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公开(公告)号：US09169323B2
公开(公告)日：2015-10-27
申请号：US13582964
申请日：2011-03-03
Applicant: Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Thomas , Carola Ries , Stefan Seeber
Inventor： Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Thomas , Carola Ries , Stefan Seeber
CPC classification number: C07K16/2866 , A61K47/6849 , C07K16/28 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to antibodies against human CSF-1R (CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：US09109027B2
公开(公告)日：2015-08-18
申请号：US13548244
申请日：2012-07-13
Applicant: Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
Inventor： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
IPC: A61K39/395 , C07K16/22 , A61K39/00 , C12N15/85
CPC classification number: C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
Abstract: The present invention relates to a method of treating a disease or disorder in a patient comprising administering, to a patient in need of such treatment, an antibody which binds specifically to human angiopoietin-2 (ANG-2). The present invention also relates to a method for preventing metastasis in a patient suffering from primary cancer comprising administering, to a patient in need of such preventative treatment, an antibody which binds specifically to human angiopoietin-2 (ANG-2).
Abstract translation: 本发明涉及一种治疗患者疾病或病症的方法，包括向需要这种治疗的患者施用特异性结合人血管生成素-2（ANG-2）的抗体。 本发明还涉及一种用于预防患有原发性癌症的患者转移的方法，包括向需要这种预防性治疗的患者施用特异性结合人血管生成素-2（ANG-2）的抗体。
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公开(公告)号：US08999327B2
公开(公告)日：2015-04-07
申请号：US12962445
申请日：2010-12-07
Applicant: Nikolaos Dimoudis , Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Pickl , Carola Ries , Stefan Seeber , Kerstin Krueger
Inventor： Nikolaos Dimoudis , Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Pickl , Carola Ries , Stefan Seeber , Martin Lanzendoerfer
IPC: C07K16/28
CPC classification number: C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to antibodies against human CSF-1R (anti-CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
Abstract translation: 本发明涉及针对人CSF-1R（抗CSF-1R抗体）的抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US08900581B2
公开(公告)日：2014-12-02
申请号：US12962445
申请日：2010-12-07
Applicant: Nikolaos Dimoudis , Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Pickl , Carola Ries , Stefan Seeber , Kerstin Krueger
Inventor： Nikolaos Dimoudis , Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Pickl , Carola Ries , Stefan Seeber , Martin Lanzendoerfer
IPC: A61K39/395
Abstract: The present invention relates to antibodies against human CSF-1R (anti-CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：US08883975B2
公开(公告)日：2014-11-11
申请号：US13218293
申请日：2011-08-25
Applicant: Michael Brandt , Jens Fischer , Stefan Jenewein , Klaus Kaluza , Eileen Samy , Stefan Seeber
Inventor： Michael Brandt , Jens Fischer , Stefan Jenewein , Klaus Kaluza , Eileen Samy , Stefan Seeber
IPC: C07K16/00
CPC classification number: C07K16/2866 , C07K2317/24 , C07K2317/33 , C07K2317/76 , C07K2317/92
Abstract: The invention provides anti-IL-18R1 antibodies and methods of using the same.
Abstract translation: 本发明提供抗IL-18R1抗体及其使用方法。
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Patent Agency Ranking
公开(公告)号：US20120213774A1
公开(公告)日：2012-08-23
申请号：US13402399
申请日：2012-02-22
Applicant: Georg Fertig , Jens Fischer , Guy Georges , Klaus Kaluza , Valeria Lifke , Joerg Moelleken , Sonja Offner , Achal Pashine , Stefan Seeber
Inventor： Georg Fertig , Jens Fischer , Guy Georges , Klaus Kaluza , Valeria Lifke , Joerg Moelleken , Sonja Offner , Achal Pashine , Stefan Seeber
IPC: A61K39/395 , C12N15/13 , C12N15/63 , C12N5/10 , A61P11/06 , C12N1/21 , C12P21/00 , A61P19/02 , A61P1/04 , C07K16/24 , C12N1/19
CPC classification number: C07K16/2866 , A61K39/395 , A61K39/39558 , A61K2039/505 , C07K2317/24 , C07K2317/30 , C07K2317/76 , C07K2317/92
Abstract: An antibody binding to IL33R characterized in that the heavy chain variable domain comprises a CDR3 region of SEQ ID NO:1, a CDR2 region of SEQ ID NO:2 and a CDR1 region of SEQ ID NO:3 and in that the light chain variable domain comprises a CDR3 region of SEQ ID NO:4, a CDR2 region of SEQ ID NO:5 and a CDR1 region of SEQ ID NO:6 or a chimeric, humanized or T cell epitope depleted antibody variant thereof has advantageous properties for the treatment of inflammatory diseases.
