公开(公告)号：US20170320830A1

公开(公告)日：2017-11-09

申请号：US14901009

申请日：2014-07-04

Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.

Inventor： Anand Natrajan ,  David Sharpe ,  Qingping Jiang ,  David Wen

IPC: C07D219/06 ,  G01N21/76 ,  F21K2/06 ,  G01N33/58 ,  C09K11/07

CPC classification number: C07D219/06 ,  C09K11/07 ,  F21K2/06 ,  G01N21/76 ,  G01N33/582

Abstract: Hydrophilic, high quantum yield, chemiluminescent acridinium compounds with increased light output, improved stability, fast light emission and decreased non specific binding are disclosed. The chemiluminescent acridinium esters possess hydrophilic, branched, electron-donating functional groups at the C2 and/or C7 positions of the acridinium nucleus.

公开(公告)号：US20220227711A1

公开(公告)日：2022-07-21

申请号：US17658438

申请日：2022-04-07

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Anand Natrajan ,  David Sharpe ,  Qingping Jiang ,  David Wen

IPC: C07D219/06 ,  G01N21/76 ,  F21K2/06 ,  G01N33/58 ,  G01N33/543 ,  C09K11/07

Abstract: Hydrophilic, high quantum yield, chemiluminescent acridinium compounds with increased light output, improved stability, fast light emission and decreased non specific binding are disclosed. The chemiluminescent acridinium esters possess hydrophilic, branched, electron-donating functional groups at the C2 and/or C7 positions of the acridinium nucleus.

公开(公告)号：US11332445B2

公开(公告)日：2022-05-17

申请号：US16801354

申请日：2020-02-26

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Anand Natrajan ,  David Sharpe ,  Qingping Jiang ,  David Wen

IPC: G01N33/543 ,  C07D219/06 ,  G01N21/76 ,  F21K2/06 ,  G01N33/58 ,  C09K11/07

Abstract: Hydrophilic, high quantum yield, chemiluminescent acridinium compounds with increased light output, improved stability, fast light emission and decreased non specific binding are disclosed. The chemiluminescent acridinium esters possess hydrophilic, branched, electron-donating functional groups at the C2 and/or C7 positions of the acridinium nucleus.

公开(公告)号：US10710962B2

公开(公告)日：2020-07-14

申请号：US15168018

申请日：2016-05-28

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Anand Natrajan ,  David Sharpe ,  David Wen ,  Qingping Jiang

IPC: G01N33/53 ,  C07C309/14 ,  C07D207/46 ,  C07D207/452 ,  C07D403/12 ,  C07D493/10 ,  C07D495/04 ,  C07F9/09 ,  C09B11/24 ,  A61K47/54 ,  A61K47/64 ,  C07K1/13 ,  C07K7/06 ,  C07K14/765

Abstract: Zwitterion-containing compounds for the modification of hydrophobic molecules to improve their solubility and/or to lower their non-specific binding as provided. The zwitterion-containing compounds may be suitable for modification of detectable labels such as biotin and fluorescein to improve their solubility. The zwitterion-containing compounds may also be useful for the preparation of conjugates of proteins, peptides and other macromolecules or for crosslinking molecules and/or macromolecules.

公开(公告)号：US20240254088A1

公开(公告)日：2024-08-01

申请号：US18442393

申请日：2024-02-15

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Anand Natrajan ,  David Sharpe ,  Qingping Jiang ,  David Wen

IPC: C07D219/06 ,  C09K11/07 ,  F21K2/06 ,  G01N21/76 ,  G01N33/543 ,  G01N33/58

CPC classification number: C07D219/06 ,  C09K11/07 ,  F21K2/06 ,  G01N21/76 ,  G01N33/543 ,  G01N33/582

Abstract: Hydrophilic, high quantum yield, chemiluminescent acridinium compounds with increased light output, improved stability, fast light emission and decreased non specific binding are disclosed. The chemiluminescent acridinium esters possess hydrophilic, branched, electron-donating functional groups at the C2 and/or C7 positions of the acridinium nucleus.

公开(公告)号：US11932603B2

公开(公告)日：2024-03-19

申请号：US17658438

申请日：2022-04-07

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Anand Natrajan ,  David Sharpe ,  Qingping Jiang ,  David Wen

IPC: C07D219/06 ,  C09K11/07 ,  F21K2/06 ,  G01N21/76 ,  G01N33/543 ,  G01N33/58

CPC classification number: C07D219/06 ,  C09K11/07 ,  F21K2/06 ,  G01N21/76 ,  G01N33/543 ,  G01N33/582

Abstract: Hydrophilic, high quantum yield, chemiluminescent acridinium compounds with increased light output, improved stability, fast light emission and decreased non specific binding are disclosed. The chemiluminescent acridinium esters possess hydrophilic, branched, electron-donating functional groups at the C2 and/or C7 positions of the acridinium nucleus.

公开(公告)号：US20160274094A1

公开(公告)日：2016-09-22

申请号：US15168018

申请日：2016-05-28

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Anand Natrajan ,  David Sharpe ,  David Wen ,  Qingping Jiang

IPC: G01N33/53 ,  C07D495/04 ,  C07D493/10 ,  C07K14/765 ,  C07D403/12 ,  C07K1/13 ,  C07K7/06 ,  C07C309/14 ,  C07D207/46

Abstract: Zwitterion-containing compounds for the modification of hydrophobic molecules to improve their solubility and/or to lower their non-specific binding as provided. The zwitterion-containing compounds may be suitable for modification of detectable labels such as biotin and fluorescein to improve their solubility. The zwitterion-containing compounds may also be useful for the preparation of conjugates of proteins, peptides and other macromolecules or for crosslinking molecules and/or macromolecules.