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    Antioxidant, antiphospholipase derivatives of ricinoleic acid
    1.
    发明授权
    Antioxidant, antiphospholipase derivatives of ricinoleic acid 失效
    蓖麻油酸的抗氧化剂，抗磷脂酶衍生物

    公开(公告)号：US5659049A

    公开(公告)日：1997-08-19

    申请号：US467690

    申请日：1995-06-06

    Applicant: Richard C. Franson ,  Raphael M. Ottenbrite

    Inventor： Richard C. Franson ,  Raphael M. Ottenbrite

    IPC: C07C69/732 ,  C11C3/00 ,  C07D207/00 ,  C07D295/00

    CPC classification number: C07C69/732 ,  C11C3/00

    Abstract: Water or lipid soluble, pharmacologically active, antioxidant, anti-phospholipase compounds that are chemically defined. The compounds protect mammalian cells by inhibiting PLA.sub.2 and preventing oxidation. In particular, each compound has at least two fatty moieties and no active hydroxy group. The compound may also have at least one ionizable group, which may a carboxyl group, and each of the fatty moieties has from sixteen to twenty carbon atoms and at least one cis-unsaturated double bond.

    Abstract translation: 化学定义的水或脂溶性，药理活性，抗氧化剂，抗磷脂酶化合物。 该化合物通过抑制PLA2并防止氧化来保护哺乳动物细胞。 特别地，每种化合物具有至少两个脂肪部分并且不具有活性羟基。 化合物还可以具有至少一个可以是羧基的可离子化基团，并且每个脂肪部分具有16至20个碳原子和至少一个顺式 - 不饱和双键。

    Cytoprotective fatty moiety compounds
    3.
    发明授权
    Cytoprotective fatty moiety compounds 失效
    细胞保护性脂肪部分化合物

    公开(公告)号：US6020489A

    公开(公告)日：2000-02-01

    申请号：US819313

    申请日：1997-03-18

    Applicant: Richard C. Franson ,  Raphael M. Ottenbrite

    Inventor： Richard C. Franson ,  Raphael M. Ottenbrite

    IPC: C07C69/732 ,  C11C3/00 ,  C07D265/32

    CPC classification number: C07C69/732 ,  C11C3/00

    Abstract: Water or lipid soluble, pharmacologically active, antioxidant, anti-phospholipase compounds that are chemically defined. The compounds protect mammalian cells by inhibiting PLA.sub.2 and preventing oxidation. In particular, each compound has at least two fatty moieties and no active hydroxy group. The compound may also have at least one ionizable group, which may be a carboxyl group, and each of the fatty moieties has from sixteen to twenty carbon atoms and at least one cis-unsaturated double bond.

    Abstract translation: 化学定义的水或脂溶性，药理活性，抗氧化剂，抗磷脂酶化合物。 该化合物通过抑制PLA2并防止氧化来保护哺乳动物细胞。 特别地，每种化合物具有至少两个脂肪部分并且不具有活性羟基。 化合物还可以具有至少一个可离子化基团，其可以是羧基，并且每个脂肪部分具有16至20个碳原子和至少一个顺式 - 不饱和双键。

    Cytoprotective compounds
    5.
    发明授权
    Cytoprotective compounds 有权

    公开(公告)号：US06423855B1

    公开(公告)日：2002-07-23

    申请号：US09481824

    申请日：2000-01-12

    Applicant: Richard C. Franson ,  Raphael M. Ottenbrite

    Inventor： Richard C. Franson ,  Raphael M. Ottenbrite

    IPC: C07C23300

    Abstract: The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly, the present invention provides compositions and methods for treating or prophylactically inhibiting phospholipase mediated injury, injury due to oxidation, and inflammation. In a very specific sense, this invention provides compositions and methods of making these compositions that are inhibitors of phospholipase.

    Bis[4-(3,4-dimethylene-pyrrolidyl)phenyl] methane
    6.
    发明授权
    Bis[4-(3,4-dimethylene-pyrrolidyl)phenyl] methane 失效
    双[4-（3,4-二甲基 - 吡咯烷基）苯基]甲烷

    公开(公告)号：US4895915A

    公开(公告)日：1990-01-23

    申请号：US311551

    申请日：1989-02-16

    Applicant: Raphael M. Ottenbrite

    Inventor： Raphael M. Ottenbrite

    IPC: C07D207/32 ,  C07D207/325 ,  C08G73/12

    CPC classification number: C07D207/325 ,  C08G73/12

    Abstract: A polyimide composition consisting essentially of recurring units having the following structural formula: ##STR1## is produced by the copolymerization of a bismaleimide and bis[4-(3,4-dimethylenepyrrolidyl)phenyl] methane.

    Abstract translation: 主要由具有以下结构式的重复单元组成的聚酰亚胺组合物：通过双马来酰亚胺和双[4-（3,4-二甲基甲酰吡咯烷基）苯基]甲烷的共聚合产生。

    Bis[4-(3,4-dimethylenepyrrolidyl)phenyl]methane
    7.
    发明授权
    Bis[4-(3,4-dimethylenepyrrolidyl)phenyl]methane 失效
    双[4-（3,4-二甲基甲酰吡咯烷基）苯基]甲烷

    公开(公告)号：US4851544A

    公开(公告)日：1989-07-25

    申请号：US221386

    申请日：1988-07-19

    Applicant: Raphael M. Ottenbrite

    Inventor： Raphael M. Ottenbrite

    IPC: C07D207/32 ,  C07D207/325 ,  C08G73/12

    CPC classification number: C07D207/325 ,  C08G73/12

    Abstract: A polyimide composition consisting essentially of recurring units having the following structural formula: ##STR1## is produced by the copolymerization of a bismaleimide and bis[4-(3,4-dimethylenepyrrolidyl)phenyl]methane.

    Abstract translation: 主要由具有以下结构式的重复单元组成的聚酰亚胺组合物：通过双马来酰亚胺和双[4-（3,4-二甲基甲酰吡咯烷基）苯基]甲烷的共聚合产生。

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