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    Method of Purifying Nucleic Acids Using Modified Solid Phases
    1.
    发明公开
    Method of Purifying Nucleic Acids Using Modified Solid Phases 审中-公开

    公开(公告)号：US20240263166A1

    公开(公告)日：2024-08-08

    申请号：US18429891

    申请日：2024-02-01

    Applicant: OMEGA BIO-TEK, INC.

    Inventor： Christopher Stuart ,  Daniel Flanigan ,  Julie Baggs

    IPC: C12N15/10

    CPC classification number: C12N15/1013

    Abstract: A method of purifying nucleic acids using solid phases that are modified by a blocking reagent to limit the binding area and/or binding site of the solid phases to reduce the binding capacity of the solid phase to the nucleic acids. The starting amount of the nucleic acids exceeds the binding capacity of the solid phase, and the amount of the purified nucleic acid is in a fix amount, not proportional to the starting amount of the nucleic acids.

    Selective Nucleic Acid Fragment Recovery
    3.
    发明申请
    Selective Nucleic Acid Fragment Recovery 有权
    选择性核酸片段恢复

    公开(公告)号：US20150166592A1

    公开(公告)日：2015-06-18

    申请号：US14556493

    申请日：2014-12-01

    Applicant: Omega Bio-Tek, Inc.

    Inventor： Qi Guo

    IPC: C07H1/06 ,  C07H21/04

    CPC classification number: C07H1/06 ,  C07H21/04 ,  C12N15/1006

    Abstract: The invention provides methods and kits for nucleic acid purification and fragment selection and recovery. By adjusting salt concentrations and/or pH of the binding buffers, only nucleic acid fragments with desired size ranges are able to reversibly and non-specifically bind to a solid surface in certain salt concentrations and/or pH conditions, and can be subsequently eluted and/or recovered from the solid surface in water and/or a low salt eluting buffer.

    Abstract translation: 本发明提供了用于核酸纯化和片段选择和回收的方法和试剂盒。 通过调节结合缓冲液的盐浓度和/或pH值，只有具有所需大小范围的核酸片段能够在某些盐浓度和/或pH条件下可逆地和非特异性地结合固体表面，并且随后可以洗脱， /或从水和/或低盐洗脱缓冲液中的固体表面回收。

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