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    Oligonucleotide analogues
    1.
    发明授权
    Oligonucleotide analogues 有权

    公开(公告)号：US08034909B2

    公开(公告)日：2011-10-11

    申请号：US12192581

    申请日：2008-08-15

    申请人： Jesper Wengel ,  Poul Nielsen

    发明人： Jesper Wengel ,  Poul Nielsen

    IPC分类号： C07H21/00 ,  C07H21/02 ,  C12Q1/68

    CPC分类号： C07H21/04

    摘要： The present invention relates to novel bicyclic and tricyclic nucleoside and nucleotide analogues as well as to oligonucleotides comprising such elements. The nucleotide analogues, LNAs (Locked Nucleoside Analogues), are able to provide valuable improvements to oligonucleotides with respect to affinity and specificity towards complementary RNA and DNA oligomers. The novel type of LNA modified oligonucleotides, as well as the LNAs as such, are useful in a wide range of diagnostic applications as well as therapeutic applications. Among these can be mentioned antisense applications, PCR applications, strand displacement oligomers, as substrates for nucleic acid polymerases, as nucleotide based drugs, etc. The present invention also relates to such applications.

    OLIGONUCLEOTIDE ANALOGUES
    2.
    发明申请
    OLIGONUCLEOTIDE ANALOGUES 有权
    寡核苷酸类似物

    公开(公告)号：US20100267018A1

    公开(公告)日：2010-10-21

    申请号：US12190939

    申请日：2008-08-13

    申请人： Jesper Wengel ,  Poul Nielsen

    发明人： Jesper Wengel ,  Poul Nielsen

    IPC分类号： C12Q1/68 ,  C07H21/00

    CPC分类号： C07H21/04

    摘要： The present invention relates to novel bicyclic and tricyclic nucleoside and nucleotide analogues as well as to oligonucleotides comprising such elements. The nucleotide analogues, LNAs (Locked Nucleoside Analogues), are able to provide valuable improvements to oligonucleotides with respect to affinity and specificity towards complementary RNA and DNA oligomers. The novel type of LNA modified oligonucleotides, as well as the LNAs as such, are useful in a wide range of diagnostic applications as well as therapeutic applications. Among these can be mentioned antisense applications, PCR applications, strand displacement oligomers, as substrates for nucleic acid polymerases, as nucleotide based drugs, etc. The present invention also relates to such applications.

    摘要翻译： 本发明涉及新型的双环和三环核苷和核苷酸类似物以及包含这些元件的寡核苷酸。 核苷酸类似物LNA（锁定核苷类似物）能够在对互补RNA和DNA寡聚体的亲和力和特异性方面为寡核苷酸提供有价值的改进。 新型LNA修饰的寡核苷酸以及LNA本身可用于广泛的诊断应用以及治疗应用。 其中可以提及反义应用，PCR应用，链置换寡聚体，作为核酸聚合酶的底物，作为核苷酸的药物等。本发明还涉及这样的应用。

    Oligonucleotide analogues
    3.
    发明授权
    Oligonucleotide analogues 有权
    寡核苷酸类似物

    公开(公告)号：US07572582B2

    公开(公告)日：2009-08-11

    申请号：US11132650

    申请日：2005-05-18

    申请人： Jesper Wengel ,  Poul Nielsen

    发明人： Jesper Wengel ,  Poul Nielsen

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/00 ,  C07H21/02

    CPC分类号： C07H21/04

    摘要： The present invention relates to novel bicyclic and tricyclic nucleoside and nucleotide analogues as well as to oligonucleotides comprising such elements. The nucleotide analogues, LNAs (Locked Nucleoside Analogues), are able to provide valuable improvements to oligonucleotides with respect to affinity and specificity towards complementary RNA and DNA oligomers. The novel type of LNA modified oligonucleotides, as well as the LNAs as such, are useful in a wide range of diagnostic applications as well as therapeutic applications. Among these can be mentioned antisense applications, PCR applications, strand displacement oligomers, as substrates for nucleic acid polymerases, as nucleotide based drugs, etc. The present invention also relates to such applications.

