公开(公告)号：US20070155791A1

公开(公告)日：2007-07-05

申请号：US11645319

申请日：2006-12-21

Applicant: Jerome Zeldis ,  Patricia Rohane ,  Peter Schafer

Inventor： Jerome Zeldis ,  Patricia Rohane ,  Peter Schafer

IPC: A61K31/454 ,  A61K31/4035

CPC classification number: A61K31/4035 ,  A61K9/2018 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/454 ,  A61K31/5575 ,  A61K45/06 ,  A61K2300/00

Abstract: Methods of treating cutaneous lupus in a human are disclosed. Specific methods encompass the administration of (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione (ACTIMID™), 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione (REVLIMID®), or cyclopropyl 2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindolin-4-yl}carboxamide, alone or alternatively, in combination with a second active agent.

Abstract translation: 公开了治疗人类皮肤狼疮的方法。 具体方法包括（+） - 2- [1-（3-乙氧基-4-甲氧基苯基）-2-甲基磺酰基乙基] -4-乙酰氨基异二氢吲哚-1,3-二酮，4-（氨基）-2-（2 ，6-二氧代（3-哌啶基）） - 异二氢吲哚-1,3-二酮（ACTIMID TM），3-（4-氨基-1-氧代-1,3-二氢 - 异吲哚-2-基） - 哌啶 -2,6-二酮（REVLIMID）或环丙基2 - [（1S）-1-（3-乙氧基-4-甲氧基苯基）-2-（甲基磺酰基）乙基] -3-氧代异二氢吲哚-4-基} 甲酰胺，单独或替代地，与第二活性剂组合。

公开(公告)号：US20100093698A1

公开(公告)日：2010-04-15

申请号：US12555018

申请日：2009-09-08

Applicant: Sogole Bahmanyar ,  R.J. Bates ,  Kate Blease ,  Andrew Antony Calabrese ,  Thomas Oran Daniel ,  Mercedes Delgado ,  Jan Elsner ,  Paul Erdman ,  Bruce Fahr ,  Gregory Ferguson ,  Branden Lee ,  Lisa Nadolny ,  Garrick Packard ,  Patrick Papa ,  Veronique Plantevin-Krenitsky ,  Jennifer Riggs ,  Patricia Rohane ,  Sabita Sankar ,  John Sapienza ,  Yoshitaka Satoh ,  Victor Sloan ,  Randall Stevens ,  Lida Tehrani ,  Jayashree Tikhe ,  Eduardo Torres ,  Andrew Wallace ,  Brandon Wade Whitefield ,  Jingjing Zhao

Inventor： Sogole Bahmanyar ,  R.J. Bates ,  Kate Blease ,  Andrew Antony Calabrese ,  Thomas Oran Daniel ,  Mercedes Delgado ,  Jan Elsner ,  Paul Erdman ,  Bruce Fahr ,  Gregory Ferguson ,  Branden Lee ,  Lisa Nadolny ,  Garrick Packard ,  Patrick Papa ,  Veronique Plantevin-Krenitsky ,  Jennifer Riggs ,  Patricia Rohane ,  Sabita Sankar ,  John Sapienza ,  Yoshitaka Satoh ,  Victor Sloan ,  Randall Stevens ,  Lida Tehrani ,  Jayashree Tikhe ,  Eduardo Torres ,  Andrew Wallace ,  Brandon Wade Whitefield ,  Jingjing Zhao

IPC: A61K31/437 ,  C07D471/02 ,  A61K31/5377 ,  A61K31/497 ,  A61K31/55

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: Provided herein are Heteroaryl Compounds of formula (I): wherein R1 and R2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.

Abstract translation: 本文提供了式（I）的杂芳基化合物：其中R 1和R 2如本文所定义，包含有效量的杂芳基化合物的组合物和用于治疗或预防炎性病症或癌症的方法，以及可通过抑制激酶治疗或预防的病症 或激酶途径，其包括向有需要的受试者施用有效量的杂芳基化合物。

公开(公告)号：US20050186144A1

公开(公告)日：2005-08-25

申请号：US11038343

申请日：2005-01-19

Applicant: Melvyn Bloom ,  Melvyn Danzig ,  Patricia Rohane ,  Heribert Staudinger

Inventor： Melvyn Bloom ,  Melvyn Danzig ,  Patricia Rohane ,  Heribert Staudinger

IPC: A61K9/00 ,  A61K9/14 ,  A61K31/58 ,  A61L9/04

CPC classification number: A61K31/58 ,  A61K9/0043 ,  A61K9/0073 ,  A61K9/008 ,  A61K31/573 ,  A61K45/06 ,  A61K2300/00

Abstract: Disclosed are methods of treating rhinosinusitis of the upper airway passages in patients afflicted with said disease, which comprises administering at least once-a-day to the surfaces of said passages of said patients an amount of aerosolized particles of mometasone furoate as a monotherapy effective for treating said disease.

