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    Methods and devices for nucleic acid amplification on a surface
    2.
    发明申请
    Methods and devices for nucleic acid amplification on a surface 审中-公开
    用于在表面上进行核酸扩增的方法和装置

    公开(公告)号：US20080076131A1

    公开(公告)日：2008-03-27

    申请号：US11809726

    申请日：2007-05-31

    申请人： Alexander Chagovetz ,  Steven Blair

    发明人： Alexander Chagovetz ,  Steven Blair

    IPC分类号： C12P19/34 ,  C07H21/00 ,  C12Q1/68 ,  C12M1/00

    CPC分类号： C12P19/34 ,  C12Q1/6844 ,  C12Q2565/501 ,  C12Q2525/197

    摘要： Methods of building surface amplification devices are disclosed. Methods and devices for detecting target nucleic acids are also disclosed. Primer pairs are seeded on the surface of a substrate using a connecting compound between the primers to optimize the distance between immobilized primers. The flexible linking compounds avoid the need to bend extension products during later amplifications.

    摘要翻译： 公开了构建表面放大器件的方法。 还公开了用于检测靶核酸的方法和装置。 引物对使用引物之间的连接化合物接种在底物的表面上，以优化固定化引物之间的距离。 灵活的连接化合物避免了在后续扩增期间弯曲延伸产物的需要。

    Process for ablating high density vias in flexible substrate
    4.
    发明授权
    Process for ablating high density vias in flexible substrate 失效
    在柔性基底中烧蚀高密度通孔的方法

    公开(公告)号：US5702662A

    公开(公告)日：1997-12-30

    申请号：US536863

    申请日：1995-09-29

    申请人： Adlai H. Smith ,  Robert O. Hunter, Jr. ,  Bruce McArthur ,  Steven Blair ,  Jim Wilkinson

    发明人： Adlai H. Smith ,  Robert O. Hunter, Jr. ,  Bruce McArthur ,  Steven Blair ,  Jim Wilkinson

    IPC分类号： B23K26/06 ,  H05K1/00 ,  H05K3/00 ,  B23K26/00

    CPC分类号： H05K3/0026 ,  B23K26/066 ,  H05K1/0393 ,  H05K2203/056 ,  H05K2203/1545

    摘要： A apparatus and process for ablating a matrix of high density vias in a flexible substrate. The apparatus is cantilevered on a horizontal shelf from a partition where it can be rigidly supported. A vacuum container reciprocates towards and away from the partition and supports the horizontal shelf by permitting supporting casters to bear on and be supported by the reciprocating container. When the container is away from the partition, servicing of the apparatus as well as the insertion an removal of substrate can occur. When the container is adjoined to the partition, a vacuum can be drawn on the apparatus and processing commenced. A continuous flexible substrate is provided extending in a circuitous path between a supply roll and a take up roll, all interior of the container. The flexible substrate is maintained under constant tension and incrementally advanced. The substrate is incrementally advanced and stopped, passing across a table. When the roll is advanced, the table releases the substrate and is cleaned of the debris resulting form previous ablations. When the roll is stopped, the table clamps and precisely levels the substrate for sequential ablation of the substrate.

    摘要翻译： 一种用于在柔性基底中烧蚀高密度通孔基质的装置和方法。 该装置悬挂在水平货架上，可从其间被刚性支撑的隔板上。 真空容器朝向和远离分隔件往复运动，并且通过允许支撑脚轮承载并由往复式容器支撑来支撑水平搁架。 当容器远离分隔件时，可能会发生装置的维修以及插入物的移除。 当容器与隔板相邻时，可以在设备上抽真空并开始处理。 提供连续的柔性基底，其在供给辊和卷取辊之间的迂回路径中延伸，容纳所有内部。 柔性基板保持恒定的张力并递增。 底物逐渐升高并停止，穿过桌子。 当辊前进时，工作台释放基材，并清除先前烧蚀后产生的碎屑。 当辊停止时，工作台夹紧并精确地平整衬底以顺序地消除衬底。

    Swim vest
    6.
    外观设计
    Swim vest 有权

    公开(公告)号：USD1045329S1

    公开(公告)日：2024-10-08

    申请号：US29761538

    申请日：2020-12-09

    申请人： Steven Blair Fountain

    设计人： Steven Blair Fountain

    摘要： FIG. 1 is a front perspective view of a swim vest showing my new design;
    FIG. 2 is a front view of the swim vest thereof;
    FIG. 3 is a rear view the swim vest thereof;
    FIG. 4 is a left side view of the swim vest thereof;
    FIG. 5 is a right-side view of a swim vest thereof;
    FIG. 6 is a top view of the swim vest thereof; and,
    FIG. 7 is a bottom view of the swim vest thereof.
    The broken lines shown illustrate partial environment of the swim vest and form no part of the claimed design.

