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公开(公告)号：US07888291B2
公开(公告)日：2011-02-15
申请号：US10801509
申请日：2004-03-16
申请人： Riqiang Yan , Alfredo G. Tomasselli , Mark E. Gurney , Thomas L. Emmons , Michael Jerome Bienkowski , Robert L. Heinrikson
发明人： Riqiang Yan , Alfredo G. Tomasselli , Mark E. Gurney , Thomas L. Emmons , Michael Jerome Bienkowski , Robert L. Heinrikson
IPC分类号： C40B40/00
CPC分类号： C07K14/4711 , C07K5/1013 , C07K7/06 , C07K7/08 , C07K14/4702 , C12Q1/37 , G01N2333/96425 , G01N2500/02
摘要： The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a β-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
摘要翻译： 本发明涉及用于Hu-Asp的新型底物。 更具体地，本发明提供了包含分泌酶切割位点的肽底物和融合多肽底物。 公开了制备和使用肽的方法和组合物。
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公开(公告)号：US07812123B2
公开(公告)日：2010-10-12
申请号：US10940867
申请日：2004-09-14
申请人： Mark E. Gurney , Michael Jerome Bienkowski , Robert Leroy Heinrikson , Luis A. Parodi , Riqiang Yan
发明人： Mark E. Gurney , Michael Jerome Bienkowski , Robert Leroy Heinrikson , Luis A. Parodi , Riqiang Yan
IPC分类号： C07K14/435
CPC分类号： C12N9/6478 , C07K14/4711 , C07K2319/00 , C12N2799/026 , C12Q1/37 , G01N2333/96472
摘要： The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays.
摘要翻译： 本发明提供了用于切割该酶的酶和酶程序。 APP蛋白的分泌酶切割位点和相关核酸，肽，载体，细胞和细胞分离物和测定。
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公开(公告)号：US20080090260A1
公开(公告)日：2008-04-17
申请号：US11753331
申请日：2007-05-24
申请人： Riqiang Yan , Alfredo Tomasselli , Mark Gurney , Thomas Emmons , Michael Bienkowski , Robert Heinrikson
发明人： Riqiang Yan , Alfredo Tomasselli , Mark Gurney , Thomas Emmons , Michael Bienkowski , Robert Heinrikson
CPC分类号： C07K14/4711 , C07K5/1013 , C07K7/06 , C07K7/08 , C07K14/4702 , C12Q1/37 , G01N2333/96425 , G01N2500/02
摘要： The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a β-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
摘要翻译： 本发明涉及用于Hu-Asp的新型底物。 更具体地，本发明提供了包含β-分泌酶切割位点的肽底物和融合多肽底物。 公开了制备和使用肽的方法和组合物。
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公开(公告)号：US06797487B2
公开(公告)日：2004-09-28
申请号：US09548366
申请日：2000-04-12
IPC分类号： C12P2106
CPC分类号： C12N9/6478 , C07K14/4711 , C07K2319/00 , C12N2799/026 , C12Q1/37 , G01N2333/96472
摘要： The present invention provides methods of reducing cellular production of amyloid beta (A&bgr;) from amyloid precursor protein (APP) by reducing Asp2 transcription or translation in cells.
