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    APPARATUS, METHOD AND SYSTEM FOR GENERATING OPTICAL RADIATION FROM BIOLOGICAL GAIN MEDIA
    2.
    发明申请
    APPARATUS, METHOD AND SYSTEM FOR GENERATING OPTICAL RADIATION FROM BIOLOGICAL GAIN MEDIA 有权
    用于从生物增益介质产生光学辐射的装置，方法和系统

    公开(公告)号：US20110266470A1

    公开(公告)日：2011-11-03

    申请号：US12772668

    申请日：2010-05-03

    Applicant: Seok-Hyun Yun ,  Malte C. Gather

    Inventor： Seok-Hyun Yun ,  Malte C. Gather

    IPC: H01S3/06 ,  G02B6/10 ,  G01N21/62

    CPC classification number: C09K11/06 ,  C09K2211/10 ,  C09K2211/14 ,  G01N21/645 ,  G01N21/7746 ,  G02B6/138 ,  G02B6/29341 ,  H01S3/08022 ,  H01S3/08059 ,  H01S3/083 ,  H01S3/094034 ,  H01S3/094076 ,  H01S3/168 ,  H01S3/20 ,  H01S3/213

    Abstract: In one exemplary embodiment, an apparatus can be provided which includes at least one biological medium that causes gain. According to another exemplary embodiment, an arrangement can be provided which is configured to be provided in an anatomical structure. This exemplary arrangement can include at least one emitter having a cross-sectional area of at most 10 microns within the anatomical structure, and which is configured to generate at least one laser radiation. In a further exemplary embodiment, an apparatus can be provided which can include at least one medium which is configured to cause gain; and at least one optical biological resonator which is configured to provide an optical feedback to the medium. In still another exemplary embodiment, a process can be whereas, a solution of an optical medium can be applied to a substrate. Further, it is possible to generate a wave guide having a shape that is defined by (i) at least one property of the solution of the optical medium, or (ii) drying properties thereof.

    Abstract translation: 在一个示例性实施例中，可以提供包括引起增益的至少一个生物介质的装置。 根据另一示例性实施例，可以提供被配置为设置在解剖结构中的布置。 该示例性布置可以包括在解剖结构内具有至多10微米的横截面积的至少一个发射器，并且被配置为产生至少一个激光辐射。 在另一示例性实施例中，可以提供可以包括被配置为引起增益的至少一个介质的装置; 以及被配置为向介质提供光反馈的至少一个光学生物谐振器。 在另一示例性实施例中，可以将光学介质的溶液施加到基板上。 此外，可以生成具有由（i）光学介质的溶液的至少一种性质或（ii）其干燥性质）定义的形状的波导。

    FUSED FIBER OPTIC COUPLER ARRANGEMENT AND METHOD FOR USE THEREOF
    3.
    发明申请
    FUSED FIBER OPTIC COUPLER ARRANGEMENT AND METHOD FOR USE THEREOF 有权
    熔融光纤耦合器布置及其使用方法

    公开(公告)号：US20110226940A1

    公开(公告)日：2011-09-22

    申请号：US12999231

    申请日：2009-06-19

    Applicant: Seok-Hyun Yun

    Inventor： Seok-Hyun Yun

    IPC: G01J1/04 ,  G02B6/255 ,  G02B6/26 ,  G01N21/47 ,  G01J1/58 ,  B01J19/12

    CPC classification number: G02B6/2835 ,  G02B6/03633

    Abstract: Exemplary embodiments of an article of manufacture and method according to the present disclosure are provided. For example, a first multi-clad fiber arrangement can be provided that comprises a first core and at least one first cladding which is structured to propagate at least one first electro-magnetic radiation therethrough. A second multi-clad fiber arrangement can also be provided that comprises a second core and at least one second cladding which is structured to propagate at least one second electro-magnetic radiation therethrough. Further, at least one portion can be provided in which the first and second claddings are fused to one another.