Abstract translation: 公开了治疗患有该疾病的患者中的上呼吸道通道的鼻鼻窦炎的方法，其包括至少每天向所述患者的所述通道的表面施用一定量的糠酸莫米他松的雾化颗粒作为单一疗法， 治疗所述疾病。

公开(公告)号：US20130005707A1

公开(公告)日：2013-01-03

申请号：US13609412

申请日：2012-09-11

Applicant: Sogole Bahmanyar ,  R.J. Bates ,  Kate Blease ,  Andrew Antony Calabrese ,  Thomas Oran Daniel ,  Mercedes Delgado ,  Jan Elsner ,  Paul Erdman ,  Bruce Fahr ,  Gregory Ferguson ,  Branden Lee ,  Lisa Nadolny ,  Garrick Packard ,  Patrick Papa ,  Veronique Plantevin-Krenitsky ,  Jennifer Riggs ,  Patricia Rohane ,  Sabita Sankar ,  John Sapienza ,  Yoshitaka Satoh ,  Victor Sloan ,  Randall Stevens ,  Lida Tehrani ,  Jayashree Tikhe ,  Eduardo Torres ,  Andrew Wallace ,  Brandon Wade Whitefield ,  Jingjing Zhao

Inventor： Sogole Bahmanyar ,  R.J. Bates ,  Kate Blease ,  Andrew Antony Calabrese ,  Thomas Oran Daniel ,  Mercedes Delgado ,  Jan Elsner ,  Paul Erdman ,  Bruce Fahr ,  Gregory Ferguson ,  Branden Lee ,  Lisa Nadolny ,  Garrick Packard ,  Patrick Papa ,  Veronique Plantevin-Krenitsky ,  Jennifer Riggs ,  Patricia Rohane ,  Sabita Sankar ,  John Sapienza ,  Yoshitaka Satoh ,  Victor Sloan ,  Randall Stevens ,  Lida Tehrani ,  Jayashree Tikhe ,  Eduardo Torres ,  Andrew Wallace ,  Brandon Wade Whitefield ,  Jingjing Zhao

IPC: A61K31/437 ,  A61K31/5377 ,  A61K31/506 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/551 ,  A61P37/00 ,  A61P37/08 ,  A61P29/00 ,  A61P7/02 ,  A61P35/00 ,  A61P31/00 ,  A61P25/28 ,  A61P9/00 ,  A61P3/00 ,  A61P37/06 ,  A61P19/02 ,  A61P17/00 ,  A61P31/12 ,  A61P3/10 ,  A61P25/00 ,  A61P21/04 ,  A61P1/00 ,  A61P11/02 ,  A61P11/00 ,  A61P17/06 ,  A61P3/04 ,  A61P19/06 ,  A61P9/10 ,  C12N5/071 ,  A61K31/4709

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: Provided herein are Heteroaryl Compounds of formula (I): wherein R1 and R2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.

Abstract translation: 本文提供了式（I）的杂芳基化合物：其中R 1和R 2如本文所定义，包含有效量的杂芳基化合物的组合物和用于治疗或预防炎性病症或癌症的方法，以及可通过抑制激酶治疗或预防的病症 或激酶途径，其包括向有需要的受试者施用有效量的杂芳基化合物。

公开(公告)号：US20060183788A1

公开(公告)日：2006-08-17

申请号：US11392846

申请日：2006-03-28

Applicant: George Muller ,  Peter Schafer ,  Patricia Rohane

Inventor： George Muller ,  Peter Schafer ,  Patricia Rohane

IPC: A61K31/4035

CPC classification number: A61K31/4035 ,  C07B2200/07 ,  C07C317/28 ,  C07D209/48

Abstract: Methods of treating, managing or preventing exercise-induced asthma are disclosed. Specific methods encompass the administration of (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione alone or in combination with a second active agent. Pharmaceutical compositions and single unit dosage forms are also disclosed.

Abstract translation: 公开了治疗，治疗或预防运动性哮喘的方法。 具体方法包括单独或与第二活性剂组合施用（+） - 2- [1-（3-乙氧基-4-甲氧基苯基）-2-甲基磺酰基乙基] -4-乙酰氨基异吲哚啉-1,3-二酮。 还公开了药物组合物和单一单位剂型。

公开(公告)号：US20060183787A1

公开(公告)日：2006-08-17

申请号：US11392845

申请日：2006-03-28

Applicant: George Muller ,  Peter Schafer ,  Patricia Rohane

Inventor： George Muller ,  Peter Schafer ,  Patricia Rohane

IPC: A61K31/4035

CPC classification number: A61K31/4035

Abstract: Methods of treating, managing or preventing psoriatic arthritis are disclosed. Specific methods encompass the administration of (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione alone or in combination with a second active agent. Pharmaceutical compositions and single unit dosage forms are also disclosed.

