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1.发明授权公开(公告)号：US08517958B2
公开(公告)日：2013-08-27
申请号：US12944792
申请日：2010-11-12
Applicant: Jonathan Eppstein , Stuart McRae
Inventor： Jonathan Eppstein , Stuart McRae
CPC classification number: A61M37/0015 , A61M37/00 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061 , A61M2205/33 , A61M2205/3303 , A61M2210/04 , A61M2230/20 , A61N1/0424 , A61N1/044 , A61N1/0476 , A61N1/325 , A61N1/326 , A61N1/327
Abstract: The invention provides for an integrated device for forming a cavity in a surface of a tissue of an animal comprising: a) a controller board connected to an energy source for actuating at least one porator; b) a fluid reservoir in fluid communication with the tissue; and c) a tissue interface layer, the tissue interface layer containing the at least one porator, the porator in contact with the tissue for forming the cavity. The invention also provides for methods of making and methods of using the same.
Abstract translation: 本发明提供了一种用于在动物组织的表面中形成空腔的集成装置，包括：a）连接到能量源的控制器板，用于致动至少一个穿孔器; b）与所述组织流体连通的流体储存器; 以及c）组织界面层，所述组织界面层包含所述至少一个穿孔器，所述穿孔器与所述组织接触以形成所述空腔。 本发明还提供了制备方法及其使用方法。
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2.发明申请公开(公告)号：US20110245728A1
公开(公告)日：2011-10-06
申请号：US12944792
申请日：2010-11-12
Applicant: Jonathan Eppstein , Stuart McRae
Inventor： Jonathan Eppstein , Stuart McRae
CPC classification number: A61M37/0015 , A61M37/00 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061 , A61M2205/33 , A61M2205/3303 , A61M2210/04 , A61M2230/20 , A61N1/0424 , A61N1/044 , A61N1/0476 , A61N1/325 , A61N1/326 , A61N1/327
Abstract: The invention provides for an integrated device for forming a cavity in a surface of a tissue of an animal comprising: a) a controller board connected to an energy source for actuating at least one porator; b) a fluid reservoir in fluid communication with the tissue; and c) a tissue interface layer, the tissue interface layer containing the at least one porator, the porator in contact with the tissue for forming the cavity. The invention also provides for methods of making and methods of using the same.
Abstract translation: 本发明提供了一种用于在动物组织的表面中形成空腔的集成装置，包括：a）连接到能量源的控制器板，用于致动至少一个穿孔器; b）与所述组织流体连通的流体储存器; 以及c）组织界面层，所述组织界面层包含所述至少一个穿孔器，所述穿孔器与所述组织接触以形成所述空腔。 本发明还提供了制备方法及其使用方法。
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公开(公告)号：US08016811B2
公开(公告)日：2011-09-13
申请号：US10691968
申请日：2003-10-24
Applicant: Alan Smith , Jonathan A. Eppstein , Bernadette Messier , Zoran Novakovic , Stuart McRae
Inventor： Alan Smith , Jonathan A. Eppstein , Bernadette Messier , Zoran Novakovic , Stuart McRae
IPC: A61M31/00
CPC classification number: A61M37/00 , A61K9/0009 , A61K9/0046 , A61M37/0015 , A61M37/0092 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061 , A61N1/0412 , A61N1/30 , A61N1/327
Abstract: A method for delivering permeant substances transdermally into a membrane of an animal includes forming at least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.
Abstract translation: 透皮物质经皮递送到动物膜中的方法包括在皮肤组织中形成至少一个输送口，其中所述至少一个输送口的平均开口深度在约40至约90微米之间。
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4.发明申请公开(公告)号：US20090264810A1
公开(公告)日：2009-10-22
申请号：US12360698
申请日：2009-01-27
Applicant: Jonathan A. Eppstein , Stuart McRae
Inventor： Jonathan A. Eppstein , Stuart McRae
IPC: A61N1/00
CPC classification number: A61M37/0015 , A61M37/00 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061 , A61M2205/33 , A61M2205/3303 , A61M2210/04 , A61M2230/20 , A61N1/0424 , A61N1/044 , A61N1/0476 , A61N1/325 , A61N1/326 , A61N1/327
Abstract: The invention provides for an integrated device for forming a cavity in a surface of a tissue of an animal comprising: a) a controller board connected to an energy source for actuating at least one porator; b) a fluid reservoir in fluid communication with the tissue; and c) a tissue interface layer, the tissue interface layer containing the at least one porator, the porator in contact with the tissue for forming the cavity. The invention also provides for methods of making and methods of using the same.
