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公开(公告)号：US20220288585A1
公开(公告)日：2022-09-15
申请号：US17587908
申请日：2022-01-28
发明人： Gottfried Reiter , Thomas Hanner
摘要： Structures for supporting the filling of wells, in particular in microfluidic devices and provides a microfluidic device, comprising a substrate with at least a first horizontal channel which continues as a first vertical chimney channel into a first well having a greater depth than the first horizontal channel with respect to an upper surface of the substrate, wherein the first vertical channel is half open to the volume of the first well. A method for filling a well of a microfluidic device using the device is also an object of the disclosure.
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公开(公告)号：US20220241781A1
公开(公告)日：2022-08-04
申请号：US17610306
申请日：2020-03-11
发明人： Sabine Ziemba , Michael Scharfenberg , Violetta Olszowka , Martina Schmidt , Juri Attner , Markus Bigler , Sascha Mario Epp , Martin Richner , Maria Bauer , Gottfried Reiter , Georg Bauer
IPC分类号： B01L3/00
摘要： A microfluidic array, a method for producing same, a measuring system comprising the microfluidic array, and a use.
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公开(公告)号：US20180178216A1
公开(公告)日：2018-06-28
申请号：US15903720
申请日：2018-02-23
发明人： Gottfried Reiter , Dario Borovic
CPC分类号： B01L3/502707 , B01L2200/12 , B01L2300/06 , B01L2300/0645 , B01L2300/0816 , B01L2300/0861 , B01L2300/0887 , B01L2300/12 , B29C65/02 , B29C65/4895 , B29C65/7817 , B29C65/8253 , B29C66/028 , B29C66/1122 , B29C66/53461 , B29C66/54 , B29C66/543 , B29C66/71 , B29C66/712 , B29C66/73365 , B29C66/9674 , B29C66/97 , B29K2023/38 , B29L2031/756 , B81B2201/058 , B81C1/00119 , B81C2203/036 , G01B11/16 , G01B11/22 , G01N3/08 , Y10T156/10 , B29K2025/06 , B29K2025/08 , B29K2077/00 , B29K2069/00 , B29K2033/12 , B29K2023/06
摘要： A microfluidic device comprises a first substrate (102) made of a first polymer material and a second substrate (104) made of a second polymer material, the first (102) and second (104) substrates having respective bonding surfaces (23, 41), at least one of the bonding surfaces (41) having channel formations (14) so that, when the bonding surfaces (23, 41) are bonded by surface deformation to one another, the bonded first and second substrates (102, 104) and the channel formations (14) form at least part of a microfluidic channel network comprising a plurality of microfluidic channels, wherein one or more indicator pits (11), separate to the channel formations (14) defining the microfluidic channel network, are formed in at least one of the bonding surfaces (23, 41), so that surface deformation caused by the bonding process causes a change of configuration of the one or more indicator pits (11).
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公开(公告)号：US20210077997A1
公开(公告)日：2021-03-18
申请号：US17086530
申请日：2020-11-02
摘要： A method of manufacturing a microfluidic or microtiter device, the method comprises fabricating, by a single compression injection molding operation, a microfluidic or microtiter device having one or more indentations, in which a base thickness of the one or more indentations is less than 400 μm. In embodiments, the fabricating step comprises: forming a mold cavity; filling the mold cavity with molten material; closing the mold cavity; and driving one or more molding formations complementary to the one or more indentations into the mold cavity.
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公开(公告)号：US10888861B2
公开(公告)日：2021-01-12
申请号：US15648977
申请日：2017-07-13
摘要： A microfluidic flow controller comprising a substrate having formations defining two or more fluid channels having channel fluid ports which are open at an outer surface of the substrate; and a flexible layer having formations defining a fluid channel which, when the flexible layer is positioned over the substrate so as to cover at least the channel fluid ports, provides a fluid communication path between the channel fluid ports but which, when a force is applied to press the flexible layer towards the substrate, deforms so as to inhibit fluid communication between the channel fluid ports.
