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1.发明申请公开(公告)号：US20170199364A1
公开(公告)日：2017-07-13
申请号：US14991208
申请日：2016-01-08
申请人： Optomak, Inc.
IPC分类号： G02B21/08 , G02B21/02 , F21V8/00 , A61B5/00 , G02B21/16 , G02B21/00 , A61N5/06 , G02B13/00 , G02B27/14
CPC分类号： G02B21/082 , A61B5/0071 , A61N5/0622 , G02B6/0006 , G02B13/0095 , G02B21/0008 , G02B21/02 , G02B21/16 , G02B27/141
摘要： A miniaturized microscope provides the combined capability for simultaneous or sequential optogenetic stimulation of light sensitive ion channels with the capability for fluorescence imaging of fluorescent proteins for applications requiring simultaneous optical stimulation and monitoring of cell activity. The microscope includes a dual illumination output coupling for providing illumination to two different regions within the sample and/or two different illumination source inputs and a dual transmission band optical filter to clean two different bands of light that are separately available for optogenetic stimulation and fluorescence imaging.
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公开(公告)号：US20140226932A1
公开(公告)日：2014-08-14
申请号：US14150141
申请日：2014-01-08
申请人： Optomak, Inc.
发明人： Sead Doric
CPC分类号： G02B6/3604 , G02B6/32 , Y10T29/49826
摘要： A dual optical path rotary joint provides a low friction coupling of optical fiber connections for optogenetic research and other applications. Two optical paths are provided through the rotary joint which are rotation-insensitive. The ends of the rotary joint rotate with respect to a common housing, which may be provided with ball-bearings or other suitable low-friction rotational mounts in which a first rotating component and a second rotating component are secured. The first and second rotating components are not mechanically linked in rotation, and their rotation is only synchronized by magnets disposed on the first rotating component and the second rotating component. A pair of optical fibers is coupled to the first rotating component and another pair of optical fiber is coupled to the second rotating component. A pair of isolated optical paths links the pairs of fibers, which are directed between the first and second rotating components by reflection.
摘要翻译： 双光路旋转接头提供光纤连接的低摩擦耦合用于光遗传研究和其他应用。 通过旋转接头提供两个光路，这些旋转接头是旋转不敏感的。 旋转接头的端部相对于公共壳体旋转，公共壳体可以设置有球轴承或其中适当的低摩擦旋转安装件，其中固定有第一旋转部件和第二旋转部件。 第一和第二旋转部件在旋转中不机械连接，并且它们的旋转仅由布置在第一旋转部件和第二旋转部件上的磁体同步。 一对光纤耦合到第一旋转部件，另一对光纤耦合到第二旋转部件。 一对孤立的光路通过反射连接在第一和第二旋转部件之间的纤维对。
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公开(公告)号：US10422506B2
公开(公告)日：2019-09-24
申请号：US16102007
申请日：2018-08-13
申请人： Optomak, Inc.
发明人： Guy Rousseau , Sead Doric
IPC分类号： B60Q1/26 , F21V7/06 , F21V29/76 , F21V5/04 , F21K9/64 , H01S5/024 , F21V9/08 , H01S5/022 , H01S5/40 , F21Y115/30
摘要： A pumped fluorescent light source includes a parabolic mirror that is positioned to focus pumping light from one or more pump sources on a fluorescent body. The resulting assembly provides for heat collection from a back surface of the light source for both the fluorescent body and the pumping sources in a compact package that may be hermetically sealed. The parabolic mirror has reflective surfaces disposed outside of a collection area of an output beam of the light sources, so that the collection area is not obstructed by the parabolic mirror. The light source also includes a collecting lens for collecting the light emitted by the body. The parabolic mirror focuses the stimulus light on the fluorescent body to stimulate emission. An additional parabolic mirror may be included behind the fluorescent body to focus the fluorescent emissions that do not directly enter the collection area at a point of collection.
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公开(公告)号：US10094536B1
公开(公告)日：2018-10-09
申请号：US15459056
申请日：2017-03-15
申请人： Optomak, Inc.
