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    Absorbable polymer formulations
    2.
    发明授权
    Absorbable polymer formulations 有权
    可吸收聚合物配方

    公开(公告)号：US08440215B2

    公开(公告)日：2013-05-14

    申请号：US11864153

    申请日：2007-09-28

    申请人： Sasa Andjelic ,  Tara Zabrosky

    发明人： Sasa Andjelic ,  Tara Zabrosky

    IPC分类号： C08G63/02

    CPC分类号： A61K8/85 ,  A61K2800/91 ,  A61L31/06 ,  A61Q19/00 ,  C08G63/60 ,  C08L67/00 ,  C08L67/04 ,  C08L2666/22

    摘要： A co-polyester which includes the reaction product of a polycondensation polyester and epsilon-caprolactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and a diol. The co-polyester is injectable and absorbable into animal, such as human, tissue and can be used for facial cosmetic or reconstructive surgery of soft tissue. Another embodiment is directed to a method for preventing adhesion using a co-polyester comprising the reaction product of a polycondensation polyester and epsilon-caprolactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and a diol, and the co-polyester comprises about 40 to 50% by weight of the polycondensation polyester based on the total weight of the co-polyester.

    摘要翻译： 包括缩聚聚酯和ε-己内酯的反应产物的共聚酯，其中缩聚聚酯包括二甘醇酸和/或其衍生物与二醇的反应产物。 共聚酯是可注射的并且可吸收到动物中，例如人，组织，并且可以用于软组织的面部化妆品或重建手术。 另一个实施方案涉及使用包含缩聚聚酯和ε-己内酯的反应产物的共聚酯来防止粘合的方法，其中缩聚聚酯包括二甘醇酸和/或其衍生物与二醇的反应产物，和 共聚酯包含基于共聚酯总重量的约40至50重量％的缩聚聚酯。

    SEMI-CRYSTALLINE, FAST ABSORBING POLYMER FORMULATION
    4.
    发明申请
    SEMI-CRYSTALLINE, FAST ABSORBING POLYMER FORMULATION 有权
    半结晶，快速吸收聚合物配方

    公开(公告)号：US20110034567A1

    公开(公告)日：2011-02-10

    申请号：US12538259

    申请日：2009-08-10

    申请人： Sasa Andjelic

    发明人： Sasa Andjelic

    IPC分类号： A61K47/34 ,  C08G63/02

    CPC分类号： C08G63/66 ,  C08G63/08 ,  C08G63/60 ,  C08G2261/126

    摘要： The present invention relates to a composition comprising a semi-crystalline, absorbable copolymer formulation wherein the first component is hydroxy-capped polycondensation product of diglycolic acid and a mixture of two idols, diethylene glycol (DEG) and ethylene glycol (EG), with DEG added in larger molar amount, and wherein the second component, glycolide is incorporated during the subsequent ring-opening polymerization. The resulting hydrophilic resin has low crystallinity level, glass transition temperature, Tg, slightly below room temperature, and may be particularly useful for making monofilaments, multifilaments, microspheres, or melt blown nonwoven constructs or other medical devices where fast hydrolysis rates and superior mechanical properties are desirable.

    摘要翻译： 本发明涉及包含半结晶可吸收共聚物制剂的组合物，其中第一组分是二甘醇酸的二羟基封端的缩聚产物和两个偶像，二甘醇（DEG）和乙二醇（EG）的混合物，与DEG 加入较大摩尔量，并且其中第二组分乙交酯在随后的开环聚合期间引入。 所得的亲水性树脂具有低的结晶度，玻璃化转变温度，Tg，略低于室温，并且可能特别适用于制造单丝，复丝，微球或熔喷非织造结构体或其它医疗器械，其中快速水解速率和优异的机械性能 是理想的。

    Absorbable copolyesters of poly(ethoxyethylene diglycolate) and glycolide
    5.
    发明授权
    Absorbable copolyesters of poly(ethoxyethylene diglycolate) and glycolide 有权
    聚（乙氧基乙二醇二乙酸酯）和乙交酯的可吸收共聚酯

    公开(公告)号：US07868127B2

    公开(公告)日：2011-01-11

    申请号：US11693118

    申请日：2007-03-29

    申请人： Sasa Andjelic ,  Modesto Erneta ,  Michel Gensini

    发明人： Sasa Andjelic ,  Modesto Erneta ,  Michel Gensini

    IPC分类号： C08G63/66 ,  C08G63/02

    CPC分类号： A61L17/12 ,  A61L31/06 ,  C08G63/664 ,  Y10T442/626 ,  C08L67/04

    摘要： A semi-crystalline, absorbable copolyester composition comprising the reaction product of a polycondensation polyester and at least one lactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and diethylene glycol; and the copolyester comprises about 30 to 60% by weight of the polycondensation polyester based on the total weight of the copolyester. Also medical devices such as absorbable sutures comprising such copolyesters and absorbable microspheres comprising such copolyesters and methods of making of such absorbable microspheres.