Abstract translation: 本发明提供了一种用于在动物组织的表面中形成空腔的集成装置，包括：a）连接到能量源的控制器板，用于致动至少一个穿孔器; b）与所述组织流体连通的流体储存器; 以及c）组织界面层，所述组织界面层包含所述至少一个穿孔器，所述穿孔器与所述组织接触以形成所述空腔。 本发明还提供了制备方法及其使用方法。
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公开(公告)号：US20070031495A1
公开(公告)日：2007-02-08
申请号：US11455899
申请日：2006-06-19
Applicant: Jonathan Eppstein , David Enscore , Frank Tagliaferri , Gaurav Tolia , Shulun Chang , Alan Smith , Yogi Patel , Stuart McRae
Inventor： Jonathan Eppstein , David Enscore , Frank Tagliaferri , Gaurav Tolia , Shulun Chang , Alan Smith , Yogi Patel , Stuart McRae
IPC: A61K9/24
CPC classification number: A61K9/7053 , A61K9/0009
Abstract: Disclosed is a device for causing the transdermal flux of a per meant into a subject via at least one formed pathway through a skin layer of the subject. The device comprises a delivery reservoir comprising: i) a non-biodegradable matrix having a bottom surface and defining a plurality of conduits therein the matrix, at least a portion of the plurality of conduits being in communication with the bottom surface; and ii)an undissolved hydrophilic per meant disposed therein at least a portion of the plurality of conduits of the matrix, wherein the hydrophilic per meant can come in contact with subcutaneous fluid from the subject when the bottom surface of the matrix is positioned in fluid communication with the at least one formed pathway. Also disclosed are systems and methods for causing the transdermal flux of a per meant into a subject via at least one formed pathway through a skin layer of the subject.
Abstract translation: 公开了一种用于通过穿过受试者的皮肤层的至少一个形成的途径使每个意图的经皮通量引入受试者的装置。 所述装置包括递送贮存器，其包括：i）具有底表面并且在其中限定所述基质中的多个导管的不可生物降解的基质，所述多个导管的至少一部分与所述底表面连通; 和ii）未溶解的亲水剂，其中每个意图在其中设置多个基质管道的至少一部分，其中，当基质的底表面位于流体连通中时，每个意图的亲水剂可以与来自受试者的皮下流体接触 与至少一个形成的途径。 还公开了用于通过穿过受试者的皮肤层的至少一个形成的途径使每个意图的经皮通量引入受试者的系统和方法。
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Patent Agency Ranking
公开(公告)号：US20150265823A1
公开(公告)日：2015-09-24
申请号：US14693592
申请日：2015-04-22
Applicant: Alan Smith , Jonathan A. Eppstein , Bernadette Messier , Zoran Novakovic , Stuart McRae
Inventor： Alan Smith , Jonathan A. Eppstein , Bernadette Messier , Zoran Novakovic , Stuart McRae
IPC: A61M37/00
CPC classification number: A61M37/00 , A61K9/0009 , A61K9/0046 , A61M37/0015 , A61M37/0092 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061 , A61N1/0412 , A61N1/30 , A61N1/327
Abstract: A method for delivering permeant substances transdermally into a membrane of an animal includes forming at least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.
Abstract translation: 透皮物质经皮递送到动物膜中的方法包括在皮肤组织中形成至少一个输送口，其中该至少一个输送口的平均开口深度在约40至约90微米之间。
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公开(公告)号：US20150190074A1
公开(公告)日：2015-07-09
申请号：US14147263
申请日：2014-01-03
Applicant: Stuart McRae
Inventor： Stuart McRae
CPC classification number: A61B5/14503 , A61B5/14532 , A61B5/15 , A61B5/685 , A61M2037/0007 , A61N1/0428 , A61N1/303 , A61N1/327
Abstract: A transdermal permeant delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substate.