发明人： Guy Rousseau , Sead Doric
IPC分类号： F21V7/00 , F21V7/06 , F21V29/76 , F21V5/04 , H01S5/40 , F21V9/08 , F21K9/64 , H01S5/024 , F21Y115/30
摘要： A pumped fluorescent light source includes a parabolic mirror that is positioned to focus pumping light from one or more pump sources on a fluorescent body. The resulting assembly provides for heat collection from a back surface of the light source for both the fluorescent body and the pumping sources in a compact package that may be hermetically sealed. The parabolic mirror has reflective surfaces disposed outside of a collection area of an output beam of the light sources, so that the collection area is not obstructed by the parabolic mirror. The light source also includes a collecting lens for collecting the light emitted by the body. The parabolic mirror focuses the stimulus light on the fluorescent body to stimulate emission. An additional parabolic mirror may be included behind the fluorescent body to focus the fluorescent emissions that do not directly enter the collection area at a point of collection.
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公开(公告)号：US20180266658A1
公开(公告)日：2018-09-20
申请号：US15459056
申请日：2017-03-15
申请人： Optomak, Inc.
发明人： Guy Rousseau , Sead Doric
摘要： A pumped fluorescent light source includes a parabolic mirror that is positioned to focus pumping light from one or more pump sources on a fluorescent body. The resulting assembly provides for heat collection from a back surface of the light source for both the fluorescent body and the pumping sources in a compact package that may be hermetically sealed. The parabolic mirror has reflective surfaces disposed outside of a collection area of an output beam of the light sources, so that the collection area is not obstructed by the parabolic mirror. The light source also includes a collecting lens for collecting the light emitted by the body. The parabolic mirror focuses the stimulus light on the fluorescent body to stimulate emission. An additional parabolic mirror may be included behind the fluorescent body to focus the fluorescent emissions that do not directly enter the collection area at a point of collection.
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公开(公告)号：US09207405B2
公开(公告)日：2015-12-08
申请号：US14088924
申请日：2013-11-25
申请人： Optomak, Inc.
发明人： Sead Doric
CPC分类号： G02B6/3604 , G02B6/32 , G02B6/3504 , G02B6/3628
摘要： A hybrid rotary joint provides both optical and fluid channels for applications such as optogenetic research. The rotary joint has a stationary component and a rotating component. The optical channel and fluid channel permit simultaneous and rotation-insensitive passage of light and fluid from the stationary to the rotating side of the hybrid rotary joint. The input to the optical channel is provided via an input optical fiber and the input to the fluid channel is fluid from a fluid source. The outputs are an optical fiber output and a fluid channel output. As light passes from the stationary side to the rotating side of the hybrid rotary joint, it is deflected off a beam deflector having an angular orientation that is passively aligned and made independent of the angular orientation of the rotating component via the interaction between magnets attached to each of the beam deflector and the stationary component.
摘要翻译： 混合旋转接头为诸如光遗传研究的应用提供光学和液体通道。 旋转接头具有固定部件和旋转部件。 光通道和流体通道允许光和流体从混合旋转接头的静止到旋转侧同时和旋转不敏感地通过。 通过输入光纤提供到光通道的输入，并且流体通道的输入是来自流体源的流体。 输出是光纤输出和流体通道输出。 当光从固定侧经过混合旋转接头的旋转侧时，它被偏转成具有被动对准的角度取向的光束偏转器，并且通过与附接到 每个光束偏转器和固定部件。
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7.发明公开公开(公告)号：US20230152228A1
公开(公告)日：2023-05-18
申请号：US17530262
申请日：2021-11-18
申请人： Optomak, Inc.
