公开(公告)号：US20080225663A1

公开(公告)日：2008-09-18

申请号：US12108180

申请日：2008-04-23

Applicant: Patrick Smith ,  Phelim O'Doherty ,  Sean McCarthy

Inventor： Patrick Smith ,  Phelim O'Doherty ,  Sean McCarthy

IPC: G11B7/00

CPC classification number: G11B23/281 ,  G11B5/865 ,  G11B7/263 ,  G11B20/00086

Abstract: A method and apparatus for determining if an optical disk originated from a valid source, the method and apparatus scanning one major surface of the optical disk for imperfections, storing the locations of the imperfections relative to a datum, comparing a parameter of each of the locations of the imperfections with corresponding parameters of a master disk of known source for determining if the disk originated from the source from which the master disk originated.

Abstract translation: 一种用于确定光盘是否源自有效源的方法和装置，所述方法和装置扫描光盘的一个主表面以获得缺陷，存储缺陷相对于基准的位置，比较每个位置的参数 具有已知源的主盘的相应参数的缺陷，用于确定盘是否源自主盘的源。

公开(公告)号：US20080075163A1

公开(公告)日：2008-03-27

申请号：US11859445

申请日：2007-09-21

Applicant: Neil Brydon ,  Danny Hunt ,  Sean McCarthy

Inventor： Neil Brydon ,  Danny Hunt ,  Sean McCarthy

IPC: H04N7/24

CPC classification number: H04N19/146 ,  H04N19/10 ,  H04N19/124 ,  H04N19/149 ,  H04N19/152 ,  H04N19/154 ,  H04N19/159 ,  H04N19/184 ,  H04N19/196 ,  H04N19/46

Abstract: A constrained variable rate coding technique limits the number of bits used in an encoding process. A quality setting indicates a maximum level of quality to be used in the encoding process which limits the number of bits used in the encoding process. A bandwidth reclamation factor which indicates an amount of bandwidth to conserve may also be used with the quality setting. The constrained variable rate coding technique using a lower quality encoding process for less complex video data and a higher quality encoding technique for higher quality video data.

Abstract translation: 受限可变速率编码技术限制了编码过程中使用的比特数。 质量设置指示在编码处理中使用的最大限度的质量水平，其限制编码处理中使用的比特数。 指示要保存的带宽量的带宽回收因子也可以与质量设置一起使用。 对于较不复杂的视频数据使用较低质量编码处理的约束可变速率编码技术和用于较高质量视频数据的较高质量编码技术。

公开(公告)号：US20070200928A1

公开(公告)日：2007-08-30

申请号：US11705280

申请日：2007-02-12

Applicant: Phelim O'Doherty ,  Sean McCarthy ,  Patrick Smith ,  Carlos Luna ,  John O'Kane ,  Fergus Taylor ,  Wayne Kearns ,  Roger Hatfield

Inventor： Phelim O'Doherty ,  Sean McCarthy ,  Patrick Smith ,  Carlos Luna ,  John O'Kane ,  Fergus Taylor ,  Wayne Kearns ,  Roger Hatfield

IPC: H04N7/18

CPC classification number: G07G3/003 ,  G07F19/20 ,  G07F19/207 ,  G08B13/19673 ,  G08B13/19676 ,  G08B13/19695 ,  H04N7/188

Abstract: A surveillance system for an ATM utilizing multiple cameras aimed at the user, the card slot, and surrounding areas is disclosed. The cameras are powered and begin to record images after a sensor is activated. The system maintains a buffer of recorded imagery such that when the sensors are activated, the video processing equipment can store a pre-defined amount of time before the sensor is activated. The buffer allows for the video capture of events just prior to the activation of the sensor. A time stamp and any other relevant data from the cameras may also be included with the stored recorded video.

Abstract translation: 公开了一种使用针对用户，卡槽和周围区域的多个摄像机的ATM的监视系统。 摄像机供电并在传感器启动后开始记录图像。 系统保持记录图像的缓冲区，使得当传感器被激活时，视频处理设备可以在传感器被激活之前存储预定义的时间量。 缓冲器允许在激活传感器之前对事件进行视频捕获。 时间戳和来自相机的任何其他相关数据也可以包含在存储的记录视频中。

公开(公告)号：US20070048771A1

公开(公告)日：2007-03-01

申请号：US11491318

申请日：2006-07-21

Applicant: Sean McCarthy ,  Christopher Fraser ,  John Sharp ,  Thomas Barnes ,  Susan Kirst ,  Paul Myers ,  Nicholas Wrighton ,  Andrew Goodearl ,  Douglas Holtzman ,  Mehran Khodadoust