Abstract translation: 将至少一种渗透性组合物的透皮渗透物递送到受试者的组织膜中，所述组织膜包括一次性基底，其具有连接到所述基底的上表面的第一释放衬垫的底表面的至少一部分和具有背衬层 以及可从第一释放衬垫的顶表面选择性地移除的储存器。 在连接位置，贴片的背衬层的第一部分可释放地安装到第一剥离衬垫的顶表面，与子层的引孔区间隔开对准。
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公开(公告)号：US09033950B2
公开(公告)日：2015-05-19
申请号：US13194328
申请日：2011-07-29
Applicant: Alan Smith , Jonathan A. Eppstein , Bernadette Messier , Zoran Novakovic , Stuart McRae
Inventor： Alan Smith , Jonathan A. Eppstein , Bernadette Messier , Zoran Novakovic , Stuart McRae
CPC classification number: A61M37/00 , A61K9/0009 , A61K9/0046 , A61M37/0015 , A61M37/0092 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061 , A61N1/0412 , A61N1/30 , A61N1/327
Abstract: A method for delivering permeant substances transdermally into a membrane of an animal includes forming at least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.
Abstract translation: 透皮物质经皮递送到动物膜中的方法包括在皮肤组织中形成至少一个输送口，其中所述至少一个输送口的平均开口深度在约40至约90微米之间。
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公开(公告)号：US08116860B2
公开(公告)日：2012-02-14
申请号：US12017996
申请日：2008-01-22
Applicant: Bernadette Messier , Zoran Novakovic , Jeremiah Peter O'Leary , Regina Spiehl , Wendy E. Bowerman , Stephen Wilson Braun , Jonathan Eppstein , David Farquhar , Mark James Fisher , Uros Kascak , Erin Koch Henkel , Loren J. Lantz , Stuart McRae
Inventor： Bernadette Messier , Zoran Novakovic , Jeremiah Peter O'Leary , Regina Spiehl , Wendy E. Bowerman , Stephen Wilson Braun , Jonathan Eppstein , David Farquhar , Mark James Fisher , Uros Kascak , Erin Koch Henkel , Loren J. Lantz , Stuart McRae
CPC classification number: A61N1/327 , A61N1/0412 , A61N1/0428 , A61N1/0476 , A61N1/325
Abstract: A transdermal permeant delivery system for delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.
Abstract translation: 一种用于将至少一种渗透性组合物输送到受试者的组织膜中的透皮渗透物递送系统，包括一次性基底，其具有连接到所述基底的上表面的第一释放衬垫的底表面的至少一部分，以及具有 背衬层和可从第一释放衬垫的顶表面选择性地移除的储存器。 在连接位置，贴片的背衬层的第一部分可释放地安装到第一剥离衬垫的顶表面，与衬底的引孔区间隔开对准。
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公开(公告)号：US20120035555A1
公开(公告)日：2012-02-09
申请号：US13272592
申请日：2011-10-13
Applicant: Bernadette Messier , Zoran Novakovic , Jeremiah Peter O'Leary , Regina Spiehl , Wendy E. Bowerman , Stephen Wilson Braun , Jonathan Eppstein , David Farquhar , Mark James Fisher , Uros Kascak , Erin Koch Henkel , Loren J. Lantz , Stuart McRae
Inventor： Bernadette Messier , Zoran Novakovic , Jeremiah Peter O'Leary , Regina Spiehl , Wendy E. Bowerman , Stephen Wilson Braun , Jonathan Eppstein , David Farquhar , Mark James Fisher , Uros Kascak , Erin Koch Henkel , Loren J. Lantz , Stuart McRae
IPC: A61M35/00
CPC classification number: A61N1/327 , A61N1/0412 , A61N1/0428 , A61N1/0476 , A61N1/325
Abstract: A transdermal permeant delivery system for delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.
Abstract translation: 一种用于将至少一种渗透性组合物输送到受试者的组织膜中的透皮渗透物递送系统，包括一次性基底，其具有连接到所述基底的上表面的第一释放衬垫的底表面的至少一部分，以及具有 背衬层和可从第一释放衬垫的顶表面选择性地移除的储存器。 在连接位置，贴片的背衬层的第一部分可释放地安装到第一剥离衬垫的顶表面，与衬底的引孔区间隔开对准。
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