公开(公告)号：US20210015805A1

公开(公告)日：2021-01-21

申请号：US17061139

申请日：2020-10-01

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.

Inventor： Nitin Krishnaji DAMLE ,  Sanjay Nandlalji MANDHANE ,  Manoj Atmaramji UPADHYA ,  Sameer Vishwanath MEHETRE ,  Gajanan Uttamrao CHIDREWAR ,  Prabal SENGUPTA ,  Trinadha Rao CHITTURI

IPC: A61K31/44 ,  A61P25/16 ,  A61K31/47

Abstract: The invention relates to a method of treating or preventing Parkinson's disease in a subject comprising administering a compound of Formula I wherein, R1 is —NHC(O) C3-6 cycloalkyl and R2 is hydrogen; or R1 and R2 along with the carbon atoms to which they are attached form a six membered aromatic ring, wherein the ring is substituted with one or more groups selected from hydrogen, halogen and C1-6 alkyl; R3 and R4 are independently selected from group comprising hydrogen, halogen, C1-3 alkyl, OC1-3 alkyl, NO2, SC1-3 alkyl, C1-3 haloalkyl, OC1-3 haloalkyl, and SC1-3 haloalkyl; or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20220273632A1

公开(公告)日：2022-09-01

申请号：US17747472

申请日：2022-05-18

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.

Inventor： Nitin Krishnaji DAMLE ,  Sanjay Nandlalji MANDHANE ,  Manoj Atmaramji UPADHYA ,  Sameer Vishwanath MEHETRE ,  Gajanan Uttamrao CHIDREWAR ,  Prabal SENGUPTA ,  Trinadha Rao CHITTURI

IPC: A61K31/44 ,  A61P25/16 ,  A61K31/47

Abstract: The invention relates to a method of treating or preventing Parkinson's disease in a subject comprising administering a compound of Formula I wherein, R1 is —NHC(O) C3-6 cycloalkyl and R2 is hydrogen; or R1 and R2 along with the carbon atoms to which they are attached form a six membered aromatic ring, wherein the ring is substituted with one or more groups selected from hydrogen, halogen and C1-6 alkyl; R3 and R4 are independently selected from group comprising hydrogen, halogen, C1-3 alkyl, OC1-3 alkyl, NO2, SC1-3 alkyl, C1-3 haloalkyl, OC1-3 haloalkyl, and SC1-3 haloalkyl; or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240066014A1

公开(公告)日：2024-02-29

申请号：US18378901

申请日：2023-10-11

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.

Inventor： Nitin Krishnaji DAMLE ,  Sanjay Nandlalji MANDHANE ,  Manoj Atmaramji UPADHYA ,  Sameer Vishwanath MEHETRE ,  Gajanan Uttamrao CHIDREWAR ,  Prabal SENGUPTA ,  Trinadha Rao CHITTURI

IPC: A61K31/44 ,  A61K31/47 ,  A61P25/16

CPC classification number: A61K31/44 ,  A61K31/47 ,  A61P25/16

Abstract: The invention relates to a method of treating or preventing Parkinson's disease in a subject comprising administering a compound of Formula I






wherein, R1 is —NHC(O) C3-6 cycloalkyl and R2 is hydrogen;
or R1 and R2 along with the carbon atoms to which they are attached form a six membered aromatic ring, wherein the ring is substituted with one or more groups selected from hydrogen, halogen and C1-6 alkyl;
R3 and R4 are independently selected from group comprising hydrogen, halogen, C1-3 alkyl, OC1-3 alkyl, NO2, SC1-3 alkyl, C1-3 haloalkyl, OC1-3 haloalkyl, and SC1-3 haloalkyl; or a pharmaceutically acceptable salt thereof.