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公开(公告)号：US08318181B2
公开(公告)日：2012-11-27
申请号：US11607436
申请日：2006-12-01
Applicant: Jonathan Edelson , Robert J. Nicolosi
Inventor： Jonathan Edelson , Robert J. Nicolosi
CPC classification number: A61K8/06 , A61K8/64 , A61K38/4893 , A61K2800/21 , A61K2800/413 , A61K2800/91 , A61Q19/08 , B82Y5/00 , Y02A50/469
Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.
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公开(公告)号：US20140017331A1
公开(公告)日：2014-01-16
申请号：US14025632
申请日：2013-09-12
Applicant: Stephen J. McCarthy , Balint Koroskenyi , Robert J. Nicolosi
Inventor： Stephen J. McCarthy , Balint Koroskenyi , Robert J. Nicolosi
CPC classification number: A61K47/36 , A61K9/1075 , A61K9/5153 , A61K38/28 , A61K51/1244 , G01N33/5088 , Y10T428/2991 , Y10T436/144444
Abstract: The invention relates to new amphiphilic linear block copolymers of polysaccharides and polymers. The amphiphilic linear block copolymers do not form a true solution in water and are able to form micelles in selective solvents. Also disclosed are particles, each of which has a shell and a core, and a diameter of about 1 to 1,000 nanometers, and methods of delivering agents or removing substances, e.g., undesirable substances, from a subject or environment, by using these particles.
Abstract translation: 本发明涉及多糖和聚合物的新型两亲线性嵌段共聚物。 两亲性线性嵌段共聚物在水中不形成真正的溶液，并且能够在选择性溶剂中形成胶束。 还公开了通过使用这些颗粒，每个颗粒具有壳和芯，直径约为1-1000纳米，以及通过使用这些颗粒从受试者或环境中递送物质或除去物质，例如不需要的物质的方法。
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公开(公告)号：US20110020227A1
公开(公告)日：2011-01-27
申请号：US12820887
申请日：2010-06-22
Applicant: Stephen P. McCarthy , Balint Koroskenyi , Robert J. Nicolosi
Inventor： Stephen P. McCarthy , Balint Koroskenyi , Robert J. Nicolosi
IPC: A61K49/00 , A61K9/14 , A61K47/36 , A61K38/02 , A61K31/7088 , A61P35/04 , A61P31/04 , A61P31/12 , A61P7/00 , A61P35/00 , A61P9/10 , A61P29/00 , A61P15/00 , A61P25/24 , A61P3/10 , A61K38/28
CPC classification number: A61K47/36 , A61K9/1075 , A61K9/5153 , A61K38/28 , A61K51/1244 , G01N33/5088 , Y10T428/2991 , Y10T436/144444
Abstract: The invention relates to new amphiphilic linear block copolymers of polysaccharides and polymers. The amphiphilic linear block copolymers do not form a true solution in water and are able to form micelles in selective solvents. Also disclosed are particles, each of which has a shell and a core, and a diameter of about 1 to 1,000 nanometers, and methods of delivering agents or removing substances, e.g., undesirable substances, from a subject or environment, by using these particles.
Abstract translation: 本发明涉及多糖和聚合物的新型两亲线性嵌段共聚物。 两亲性线性嵌段共聚物在水中不形成真正的溶液，并且能够在选择性溶剂中形成胶束。 还公开了通过使用这些颗粒，每个颗粒具有壳和芯，直径约为1-1000纳米，以及通过使用这些颗粒从受试者或环境中递送物质或除去物质，例如不需要的物质的方法。
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公开(公告)号：US5843499A
公开(公告)日：1998-12-01
申请号：US947018
申请日：1997-10-08
Applicant: Robert A. Moreau , Kevin B. Hicks , Robert J. Nicolosi , Robert A. Norton
Inventor： Robert A. Moreau , Kevin B. Hicks , Robert J. Nicolosi , Robert A. Norton
CPC classification number: C11B1/104 , A23D9/007 , A23L33/115 , C11B1/04 , C11B1/10
Abstract: An oil extractable from corn fiber contains ferulate esters, in particular sitostanyl ester, which has been shown to have cholesterol-lowering activity. The oil is extracted by a novel process which includes a grinding step carried out before extraction with an effective organic solvent such as hexane. The corn fiber oil may be combined with an ingestible and/or edible carrier for administration as a dietary supplement for cholesterol-lowering purposes.
