公开(公告)号：US20210115038A1

公开(公告)日：2021-04-22

申请号：US17073017

申请日：2020-10-16

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD

Inventor： Gaurav Sanjivkumar Sheth ,  Sabbirhusen Yusufbhai Chimanwala ,  Tushar Mukund Jarag ,  Aishwarya Hampiholi ,  Saikat Maity ,  Prabal Sengupta ,  Gulamnizami Abdulsattar Qureshi ,  Umesh Vishnu Chaudhari ,  Raj Gopal Venkat ,  V.S.N. Murty Kadiyala ,  Sairam VVM Kalapatapu ,  Vaibhav Jain ,  Trinadha Rao Chitturi

IPC: C07D471/04 ,  C07D295/182 ,  C07D213/81 ,  C07D213/74 ,  C07D401/14 ,  C07D409/12 ,  C07D493/08 ,  C07D209/42 ,  C07D209/18 ,  C07D401/12 ,  C07D209/08

Abstract: The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans.