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公开(公告)号：US20240335839A1
公开(公告)日：2024-10-10
申请号：US18696338
申请日：2022-09-28
发明人： George Sorensen
IPC分类号： B01L9/06
CPC分类号： B01L9/06 , B01L2200/025 , B01L2300/0848 , B01L2300/123 , B01L2300/14
摘要： Embodiments provide a tube retainer system, including: an outer body; a diaphragm having a circular opening; a valve including a valve head and a valve stem attached to the valve head; a cam; a camshaft extending through the cam; a drive gear attached to the camshaft; a restraint gear attached to the camshaft; a push bar located below the diaphragm; and a pawl. The diaphragm, the cam, the drive gear, the restraint gear, the push bar, and the pawl are all provided in the outer body, when a bottom of a tube is inserted into the circular opening and a downward pressure is applied on the diaphragm, the cam is oriented to close the valve to form a partial vacuum in the outer body to secure the bottom of the tube within the circular opening.
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公开(公告)号：US20240329628A1
公开(公告)日：2024-10-03
申请号：US18579318
申请日：2022-07-12
CPC分类号： G05B23/024 , G01N35/1016 , G05B23/0281
摘要： Methods of early real-time detection or prediction of aspiration faults in an automated diagnostic analysis system include an artificial intelligence algorithm configured to use either cluster analysis or probabilistic graphical modeling based on an aspiration pressure measurement signal waveform. Aspiration faults may include short-volume aspiration and unwanted gel pick-up. These methods may allow for timely termination of an aspiration process so as to avoid or minimize possible detrimental downstream consequences such as faulty sample test results and/or instrument downtime for servicing and cleanup. Apparatus for early real-time detection or prediction of aspiration faults are provided as are other aspects.
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公开(公告)号：US20240310395A1
公开(公告)日：2024-09-19
申请号：US18546959
申请日：2022-02-17
发明人： Yao-Jen Chang , Rayal Raj Prasad Nalam Venkat , Benjamin S. Pollack , Vivek Singh , Venkatesh NarasimhaMurthy , Ankur Kapoor
CPC分类号： G01N35/00712 , G01N35/1016 , G01N2035/1025
摘要： Methods of operating a diagnostic laboratory system include providing a module configured to perform a function on an item in the diagnostic laboratory system; providing a plurality of sensors, each of the plurality of sensors configured to monitor the function or the item and generate sensor data in response to the monitoring; checking an operational status of a first sensor of the plurality of sensors; receiving sensor data from at least one of the plurality of sensors; and scaling sensor data from the first sensor in response to the operational status and the sensor data to generate revised sensor data. Systems including a middleware server configured to carry out the methods are provided as are other aspects.
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公开(公告)号：US20240302370A1
公开(公告)日：2024-09-12
申请号：US18261427
申请日：2022-01-14
IPC分类号： G01N33/569
CPC分类号： G01N33/56983 , G01N2333/165 , G01N2469/10
摘要： Methods of utilizing sample lysis reagent compositions in the handling of samples containing viruses, such as (but not limited to) severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), are disclosed. Kits containing the sample lysis reagent compositions are also disclosed.
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5.发明公开公开(公告)号：US20240255533A1
公开(公告)日：2024-08-01
申请号：US18636098
申请日：2024-04-15
CPC分类号： G01N35/00623 , G01N35/00871 , G16H40/40
摘要： Methods of predicting failures of in vitro diagnostic instruments include monitoring, with one or more monitoring devices associated with one or more components of the in vitro diagnostic instrument, one or more condition-based maintenance (CBM) parameters of the in vitro diagnostic instrument, providing the one or more condition-based maintenance parameters to a local database, transmitting condition-based maintenance data to a remote service location, storing the condition-based maintenance data at the remote service location, analyzing the condition-based maintenance data according to a failure prediction engine including failure prediction criteria, and performing an action based on predefined deviation from the failure prediction criteria. Apparatus configured to carry out the methods are provided, as are other aspects.