Abstract translation: 公开了治疗，治疗或预防银屑病关节炎的方法。 具体方法包括单独或与第二活性剂组合施用（+） - 2- [1-（3-乙氧基-4-甲氧基苯基）-2-甲基磺酰基乙基] -4-乙酰氨基异吲哚啉-1,3-二酮。 还公开了药物组合物和单一单位剂型。

公开(公告)号：US20060148882A1

公开(公告)日：2006-07-06

申请号：US11299702

申请日：2005-12-13

Applicant: Jerome Zeldis ,  Patricia Rohane ,  Peter Schafer

Inventor： Jerome Zeldis ,  Patricia Rohane ,  Peter Schafer

IPC: A61K31/4035 ,  A61K31/522 ,  A61K31/557

CPC classification number: A61K31/4245 ,  A61K31/00 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/522 ,  A61K31/557 ,  A61K45/06 ,  A61K2300/00

Abstract: Methods of treating, preventing, and managing airway inflammation and other airway or pulmonary diseases and disorders are disclosed. Specific methods comprise the administration of a PDE4 modulator, or a pharmaceutically acceptable salt, solvate, stereoisomer, or prodrug thereof, alone or in combination with a second active agent and/or other conventional therapies. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

Abstract translation: 公开了治疗，预防和管理气道炎症和其它气道或肺部疾病和病症的方法。 具体方法包括单独或与第二活性剂和/或其它常规疗法组合施用PDE4调节剂或其药学上可接受的盐，溶剂合物，立体异构体或前药。 还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。

公开(公告)号：US08299056B2

公开(公告)日：2012-10-30

申请号：US12555018

申请日：2009-09-08

Applicant: Sogole Bahmanyar ,  R.J. Bates ,  Kate Blease ,  Andrew Calabrese ,  Thomas Daniel ,  Mercedes Delgado ,  Jan Elsner ,  Paul Erdman ,  Bruce Fahr ,  Gregory Ferguson ,  Branden Lee ,  Lisa Nadolny ,  Garrick Packard ,  Patrick Papa ,  Veronique Plantevin-Krenitsky ,  Jennifer Riggs ,  Patricia Rohane ,  Sabita Sankar ,  John Sapienza ,  Yoshitaka Satoh ,  Victor Sloan ,  Randall Stevens ,  Lida Tehrani ,  Jayashree Tikhe ,  Eduardo Torres ,  Andrew Wallace ,  Brandon Wade Whitefield ,  Jingjing Zhao

Inventor： Sogole Bahmanyar ,  R.J. Bates ,  Kate Blease ,  Andrew Calabrese ,  Thomas Daniel ,  Mercedes Delgado ,  Jan Elsner ,  Paul Erdman ,  Bruce Fahr ,  Gregory Ferguson ,  Branden Lee ,  Lisa Nadolny ,  Garrick Packard ,  Patrick Papa ,  Veronique Plantevin-Krenitsky ,  Jennifer Riggs ,  Patricia Rohane ,  Sabita Sankar ,  John Sapienza ,  Yoshitaka Satoh ,  Victor Sloan ,  Randall Stevens ,  Lida Tehrani ,  Jayashree Tikhe ,  Eduardo Torres ,  Andrew Wallace ,  Brandon Wade Whitefield ,  Jingjing Zhao

IPC: A61K31/437 ,  A61K31/5377 ,  A61K31/497 ,  A61K31/55 ,  C07D471/02

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: Provided herein are Heteroaryl Compounds of formula (I): wherein R1 and R2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.

Abstract translation: 本文提供了式（I）的杂芳基化合物：其中R 1和R 2如本文所定义，包含有效量的杂芳基化合物的组合物和用于治疗或预防炎性病症或癌症的方法，以及可通过抑制激酶治疗或预防的病症 或激酶途径，其包括向有需要的受试者施用有效量的杂芳基化合物。

公开(公告)号：US20090022671A1

公开(公告)日：2009-01-22

申请号：US12171989

申请日：2008-07-11

Applicant: Melvyn Bloom ,  Melvyn R. Danzig ,  Patricia Rohane ,  Heribert W. Staudinger

Inventor： Melvyn Bloom ,  Melvyn R. Danzig ,  Patricia Rohane ,  Heribert W. Staudinger

IPC: A61K9/14 ,  A61K31/58 ,  A61K31/573 ,  A61K31/56

CPC classification number: A61K31/58 ,  A61K9/0043 ,  A61K9/0073 ,  A61K9/008 ,  A61K31/573 ,  A61K45/06 ,  A61K2300/00

Abstract: Disclosed are methods of treating rhinosinusitis of the upper airway passages in patients afflicted with said disease, which comprises administering at least once-a-day to the surfaces of said passages of said patients an amount of aerosolized particles of mometasone furoate as a monotherapy effective for treating said disease.

Abstract translation: 公开了治疗患有该疾病的患者中的上呼吸道通道的鼻鼻窦炎的方法，其包括至少每天向所述患者的所述通道的表面施用一定量的糠酸莫米他松的雾化颗粒作为单一疗法， 治疗所述疾病。

公开(公告)号：US20060276495A1

公开(公告)日：2006-12-07

申请号：US11406837

申请日：2006-04-19

Applicant: Luis Salmun ,  Patricia Rohane ,  Richard Lorber

Inventor： Luis Salmun ,  Patricia Rohane ,  Richard Lorber

IPC: A61K31/473

CPC classification number: A61K31/137 ,  A61K31/473 ,  A61K2300/00

Abstract: The use of desloratadine and/or other antihistamines for treating and/or preventing severe nasal congestion and/or nasal blockage associated with allergic and inflammatory conditions of the upper and lower airway passages in a human.