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公开(公告)号：US10849887B2
公开(公告)日：2020-12-01
申请号：US16304914
申请日：2017-06-02
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.
Inventor： Nitin Krishnaji Damle , Sanjay Nandlalji Mandhane , Manoj Atmaramji Upadhya , Sameer Vishwanath Mehetre , Gajanan Uttamrao Chidrewar , Prabal Sengupta , Trinadha Rao Chitturi
Abstract: The invention relates to a method of treating or preventing Parkinson's disease in a subject comprising administering a compound of Formula I wherein, R1 is —NHC(O) C3-6 cycloalkyl and R2 is hydrogen; or R1 and R2 along with the carbon atoms to which they are attached form a six membered aromatic ring, wherein the ring is substituted with one or more groups selected from hydrogen, halogen and C1-6 alkyl; R3 and R4 are independently selected from group comprising hydrogen, halogen, C1-3 alkyl, OC1-3 alkyl, NO2, SC1-3, alkyl, C1-3, haloalkyl, OC1-3 haloalkyl, and SC1-3 haloalkyl; or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20210115038A1
公开(公告)日：2021-04-22
申请号：US17073017
申请日：2020-10-16
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD
Inventor： Gaurav Sanjivkumar Sheth , Sabbirhusen Yusufbhai Chimanwala , Tushar Mukund Jarag , Aishwarya Hampiholi , Saikat Maity , Prabal Sengupta , Gulamnizami Abdulsattar Qureshi , Umesh Vishnu Chaudhari , Raj Gopal Venkat , V.S.N. Murty Kadiyala , Sairam VVM Kalapatapu , Vaibhav Jain , Trinadha Rao Chitturi
IPC: C07D471/04 , C07D295/182 , C07D213/81 , C07D213/74 , C07D401/14 , C07D409/12 , C07D493/08 , C07D209/42 , C07D209/18 , C07D401/12 , C07D209/08
Abstract: The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans.
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Patent Agency Ranking
公开(公告)号：US11813252B2
公开(公告)日：2023-11-14
申请号：US17747472
申请日：2022-05-18
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.
Inventor： Nitin Krishnaji Damle , Sanjay Nandlalji Mandhane , Manoj Atmaramji Upadhya , Sameer Vishwanath Mehetre , Gajanan Uttamrao Chidrewar , Prabal Sengupta , Trinadha Rao Chitturi
Abstract: The invention relates to a method of treating or preventing Parkinson's disease in a subject comprising administering a compound of Formula I
wherein, R1 is —NHC(O) C3-6 cycloalkyl and R2 is hydrogen;
or R1 and R2 along with the carbon atoms to which they are attached form a six membered aromatic ring, wherein the ring is substituted with one or more groups selected from hydrogen, halogen and C1-6 alkyl;
R3 and R4 are independently selected from group comprising hydrogen, halogen, C1-3 alkyl, OC1-3 alkyl, NO2, SC1-3 alkyl, C1-3 haloalkyl, OC1-3 haloalkyl, and SC1-3 haloalkyl; or a pharmaceutically acceptable salt thereof.-
公开(公告)号：US11583522B2
公开(公告)日：2023-02-21
申请号：US17061139
申请日：2020-10-01
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.
Inventor： Nitin Krishnaji Damle , Sanjay Nandlalji Mandhane , Manoj Atmaramji Upadhya , Sameer Vishwanath Mehetre , Gajanan Uttamrao Chidrewar , Prabal Sengupta , Trinadha Rao Chitturi
Abstract: The invention relates to a method of treating or preventing Parkinson's disease in a subject comprising administering a compound of Formula I wherein, R1 is —NHC(O) C3-6 cycloalkyl and R2 is hydrogen; or R1 and R2 along with the carbon atoms to which they are attached form a six membered aromatic ring, wherein the ring is substituted with one or more groups selected from hydrogen, halogen and C1-6 alkyl; R3 and R4 are independently selected from group comprising hydrogen, halogen, C1-3 alkyl, OC1-3 alkyl, NO2, SC1-3 alkyl, C1-3 haloalkyl, OC1-3 haloalkyl, and SC1-3 haloalkyl; or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20220127266A1
公开(公告)日：2022-04-28
申请号：US17646897
申请日：2022-01-04
Applicant: Sun Pharma Advanced Research Company Ltd
Inventor： Gaurav Sanjivkumar Sheth , Sabbirhusen Yusufbhai Chimanwala , Tushar Mukund Jarag , Aishwarya Hampiholi , Saikat Maity , Prabal Sengupta , Gulamnizami Abdulsattar Qureshi , Umesh Vishnu Chaudhari , Raj Gopal Venkat , V.S.N Murty Kadiyala , Sairam VVM Kalapatapu , Vaibhav Jain , Trinadha Rao Chitturi
IPC: C07D471/04 , C07D209/08 , C07D209/18 , C07D209/42 , C07D213/74 , C07D213/81 , C07D295/182 , C07D401/12 , C07D401/14 , C07D409/12 , C07D493/08
Abstract: The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans.
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公开(公告)号：US11225480B2
公开(公告)日：2022-01-18
申请号：US17073017
申请日：2020-10-16
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD
Inventor： Gaurav Sanjivkumar Sheth , Sabbirhusen Yusufbhai Chimanwala , Tushar Mukund Jarag , Aishwarya Hampiholi , Saikat Maity , Prabal Sengupta , Gulamnizami Abdulsattar Qureshi , Umesh Vishnu Chaudhari , Raj Gopal Venkat , V. S. N. Murty Kadiyala , Sairam V V M Kalapatapu , Vaibhav Jain , Trinadha Rao Chitturi
IPC: C07D401/12 , C07D401/14 , C07D409/12 , C07D413/14 , C07D471/04 , C07D209/08 , C07D209/18 , C07D209/42 , C07D213/74 , C07D213/81 , C07D295/182 , C07D493/08
Abstract: The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans. The novel compounds have a structure according to Formula I or a pharmaceutically acceptable salt, stereoisomer or deuterated analog thereof, wherein X, R1, R2 and Y are as described herein.
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公开(公告)号：US10150733B2
公开(公告)日：2018-12-11
申请号：US15574967
申请日：2016-05-18
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.
Inventor： Hemant Ashvinbhai Chokshi , Sabbirhusen Yusufbhai Chimanwala , Varun Anilkumar Mehta , Prabal Sengupta , Chitturi Trinadha Rao
IPC: C07D213/75 , C07D401/12 , C07B43/06
Abstract: The present invention relates to novel amidoheteroaryl aroyl hydrazide ethynes as tyrosine kinase inhibitors, process of preparation thereof, and use of the compounds for preparation of pharmaceutical compositions in the therapeutic treatment of disorders related to tyrosine kinases in humans.
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