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公开(公告)号：US20120321627A1
公开(公告)日：2012-12-20
申请号：US13570333
申请日：2012-08-09
申请人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
发明人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
IPC分类号： A61K39/395 , A61P9/00 , A61P35/00
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人VEGF和针对人ANG-2的双特异性抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US08133979B2
公开(公告)日：2012-03-13
申请号：US12635825
申请日：2009-12-11
申请人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
发明人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
CPC分类号： C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
摘要： The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及抗人血管生成素2（抗ANG-2抗体）的抗体，其生产方法，含有所述抗体的药物组合物及其应用。
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公开(公告)号：US20100111967A1
公开(公告)日：2010-05-06
申请号：US12572289
申请日：2009-10-02
申请人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
发明人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
IPC分类号： C07K16/22 , A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人VEGF和针对人ANG-2的双特异性抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US09109027B2
公开(公告)日：2015-08-18
申请号：US13548244
申请日：2012-07-13
申请人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
发明人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
IPC分类号： A61K39/395 , C07K16/22 , A61K39/00 , C12N15/85
CPC分类号： C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
摘要： The present invention relates to a method of treating a disease or disorder in a patient comprising administering, to a patient in need of such treatment, an antibody which binds specifically to human angiopoietin-2 (ANG-2). The present invention also relates to a method for preventing metastasis in a patient suffering from primary cancer comprising administering, to a patient in need of such preventative treatment, an antibody which binds specifically to human angiopoietin-2 (ANG-2).
摘要翻译： 本发明涉及一种治疗患者疾病或病症的方法，包括向需要这种治疗的患者施用特异性结合人血管生成素-2（ANG-2）的抗体。 本发明还涉及一种用于预防患有原发性癌症的患者转移的方法，包括向需要这种预防性治疗的患者施用特异性结合人血管生成素-2（ANG-2）的抗体。
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公开(公告)号：US08703130B2
公开(公告)日：2014-04-22
申请号：US13570333
申请日：2012-08-09
申请人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
发明人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人VEGF和针对人ANG-2的双特异性抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20120141500A1
公开(公告)日：2012-06-07
申请号：US13358831
申请日：2012-01-26
申请人： ULRICH BRINKMANN , REMKO ALBERT GRIEP , KLAUS KALUZA , ANITA KAVLIE , CHRISTIAN KLEIN , JOERG THOMAS REGULA , WERNER SCHEUER
发明人： ULRICH BRINKMANN , REMKO ALBERT GRIEP , KLAUS KALUZA , ANITA KAVLIE , CHRISTIAN KLEIN , JOERG THOMAS REGULA , WERNER SCHEUER
CPC分类号： C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
摘要： The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及抗人血管生成素2（抗ANG-2抗体）的抗体，其生产方法，含有所述抗体的药物组合物及其应用。
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公开(公告)号：US08034905B2
公开(公告)日：2011-10-11
申请号：US12267515
申请日：2008-11-07
申请人： Anita Kavlie , Kyle Schlunegger
发明人： Anita Kavlie , Kyle Schlunegger
IPC分类号： C12P21/08
CPC分类号： A61K39/3955 , A61K45/06 , A61K47/6845 , A61K2039/505 , C07K16/22 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Disclosed are human antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two primary VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet have improved safety due to their specificity. The present invention thus provides new human antibody-based compositions, methods and combined protocols for treating cancer and other angiogenic diseases. Advantageous immunoconjugate compositions and methods using the new VEGF-specific human antibodies are also provided.
摘要翻译： 公开了特异性抑制VEGF仅与两种主要VEGF受体中的一种（VEGFR2）结合的人抗体。 抗体有效抑制血管生成并诱导肿瘤消退，但由于其特异性而具有改善的安全性。 因此，本发明提供了新的基于人抗体的组合物，用于治疗癌症和其它血管生成疾病的方法和组合方案。 还提供了有利的免疫缀合物组合物和使用新的VEGF特异性人抗体的方法。
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公开(公告)号：US08945552B2
公开(公告)日：2015-02-03
申请号：US13071127
申请日：2011-03-24
申请人： Monika Baehner , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas , Wolfgang Schaefer , Kay-Gunnar Stubenrauch , Markus Thomas
发明人： Monika Baehner , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas , Wolfgang Schaefer , Kay-Gunnar Stubenrauch , Markus Thomas
IPC分类号： A61K39/395 , C07K16/22 , A61K39/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/3015 , C07K16/3046 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/522 , C07K2317/56 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to bispecific, bivalent antibodies against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人血管内皮生长因子（VEGF / VEGF-A）和针对人血管生成素-2（ANG-2）的双特异性二价抗体，其生产方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20140065151A1
公开(公告)日：2014-03-06
申请号：US13548244
申请日：2012-07-13
申请人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
发明人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
摘要： The present invention relates to a method of treating a disease or disorder in a patient comprising administering, to a patient in need of such treatment, an antibody which binds specifically to human angiopoietin-2 (ANG-2). The present invention also relates to a method for preventing metastasis in a patient suffering from primary cancer comprising administering, to a patient in need of such preventative treatment, an antibody which binds specifically to human angiopoietin-2 (ANG-2).
摘要翻译： 本发明涉及治疗患者疾病或病症的方法，包括向需要这种治疗的患者施用特异性结合人血管生成素-2（ANG-2）的抗体。 本发明还涉及一种用于预防患有原发性癌症的患者转移的方法，包括向需要这种预防性治疗的患者施用特异性结合人血管生成素-2（ANG-2）的抗体。
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公开(公告)号：US08399626B2
公开(公告)日：2013-03-19
申请号：US13358831
申请日：2012-01-26
申请人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
发明人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
CPC分类号： C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
摘要： The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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