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1.发明申请Nitrogen-containing heterocycle derivatives, pharmaceutical compositions, and methods of use thereof as antiviral agents 审中-公开含氮杂环衍生物，药物组合物及其作为抗病毒剂的使用方法公开(公告)号：US20070219239A1
公开(公告)日：2007-09-20
申请号：US11704763
申请日：2007-02-09
申请人： Adnan Mjalli , Jeremy Cooper , Murty Arimilli , Robert Andrews , Robert Rothlein , Taleb AlTel
发明人： Adnan Mjalli , Jeremy Cooper , Murty Arimilli , Robert Andrews , Robert Rothlein , Taleb AlTel
IPC分类号： A61K31/4709 , A61K31/4439 , A61K31/4164 , C07D403/04
CPC分类号： C07D401/02 , A61K31/4164 , A61K31/4178 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K45/06 , C07D233/64 , C07D401/04 , C07D401/14 , Y02A50/463 , A61K2300/00
摘要： The present application provides nitrogen-containing heterocycle derivatives that are antiviral compounds that may be useful in the treatment of a viral infection. Compounds of Formula (I) and pharmaceutical compositions comprising a compound of Formula (I) may be administered to a subject for antiviral therapy or prophylaxis.
摘要翻译： 本申请提供了可用于治疗病毒感染的抗病毒化合物的含氮杂环衍生物。 可将式（I）化合物和包含式（I）化合物的药物组合物施用于受试者进行抗病毒治疗或预防。
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2.发明授权
公开(公告)号：US5730983A
公开(公告)日：1998-03-24
申请号：US224000
申请日：1994-05-19
IPC分类号： A61K38/00 , A61K38/17 , C07K14/705 , C07K16/28 , A61K39/395
CPC分类号： C07K16/2821 , C07K14/70525 , C07K14/70553 , C07K16/2845 , A61K38/00 , Y10S530/866 , Y10S530/868
摘要： The present invention relates to the use of intercellular adhesion molecule-1 (ICAM-1) or fragments thereof, anti-CD18 antibodies or fragments thereof, and members of the CD18 family of proteins or fragments thereof in the treatment of asthma.
摘要翻译： 本发明涉及细胞间粘附分子-1（ICAM-1）或其片段，抗CD18抗体或其片段以及蛋白质或其片段的CD18家族成员在哮喘治疗中的用途。
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3.发明授权
公开(公告)号：US5475091A
公开(公告)日：1995-12-12
申请号：US186457
申请日：1994-01-25
IPC分类号： A61K38/00 , A61K38/17 , A61K39/00 , C07K14/705 , C07K16/28 , C12N15/12 , G01N33/574
CPC分类号： A61K31/573 , A61K31/52 , A61K38/13 , C07K14/70525 , C07K16/2821 , C07K16/2845 , G01N33/5743 , A61K39/00 , C07K2317/34 , C07K2317/73 , Y10S530/808 , Y10S530/868
摘要： The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.
摘要翻译： 本发明涉及细胞间粘附分子（ICAM-1），其涉及淋巴细胞识别和迁移到炎症部位以及在炎症期间附着于细胞底物的过程。 本发明涉及这样的分子，筛选用于鉴定能够结合这些分子的分子和抗体的测定。 本发明还包括用于粘附分子和能够结合它们的抗体的用途。
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公开(公告)号：US5284931A
公开(公告)日：1994-02-08
申请号：US515478
申请日：1990-04-27
IPC分类号： A61K38/00 , A61K38/17 , A61K39/00 , C07K14/705 , C07K16/28 , C12N15/12 , G01N33/574 , A61K39/395
CPC分类号： A61K31/573 , A61K31/52 , A61K38/13 , C07K14/70525 , C07K16/2821 , C07K16/2845 , G01N33/5743 , A61K39/00 , C07K2317/34 , C07K2317/73 , Y10S530/808 , Y10S530/868
摘要： Pharmaceutical compositions comprising antibodies to intercellular adhesion molecule-1 (ICAM-1 or CD54) are useful in methods of decreasing the severity of inflammation associated with the adhesion of leukocytes to cells bearing ICAM-1. Treatment with anti-ICAM-1 antibodies reduced the severity of inflammation associated with acute organ or tissue rejection and prolonged allograft survival time. Such compositions may optionally contain other immunsuppressive agents.