    摘要翻译： 本发明涉及新型的双环和三环核苷和核苷酸类似物以及包含这些元件的寡核苷酸。 核苷酸类似物LNA（锁定核苷类似物）能够在对互补RNA和DNA寡聚体的亲和力和特异性方面为寡核苷酸提供有价值的改进。 新型LNA修饰的寡核苷酸以及LNA本身可用于广泛的诊断应用以及治疗应用。 其中可以提及反义应用，PCR应用，链置换寡聚体，作为核酸聚合酶的底物，作为核苷酸的药物等。本发明还涉及这样的应用。

    Process for the preparation of hydrogen and synthesis gas
    4.
    发明申请
    Process for the preparation of hydrogen and synthesis gas 有权
    氢气和合成气的制备方法

    公开(公告)号：US20050108941A1

    公开(公告)日：2005-05-26

    申请号：US10989306

    申请日：2004-11-17

    申请人： Poul Nielsen ,  Jens Perregaard

    发明人： Poul Nielsen ,  Jens Perregaard

    IPC分类号： B01J23/80 ,  C01B3/02 ,  C01B3/32 ,  C01B3/40 ,  C01B3/42

    CPC分类号： C01B3/323 ,  C01B3/326 ,  C01B2203/0233 ,  C01B2203/1076 ,  C01B2203/1223 ,  Y02P20/52

    摘要： Process for production of synthesis gas comprising carbon monoxide, carbon dioxide and hydrogen by reforming of methanol including the steps of: (a) introducing methanol in liquid phase into a reactor containing a solid methanol reforming catalyst suspended in a liquid phase of methanol and water; (b) reacting the liquid phase of methanol and water in presence of the suspended catalyst at a pressure and temperature, where methanol is maintained in the liquid phase; and (c) withdrawing from the reactor a gas phase of synthesis gas being produced during reaction of the liquid methanol and water phase.

    摘要翻译： 包括以下步骤生产包括一氧化碳，二氧化碳和氢的合成气的方法包括以下步骤：（a）将液相中的甲醇引入到悬浮在甲醇和水的液相中的固体甲醇重整催化剂的反应器中; （b）在甲醇保持在液相的压力和温度下，在悬浮催化剂存在下使甲醇和水的液相反应; 和（c）从反应器中取出在液体甲醇和水相反应期间产生的合成气的气相。

    Oligonucleotide Analogues
    5.
    发明申请
    Oligonucleotide Analogues 有权
    寡核苷酸类似物

    公开(公告)号：US20110245327A1

    公开(公告)日：2011-10-06

    申请号：US12793565

    申请日：2010-06-03

    申请人： Jesper WENGEL ,  Poul Nielsen

    发明人： Jesper WENGEL ,  Poul Nielsen

    IPC分类号： A61K31/7088 ,  C07H21/02 ,  C07H21/04 ,  A61K31/713 ,  A61P35/00 ,  C12Q1/68 ,  C12P19/34 ,  G01N33/53 ,  C07H1/06

    CPC分类号： C07H21/04

    摘要： The present invention relates to novel bicyclic and tricyclic nucleoside and nucleotide analogues as well as to oligonucleotides comprising such elements. The nucleotide analogues, LNAs (Locked Nucleoside Analogues), are able to provide valuable improvements to oligonucleotides with respect to affinity and specificity towards complementary RNA and DNA oligomers. The novel type of LNA modified oligonucleotides, as well as the LNAs as such, are useful in a wide range of diagnostic applications as well as therapeutic applications. Among these can be mentioned antisense applications, PCR applications, strand displacement oligomers, as substrates for nucleic acid polymerases, as nucleotide based drugs, etc. The present invention also relates to such applications.

    摘要翻译： 本发明涉及新型的双环和三环核苷和核苷酸类似物以及包含这些元件的寡核苷酸。 核苷酸类似物LNA（锁定核苷类似物）能够在对互补RNA和DNA寡聚体的亲和力和特异性方面为寡核苷酸提供有价值的改进。 新型LNA修饰的寡核苷酸以及LNA本身可用于广泛的诊断应用以及治疗应用。 其中可以提及反义应用，PCR应用，链置换寡聚体，作为核酸聚合酶的底物，作为核苷酸的药物等。本发明还涉及这样的应用。

    OLIGONUCLEOTIDE ANALOGUES
    6.
    发明申请
    OLIGONUCLEOTIDE ANALOGUES 有权

    公开(公告)号：US20100279895A1

    公开(公告)日：2010-11-04

    申请号：US12192581

    申请日：2008-08-15

    申请人： Jesper Wengel ,  Poul Nielsen

    发明人： Jesper Wengel ,  Poul Nielsen

    IPC分类号： C40B40/06 ,  C07H21/00

    CPC分类号： C07H21/04

    摘要： The present invention relates to novel bicyclic and tricyclic nucleoside and nucleotide analogues as well as to oligonucleotides comprising such elements. The nucleotide analogues, LNAs (Locked Nucleoside Analogues), are able to provide valuable improvements to oligonucleotides with respect to affinity and specificity towards complementary RNA and DNA oligomers. The novel type of LNA modified oligonucleotides, as well as the LNAs as such, are useful in a wide range of diagnostic applications as well as therapeutic applications. Among these can be mentioned antisense applications, PCR applications, strand displacement oligomers, as substrates for nucleic acid polymerases, as nucleotide based drugs, etc. The present invention also relates to such applications.