发明人： Alex Côté , Jean-Luc Néron , Emir Karamehmedovic , Sead Doric
CPC分类号： G01N21/6456 , A61B5/0071 , G01N2021/6484
摘要： A optical system and imaging device provide simultaneous or sequential optogenetic stimulation of different locations within a biological sample and fluorescence imaging of the locations. The systems include an illumination array with multiple electrically addressable elements that select a spatial pattern of illumination, an optical fiber bundle with fibers coupled between the array element and target locations at the sample, a fluorescence illumination source, and an imaging system for measuring fluorescence returning from the target locations. The optical imaging devices include a housing and a sample connector configured for receiving a first optical fiber bundle connection including multiple optical fibers. The sample connector has an indexing feature to maintain a fixed relationship between the fibers and internal optical paths of the device. The imaging devices also include an indexed input connector to receive another fiber bundle that carries the stimulus pattern, and a fluorescence excitation input connector.
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公开(公告)号：US10564101B1
公开(公告)日：2020-02-18
申请号：US16179254
申请日：2018-11-02
申请人： Optomak, Inc.
摘要： A multi-site fluorescence recording system provides simultaneous monitoring of cell activity in different brain regions of a freely moving animal. The system includes an electrical rotary joint that couples signals to and from an external data acquisition and control unit connected to a stator of the rotary joint, which releases twisting of the optical fibers connected to the animal. Electrical signals are coupled to one or more fluorescence stimulation/detection units on the rotor of the rotary joint. The fluorescence stimulation/detection units receive one or more connections from optical fibers that connect the stimulation/detection unit(s) to the different brain sites. The rotating stimulation/detection units include spectral filters to separate the excitation light from the fluorescence signal, light sensors (an image sensor or photodiodes) and excitation light sources.
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公开(公告)号：US10274712B2
公开(公告)日：2019-04-30
申请号：US15695484
申请日：2017-09-05
申请人： Optomak, Inc.
发明人： Sead Doric , Harold Dehez , Marie-Andrée Houle
IPC分类号： G02B21/00 , G02B21/08 , G02B13/00 , G02B21/02 , F21V8/00 , G02B27/14 , G02B21/16 , A61N5/06 , A61B5/00 , G02B13/14 , G02B21/18 , G02B21/36
摘要： A miniaturized microscope having a tunable focal length provides for fluorescence measurements at an adjustable focus, providing for autofocus and/or depth adjustment of an image measurement without altering or adjusting a probe implanted in a sample and while providing collimated illumination of an area within the sample. The microscope includes an objective lens having a fixed position with respect to a second connector for receiving light returning from the sample and focusing it on an image sensor within the microscope that generates an image output, a beamsplitter for separating light returning from the sample, and an electrically-tunable lens positioned between the objective lens and the image sensor for adjusting an optical path length from the optical interface to the image sensor. The illumination is focused at or near a back focal plane of the objective lens to the sample, providing collimated or quasi-collimated illumination on or within the sample.
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公开(公告)号：US20170363849A1
公开(公告)日：2017-12-21
申请号：US15695484
申请日：2017-09-05
申请人： Optomak, Inc.
发明人： Sead Doric , Harold Dehez , Marie-Andrée Houle
IPC分类号： G02B21/08 , G02B21/16 , G02B21/02 , G02B21/00 , G02B13/00 , F21V8/00 , A61N5/06 , G02B27/14 , A61B5/00
CPC分类号： G02B21/082 , A61B5/0071 , A61B5/0084 , A61N5/0622 , G02B6/0006 , G02B13/0095 , G02B13/14 , G02B21/0008 , G02B21/02 , G02B21/16 , G02B21/18 , G02B21/361 , G02B27/141
摘要： A miniaturized microscope having a tunable focal length provides for fluorescence measurements at an adjustable focus, providing for autofocus and/or depth adjustment of an image measurement without altering or adjusting a probe implanted in a sample and while providing collimated illumination of an area within the sample. The microscope includes an objective lens having a fixed position with respect to a second connector for receiving light returning from the sample and focusing it on an image sensor within the microscope that generates an image output, a beamsplitter for separating light returning from the sample, and an electrically-tunable lens positioned between the objective lens and the image sensor for adjusting an optical path length from the optical interface to the image sensor. The illumination is focused at or near a back focal plane of the objective lens to the sample, providing collimated or quasi-collimated illumination on or within the sample.
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