Abstract translation: 结合IL33R的抗体，其特征在于重链可变结构域包含SEQ ID NO：1的CDR3区，SEQ ID NO：2的CDR2区和SEQ ID NO：3的CDR1区，并且其中轻链可变区 结构域包含SEQ ID NO：4的CDR3区，SEQ ID NO：5的CDR2区和SEQ ID NO：6的CDR1区或嵌合，人源化或T细胞表位缺失的抗体变体具有治疗的有利性质 的炎性疾病。
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公开(公告)号：US20120141500A1
公开(公告)日：2012-06-07
申请号：US13358831
申请日：2012-01-26
Applicant: ULRICH BRINKMANN , REMKO ALBERT GRIEP , KLAUS KALUZA , ANITA KAVLIE , CHRISTIAN KLEIN , JOERG THOMAS REGULA , WERNER SCHEUER
Inventor： ULRICH BRINKMANN , REMKO ALBERT GRIEP , KLAUS KALUZA , ANITA KAVLIE , CHRISTIAN KLEIN , JOERG THOMAS REGULA , WERNER SCHEUER
CPC classification number: C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
Abstract: The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
Abstract translation: 本发明涉及抗人血管生成素2（抗ANG-2抗体）的抗体，其生产方法，含有所述抗体的药物组合物及其应用。
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8.发明申请Heterocyclic Carbamate Derivatives, Their Manufacture And Use As Pharmaceutical Agents 失效杂环氨基甲酸酯衍生物，其制造和用作药剂公开(公告)号：US20080009492A1
公开(公告)日：2008-01-10
申请号：US11793750
申请日：2005-12-22
Applicant: Konrad Honold , Klaus Kaluza , Birgit Masjost , Wolfgang Schaefer , Stefan Scheiblich
Inventor： Konrad Honold , Klaus Kaluza , Birgit Masjost , Wolfgang Schaefer , Stefan Scheiblich
IPC: A61K31/437 , A61K31/496 , A61K31/5377 , A61P35/00 , C07D403/00 , C07D413/14 , C07D471/04
CPC classification number: C07D471/04
Abstract: Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
Abstract translation: 本发明的目的是式I化合物，其药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述化合物 控制或预防癌症等疾病。
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9.发明授权Thermolabile uracil-DNA-glycosylas, process for its preparation and use for removing uracil from DNA 有权Thermolabile尿嘧啶-DNA-糖基，其制备方法和用于从DNA中去除尿嘧啶公开(公告)号：US06187575B1
公开(公告)日：2001-02-13
申请号：US09077312
申请日：1998-08-06
Applicant: Harald Sobek , Manfred Schmidt , Bruno Frey , Klaus Kaluza
Inventor： Harald Sobek , Manfred Schmidt , Bruno Frey , Klaus Kaluza
IPC: C12N914
CPC classification number: C12Q1/6848 , C12N9/2497 , C12Q2521/531
Abstract: Thermolabile enzyme with uracil-DNA-glycosylase activity which is in particular characterized by a high degree of purity, short half-lives and a content of contaminating foreign activities of less than 2%, a process for its isolation as well as the use thereof to remove the base uracil from DNA and in particular from PCR products containing uracil. The enzyme is obtainable from gram-positive microorganisms such as e.g. Arthrobacter or Micrococcus.
Abstract translation: 具有尿嘧啶-DNA-糖基化酶活性的耐热不溶性酶，其特征在于其纯度高，半衰期短，外来污染物含量小于2％，其分离方法及其用途 从DNA中去除碱基尿嘧啶，特别是从含有尿嘧啶的PCR产物中除去。 该酶可从革兰氏阳性微生物获得，例如， 节杆菌属或微球菌属。
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公开(公告)号：US5153122A
公开(公告)日：1992-10-06
申请号：US573175
申请日：1990-07-25
Applicant: Klaus Kaluza , Gudrun Schmitz , Michael Jarsch , Christoph Kessler
Inventor： Klaus Kaluza , Gudrun Schmitz , Michael Jarsch , Christoph Kessler
CPC classification number: C12N9/22 , Y10S435/822
Abstract: New type II restriction endonuclease MamI has recognition sequence: ##STR1## and a cleavage site indicated by the arrows. It is preferably obtained from microorganisms of the genus Microbacterium.
Abstract translation: PCT No.PCT / EP89 / 01460 Sec。 371日期1990年7月25日第 102（e）日期1990年7月25日PCT提交1989年11月25日PCT公布。 出版物WO90 / 06361 日期：1990年6月14日。新型II限制性内切核酸酶MamI具有识别序列：
和箭头指示的切割位点。 优选从微杆菌属的微生物获得。
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