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    NOVEL RADIOLABELLED CXCR4-TARGETING COMPOUNDS FOR DIAGNOSIS AND THERAPY
    7.
    发明申请
    NOVEL RADIOLABELLED CXCR4-TARGETING COMPOUNDS FOR DIAGNOSIS AND THERAPY 有权

    公开(公告)号：US20220218852A1

    公开(公告)日：2022-07-14

    申请号：US17604708

    申请日：2020-04-17

    申请人： PROVINCIAL HEALTH SERVICES AUTHORITY ,  THE UNIVERSITY OF BRITISH COLUMBIA

    发明人： François BÉNARD ,  Kuo-Shyan LIN ,  Etienne ROUSSEAU ,  Zhengxing ZHANG ,  Daniel KWON ,  Joseph LAU ,  Carlos Uribe MUNOZ ,  Jerome LOZADA ,  David PERRIN

    IPC分类号： A61K51/08 ,  A61K51/04 ,  A61P35/00

    摘要： This application relates to compounds of Formula (I): [targeting peptide]-N(R1)—X1(R2)L1-[linker]-RXn1 (I). The targeting peptide is cyclo[L-Phe-L-Tyr-L-Lys(iPr)-D-Arg-L-2-Nal-Gly-D-Glu]-L-Lys(iPr). R1 is H or methyl. X1 is an optionally substituted C1-C15 hydrocarbon optionally comprising heteroatoms. R2 is C(O)OH or C(O)NH2. L1 is a linkage (thiolether, amide, maleimide-thiol, triazole). The linker has a net negative charge at physiological pH and is a linear or branched chain of 1-10 units of X2L2 and/or X2(L2)2, wherein: each X2 is, independently, an optionally substituted C1-C15 hydrocarbon optionally comprising heteroatoms; and each L2 is a linkage. The linker optionally further comprises an albumin binder bonded to an L2. Each RX is a radiolabelling group linked through a separate L2, selected from: a metal chelator; a prosthetic group containing trifluoroborate (BF3); or a prosthetic group containing a silicon-fluorine-acceptor moiety. The compounds may be useful for imaging CXCR4-expressing tissues or for treating CXCR4-associated diseases or conditions (e.g. cancer).

    Methods for evaluating head and neck cancers
    9.
    发明授权
    Methods for evaluating head and neck cancers 有权

    公开(公告)号：US11377699B2

    公开(公告)日：2022-07-05

    申请号：US16767090

    申请日：2018-11-30

    申请人： PROVINCIAL HEALTH SERVICES AUTHORITY

    发明人： Catherine Garnis ,  Martial Guillaud

    IPC分类号： C12Q1/6886

    摘要： The present disclosure provides a method for diagnosing a head and neck cancer in a subject. The method comprises the steps of: a) measuring an expression level of miR-125b or miR-342 and miR-125b in a sample from the subject; b) measuring an expression level of a normalizing miR in the sample and normalizing the measured expression level of miR-125b or miR-342 and miR-125b using the measured expression level of the normalizing miR; and c) diagnosing a head and neck cancer in a subject having a normalized measured expression level of miR-125b elevated relative to a reference expression level of miR-125b or having a ratio of normalized measured expression level of miR-342 to normalized measured expression level of miR-125b reduced relative to a reference ratio of expression level of miR-342 to expression level of miR-125b. Uses and kits associated with the herein disclosed methods are also disclosed.

    MOTION SYNCHRONIZED ARC RADIOTHERAPY
    10.
    发明申请
    MOTION SYNCHRONIZED ARC RADIOTHERAPY 有权

    公开(公告)号：US20210370097A1

    公开(公告)日：2021-12-02

    申请号：US17309457

    申请日：2019-11-28

    申请人： PROVINCIAL HEALTH SERVICES AUTHORITY

    发明人： Steven THOMAS ,  Kirpal KOHLI ,  Justin Jeremy Jeun-Ming POON

    IPC分类号： A61N5/10

    摘要： Apparatus and methods for planning and/or delivering radiation treatment and controlling a radiation delivery system are described. Apparatus for delivering radiation treatment includes a radiation source, a drive connected to move the radiation source along a trajectory, a stored radiation treatment plan specifying a plurality of beam ON segments and beam OFF portions of the trajectory interleaved with the plurality of beam ON segments, and a monitor connected to detect progress of a physiological cycle of the patient, the physiological cycle has cycles that include quiescent periods. One or more data processors are connected to control the drive to advance the radiation source along the trajectory, control the radiation source to deliver radiation in each of the plurality of beam ON segments of the trajectory and to deliver no or negligible radiation in each of the beam OFF portions of the trajectory, process an output of the monitor to estimate a time for a next one of the quiescent periods, and control a speed at which the radiation source is advanced along the trajectory to cause the radiation source to arrive at a start of a next one of the beam ON segments at a time that coincides with the next one of the quiescent periods.