Abstract translation: 可从玉米纤维中提取的油包含阿魏酸酯，特别是苯基硅烷基酯，已被证明具有降低胆固醇的活性。 通过新方法提取油，其包括在用有效的有机溶剂如己烷萃取之前进行的研磨步骤。 玉米纤维油可以与可摄入和/或可食用的载体组合，作为用于胆固醇降低目的的膳食补充剂。
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5.发明申请COMPOSITIONS AND METHODS FOR TREATING CANCER WITH DACARBAZINE NANOEMULSIONS 审中-公开用DACARBAZAN NANOEMULSION治疗癌症的组合物和方法公开(公告)号：US20140294964A1
公开(公告)日：2014-10-02
申请号：US14208635
申请日：2014-03-13
Applicant: Robert J. Nicolosi , Jean-Bosco Tagne
Inventor： Robert J. Nicolosi , Jean-Bosco Tagne
IPC: A61K9/107 , A61K31/655 , A61K45/06
CPC classification number: A61K9/107 , A61K9/0014 , A61K9/0019 , A61K9/1075 , A61K31/655 , A61K45/06 , A61K47/26 , A61K47/44
Abstract: A uniform microfluidized nanoemulsion is disclosed containing an anti-cancer agent, such as dacarbazine. The microfluidized nanoemulsion improves the combination's cell membrane permeability by at least four-fold over conventional nanoemulsion compositions, which significantly increases the intracellular concentration of anticancer agents. As a nanoemulsion, dacarbazine has a greater anti-cancer efficacy than when applied as a free solution.
Abstract translation: 公开了含有抗癌剂如达卡巴嗪的均匀微流化纳米乳剂。 微流化纳米乳液将组合的细胞膜通透性提高至常规纳米乳剂组合物的四倍以上，其显着增加抗癌剂的细胞内浓度。 作为纳米乳剂，达卡巴嗪具有比作为游离溶液应用时更大的抗癌功效。
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Patent Agency Ranking
公开(公告)号：US08173618B2
公开(公告)日：2012-05-08
申请号：US10898393
申请日：2004-07-23
Applicant: Thomas B. Shea , Robert J. Nicolosi , Eugene Rogers
Inventor： Thomas B. Shea , Robert J. Nicolosi , Eugene Rogers
IPC: A61K31/70 , A61K31/52 , A61K31/195 , A61K31/50 , A61K31/495 , A61K31/22 , A61K31/355
CPC classification number: A61K31/525 , A23L33/15 , A23V2002/00 , A61K31/00 , A61K31/22 , A61K31/355 , A61K2300/00 , A23V2250/704 , A23V2250/712 , A23V2250/0612
Abstract: Nutriceutical and pharmaceutical formulations for treating neurodegenerative disorders such as Alzheimer's disease are provided. Nutriceutical formulations include two or more of folate, vitamin E, and acetyl-L-carnitine (ALCAR). Pharmaceutical formulations include two or more of 3-deaza-adenosine (DZA), N-acetyl-L-cysteine (NAC), and S-adenosylmethionine (SAM).
Abstract translation: 提供了用于治疗神经变性疾病如阿尔茨海默病的营养制剂和药物制剂。 营养制剂包括叶酸，维生素E和乙酰基左旋肉碱（ALCAR）中的两种或更多种。 药物制剂包括3-脱氮腺苷（DZA），N-乙酰基-L-半胱氨酸（NAC）和S-腺苷甲硫氨酸（SAM）中的两种或更多种。
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公开(公告)号：US07763663B2
公开(公告)日：2010-07-27
申请号：US10324825
申请日：2002-12-19
Applicant: Stephen P. McCarthy , Balint Koroskenyi , Robert J. Nicolosi
Inventor： Stephen P. McCarthy , Balint Koroskenyi , Robert J. Nicolosi
IPC: A61K47/00
CPC classification number: A61K47/36 , A61K9/1075 , A61K9/5153 , A61K38/28 , A61K51/1244 , G01N33/5088 , Y10T428/2991 , Y10T436/144444
Abstract: The invention relates to new amphiphilic linear block copolymers of polysaccharides and polymers. The amphiphilic linear block copolymers do not form a true solution in water and are able to form micelles in selective solvents. Also disclosed are particles, each of which has a shell and a core, and a diameter of about 1 to 1,000 nanometers, and methods of delivering agents or removing substances, e.g., undesirable substances, from a subject or environment, by using these particles.