    摘要翻译： 包含缩聚聚酯和至少一种内酯的反应产物的半结晶可吸收的共聚酯组合物，其中所述缩聚聚酯包括二甘醇酸和/或其衍生物与二甘醇的反应产物; 共聚聚酯包含基于共聚酯总重量的约30至60重量％的缩聚聚酯。 还可以使用包括这种共聚酯和包含这种共聚酯的可吸收微球的可吸收缝合线的医疗装置和制造这种可吸收的微球的方法。

    Method of preventing post-operative surgical adhesion
    6.
    发明授权
    Method of preventing post-operative surgical adhesion 有权
    防止术后手术粘连的方法

    公开(公告)号：US07754233B2

    公开(公告)日：2010-07-13

    申请号：US10934066

    申请日：2004-09-03

    申请人： Sasa Andjelic ,  Rao S. Bezwada ,  Dennis D. Jamiolkowski

    发明人： Sasa Andjelic ,  Rao S. Bezwada ,  Dennis D. Jamiolkowski

    IPC分类号： A61F2/02 ,  C08G63/02 ,  C08G63/08 ,  C08G63/82

    CPC分类号： A61L31/06 ,  C08L67/04

    摘要： A method for preventing adhesion using a co-polyester comprising the reaction product of a polycondensation polyester and at least one lactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and ethylene glycol; and the co-polyester comprises about 40 to 50% by weight of the polycondensation polyester based on the total weight of the co-polyester.

    摘要翻译： 一种防止使用包含缩聚聚酯和至少一种内酯的反应产物的共聚酯粘合的方法，其中缩聚聚酯包括二甘醇酸和/或其衍生物与乙二醇的反应产物; 共聚酯包含基于共聚酯总重量的约40至50重量％的缩聚聚酯。

    ABSORBABLE POLYMER FORMULATIONS
    7.
    发明申请
    ABSORBABLE POLYMER FORMULATIONS 有权
    可吸收的聚合物配方

    公开(公告)号：US20080243101A1

    公开(公告)日：2008-10-02

    申请号：US11864153

    申请日：2007-09-28

    申请人： Sasa Andjelic ,  Tara Zabrosky

    发明人： Sasa Andjelic ,  Tara Zabrosky

    IPC分类号： A61M5/00 ,  C08G63/08

    CPC分类号： A61K8/85 ,  A61K2800/91 ,  A61L31/06 ,  A61Q19/00 ,  C08G63/60 ,  C08L67/00 ,  C08L67/04 ,  C08L2666/22

    摘要： A co-polyester which includes the reaction product of a polycondensation polyester and epsilon-caprolactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and a diol. The co-polyester is injectable and absorbable into animal, such as human, tissue and can be used for facial cosmetic or reconstructive surgery of soft tissue. Another embodiment is directed to a method for preventing adhesion using a co-polyester comprising the reaction product of a polycondensation polyester and epsilon-caprolactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and a diol, and the co-polyester comprises about 40 to 50% by weight of the polycondensation polyester based on the total weight of the co-polyester.

    摘要翻译： 包括缩聚聚酯和ε-己内酯的反应产物的共聚酯，其中缩聚聚酯包括二甘醇酸和/或其衍生物与二醇的反应产物。 共聚酯是可注射的并且可吸收到动物中，例如人，组织，并且可以用于软组织的面部化妆品或重建手术。 另一个实施方案涉及使用包含缩聚聚酯和ε-己内酯的反应产物的共聚酯来防止粘合的方法，其中缩聚聚酯包括二甘醇酸和/或其衍生物与二醇的反应产物，和 共聚酯包含基于共聚酯总重量的约40至50重量％的缩聚聚酯。

    Semi-crystalline, fast absorbing polymer formulation
    8.
    发明授权
    Semi-crystalline, fast absorbing polymer formulation 有权
    半结晶，快速吸收聚合物配方

    公开(公告)号：US09200112B2

    公开(公告)日：2015-12-01

    申请号：US12538259

    申请日：2009-08-10

    申请人： Sasa Andjelic

    发明人： Sasa Andjelic

    IPC分类号： C08G63/02 ,  A61K47/34 ,  C08G63/66 ,  C08G63/08 ,  C08G63/60

    CPC分类号： C08G63/66 ,  C08G63/08 ,  C08G63/60 ,  C08G2261/126

    摘要： The present invention relates to a composition comprising a semi-crystalline, absorbable copolymer formulation wherein the first component is hydroxy-capped polycondensation product of diglycolic acid and a mixture of two idols, diethylene glycol (DEG) and ethylene glycol (EG), with DEG added in larger molar amount, and wherein the second component, glycolide is incorporated during the subsequent ring-opening polymerization. The resulting hydrophilic resin has low crystallinity level, glass transition temperature, Tg, slightly below room temperature, and may be particularly useful for making monofilaments, multifilaments, microspheres, or melt blown nonwoven constructs or other medical devices where fast hydrolysis rates and superior mechanical properties are desirable.

