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公开(公告)号：US20220273632A1
公开(公告)日：2022-09-01
申请号：US17747472
申请日：2022-05-18
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.
Inventor： Nitin Krishnaji DAMLE , Sanjay Nandlalji MANDHANE , Manoj Atmaramji UPADHYA , Sameer Vishwanath MEHETRE , Gajanan Uttamrao CHIDREWAR , Prabal SENGUPTA , Trinadha Rao CHITTURI
Abstract: The invention relates to a method of treating or preventing Parkinson's disease in a subject comprising administering a compound of Formula I wherein, R1 is —NHC(O) C3-6 cycloalkyl and R2 is hydrogen; or R1 and R2 along with the carbon atoms to which they are attached form a six membered aromatic ring, wherein the ring is substituted with one or more groups selected from hydrogen, halogen and C1-6 alkyl; R3 and R4 are independently selected from group comprising hydrogen, halogen, C1-3 alkyl, OC1-3 alkyl, NO2, SC1-3 alkyl, C1-3 haloalkyl, OC1-3 haloalkyl, and SC1-3 haloalkyl; or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US10849887B2
公开(公告)日：2020-12-01
申请号：US16304914
申请日：2017-06-02
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.
Inventor： Nitin Krishnaji Damle , Sanjay Nandlalji Mandhane , Manoj Atmaramji Upadhya , Sameer Vishwanath Mehetre , Gajanan Uttamrao Chidrewar , Prabal Sengupta , Trinadha Rao Chitturi
Abstract: The invention relates to a method of treating or preventing Parkinson's disease in a subject comprising administering a compound of Formula I wherein, R1 is —NHC(O) C3-6 cycloalkyl and R2 is hydrogen; or R1 and R2 along with the carbon atoms to which they are attached form a six membered aromatic ring, wherein the ring is substituted with one or more groups selected from hydrogen, halogen and C1-6 alkyl; R3 and R4 are independently selected from group comprising hydrogen, halogen, C1-3 alkyl, OC1-3 alkyl, NO2, SC1-3, alkyl, C1-3, haloalkyl, OC1-3 haloalkyl, and SC1-3 haloalkyl; or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20200000803A1
公开(公告)日：2020-01-02
申请号：US16569909
申请日：2019-09-13
Applicant: Sun Pharma Advanced Research Company Ltd.
Inventor： Nitin Bhalachandra Dharmadikari , Yashoraj Zala , Ashwini Gadkari
IPC: A61K31/505 , A61K9/16 , A61K9/48 , A61K9/50
Abstract: A stable multi-particulate pharmaceutical composition comprising pellets, the pellets comprising a mixture of rosuvastatin or its pharmaceutically acceptable salts as a sole active ingredient, one or more osmotic release modifiers and one or more stabilizers.
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公开(公告)号：US20180235983A1
公开(公告)日：2018-08-23
申请号：US15552887
申请日：2016-02-25
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.
Inventor： Madhusudhan BOMMAGANI , Subhas Balaram BHOWMICK , Prashant KANE , Vaibhav DUBEY
CPC classification number: A61K31/65 , A61K9/0014 , A61K9/06 , A61K9/10 , A61K9/122 , A61K9/143 , A61K9/146
Abstract: The present invention relates to a method of preparing a nanoparticulate topical composition of a water soluble, water-susceptible active ingredient or its pharmaceutically acceptable salt, the method comprising steps of milling the water soluble, water-susceptible active ingredient or its salt, a wetting agent and a non-aqueous liquid vehicle to obtain a non-aqueous nanosuspension and converting the non-aqueous nanosuspension into a topical composition.
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公开(公告)号：US20180140549A1
公开(公告)日：2018-05-24
申请号：US15580732
申请日：2016-06-08
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD
Inventor： Wen Wee MA , Alex ADJEI , Lynne BUI , Ronald HARNING , Ajay KHOPADE , Subhas BHOWMICK , Natarajan ARULSUDAR , Narendra LAKKAD
CPC classification number: A61K9/10 , A61K9/0019 , A61K9/5123 , A61K9/5138 , A61K9/5146 , A61K31/337 , A61K47/10 , A61K47/12 , A61K47/28 , A61K47/32 , A61P35/00
Abstract: A method of treating patients suffering from carcinoma of intrahepatic or extra hepatic bile duct or gall bladder which is locally advanced or metastatic, by intravenously administering to the patient, paclitaxel in the form of a nanodispersion. The nanodispersion comprises particles with a mean particle size less than 300 nm and is free of polyoxyethylated castor oil and free of a protein.