Inventor： Sean McCarthy ,  Christopher Fraser ,  John Sharp ,  Thomas Barnes ,  Susan Kirst ,  Paul Myers ,  Nicholas Wrighton ,  Andrew Goodearl ,  Douglas Holtzman ,  Mehran Khodadoust

IPC: C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC classification number: C07K14/47

Abstract: The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

Abstract translation: 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了使用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

公开(公告)号：US20060211848A1

公开(公告)日：2006-09-21

申请号：US11441587

申请日：2006-05-26

Applicant: Douglas Holtzman ,  Andrew Goodearl ,  Sean McCarthy

Inventor： Douglas Holtzman ,  Andrew Goodearl ,  Sean McCarthy

IPC: C07K14/705 ,  C07H21/04 ,  C12P21/06

CPC classification number: C12N9/6489 ,  A01K2217/05 ,  A01K2227/105 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70578 ,  C07K2319/00

Abstract: The invention relates to Tango-73, Tango-74, Tango-76, Tango-78, and Tango-83 polypeptides, nucleic acid molecules encoding Tango-73, Tango-74, Tango-76, Tango-78, and Tango-83, and uses thereof. The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

公开(公告)号：US20050119209A1

公开(公告)日：2005-06-02

申请号：US10838852

申请日：2004-05-03

Applicant: Douglas Levinson ,  Clare Lloyd ,  Sean McCarthy

Inventor： Douglas Levinson ,  Clare Lloyd ,  Sean McCarthy

IPC: A01K67/027 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K19/00 ,  C12N9/64 ,  C12N15/85 ,  C12Q1/68 ,  A61K48/00 ,  C07H21/04

CPC classification number: C12N15/8509 ,  A01K67/0275 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0325 ,  A01K2267/0368 ,  A01K2267/0375 ,  A01K2267/0381 ,  A01K2267/0387 ,  A01K2267/0393 ,  A61K38/00 ,  C07K14/47 ,  C07K14/70503 ,  C07K19/00 ,  C07K2319/00 ,  C12N9/6467 ,  C12N9/6472 ,  C12Q1/6809

Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders, and also for the treatment of mast cell-related processes and disorders, ischemic disorders and injuries, including ischemic renal disorders and injuries. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders. Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation-related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders, and for monitoring the efficacy of compounds used in clinical trials. Methods are also provided for the treatment of symptoms associated with mast cell-related processes or disorders and ischemic disorders and injuries using the genes, gene products and antibodies of the invention.

Abstract translation: 本发明涉及用于治疗和诊断免疫疾病，特别是T辅助淋巴细胞相关病症的方法和组合物，还涉及治疗肥大细胞相关过程和病症，缺血性疾病和损伤，包括缺血性肾病和损伤 。 例如，识别在T辅助细胞（TH）细胞和TH细胞亚群内部和之间差异表达的基因，其包括但不限于TH0，TH1和TH2细胞亚群。 基因也通过其基因产物与涉及TH细胞和TH细胞亚群的分化，维持和效应子功能的基因产物相互作用的能力进行鉴定。 所鉴定的基因可以诊断使用或作为治疗干预的靶标。 在这方面，本发明提供了用于鉴定和治疗性使用化合物作为免疫疾病，特别是TH细胞亚群相关病症治疗的方法。 另外，提供了用于TH细胞亚群相关病症的诊断评估和预后的方法，用于鉴定表现出对这些病症倾向的受试者，用于监测接受临床评估治疗这种病症的患者，以及用于监测 化合物用于临床试验。 还提供了使用本发明的基因，基因产物和抗体治疗与肥大细胞相关过程或病症相关的症状以及缺血性疾病和损伤的方法。

公开(公告)号：US20110001379A1

公开(公告)日：2011-01-06

申请号：US12829457

申请日：2010-07-02

Applicant: Sean McCarthy ,  Seamus Flanagan ,  Alan Simpson ,  Maxime Sorin

Inventor： Sean McCarthy ,  Seamus Flanagan ,  Alan Simpson ,  Maxime Sorin

IPC: H02K7/09

CPC classification number: F16C32/0425 ,  F16C19/10 ,  F16C32/0402

Abstract: A passive magnetic bearing which has an exceptionally low friction couple. Radial and axial restraint is achieved through magnetic and mechanical means. The embodiment of the passive magnetic bearing has two axially magnetized rings, which each exhibit at least one pair of north and south poles. The magnetized rings are positioned in a manner where the poles are in a repulsive magnetic interaction such that the plane of symmetry which separates the like poles lies perpendicular to the axis of the rotation of a shaft and this radially constrains the movement of the shaft. Axial rigidity is added to the system by the use of ceramic bearings and related axial retaining mechanisms on one of the ring magnets thus maintaining the magnetic bearing in an otherwise unstable axial plane.