    Abstract translation: 提供了根据本公开的制品和方法的示例性实施例。 例如，可以提供第一多包层光纤配置，其包括第一芯和至少一个第一包层，其被构造成传播至少一个第一电磁辐射通过其中。 还可以提供第二多包层光纤布置，其包括第二芯和至少一个第二覆层，其被构造成传播至少一个第二电磁辐射通过其中。 此外，可以提供至少一个部分，其中第一和第二包层彼此熔合。

    System and method for optical coherence imaging
    5.
    发明授权
    System and method for optical coherence imaging 有权
    光学相干成像系统和方法

    公开(公告)号：US07365859B2

    公开(公告)日：2008-04-29

    申请号：US11225840

    申请日：2005-09-12

    Applicant: Seok-Hyun Yun ,  Brett Eugene Bouma ,  Guillermo J. Tearney ,  Johannes F. deBoer

    Inventor： Seok-Hyun Yun ,  Brett Eugene Bouma ,  Guillermo J. Tearney ,  Johannes F. deBoer

    IPC: G01B11/02

    CPC classification number: G01B9/02014 ,  G01B9/02004 ,  G01B9/02044 ,  G01B9/02069 ,  G01B9/02077 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70 ,  G01N21/4795

    Abstract: A system and method for imaging of a sample, e.g., biological sample, are provided. In particular, at least one source electro-magnetic radiation forwarded to the sample and a reference may be generated. A plurality of detectors may be used, at least one of the detectors capable of detecting a signal associated with a combination of at least one first electro-magnetic radiation received from the sample and at least one second electro-magnetic radiation received from the reference. At least one particular detector may have a particular electrical integration time, and can receive at least a portion of the signal for a time duration which has a first portion with a first power level greater than a predetermined threshold and a second portion immediately preceding or following the first portion. The second portion may have a second power level that is less than the predetermined threshold, and extends for a time period which may be, e.g., approximately more than 10% of the particular electrical integration time.

    Abstract translation: 提供了用于成像样品例如生物样品的系统和方法。 特别地，可以产生转发到样品的至少一个源电磁辐射和参考。 可以使用多个检测器，所述检测器中的至少一个检测器能够检测与从样本接收的至少一个第一电磁辐射的组合相关联的信号和从参考接收的至少一个第二电磁辐射。 至少一个特定检测器可以具有特定的电积分时间，并且可以接收信号的至少一部分持续一段持续时间，该持续时间具有第一部分具有大于预定阈值的第一功率电平，以及紧接在之前或之后的第二部分 第一部分。 第二部分可以具有小于预定阈值的第二功率电平，并且延伸可以是例如大约超过特定电积分时间的10％的时间段。

    PROCESS, ARRANGEMENTS AND SYSTEMS FOR PROVIDING FREQUENCY DOMAIN IMAGING OF A SAMPLE
    6.
    发明申请
    PROCESS, ARRANGEMENTS AND SYSTEMS FOR PROVIDING FREQUENCY DOMAIN IMAGING OF A SAMPLE 有权
    用于提供样品的频域成像的过程，安排和系统

    公开(公告)号：US20070276269A1

    公开(公告)日：2007-11-29

    申请号：US11744287

    申请日：2007-05-04

    Applicant: Seok-Hyun Yun ,  Johannes F. De Boer

    Inventor： Seok-Hyun Yun ,  Johannes F. De Boer

    IPC: A61B5/02

    CPC classification number: A61B3/102 ,  A61B3/0025 ,  A61B3/1233 ,  A61B3/14 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/418 ,  G01N21/45 ,  G01N21/4795

    Abstract: Apparatus, arrangement and method are provided for obtaining information associated with an anatomical structure or a sample using optical microscopy. For example, a radiation can be provided which includes at least one first electromagnetic radiation directed to be provided to an anatomical sample and at least one second electro-magnetic radiation directed to a reference. A wavelength of the radiation can vary over time, and the wavelength is shorter than approximately 1150 nm. An interference can be detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. At least one image corresponding to at least one portion of the sample can be generated using data associated with the interference. In addition, at least one source arrangement can be provided which is configured to provide an electromagnetic radiation which has a wavelength that varies over time. A period of a variation of the wavelength of the first electromagnetic radiation can be shorter than 1 millisecond, and the wavelength is shorter than approximately 1150 nm.

