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1.发明授权公开(公告)号：US08895007B2
公开(公告)日：2014-11-25
申请号：US13313541
申请日：2011-12-07
申请人： Urs Beat Hagemann , Remko Albert Griep , Herald Reiersen , Sergej Michailovi{hacek over (c)} Kiprijanov
发明人： Urs Beat Hagemann , Remko Albert Griep , Herald Reiersen , Sergej Michailovi{hacek over (c)} Kiprijanov
IPC分类号： C07K16/28 , C07K5/10 , A61K39/395 , A61K39/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/41 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/76 , G01N2333/7158
摘要： The present invention provides antibodies which bind to an epitope in the extracellular domain of human CC chemokine receptor 4 (CCR4) and which are capable of inhibiting the binding of macrophage-derived chemokine (MDC) and/or thymus and activation regulated chemokine (TARC) to CCR4. Also provided are inter alia immunoconjugates and compositions comprising such antibodies and methods and uses involving such antibodies, particularly in the medical and diagnostic fields.
摘要翻译： 本发明提供与人CC趋化因子受体4（CCR4）的细胞外结构域中的表位结合并且能够抑制巨噬细胞来源的趋化因子（MDC）和/或胸腺和活化调节的趋化因子（TARC）的结合的抗体， 到CCR4。 还提供了免疫缀合物和包含此类抗体的组合物，以及涉及此类抗体的方法和用途，特别是在医学和诊断领域。
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公开(公告)号：US08361747B2
公开(公告)日：2013-01-29
申请号：US13358813
申请日：2012-01-26
申请人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
发明人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
CPC分类号： C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
摘要： The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：US08268314B2
公开(公告)日：2012-09-18
申请号：US12572289
申请日：2009-10-02
申请人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
发明人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人VEGF和针对人ANG-2的双特异性抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20120321627A1
公开(公告)日：2012-12-20
申请号：US13570333
申请日：2012-08-09
申请人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
发明人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
IPC分类号： A61K39/395 , A61P9/00 , A61P35/00
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人VEGF和针对人ANG-2的双特异性抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20120164161A1
公开(公告)日：2012-06-28
申请号：US13313541
申请日：2011-12-07
IPC分类号： A61K39/395 , C12N15/13 , C12N15/63 , C12N7/01 , C12N1/19 , C12N1/21 , C12N1/15 , C12N5/10 , C12P21/02 , G01N33/566 , C40B30/04 , G01N33/574 , G01N33/569 , A61P37/08 , A61P11/00 , A61P1/00 , A61P1/04 , A61P15/02 , A61P17/06 , A61P17/00 , A61P17/04 , A61P11/06 , A61P9/00 , A61P29/00 , A61P11/02 , A61P37/06 , A61P19/02 , A61P25/00 , A61P3/10 , A61P13/12 , A61P9/10 , A61P25/28 , A61P21/00 , A61P1/16 , A61P27/14 , A61P19/06 , A61P35/00 , A61P35/02 , A61P31/18 , A61P31/12 , A61P31/22 , C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/41 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/76 , G01N2333/7158
摘要： The present invention provides antibodies which bind to an epitope in the extracellular domain of human CC chemokine receptor 4 (CCR4) and which are capable of inhibiting the binding of macrophage-derived chemokine (MDC) and/or thymus and activation regulated chemokine (TARC) to CCR4. Also provided are inter alia immunoconjugates and compositions comprising such antibodies and methods and uses involving such antibodies, particularly in the medical and diagnostic fields.
摘要翻译： 本发明提供与人CC趋化因子受体4（CCR4）的细胞外结构域中的表位结合并且能够抑制巨噬细胞来源的趋化因子（MDC）和/或胸腺和活化调节的趋化因子（TARC）的结合的抗体， 到CCR4。 还提供了免疫缀合物和包含此类抗体的组合物，以及涉及此类抗体的方法和用途，特别是在医学和诊断领域。
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公开(公告)号：US08133979B2
公开(公告)日：2012-03-13
申请号：US12635825
申请日：2009-12-11
申请人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
发明人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
CPC分类号： C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
摘要： The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及抗人血管生成素2（抗ANG-2抗体）的抗体，其生产方法，含有所述抗体的药物组合物及其应用。
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公开(公告)号：US20100111967A1
公开(公告)日：2010-05-06
申请号：US12572289
申请日：2009-10-02
申请人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
发明人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
IPC分类号： C07K16/22 , A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人VEGF和针对人ANG-2的双特异性抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US08637017B2
公开(公告)日：2014-01-28
申请号：US12797052
申请日：2010-06-09
申请人： Lavinia Diana Cicortas Gunnarsson , Didrik Paus , Jenny Margareta Karlsson , Remko Albert Griep , Sergej Michailovic Kiprijanov
发明人： Lavinia Diana Cicortas Gunnarsson , Didrik Paus , Jenny Margareta Karlsson , Remko Albert Griep , Sergej Michailovic Kiprijanov
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： Disclosed are antibodies that bind to Epithelial Cell Adhesion Molecule (EpCAM) and display certain advantages over known antibodies which bind to EpCAM, for example, the antibodies of the invention show good affinity, good cross-reactivity profiles and excellent ADCC and CDCC activity. Antibodies comprising specific heavy and light chain CDRs are disclosed. The invention thus relates to these antibodies and all uses thereof, in particular in the treatment of cancer. The present invention thus provides new antibody-based compositions, methods and combined protocols for treating cancer. Advantageous immunoconjugate compositions and methods using the new anti-EpCAM antibodies are also provided.
摘要翻译： 公开了结合上皮细胞粘附分子（EpCAM）的抗体并且与已知的结合EpCAM的抗体相比显示某些优点，例如，本发明的抗体显示出良好的亲和力，良好的交叉反应性谱和优异的ADCC和CDCC活性。 公开了包含特定重链和轻链CDR的抗体。 因此，本发明涉及这些抗体及其所有用途，特别是癌症的治疗。 因此，本发明提供了新的基于抗体的组合物，用于治疗癌症的方法和组合方案。 还提供了有利的免疫偶联物组合物和使用新的抗EpCAM抗体的方法。
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公开(公告)号：US20120142091A1
公开(公告)日：2012-06-07
申请号：US13358813
申请日：2012-01-26
申请人： ULRICH BRINKMANN , REMKO ALBERT GRIEP , KLAUS KALUZA , ANITA KAVLIE , CHRISTIAN KLEIN , JOERG THOMAS REGULA , WERNER SCHEUER
发明人： ULRICH BRINKMANN , REMKO ALBERT GRIEP , KLAUS KALUZA , ANITA KAVLIE , CHRISTIAN KLEIN , JOERG THOMAS REGULA , WERNER SCHEUER
CPC分类号： C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
摘要： The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：US20100159587A1
公开(公告)日：2010-06-24
申请号：US12635825
申请日：2009-12-11
申请人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
发明人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
CPC分类号： C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
摘要： The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及抗人血管生成素2（抗ANG-2抗体）的抗体，其生产方法，含有所述抗体的药物组合物及其应用。
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