    摘要翻译： 本发明涉及包含半结晶可吸收共聚物制剂的组合物，其中第一组分是二甘醇酸的二羟基封端的缩聚产物和两个偶像，二甘醇（DEG）和乙二醇（EG）的混合物，与DEG 加入较大摩尔量，并且其中第二组分乙交酯在随后的开环聚合期间引入。 所得的亲水性树脂具有低的结晶度，玻璃化转变温度，Tg，略低于室温，并且可能特别适用于制造单丝，复丝，微球或熔喷非织造结构体或其它医疗器械，其中快速水解速率和优异的机械性能 是理想的。

    Polyglyceryl compounds and compositions
    9.
    发明授权
    Polyglyceryl compounds and compositions 有权
    聚甘油化合物和组合物

    公开(公告)号：US08394755B2

    公开(公告)日：2013-03-12

    申请号：US13075362

    申请日：2011-03-30

    申请人： Sasa Andjelic ,  Modesto Erneta ,  Michael J. Fevola ,  Frank C. Sun

    发明人： Sasa Andjelic ,  Modesto Erneta ,  Michael J. Fevola ,  Frank C. Sun

    IPC分类号： C11D3/20 ,  C11D1/68 ,  C11D3/22 ,  C11D7/26 ,  C07D307/00 ,  C07D309/00

    CPC分类号： A61K8/39 ,  A61K8/604 ,  A61K2800/48 ,  A61Q19/10

    摘要： Provided are compositions comprising one or more compounds having a structure comprising a node structure with from four to twelve carbon atoms, one or more (poly)glyceryl groups, and one or more hydrophobic moieties, wherein each of the one or more (poly)glyceryl groups is linked to the node structure by a first primary linking group, the one or more hydrophobic moieties are each independently linked either to the node structure by a primary linking group or to one of the (poly)glyceryl groups by a secondary linking group, and wherein the polyglyceryl thickener has an average degree of glyceryl polymerization of from greater than 3 to less than about 11 and an average number of hydrophobic groups per primary linking group of about 0.35 or greater. Also provided are polyglyceryl compounds, compositions comprising water, a surfactant, and a polyglyceryl thickener, as well as, methods of making polyglyceryl compounds and compositions of the present invention.

    摘要翻译： 提供的是包含一种或多种具有包含具有四至十二个碳原子的结构结构，一个或多个（多）甘油基和一个或多个疏水部分的结构的化合物的组合物，其中所述一种或多种（聚）甘油基 基团通过第一个主要连接基团与节点结构连接，所述一个或多个疏水性部分各自独立地通过第一连接基团连接到节点结构，或者通过次连接基团连接到（聚）甘油基之一， 并且其中所述聚甘油增稠剂的平均甘油聚合度为大于3至小于约11，并且每个连接基团的疏水基团的平均数为约0.35或更大。 还提供了聚甘油化合物，包含水，表面活性剂和聚甘油增稠剂的组合物，以及制备本发明的聚甘油化合物和组合物的方法。

    POLYGLYCERYL COMPOUNDS AND COMPOSITIONS
    10.
    发明申请
    POLYGLYCERYL COMPOUNDS AND COMPOSITIONS 有权

    公开(公告)号：US20120123104A1

    公开(公告)日：2012-05-17

    申请号：US13075388

    申请日：2011-03-30

    申请人： Sasa Andjelic ,  Modesto Erneta ,  Michael J. Fevola ,  Frank C. Sun

    发明人： Sasa Andjelic ,  Modesto Erneta ,  Michael J. Fevola ,  Frank C. Sun

    IPC分类号： C07H15/10 ,  C07C69/604 ,  C07D307/20

    CPC分类号： A61K8/39 ,  A61K8/604 ,  A61K2800/48 ,  A61Q19/10

    摘要： Provided are compositions comprising one or more compounds having a structure comprising a node structure with from four to twelve carbon atoms, one or more (poly)glyceryl groups, and one or more hydrophobic moieties, wherein each of the one or more (poly)glyceryl groups is linked to the node structure by a first primary linking group, the one or more hydrophobic moieties are each independently linked either to the node structure by a primary linking group or to one of the (poly)glyceryl groups by a secondary linking group, and wherein the polyglyceryl thickener has an average degree of glyceryl polymerization of from greater than 3 to less than about 11 and an average number of hydrophobic groups per primary linking group of about 0.35 or greater. Also provided are polyglyceryl compounds, compositions comprising water, a surfactant, and a polyglyceryl thickener, as well as, methods of making polyglyceryl compounds and compositions of the present invention.