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公开(公告)号：US20210335515A1
公开(公告)日：2021-10-28
申请号：US17345719
申请日：2021-06-11
申请人： TRIUMF INC.
发明人： Paul SCHAFFER , Francois BENARD , Kenneth R. BUCKLEY , Victoire HANEMAAYER , Cornelia Hoehr MANUELA , Julius Alexander KLUG , Michael S. KOVACS , Thomas J. MORLEY , Thomas J. RUTH , John VALLIANT , Stefan K. ZEISLER , Maurice G. DODD
摘要： A system for producing technetium-99m from molybdate-100. The system comprises: a target capsule apparatus for housing a Mo-100-coated target plate; a target capsule pickup apparatus for engaging, and delivering. the target cell apparatus into a target station apparatus target station apparatus for receiving and mounting therein the target capsule apparatus. The target station apparatus is engaged with a cyclotron for irradiating the Mo-100-coated target plate with protons. The irradiated target capsule apparatus is transferred to a receiving cell apparatus comprising a dissolution/purification module for receiving therein a proton-irradiated Mo-100-coated target plate. A conveyance conduit infrastructure interconnects: (i) the target capsule pickup apparatus with the target station apparatus, (ii) the target station apparatus and the receiving cell apparatus, and (iii) the receiving cell apparatus and the dissolution/purification module.
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公开(公告)号：US11661668B2
公开(公告)日：2023-05-30
申请号：US17345719
申请日：2021-06-11
申请人： TRIUMF INC.
发明人： Paul Schaffer , Francois Benard , Kenneth R. Buckley , Victoire Hanemaayer , Cornelia Manuela Hoehr , Julius Alexander Klug , Michael S. Kovacs , Thomas J. Morley , Thomas J. Ruth , John Valliant , Stefan K. Zeisler , Maurice G. Dodd
IPC分类号： G21G1/00 , C25D13/02 , C25D13/22 , G21F5/14 , G21K5/08 , B22F1/145 , H05H6/00 , B22F7/02 , G21G1/10 , B22F3/10
CPC分类号： G21G1/001 , B22F1/145 , C25D13/02 , C25D13/22 , G21F5/14 , G21K5/08 , B22F3/10 , B22F7/02 , B22F2998/10 , B22F2999/00 , G21G1/10 , G21G2001/0042 , H05H6/00 , B22F2999/00 , B22F1/145 , B22F9/22 , B22F2999/00 , B22F9/22 , B22F2201/013 , B22F2998/10 , B22F1/145 , B22F3/10
摘要： A system for producing technetium-99m from molybdate-100. The system comprises: a target capsule apparatus for housing a Mo-100-coated target plate; a target capsule pickup apparatus for engaging, and delivering the target cell apparatus into a target station apparatus; target station apparatus for receiving and mounting therein the target capsule apparatus. The target station apparatus is engaged with a cyclotron for irradiating the Mo-100-coated target plate with protons. The irradiated target capsule apparatus is transferred to a receiving cell apparatus comprising a dissolution/purification module for receiving therein a proton-irradiated Mo-100-coated target plate. A conveyance conduit infrastructure interconnects: (i) the target capsule pickup apparatus with the target station apparatus, (ii) the target station apparatus and the receiving cell apparatus; and (iii) the receiving cell apparatus and the dissolution/purification module.
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公开(公告)号：US20230402200A1
公开(公告)日：2023-12-14
申请号：US18239013
申请日：2023-08-28
CPC分类号： G21G1/001 , C01F17/13 , B01D15/1871 , B01D15/362 , B01D15/363 , C01B15/0475 , G21G1/10 , G21G2001/0094 , G21G2001/0089
摘要： A method of separating actinium and/or radium from proton-irradiated thorium metal. The thorium metal is irradiated to produce isotopes including thorium, actinium and/or radium. The resultant product is dissolved in solution and a selective precipitant is used to precipitate a bulk portion of the thorium. The precipitated thorium can be recovered. Chromatography is carried out on the remaining solution to remove residual thorium and to separate the actinium from the radium.
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公开(公告)号：US20240011179A1
公开(公告)日：2024-01-11
申请号：US18137877
申请日：2023-04-21
申请人： TRIUMF INC.
发明人： Paul SCHAFFER , Francois BENARD , Kenneth R. BUCKLEY , Victoire HANEMAAYER , Cornelia Manuela HOEHR , Julius Alexander KLUG , Michael S. KOVACS , Thomas J. MORLEY , Thomas J. RUTH , John VALLIANT , Stefan K. ZEISLER , Maurice G. DODD
摘要： A system for producing technetium-99m from molybdate-100. The system comprises: a target capsule apparatus for housing a Mo-100-coated target plate; a target capsule pickup apparatus for engaging and delivering the target cell apparatus into a target station apparatus; a target station apparatus for receiving and mounting therein the target capsule apparatus. The target station apparatus is engaged with a cyclotron for irradiating the Mo-100-coated target plate with protons. The irradiated target capsule apparatus is transferred to a receiving cell apparatus comprising a dissolution/purification module for receiving therein a proton-irradiated Mo-100-coated target plate. A conveyance conduit infrastructure interconnects: (i) the target capsule pickup apparatus with the target station apparatus, (ii) the target station apparatus and the receiving cell apparatus; and (iii) the receiving cell apparatus and the dissolution/purification module.
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公开(公告)号：US11798700B2
公开(公告)日：2023-10-24
申请号：US17040652
申请日：2019-03-26
CPC分类号： G21G1/001 , B01D15/1871 , B01D15/362 , B01D15/363 , C01B15/0475 , C01F17/13 , G21G1/10 , G21G2001/0089 , G21G2001/0094
摘要： A method of separating actinium and/or radium from proton-irradiated thorium metal. The thorium metal is irradiated to produce isotopes including thorium, actinium and/or radium. The resultant product is dissolved in solution and a selective precipitant is used to precipitate a bulk portion of the thorium. The precipitated thorium can be recovered. Chromatography is carried out on the remaining solution to remove residual thorium and to separate the actinium from the radium.
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公开(公告)号：US20230270892A1
公开(公告)日：2023-08-31
申请号：US17801777
申请日：2021-02-25
发明人： Hua YANG , Feng GAO , Paul SCHAFFER , Zheliang YUAN , Chengcheng ZHANG , Francois BENARD , Luke WHARTON
IPC分类号： A61K51/04 , C07D273/00 , A61K51/08
CPC分类号： A61K51/044 , A61K51/088 , C07D273/00
摘要： A chelator having the general structure (I) for chelating ra-diometals such as 225Ac under mild conditions is provided. (I) The chelator can be coupled to a biological targeting moiety to facilitate targeted delivery of the chelated radiometal in a mammalian subject.
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