    Abstract translation: 提供了用于使用光学显微镜获得与解剖结构或样品相关联的信息的装置，布置和方法。 例如，可以提供辐射，其包括至少一个被引导到解剖样品的第一电磁辐射和指向参考的至少一个第二电磁辐射。 辐射的波长可随时间变化，波长比约1150nm短。 可以在与第一辐射相关联的至少一个第三辐射与与第二辐射相关联的至少一个第四辐射之间检测干扰。 可以使用与干扰相关联的数据来生成对应于样本的至少一部分的至少一个图像。 此外，可以提供至少一个源装置，其被配置为提供具有随时间变化的波长的电磁辐射。 第一电磁辐射的波长变化的周期可以短于1毫秒，并且波长比约1150nm短。

    System, method and arrangement which can use spectral encoding heterodyne interferometry techniques for imaging
    7.
    发明申请
    System, method and arrangement which can use spectral encoding heterodyne interferometry techniques for imaging 有权
    可以使用频谱编码外差干涉测量技术进行成像的系统，方法和布置

    公开(公告)号：US20060270929A1

    公开(公告)日：2006-11-30

    申请号：US11445131

    申请日：2006-05-31

    Applicant: Brett Bouma ,  Guillermo Tearney ,  Dvir Yelin ,  Seok-Hyun Yun

    Inventor： Brett Bouma ,  Guillermo Tearney ,  Dvir Yelin ,  Seok-Hyun Yun

    IPC: A61B5/05

    CPC classification number: G01N21/4795 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/7257

    Abstract: Systems, arrangements and methods for obtaining three-dimensional imaging data are provided. For example, a broadband light source can provide a particular radiation. A first electro-magnetic radiation can be focused and diffracted, and then provided to at least one sample to generate a spectrally-encoded line. A second electro-magnetic radiation may be provided to a reference, which may include a double-pass rapidly-scanning optical delay, where the first and second electro-magnetic radiations can be based on the particular radiation. An interference between a third electro-magnetic radiation (associated with the first electro-magnetic radiation) and a fourth electro-magnetic radiation (associated with the second electro-magnetic radiation) can be detected. The spectrally-encoded line may be scanned over the sample in a direction approximately perpendicular to the line. Image data containing three-dimensional information can then be obtained based on the interference. The exemplary imaging methods and systems can be used in a small fiber optic or endoscopic probe.

    Abstract translation: 提供了用于获得三维成像数据的系统，布置和方法。 例如，宽带光源可以提供特定的辐射。 可以将第一电磁辐射聚焦和衍射，然后提供给至少一个样品以产生光谱编码的线。 可以将第二电磁辐射提供给参考，其可以包括双遍快速扫描光学延迟，其中第一和第二电磁辐射可以基于特定辐射。 可以检测第三电磁辐射（与第一电磁辐射相关联）和第四电磁辐射（与第二电磁辐射相关联）之间的干扰。 光谱编码的线可以在大致垂直于线的方向上扫描样品。 然后可以基于干扰获得包含三维信息的图像数据。 示例性的成像方法和系统可以用于小型光纤或内窥镜探针。

    System and method for optical coherence imaging
    9.
    发明申请
    System and method for optical coherence imaging 有权

    公开(公告)号：US20060055936A1

    公开(公告)日：2006-03-16

    申请号：US11225840

    申请日：2005-09-12

    Applicant: Seok-Hyun Yun ,  Brett Bouma ,  Guillermo Tearney ,  Johannes deBoer

    Inventor： Seok-Hyun Yun ,  Brett Bouma ,  Guillermo Tearney ,  Johannes deBoer

    IPC: G01B9/02

    CPC classification number: G01B9/02014 ,  G01B9/02004 ,  G01B9/02044 ,  G01B9/02069 ,  G01B9/02077 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70 ,  G01N21/4795

    Abstract: A system and method for imaging of a sample, e.g., biological sample, are provided. In particular, at least one source electro-magnetic radiation forwarded to the sample and a reference may be generated. A plurality of detectors may be used, at least one of the detectors capable of detecting a signal associated with a combination of at least one first electro-magnetic radiation received from the sample and at least one second electro-magnetic radiation received from the reference. At least one particular detector may have a particular electrical integration time, and can receive at least a portion of the signal for a time duration which has a first portion with a first power level greater than a predetermined threshold and a second portion immediately preceding or following the first portion. The second portion may have a second power level that is less than the predetermined threshold, and extends for a time period which may be, e.g., approximately more than 10% of the particular electrical integration time.

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