公开(公告)号：US20230402200A1

公开(公告)日：2023-12-14

申请号：US18239013

申请日：2023-08-28

申请人： TRIUMF Inc. ,  THE UNIVERSITY OF BRITISH COLUMBIA

发明人： Andrew Kyle Henderson ROBERTSON ,  Hua YANG ,  Stefan ZEISLER ,  Paul SCHAFFER

IPC分类号： G21G1/00 ,  C01F17/13 ,  B01D15/18 ,  B01D15/36 ,  C01B15/047 ,  G21G1/10

CPC分类号： G21G1/001 ,  C01F17/13 ,  B01D15/1871 ,  B01D15/362 ,  B01D15/363 ,  C01B15/0475 ,  G21G1/10 ,  G21G2001/0094 ,  G21G2001/0089

摘要： A method of separating actinium and/or radium from proton-irradiated thorium metal. The thorium metal is irradiated to produce isotopes including thorium, actinium and/or radium. The resultant product is dissolved in solution and a selective precipitant is used to precipitate a bulk portion of the thorium. The precipitated thorium can be recovered. Chromatography is carried out on the remaining solution to remove residual thorium and to separate the actinium from the radium.

公开(公告)号：US20230270892A1

公开(公告)日：2023-08-31

申请号：US17801777

申请日：2021-02-25

申请人： TRIUMF INC. ,  Provincial Health Services Authority ,  The University of British Columbia

发明人： Hua YANG ,  Feng GAO ,  Paul SCHAFFER ,  Zheliang YUAN ,  Chengcheng ZHANG ,  Francois BENARD ,  Luke WHARTON

IPC分类号： A61K51/04 ,  C07D273/00 ,  A61K51/08

CPC分类号： A61K51/044 ,  A61K51/088 ,  C07D273/00

摘要： A chelator having the general structure (I) for chelating ra-diometals such as 225Ac under mild conditions is provided. (I) The chelator can be coupled to a biological targeting moiety to facilitate targeted delivery of the chelated radiometal in a mammalian subject.