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6.发明公开公开(公告)号：US20240254088A1
公开(公告)日：2024-08-01
申请号：US18442393
申请日：2024-02-15
发明人： Anand Natrajan , David Sharpe , Qingping Jiang , David Wen
IPC分类号： C07D219/06 , C09K11/07 , F21K2/06 , G01N21/76 , G01N33/543 , G01N33/58
CPC分类号： C07D219/06 , C09K11/07 , F21K2/06 , G01N21/76 , G01N33/543 , G01N33/582
摘要： Hydrophilic, high quantum yield, chemiluminescent acridinium compounds with increased light output, improved stability, fast light emission and decreased non specific binding are disclosed. The chemiluminescent acridinium esters possess hydrophilic, branched, electron-donating functional groups at the C2 and/or C7 positions of the acridinium nucleus.
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公开(公告)号：US20240201083A1
公开(公告)日：2024-06-20
申请号：US18554988
申请日：2022-03-25
IPC分类号： G01N21/3577 , G01N21/33 , G01N21/359 , G01N33/487
CPC分类号： G01N21/3577 , G01N21/33 , G01N21/359 , G01N33/487
摘要： A method of operating a diagnostic instrument includes illuminating an imaging location of the diagnostic instrument with first light having a first spectrum for a first period and capturing a first image of the imaging location illuminated by the first light. The method further includes illuminating the imaging location of the diagnostic instrument with second light having a second spectrum for a second period, the second spectrum being more destructive to a chemical configured to be received in the diagnostic instrument than the first spectrum; and capturing a second image of the imaging location illuminated by the second light. Other methods and diagnostic instruments are disclosed.
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公开(公告)号：US20240183872A1
公开(公告)日：2024-06-06
申请号：US18553166
申请日：2022-03-25
发明人： Muhammad Ahmed , Hadi Arbabi , Shane Manning , Navneet Jain
CPC分类号： G01N35/00871 , G01N35/0092 , G01N2035/0406
摘要： Diagnostic instruments and methods of operating diagnostic instruments are provided. Methods of operating a diagnostic instrument includes providing the diagnostic instrument having one or more modules, wherein the one or more modules are configured to analyze specimens; providing a specimen sorter coupled to the diagnostic instrument; and sorting specimens into at least first group and a second group, wherein specimens in the first group are to be analyzed by at least one of the one or more modules, and specimens in the second group are not to be analyzed by any of the one or more modules. Other sorting methods and diagnostic instruments are provided.
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公开(公告)号：US11994517B2
公开(公告)日：2024-05-28
申请号：US18000944
申请日：2021-06-16
发明人： Aaron Kauffmann , Jon Stradinger
IPC分类号： G01N33/543 , B01L3/00 , G01N33/68
CPC分类号： G01N33/54326 , B01L3/502761 , G01N33/54386 , G01N33/6872 , B01L2200/04 , B01L2200/0668 , B01L2200/16 , B01L2400/043 , G01N2333/4737
摘要： Analytical assay reaction cartridges, kits containing same, and methods of production and use thereof are disclosed. These cartridges include a magnetic assembly that surrounds at least a portion of a sample read window on the cartridge. The cartridge also includes an analytical reagent positioned therewithin, wherein the analytical reagent comprises magnetic beads coated with at least one anti-red blood cell antibody.
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公开(公告)号：US20240169093A1
公开(公告)日：2024-05-23
申请号：US17755463
申请日：2020-10-22
发明人： Venkatesh NarasimhaMurthy , Vivek Singh , Yao-Jen Chang , Benjamin S. Pollack , Ankur Kapoor , Rayal Raj Prasad Nalam Venkat
CPC分类号： G06F21/6254 , G06T5/77 , G06T7/0004 , G06T11/60 , G06T2207/20081 , G06T2207/20084
摘要： A method of characterizing a specimen and specimen container to be analyzed in an automated diagnostic analysis system. The method can provide a segmentation determination and/or an HILN determination (hemolysis, icterus, lipemia, or normal) of the specimen while protecting patient information. The method includes capturing an image of a specimen container via an image capture device, identifying a label affixed to the specimen container in the captured image via an anonymization network, and editing the captured image via the anonymization network to mask some or all information present in the label so that it is removed from the captured image. Quality check modules and systems configured to carry out the method are also described, as are other aspects.
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