Abstract translation: 一种具有极低摩擦力的无源磁轴承。 通过磁力和机械方式实现径向和轴向约束。 无源磁轴承的实施例具有两个轴向磁化的环，每个环表现出至少一对北极和南极。 磁化环以这样的方式定位，其中磁极处于排斥磁相互作用，使得分离相同磁极的对称平面垂直于轴的旋转轴线，并且这径向地限制轴的运动。 通过在其中一个环形磁体上使用陶瓷轴承和相关的轴向保持机构将轴向刚度加到系统上，从而将磁轴承保持在另外不稳定的轴向平面。

公开(公告)号：US20080177600A1

公开(公告)日：2008-07-24

申请号：US11971677

申请日：2008-01-09

Applicant: Michael Sean McCarthy ,  Donna Cohen ,  Daniel R. McManus ,  Jim Van Baalen

Inventor： Michael Sean McCarthy ,  Donna Cohen ,  Daniel R. McManus ,  Jim Van Baalen

IPC: G06Q10/00 ,  G06F15/177

CPC classification number: G06Q10/10 ,  G06Q10/0639 ,  G06Q30/0204

Abstract: Methods and systems for measuring chat performance are described. Certain users accessing a website are inhibited by a chat system from receiving online chat service, while other users are provided with online chat service, wherein users can textually communicate with another entity. Optionally, the chat system causes web beacons or other activity trackers to be downloaded to terminals associated with website visitors. The beacons provide website activity information for respective users. The chat system or another system monitors and processes the website activity information, to determine or provide information for determining chat performance.

Abstract translation: 描述测量聊天性能的方法和系统。 访问网站的某些用户被聊天系统禁止接收在线聊天服务，而其他用户被提供在线聊天服务，其中用户可以文本地与另一实体通信。 可选地，聊天系统使得网络信标或其他活动跟踪器被下载到与网站访问者相关联的终端。 信标为各个用户提供网站活动信息。 聊天系统或其他系统监视和处理网站活动信息，以确定或提供用于确定聊天表现的信息。

公开(公告)号：US20060227993A1

公开(公告)日：2006-10-12

申请号：US11352608

申请日：2006-02-13

Applicant: Phelim O'Doherty ,  Patrick Smith ,  Carlos Luna ,  Sean McCarthy

Inventor： Phelim O'Doherty ,  Patrick Smith ,  Carlos Luna ,  Sean McCarthy

IPC: G06K9/00

CPC classification number: G01N21/9506 ,  G06K9/00577 ,  G06K9/2036 ,  G11B20/00086 ,  G11B20/0013 ,  G11B20/00173 ,  G11B23/284

Abstract: A method and apparatus for determining if an optical disk originated from a valid source, the method and apparatus scanning one major surface of the optical disk for mechanical surface imperfections, storing the locations of the surface imperfections relative to a datum, comparing a parameter of each of the locations of the surface imperfections with corresponding parameters of a master disk of known source for determining if the disk originated from the source from which the master disk originated.

Abstract translation: 一种用于确定光盘是否源自有效源的方法和装置，所述方法和装置扫描光盘的一个主表面用于机械表面缺陷，存储表面缺陷相对于基准的位置，比较每个 表面缺陷的位置与已知源的主盘的相应参数相关联，以确定磁盘是否源自主盘的源。

公开(公告)号：US20060205034A1

公开(公告)日：2006-09-14

申请号：US11265762

申请日：2005-11-02

Applicant: Christopher Fraser ,  Sean McCarthy ,  John Sharp ,  Thomas Barnes ,  Nicholas Wrighton ,  Charles Mackay ,  Kevin Leiby ,  Douglas Holtzman

Inventor： Christopher Fraser ,  Sean McCarthy ,  John Sharp ,  Thomas Barnes ,  Nicholas Wrighton ,  Charles Mackay ,  Kevin Leiby ,  Douglas Holtzman

IPC: C07K14/715 ,  C07H21/04 ,  C12P21/06 ,  C07K16/28

CPC classification number: C07K16/18

Abstract: The invention provides isolated nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.