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公开(公告)号：US20180235983A1
公开(公告)日：2018-08-23
申请号：US15552887
申请日：2016-02-25
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.
Inventor： Madhusudhan BOMMAGANI , Subhas Balaram BHOWMICK , Prashant KANE , Vaibhav DUBEY
CPC classification number: A61K31/65 , A61K9/0014 , A61K9/06 , A61K9/10 , A61K9/122 , A61K9/143 , A61K9/146
Abstract: The present invention relates to a method of preparing a nanoparticulate topical composition of a water soluble, water-susceptible active ingredient or its pharmaceutically acceptable salt, the method comprising steps of milling the water soluble, water-susceptible active ingredient or its salt, a wetting agent and a non-aqueous liquid vehicle to obtain a non-aqueous nanosuspension and converting the non-aqueous nanosuspension into a topical composition.
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公开(公告)号：US20180036243A1
公开(公告)日：2018-02-08
申请号：US15552966
申请日：2016-02-25
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.
Inventor： Madhusudhan BOMMAGANI , Subhas Balaram BHOWMICK , Prashant KANE , Vaibhav DUBEY
CPC classification number: A61K9/146 , A61K9/0014 , A61K9/06 , A61K9/10 , A61K9/122 , A61K31/65 , A61K47/14 , Y02A50/473
Abstract: The present invention relates to a nanoparticulate topical composition comprising (i) nanoparticles of a water soluble and water susceptible active ingredient or its pharmaceutically acceptable salt, having a particle size distribution such that 90% of the particles are less than 1000 nm, (ii) one or more wetting agent and (iii) a non-aqueous liquid vehicle, wherein the composition is free of water.The present invention also relates to a method of treating acne, rosacea, impetigo or a skin disease caused by a bacteria, by topical application of a nanoparticulate topical composition comprising nanoparticles of a water soluble and water susceptible active ingredient or its pharmaceutically acceptable salt, having a particle size distribution such that 90% of the particles are less than 1000 nm.
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