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公开(公告)号：US10675619B2
公开(公告)日：2020-06-09
申请号：US15903720
申请日：2018-02-23
发明人： Gottfried Reiter , Dario Borovic
IPC分类号： B01L3/00 , G01N3/08 , B81C1/00 , B29C65/48 , B29C65/82 , B29C65/00 , B29C65/02 , G01B11/16 , G01B11/22 , B29L31/00 , B29C65/78 , B29K23/00
摘要： A microfluidic device comprises a first substrate (102) made of a first polymer material and a second substrate (104) made of a second polymer material, the first (102) and second (104) substrates having respective bonding surfaces (23, 41), at least one of the bonding surfaces (41) having channel formations (14) so that, when the bonding surfaces (23, 41) are bonded by surface deformation to one another, the bonded first and second substrates (102, 104) and the channel formations (14) form at least part of a microfluidic channel network comprising a plurality of microfluidic channels, wherein one or more indicator pits (11), separate to the channel formations (14) defining the microfluidic channel network, are formed in at least one of the bonding surfaces (23, 41), so that surface deformation caused by the bonding process causes a change of configuration of the one or more indicator pits (11).
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公开(公告)号：US20180200712A1
公开(公告)日：2018-07-19
申请号：US15909025
申请日：2018-03-01
CPC分类号： B01L3/5085 , B01L3/502707 , B01L2200/12 , B01L2300/0829 , B29C45/561 , B29C2045/0094 , B29C2045/564
摘要： A method of manufacturing a microfluidic or microtiter device, the method comprises fabricating, by a single compression injection molding operation, a microfluidic or microtiter device having one or more indentations, in which a base thickness of the one or more indentations is less than 400 μm. In embodiments, the fabricating step comprises: forming a mold cavity; filling the mold cavity with molten material; closing the mold cavity; and driving one or more molding formations complementary to the one or more indentations into the mold cavity.
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公开(公告)号：US09823221B2
公开(公告)日：2017-11-21
申请号：US14379209
申请日：2013-02-13
IPC分类号： G01N27/447 , B01L3/00 , C09D5/24 , H05K3/10 , H05K3/12 , G06K19/077
CPC分类号： G01N27/44791 , B01L3/502707 , B01L3/502792 , B01L2300/0645 , B01L2300/0816 , B01L2400/0415 , B01L2400/0427 , C09D5/24 , G06K19/0775 , H05K3/107 , H05K3/1208 , H05K3/1258
摘要： A method of manufacturing a device with a planar electrode structure, the method comprising: (a) forming a microfluidic channel on a substrate; (b) applying a primer layer to at least part of the microfluidic channel, (c) applying a conductive liquid to the microfluidic channel, the conductive liquid comprising electrically conductive particles dispersed in a carrier medium, the carrier medium including a solvent; (d) allowing the conductive liquid to flow throughout the microfluidic channel by capillary action to form the planar electrode structure; and (e) evaporating the solvent from the carrier medium, is described. Devices obtainable using the method and their applications are also described.
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公开(公告)号：US20180195956A1
公开(公告)日：2018-07-12
申请号：US15759347
申请日：2016-09-16
IPC分类号： G01N21/3563 , G01N21/64 , G01N15/14 , B82Y35/00 , B82Y30/00
CPC分类号： G01N21/3563 , B82Y30/00 , B82Y35/00 , G01N15/147 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N21/648 , G01N33/54366 , G01N2015/0668 , G01N2021/6482
摘要： The present invention relates to the use of a substrate for enhancing the fluorescence of a fluorescent molecule, wherein the substrate comprises a solid polymer carrier having a plurality of recesses separated from each other and wherein the solid carrier is coated at least in part by a metal.
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公开(公告)号：US20180015469A1
公开(公告)日：2018-01-18
申请号：US15648977
申请日：2017-07-13
发明人： Wolfgang Reiter , Alfred Paris , Daniel Horner , Thomas Umundum
CPC分类号： B01L3/502738 , B01L3/502707 , B01L9/527 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2400/0633 , B01L2400/0655 , B32B37/06 , B32B37/10 , B32B37/12 , B32B38/0008 , F16K99/0015 , F16K99/0026 , F16K2099/008
摘要： A microfluidic flow controller comprising a substrate having formations defining two or more fluid channels having channel fluid ports which are open at an outer surface of the substrate; and a flexible layer having formations defining a fluid channel which, when the flexible layer is positioned over the substrate so as to cover at least the channel fluid ports, provides a fluid communication path between the channel fluid ports but which, when a force is applied to press the flexible layer towards the substrate, deforms so as to inhibit fluid communication between the channel fluid ports.
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