摘要翻译： 包含细胞间粘附分子-1（ICAM-1或CD54）抗体的药物组合物可用于降低与白细胞与携带ICAM-1的细胞粘附相关的炎症严重程度的方法。 用抗ICAM-1抗体治疗降低了与急性器官或组织排斥相关的炎症严重程度和延长的同种异体移植物存活时间。 这样的组合物可以任选地含有其它免疫抑制剂。
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公开(公告)号：US5028630A
公开(公告)日：1991-07-02
申请号：US477785
申请日：1990-02-09
申请人： Robert Rothlein , Ronald Faanes , Genus Possanza
发明人： Robert Rothlein , Ronald Faanes , Genus Possanza
IPC分类号： A61K31/04 , A61K31/135
CPC分类号： A61K31/04 , A61K31/135
摘要： A method for treating inflammation in a patient which comprises administering to the patient a therapeutically effective amount of a compound of the formula: ##STR1## wherein A and R.sub.1 -R.sub.6 are defined herein.
摘要翻译： 一种治疗患者炎症的方法，其包括向患者施用治疗有效量的下式化合物：其中A和R 1 -R 6在本文中定义。
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公开(公告)号：US20110282035A1
公开(公告)日：2011-11-17
申请号：US13158748
申请日：2011-06-13
CPC分类号： C07K14/70503 , A61K38/00 , C07K2319/30 , C12N15/62
摘要： Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to the N-terminus of an immunoglobulin CH2 domain. Also disclosed are RAGE fusion protein formulations and the use of the RAGE fusion proteins and RAGE fusion protein formulations as therapeutics for RAGE-mediated pathologies.
摘要翻译： 公开了包含与第二非RAGE多肽连接的RAGE多肽序列的RAGE融合蛋白。 RAGE融合蛋白可以利用包含RAGE配体结合位点的RAGE多肽结构域和直接连接到免疫球蛋白CH2结构域的N末端的域间连接。 还公开了RAGE融合蛋白制剂以及使用RAGE融合蛋白和RAGE融合蛋白制剂作为RAGE介导的病理学的治疗剂。
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公开(公告)号：US20090060925A1
公开(公告)日：2009-03-05
申请号：US11630916
申请日：2005-08-03
申请人： Adnan M.M. Mjalli , Ye Edward Tian , Jeffrey C. Webster , Robert Rothlein , David M. Stern , Ann Marie Schmidt , Shi Du Yan
发明人： Adnan M.M. Mjalli , Ye Edward Tian , Jeffrey C. Webster , Robert Rothlein , David M. Stern , Ann Marie Schmidt , Shi Du Yan
IPC分类号： A61K39/395 , C07K14/00 , C07K16/00 , C12N15/63 , A61P3/10 , A61P25/28 , A61P29/00 , A61P13/12 , A61P35/00 , A61P9/00 , G01N33/53 , C07H21/00 , A61K38/16
CPC分类号： C07K16/2803 , A61K38/00 , C07K14/705 , C07K2319/30 , G01N33/6893 , G01N33/6896 , G01N2500/00 , G01N2800/042
摘要： Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.
摘要翻译： 公开了包含与第二非RAGE多肽连接的RAGE多肽序列的RAGE融合蛋白。 RAGE融合蛋白可以利用包含RAGE配体结合位点和直接连接到免疫球蛋白CH2结构域的域间连接体的RAGE多肽结构域。 这样的融合蛋白可以提供与RAGE配体的特异的高亲和力结合。 还公开了RAGE融合蛋白作为RAGE介导的病理学的治疗剂的用途。
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8.发明授权Functional derivatives of ICAM-1 with altered ability to bind LFA-1 or HRV 失效具有改变LFA-1或HRV结合能力的ICAM-1功能衍生物公开(公告)号：US07354588B1
公开(公告)日：2008-04-08
申请号：US08474388
申请日：1995-06-07
IPC分类号： A61K38/17 , A61K38/16 , C07K14/435 , C07K14/705
CPC分类号： C07K16/2845 , A61K38/00 , A61K39/00 , C07K14/70525 , C07K16/2821 , C07K2317/34 , G01N33/5743
摘要： The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.
