： Satoko Mita ,  Tsuneaki Koike ,  Takeshi Ishitoku ,  Tatsuyoshi Ishida ,  Yoshinori Takamuku ,  Hideki Shimamoto

发明人： Satoko Mita ,  Tsuneaki Koike ,  Takeshi Ishitoku ,  Tatsuyoshi Ishida ,  Yoshinori Takamuku ,  Hideki Shimamoto

IPC分类号： H01M1040

CPC分类号： H01G9/038 ,  H01G11/60 ,  Y02E60/13

摘要： Non-aqueous electrolytic solutions for capacitors which release a little gas, have excellent potential window of electrochemical stability and enable capacitors to show excellent charging/discharging cycle properties and safety performance, and capacitors containing such non-aqueous electrolytic solutions. The non-aqueous electrolytic solution for capacitors comprises an electrolytic solution containing at least one cyclic carbonic ester selected from specified compounds and an electrolyte.

摘要翻译： 用于释放少量气体的电容器的非水电解液具有优异的电化学稳定性的窗口，并且使电容器显示出优异的充放电循环性能和安全性能，以及含有这种非水电解液的电容器。非水电解质 用于电容器的溶液包括含有至少一种选自特定化合物的环状碳酸酯和电解质的电解液。

公开(公告)号：US5932759A

公开(公告)日：1999-08-03

申请号：US800149

申请日：1997-02-13

申请人： Yoshio Motoyama ,  Naoshi Nagai ,  Takeshi Ishitoku ,  Noriaki Kihara

发明人： Yoshio Motoyama ,  Naoshi Nagai ,  Takeshi Ishitoku ,  Noriaki Kihara

IPC分类号： C07C239/20 ,  C07C261/00

CPC分类号： C07C239/20

摘要： The present invention relates to a process for producing a substituted amine represented by the general formula (IV):R.sup.2 NHOR.sup.3 (IV)(wherein R.sup.2 represents a hydrogen atom, a hydrocarbon group or a heteroatom-containing hydrocarbon group, and R.sup.3 represents a hydrocarbon group or a heteroatom-containing hydrocarbon group), which comprises the steps of:(b) reacting a hydroxamic acid represented by the general formula (II):R.sup.1 CONHOH (II)(wherein R.sup.1 represents a hydrogen atom or a hydrocarbon group) in the presence of a base with a reaction reagent capable of introducing a hydrocarbon or a heteroatom-containing hydrocarbon group to an oxygen atom and/or a nitrogen atom to form a substituted hydroxamic acid represented by the general formula (III): ##STR1## (wherein R.sup.1, R.sup.2 and R.sup.3 possess the same meanings as defined above),(c) hydrolyzing said substituted hydroxamic acid (III) in the presence of a base or an acid to produce a substituted amine represented by the general formula (IV):R.sup.2 NHOR.sup.3 (IV)(wherein R.sup.2 and R.sup.3 possess the same meanings as defined above). The present further relates to a method for purifying a synthetic intermediate for said substituted amine.

摘要翻译： 本发明涉及由通式（IV）表示的取代胺的制备方法：R2NHOR3（IV）（其中R2表示氢原子，烃基或含杂原子的烃基，R3表示烃基 或含杂原子的烃基），其包括以下步骤：（b）使通式（II）表示的异羟肟酸：R 1 CONHOH（II）（其中R 1表示氢原子或烃基） 的具有能够将烃或含杂原子的烃基引入氧原子和/或氮原子的反应试剂形成由通式（III）表示的取代的异羟肟酸的反应试剂：其中R1，R2和 R3具有与上述相同的含义），（c）在碱或酸的存在下水解所述取代的异羟肟酸（III）以产生由通式（IV）表示的取代胺：R2NHOR3（IV）（其中 R 2和R3具有与上述相同的含义）。 本发明还涉及纯化所述取代胺的合成中间体的方法。