Abstract translation: 本发明涉及多糖和聚合物的新型两亲线性嵌段共聚物。 两亲性线性嵌段共聚物在水中不形成真正的溶液，并且能够在选择性溶剂中形成胶束。 还公开了通过使用这些颗粒，每个颗粒具有壳和芯，直径约为1-1000纳米，以及通过使用这些颗粒从受试者或环境中递送物质或除去物质，例如不需要的物质的方法。
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公开(公告)号：US20120252750A1
公开(公告)日：2012-10-04
申请号：US13437487
申请日：2012-04-02
Applicant: Thomas B. SHEA , Robert J. NICOLOSI , Eugene ROGERS
Inventor： Thomas B. SHEA , Robert J. NICOLOSI , Eugene ROGERS
IPC: A61K31/7076 , A61P25/16 , A61P25/28
CPC classification number: A61K31/525 , A23L33/15 , A23V2002/00 , A61K31/00 , A61K31/22 , A61K31/355 , A61K2300/00 , A23V2250/704 , A23V2250/712 , A23V2250/0612
Abstract: Nutriceutical and pharmaceutical formulations for treating neurodegenerative disorders such as Alzheimer's disease are provided. Nutriceutical formulations include two or more of folate, vitamin E, and acetyl-L-carnitine (ALCAR). Pharmaceutical formulations include two or more of 3-deaza-adenosine (DZA), N-acetyl-L-cysteine (NAC), and S-adenosylmethionine (SAM).
Abstract translation: 提供了用于治疗神经变性疾病如阿尔茨海默病的营养制剂和药物制剂。 营养制剂包括叶酸，维生素E和乙酰基左旋肉碱（ALCAR）中的两种或更多种。 药物制剂包括3-脱氮腺苷（DZA），N-乙酰基-L-半胱氨酸（NAC）和S-腺苷甲硫氨酸（SAM）中的两种或更多种。
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公开(公告)号：US20110206739A1
公开(公告)日：2011-08-25
申请号：US12935180
申请日：2009-03-30
Applicant: Robert J. Nicolosi , Fonghsu Kuo , SriKanth Kakumanu , Shawn Konecni , Carl W. Lawton
Inventor： Robert J. Nicolosi , Fonghsu Kuo , SriKanth Kakumanu , Shawn Konecni , Carl W. Lawton
IPC: A61K9/107 , A61K31/37 , A61K31/12 , A61K31/513 , A61K31/655 , A61K31/337 , A61K31/352 , A61K31/045 , A61K38/28 , A61P5/50 , A61P39/06 , A61P35/00
CPC classification number: A61K31/355 , A61K9/1075 , A61K31/337 , A61K38/28 , A61K47/14 , A61K47/46 , A61K49/0039 , A61K49/0078
Abstract: The disclosure relates to compositions and methods of forming nanoemulsions, e.g., containing an active component, in combination with lipophilic components such as oils, hydrophilic components such as water, and one or more surfactants capable of causing a temperature-dependent phase inversion, such as a nonionic polyethoxylated surfactant. Nanoemulsions containing the active component can be produced having average oil droplet sizes of less than 100 nm, 50 nm, or 25 nm without the need for high energy emulsion forming methods (such as microfluidization) by combining the surfactant and the oil in specified weight ratios (e.g., at least 3:1) prior to forming the nanoemulsion.
Abstract translation: 本公开涉及形成纳米乳剂的组合物和方法，例如含有活性组分，与亲脂性组分如油，亲水组分如水和一种或多种能导致温度依赖性相转化的表面活性剂组合，例如 非离子聚乙氧基化表面活性剂。 可以制备含有活性成分的纳米乳液，其具有小于100nm，50nm或25nm的平均油滴尺寸，而不需要通过以特定重量比组合表面活性剂和油的高能乳液形成方法（例如微流化） （例如，至少3:1），然后形成纳米乳液。
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公开(公告)号：US20100040883A1
公开(公告)日：2010-02-18
申请号：US10324825
申请日：2002-12-19
Applicant: Stephen P. McCarthy , Balint Koroskenyi , Robert J. Nicolosi
Inventor： Stephen P. McCarthy , Balint Koroskenyi , Robert J. Nicolosi
CPC classification number: A61K47/36 , A61K9/1075 , A61K9/5153 , A61K38/28 , A61K51/1244 , G01N33/5088 , Y10T428/2991 , Y10T436/144444
Abstract: The invention relates to new amphiphilic linear block copolymers of polysaccharides and polymers. The amphiphilic linear block copolymers do not form a true solution in water and are able to form micelles in selective solvents. Also disclosed are particles, each of which has a shell and a core, and a diameter of about 1 to 1,000 nanometers, and methods of delivering agents or removing substances, e.g., undesirable substances, from a subject or environment, by using these particles.
Abstract translation: 本发明涉及多糖和聚合物的新型两亲线性嵌段共聚物。 两亲性线性嵌段共聚物在水中不形成真正的溶液，并且能够在选择性溶剂中形成胶束。 还公开了通过使用这些颗粒，每个颗粒具有壳和芯，直径约为1-1000纳米，以及通过使用这些颗粒从受试者或环境中递送物质或除去物质，例如不需要的物质的方法。
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