摘要翻译： 本发明提供了通过降低细胞中的Asp2转录或翻译来从淀粉样蛋白前体蛋白（APP）减少淀粉样蛋白β（Abeta）的细胞产生的方法。
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5.发明授权公开(公告)号：US06867018B1
公开(公告)日：2005-03-15
申请号：US09548365
申请日：2000-04-12
IPC分类号： C07K14/47 , C12N1/21 , C12N5/02 , C12N5/08 , C12N9/64 , C12N15/12 , C12N15/57 , C12Q1/37 , C12P21/06 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C12N9/6478 , C07K14/4711 , C07K2319/00 , C12N2799/026 , C12Q1/37 , G01N2333/96472
摘要： The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
摘要翻译： 本发明提供用于切割APP蛋白和相关核酸，肽，载体，细胞和细胞分离物和测定的β分泌酶切割位点的酶和酶程序。 本发明还提供了修饰的APP蛋白和相关核酸，肽，载体，细胞和细胞分离物以及特别可用于鉴定用于治疗或预防阿尔茨海默病的候选治疗剂的测定。
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公开(公告)号：US20050026256A1
公开(公告)日：2005-02-03
申请号：US10940867
申请日：2004-09-14
申请人： Mark Gurney , Michael Bienkowski , Robert Heinrikson , Luis Parodi , Riqiang Yan
发明人： Mark Gurney , Michael Bienkowski , Robert Heinrikson , Luis Parodi , Riqiang Yan
IPC分类号： G01N33/50 , A61K38/48 , A61K45/00 , A61P25/28 , C07K20060101 , C07K5/00 , C07K14/00 , C07K14/435 , C07K14/47 , C07K16/18 , C07K19/00 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/06 , C12N5/10 , C12N5/16 , C12N9/50 , C12N9/64 , C12N9/82 , C12N15/09 , C12N15/12 , C12N15/57 , C12N15/62 , C12N15/63 , C12N15/79 , C12N15/85 , C12N15/86 , C12P21/00 , C12P21/02 , C12P21/08 , C12Q20060101 , C12Q1/37 , C12R1/19 , G01N20060101 , G01N33/15 , G01N33/68 , C12Q1/68 , C07H21/04 , C07K14/705
CPC分类号： C12N9/6478 , C07K14/4711 , C07K2319/00 , C12N2799/026 , C12Q1/37 , G01N2333/96472
摘要： The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays.
摘要翻译： 本发明提供用于切割APP蛋白和相关核酸，肽，载体，细胞和细胞分离物和测定的β分泌酶切割位点的酶和酶程序。
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公开(公告)号：US06727074B2
公开(公告)日：2004-04-27
申请号：US09794927
申请日：2001-02-27
IPC分类号： C12Q137
CPC分类号： C12N9/6478 , C07K14/4711 , C07K2319/00 , C12N2799/026 , C12Q1/37 , G01N2333/96472
摘要： The present invention provides the enzyme and enzymatic procedures for cleaving the &bgr; secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
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公开(公告)号：US06699671B1
公开(公告)日：2004-03-02
申请号：US09416901
申请日：1999-10-13
IPC分类号： G01N3353
CPC分类号： C12N9/6478 , C07K14/4711 , C07K2319/00 , C12N2799/026 , C12Q1/37 , G01N2333/96472
摘要： The present invention provides the enzyme and enzymatic procedures for cleaving the &bgr; secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
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公开(公告)号：US06500667B1
公开(公告)日：2002-12-31
申请号：US09551853
申请日：2000-04-18
IPC分类号： C12N500
CPC分类号： C12N9/6478 , C07K14/4711 , C07K2319/00 , C12N2799/026 , C12Q1/37 , G01N2333/96472
摘要： The present invention provides the enzyme and enzymatic procedures for cleaving the &bgr; secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
摘要翻译： 本发明提供用于切割APP蛋白和相关核酸，肽，载体，细胞和细胞分离物和测定的β分泌酶切割位点的酶和酶程序。 本发明还提供了修饰的APP蛋白和相关核酸，肽，载体，细胞和细胞分离物以及特别可用于鉴定用于治疗或预防阿尔茨海默病的候选治疗剂的测定。
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公开(公告)号：US20080299596A1
公开(公告)日：2008-12-04
申请号：US11713091
申请日：2007-03-01
申请人： Riqiang Yan , Alfredo G. Tomasselli , Mark E. Gurney , Thomas L. Emmons , Michael Jerome Bienkowski , Robert L. Heinrikson
发明人： Riqiang Yan , Alfredo G. Tomasselli , Mark E. Gurney , Thomas L. Emmons , Michael Jerome Bienkowski , Robert L. Heinrikson
CPC分类号： C07K14/4711 , C07K5/1013 , C07K7/06 , C07K7/08 , C07K14/4702 , C12Q1/37 , G01N2333/96425 , G01N2500/02
摘要： The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a β-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
摘要翻译： 本发明涉及用于Hu-Asp的新型底物。 更具体地，本发明提供了包含β-分泌酶切割位点的肽底物和融合多肽底物。 公开了制备和使用肽的方法和组合物。
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