    BUOYANCY ADJUSTABLE SWIM TRAINING VEST
    7.
    发明申请
    BUOYANCY ADJUSTABLE SWIM TRAINING VEST 有权

    公开(公告)号：US20220177090A1

    公开(公告)日：2022-06-09

    申请号：US17535604

    申请日：2021-11-25

    申请人： STEVEN BLAIR FOUNTAIN

    发明人： STEVEN BLAIR FOUNTAIN

    IPC分类号： B63C9/115 ,  A63B69/12

    摘要： A buoyancy-adjustable swim training vest for a user has a polymer-neoprene fabric formed garment member designed to substantially circumscribe the user's torso from neck to waist. A lower front of the vest has a front cover coupled to the vest and is vertically liftable. A back portion has a right side and a left side elastic wing members extending from a lower back portion designed to wrap frontward around the user's torso and detachably couple by respective hook and loop assemblies to each other, the vest, and the front cover, all coupled beneath the cover. An at least one polymer strap may be coupled detachably and adjustably by a latch to a buckle disposed on a lower edge of the front of the vest. At least one substantially sealable back pocket is disposed on an outer surface of the lower back portion of the vest designed to hold removable buoyant pads.

    Three Dimensional Penetrating Optical-Electrical Neural Interface for Selective Stimulation and Recording
    8.
    发明申请
    Three Dimensional Penetrating Optical-Electrical Neural Interface for Selective Stimulation and Recording 审中-公开
    用于选择性刺激和记录的三维穿透光电神经接口

    公开(公告)号：US20130046148A1

    公开(公告)日：2013-02-21

    申请号：US13508969

    申请日：2010-11-09

    申请人： Prashant Tathireddy ,  Loren Rieth ,  Gregory Arthur Clark ,  Richard A. Normann ,  Florian Solzbacher ,  Steven Blair

    发明人： Prashant Tathireddy ,  Loren Rieth ,  Gregory Arthur Clark ,  Richard A. Normann ,  Florian Solzbacher ,  Steven Blair

    IPC分类号： A61N5/06 ,  A61B5/05

    CPC分类号： A61N1/0551 ,  A61B5/04001 ,  A61B5/04888 ,  A61B5/685 ,  A61B2562/0233 ,  A61B2562/046 ,  A61N1/0531 ,  A61N5/0601 ,  A61N5/0622 ,  A61N2005/063

    摘要： A hybrid optical-electrical neural interface is disclosed and described. The neural interface can include an array (100) having a plurality of micro-optrodes (HO). The micro-optrodes (110) are capable of optical and optionally electrical stimulation and recording, allowing bidirectional, multi-modal communication with neural tissue. At least a portion of the plurality of micro-optrodes (110) are independently optically addressable and include an optical waveguide along each micro-optrode (HO). Combining optical stimulation with electrical recording can allow artifact-free recording from nearby electrodes and in some cases even the same electrode, which is difficult to achieve with combined electrical recording and stimulation. The optical waveguide is configured to direct light towards a distal end (125) of the micro-optrode, allowing focal stimulation and recording. Penetrating micro-optrodes (110) can allow access to deep tissue, while non-penetrating micro-optrodes can be used for extraneural stimulation.

    摘要翻译： 公开并描述了混合光电神经接口。 神经接口可以包括具有多个微光栅（HO）的阵列（100）。 微光学（110）能够进行光学和可选的电刺激和记录，允许与神经组织的双向多模式通信。 多个微光栅（110）的至少一部分是独立的可光学寻址的并且包括沿着每个微光栅（HO）的光波导。 将光学刺激与电气记录结合可以允许来自附近电极的无伪影记录，并且在某些情况下甚至可以使用组合的电记录和刺激难以实现的相同电极。 光波导被配置为将光引导到微电极的远端（125），从而允许焦点刺激和记录。 穿透性微电极（110）可以允许进入深层组织，而非穿透性微电极可用于外部刺激。

    Methods and systems for acquiring real-time quantitative melt data
    9.
    发明申请
    Methods and systems for acquiring real-time quantitative melt data 审中-公开
    获取实时定量熔融数据的方法和系统

    公开(公告)号：US20070148677A1

    公开(公告)日：2007-06-28

    申请号：US11633980

    申请日：2006-12-04

    申请人： Alexander Chagovetz ,  Steven Blair

    发明人： Alexander Chagovetz ,  Steven Blair

    IPC分类号： C12Q1/68 ,  G06F19/00

    CPC分类号： C12Q1/6813 ,  C12Q2565/518 ,  C12Q2563/107 ,  C12Q2527/107

    摘要： Described are methods and systems for acquiring real-time quantified melt data. A first Double-stranded nucleic acid are immobilized on a support. The temperature of the double-stranded nucleic acids is slowly ramped up until the double-stranded nucleic acids melt. Differences in fluorescence emission are used to signal when the melt occurred. An evanescent field is used to generate fluorescence emission.

    摘要翻译： 描述了用于获取实时量化熔体数据的方法和系统。 将第一双链核酸固定在载体上。 双链核酸的温度缓慢升高直至双链核酸融化。 荧光发射的差异用于在熔体发生时发出信号。 消逝场用于产生荧光发射。