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    ANALYTE SENSOR
    2.
    发明申请
    ANALYTE SENSOR 有权

    公开(公告)号：US20220304599A1

    公开(公告)日：2022-09-29

    申请号：US17638405

    申请日：2020-08-31

    申请人： Bradley LIANG ,  Rajiv SHAH ,  PERCUSENSE, INC.

    发明人： Bradley LIANG ,  Rajiv SHAH

    IPC分类号： A61B5/1486 ,  G01N27/327 ,  C12Q1/00 ,  C12Q1/32

    摘要： In one embodiment, a working electrode measuring the presence of a first analyte is disclosed. The working electrode includes a working conductor that has a first electrode reactive surface. The working electrode further includes a first transport material that enables flux of the first analyte to the first reactive chemistry. Additionally, a first reactive chemistry that is responsive to the first analyte is included in the working electrode. The first reactive chemistry includes a mediator, an enzyme and a cofactor. Wherein the first reactive chemistry is located between the working conductor and the first transport material.

    Fabrication of multi-sensor arrays
    7.
    发明授权
    Fabrication of multi-sensor arrays 有权
    多传感器阵列的制作

    公开(公告)号：US08414489B2

    公开(公告)日：2013-04-09

    申请号：US11034371

    申请日：2005-01-12

    申请人： Rajiv Shah ,  Shaun M. Pendo ,  Rebecca K. Gottlieb ,  Gil Bruso ,  Gopikrishnan Soundararajan ,  Katherine T. Wolfe

    发明人： Rajiv Shah ,  Shaun M. Pendo ,  Rebecca K. Gottlieb ,  Gil Bruso ,  Gopikrishnan Soundararajan ,  Katherine T. Wolfe

    IPC分类号： A61B5/00 ,  A61B5/05

    CPC分类号： A61B5/14532 ,  A61B5/0031 ,  A61B5/14865 ,  A61B5/412 ,  C12Q1/006

    摘要： The disclosure provides methods for fabricating a long-term analyte sensor for measuring at least one analyte in the body of a user. The analyte sensors made by these methods include a plurality of analyte contacting sensor elements and at least one structure for relaying information to and from the sensor. The analyte sensor so fabricated further includes at least one sensor protection membrane that is controllable in a manner such that sensor elements may be activated (e.g. exposed to the external environment) at different times so as to extend the useful life of the sensor. In illustrative analyte sensors, the analyte is glucose.

    摘要翻译： 本公开提供了制造用于测量使用者身体中的至少一种分析物的长期分析物传感器的方法。 通过这些方法制造的分析物传感器包括多个分析物接触传感器元件和用于将信息传递到传感器和从传感器传递信息的至少一个结构。 如此制造的分析物传感器还包括至少一个传感器保护膜，该传感器保护膜可以以不同时间使得传感器元件被激活（例如暴露于外部环境）的方式被控制，以延长传感器的使用寿命。 在说明性的分析物传感器中，分析物是葡萄糖。

    Implantable sensor method and system
    9.
    发明授权
    Implantable sensor method and system 有权
    植入式传感器方法和系统

    公开(公告)号：US08292808B2

    公开(公告)日：2012-10-23

    申请号：US12211783

    申请日：2008-09-16

    申请人： Michael E. Miller ,  Rajiv Shah

    发明人： Michael E. Miller ,  Rajiv Shah

    IPC分类号： A61B5/00 ,  A61B5/05 ,  A61M31/00

    CPC分类号： A61B5/6847 ,  A61B5/0031 ,  A61B5/04 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14552 ,  A61B5/14865 ,  A61B5/6882 ,  A61B17/3468 ,  A61M1/1698 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2230/20 ,  A61M2230/201 ,  G06F19/00

    摘要： Systems and methods for non-vascular sensor implantation and for measuring physiological parameters in areas of a body where the physiological parameters are heterogeneous. An implant unit is implanted in an area of a body and a foreign body capsule is allowed to form around the implant unit area. A sensor may be directed into a body cavity such as, for example, the peritoneal space, subcutaneous tissues, the foreign body capsule, or other area. A subcutaneous area of the body may be tunneled for sensor placement. Spatially separated sensing elements may be used for detecting individual amounts of the physiological parameter. An overall amount of the physiological parameter may be determined by calculating a statistical measurement of the individual sensed amounts in the area. Another embodiment of the invention, a multi-analyte measuring device, may include a substrate having an electrode array on one side and an integrated circuit on another side.

    摘要翻译： 用于非血管传感器植入和用于测量生理参数异质的身体的生理参数的系统和方法。 植入单元植入身体的一个区域，允许在植入单元区域周围形成异物胶囊。 传感器可以被引导到诸如腹膜空间，皮下组织，异物胶囊或其他区域的体腔中。 身体的皮下区域可以被隧道用于传感器放置。 空间分离的感测元件可用于检测生理参数的各个量。 生理参数的总量可以通过计算该区域中各个感测量的统计测量来确定。 本发明的多分析物测量装置的另一实施例可以包括在一侧具有电极阵列的基板和在另一侧的集成电路。

    Real-time self-calibrating sensor system and method
    10.
    发明授权
    Real-time self-calibrating sensor system and method 有权
    实时自校准传感器系统及方法

    公开(公告)号：US08249683B2

    公开(公告)日：2012-08-21

    申请号：US12826497

    申请日：2010-06-29

    申请人： Lu Wang ,  Rajiv Shah ,  Wayne A. Morgan ,  Barry Keenan

    发明人： Lu Wang ,  Rajiv Shah ,  Wayne A. Morgan ,  Barry Keenan

    IPC分类号： A61B5/05 ,  A61B5/00

    CPC分类号： A61B5/1495 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/14865 ,  A61B2560/0223 ,  A61M2005/1726

    摘要： A system and method for calibrating a sensor of a characteristic monitoring system in real time utilizes a self-calibration module for periodic determination of, and compensation for, the IR drop across unwanted resistances in a cell. A current-interrupt switch is used to open the self-calibration module circuit and either measure the IR drop using a high-frequency (MHz) ADC module, or estimate it through linear regression of acquired samples of the voltage across the sensor's working and reference electrodes (Vmeasured) over time. The IR drop is then subtracted from the closed-circuit value of Vmeasured to calculate the overpotential that exists in the cell (Vimportant). Vimportant may be further optimized by subtracting the value of the open-circuit voltage (Voc) across the sensor's working and reference electrodes. The values of Vmeasured and Vimportant are then controlled by respective first and second control units to compensate for the IR drop.

    摘要翻译： 用于校准特征监测系统的传感器的系统和方法实时地利用自校准模块来周期性地确定和补偿细胞中不需要的电阻的IR降。 使用电流中断开关来打开自校准模块电路，并使用高频（MHz）ADC模块测量IR降压，或通过传感器工作和参考电压的采集样本的线性回归进行估计 电极（Vmeasured）随着时间的推移。 然后从Vmeasured的闭路电流值中减去IR降，以计算存在于电池（Vimportant）中的超电势。 可以通过减去传感器的工作参考电极和参考电极之间的开路电压（Voc）的值来进一步优化V重量。 然后由相应的第一和第二控制单元控制V测量和V重量的值以补偿IR下降。