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Patent Agency Ranking
公开(公告)号：US20180127372A1
公开(公告)日：2018-05-10
申请号：US15574967
申请日：2016-05-18
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.
Inventor： Hemant Ashvinbhai CHOKSHI , Sabbirhusen Yusufbhai CHIMANWALA , Varun Anilkumar MEHTA , Prabal SENGUPTA , Chitturi Trinadha RAO
IPC: C07D213/75 , C07D401/12 , C07B43/06
CPC classification number: C07D213/75 , C07B43/06 , C07D401/12
Abstract: The present invention relates to novel amidoheteroaryl aroyl hydrazide ethynes as tyrosine kinase inhibitors, process of preparation thereof, and use of the compounds for preparation of pharmaceutical compositions in the therapeutic treatment of disorders related to tyrosine kinases in humans.
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公开(公告)号：US20230098352A1
公开(公告)日：2023-03-30
申请号：US18061848
申请日：2022-12-05
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.
Inventor： Ajay Jaysingh KHOPADE , Arindam HALDER
Abstract: The present invention relates to a method of increasing the bioavailability and/or prolonging ophthalmic action of a drug, the method comprising instilling into the eye an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters having a D50 value of at least 2 micrometer and said drug loaded nano-resin particles have a particle size distribution characterized in that the D90 value is 70 nanometer to 900 nanometer. The present invention further relates to an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters have a D50 value of at least 2 micrometers and said drug loaded nano-resin particles have a particle size distribution characterized in that the D90 value is 70 nanometers to 900 nanometers.
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公开(公告)号：US11304898B2
公开(公告)日：2022-04-19
申请号：US15580732
申请日：2016-06-08
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD
Inventor： Wen Wee Ma , Alex Adjei , Lynne Bui , Ronald Harning , Ajay Khopade , Subhas Bhowmick , Natarajan Arulsudar , Narendra Lakkad
IPC: A61K9/10 , A61K31/337 , A61K9/00 , A61K9/51 , A61P35/00 , A61K47/10 , A61K47/12 , A61K47/28 , A61K47/32
Abstract: A method of treating patients suffering from carcinoma of intrahepatic or extra hepatic bile duct or gall bladder which is locally advanced or metastatic, by intravenously administering to the patient, paclitaxel in the form of a nanodispersion. The nanodispersion comprises particles with a mean particle size less than 300 nm and is free of polyoxyethylated castor oil and free of a protein.
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公开(公告)号：US20210308130A1
公开(公告)日：2021-10-07
申请号：US17304309
申请日：2021-06-17
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.
Inventor： Ajay Jaysingh Khopade , Arindam Halder
Abstract: The present invention relates to a method of increasing the bioavailability and/or prolonging ophthalmic action of a drug, the method comprising instilling into the eye an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters having a D50 value of at least 2 micrometer and said drug loaded nano-resin particles have a particle size distribution characterized in that the D90 value is 70 nanometer to 900 nanometer. The present invention further relates to an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters have a D50 value of at least 2 micrometers and said drug loaded nano-resin particles have a particle size distribution characterized in that the D90 value is 70 nanometers to 900 nanometers.
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公开(公告)号：US20210137921A1
公开(公告)日：2021-05-13
申请号：US17157047
申请日：2021-01-25
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.
Inventor： Nitin Bhalachandra DHARMADIKARI , Yashoraj R. ZALA , Ashwini GADKARI
IPC: A61K31/505 , A61K9/16 , A61K9/48 , A61K9/50
Abstract: A stable multi-particulate pharmaceutical composition comprising pellets, the pellets comprising a mixture of rosuvastatin or its pharmaceutically acceptable salts as a sole active ingredient, one or more osmotic release modifiers and one or more stabilizers.
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