摘要翻译： 本发明涉及细胞间粘附分子（ICAM-1），其涉及淋巴细胞识别和迁移到炎症部位以及在炎症期间附着于细胞底物的过程。 本发明涉及这样的分子，筛选用于鉴定能够结合这些分子的分子和抗体的测定。 本发明还包括用于粘附分子和能够结合它们的抗体的用途。
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公开(公告)号：US20060078562A1
公开(公告)日：2006-04-13
申请号：US11197644
申请日：2005-08-03
申请人： Adnan Mjalli , David Stern , Ye Tian , Jeffrey Webster , Robert Rothlein
发明人： Adnan Mjalli , David Stern , Ye Tian , Jeffrey Webster , Robert Rothlein
IPC分类号： A61K39/00 , G01N33/53 , C07H21/04 , C12P21/04 , C07K14/705
CPC分类号： C07K16/2803 , A61K38/00 , C07K14/705 , C07K2319/30 , G01N33/6893 , G01N33/6896 , G01N2500/00 , G01N2800/042
摘要： Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.
摘要翻译： 公开了包含与第二非RAGE多肽连接的RAGE多肽序列的RAGE融合蛋白。 RAGE融合蛋白可以利用包含RAGE配体结合位点的RAGE多肽结构域和直接连接到免疫球蛋白H 2结构域的域间连接。 这样的融合蛋白可以提供与RAGE配体的特异的高亲和力结合。 还公开了RAGE融合蛋白作为RAGE介导的病理学的治疗剂的用途。
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公开(公告)号：US20050059705A1
公开(公告)日：2005-03-17
申请号：US10913168
申请日：2004-08-06
申请人： Adnan Mjalli , Robert Andrews , Xiao-Chuan Guo , Daniel Christen , Devi Gohimmukkula , Guoxiang Huang , Robert Rothlein , Sameer Tyagi , Tripura Yaramasu , Christopher Behme
发明人： Adnan Mjalli , Robert Andrews , Xiao-Chuan Guo , Daniel Christen , Devi Gohimmukkula , Guoxiang Huang , Robert Rothlein , Sameer Tyagi , Tripura Yaramasu , Christopher Behme
IPC分类号： A61P31/12 , C07C233/87 , C07C235/42 , C07C235/52 , C07C235/60 , C07C235/66 , C07C237/36 , C07C237/42 , C07C271/20 , C07C311/08 , C07C311/09 , C07C311/21 , C07C311/44 , C07C317/32 , C07C323/36 , C07D295/155 , C07D41/02 , A61K31/4439 , C07D43/02
CPC分类号： C07D295/155 , C07C233/87 , C07C235/42 , C07C235/52 , C07C235/60 , C07C235/66 , C07C237/36 , C07C237/42 , C07C271/20 , C07C311/08 , C07C311/09 , C07C311/21 , C07C311/44 , C07C317/32 , C07C323/36 , C07C2601/08
摘要： This invention provides aryl and heteroaryl compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention may be antagonists, or partial antagonist of factor IX and/or factor XI and thus, may be useful for inhibiting the intrinsic pathway of blood coagulation. The compounds may be useful in a variety of applications including the management, treatment and/or control of diseases caused in part by the intrinsic clotting pathway.
摘要翻译： 本发明提供芳基和杂芳基化合物，其制备方法，包含该化合物的药物组合物及其在治疗人或动物病症中的用途。 本发明的化合物可以是拮抗剂或因子IX和/或因子XI的部分拮抗剂，因此可用于抑制凝血的内在途径。 所述化合物可用于各种应用，包括部分由内在凝血途径引起的疾病的管理，治疗和/或控制。
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