    Process for synthesis of methanol
    7.
    发明申请
    Process for synthesis of methanol 审中-公开
    合成甲醇的方法

    公开(公告)号：US20060235090A1

    公开(公告)日：2006-10-19

    申请号：US10541224

    申请日：2003-12-09

    申请人： Poul Nielsen ,  Susanne Jorgensen

    发明人： Poul Nielsen ,  Susanne Jorgensen

    IPC分类号： C07C27/26

    CPC分类号： C07C29/145 ,  B01J23/72 ,  B01J23/80 ,  C07C29/141 ,  C07C29/1516 ,  C07C29/154 ,  C07C29/156 ,  Y02P20/142 ,  Y02P20/52 ,  C07C31/04 ,  C07C31/10 ,  C07C31/12

    摘要： The invention provides a process for production of methanol from a feed stream rich in hydrogen carbon monoxide and carbon dioxide. The feed stream is converted to a converted process stream comprising methanol and small amounts of higher alcohols, aldehydes and ketones in the presence of a catalyst active in conversion of hydrogen and carbon monoxide into methanol. The converted process stream is cooled to a cooled process stream to 20-200° C. The cooled process stream is hydrogenated into a hydrogenated process stream rich in methanol and depleted in aldehydes and ketones in presence of a hydrogenation catalyst. The catalyst is active in conversion of aldehydes and ketones into alcohols in a process stream rich in methanol and further comprising hydrogen, carbon monoxide and carbon dioxide. The hydrogenated process stream is cooled to a cooled, condensed process stream, and subsequently the cooled, condensed process stream is separated into a gas phase and a liquid crude methanol phase.

    摘要翻译： 本发明提供从富含氢一氧化碳和二氧化碳的进料流中生产甲醇的方法。 在催化剂存在下，将氢气和一氧化碳转化成甲醇，将原料流转化成包含甲醇和少量高级醇，醛和酮的转化过程物流。 将转化的工艺流冷却至冷却的工艺流至20-200℃。将冷却的工艺流体氢化成氢化催化剂存在下富含甲醇并在醛和酮中消耗的氢化工艺流。 催化剂在富含甲醇的工艺流中将醛和酮转化为醇是有活性的，并且还包含氢气，一氧化碳和二氧化碳。 将氢化工艺流冷却至冷却的冷凝工艺物流，随后将冷却的冷凝工艺物流分离成气相和液体粗甲醇相。

    Oligonucleotide analogues
    9.
    发明申请
    Oligonucleotide analogues 有权
    寡核苷酸类似物

    公开(公告)号：US20050287566A1

    公开(公告)日：2005-12-29

    申请号：US11132650

    申请日：2005-05-18

    申请人： Jesper Wengel ,  Poul Nielsen

    发明人： Jesper Wengel ,  Poul Nielsen

    IPC分类号： C07H21/04 ,  C12Q1/68

    CPC分类号： C07H21/04

    摘要： The present invention relates to novel bicyclic and tricyclic nucleoside and nucleotide analogues as well as to oligonucleotides comprising such elements. The nucleotide analogues, LNAs (Locked Nucleoside Analogues), are able to provide valuable improvements to oligonucleotides with respect to affinity and specificity towards complementary RNA and DNA oligomers. The novel type of LNA modified oligonucleotides, as well as the LNAs as such, are useful in a wide range of diagnostic applications as well as therapeutic applications. Among these can be mentioned antisense applications, PCR applications, strand displacement oligomers, as substrates for nucleic acid polymerases, as nucleotide based drugs, etc. The present invention also relates to such applications.

    摘要翻译： 本发明涉及新型的双环和三环核苷和核苷酸类似物以及包含这些元件的寡核苷酸。 核苷酸类似物LNA（锁定核苷类似物）能够在对互补RNA和DNA寡聚体的亲和力和特异性方面为寡核苷酸提供有价值的改进。 新型LNA修饰的寡核苷酸以及LNA本身可用于广泛的诊断应用以及治疗应用。 其中可以提及反义应用，PCR应用，链置换寡聚体，作为核酸聚合酶的底物，作为核苷酸的药物等。本发明还涉及这样的应用。